SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing 17892 FitnessBrowser__Keio:17892 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P21177 Fatty acid oxidation complex subunit alpha; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Escherichia coli (strain K12) (see 2 papers)
100% identity, 100% coverage: 1:729/729 of query aligns to 1:729/729 of P21177

query
sites
P21177

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G116 (= G116) mutation to F: Absence of both enoyl-CoA hydratase and 3-hydroxyacyl-CoA epimerase activities. Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase is only slightly affected.
G322 (= G322) mutation to A: 10-fold increase in KM for NADH.
H450 (= H450) active site, For 3-hydroxyacyl-CoA dehydrogenase activity; mutation H->A,Q: Almost complete loss of 3-hydroxyacyl-CoA dehydrogenase activity.

6tnmA E. Coli aerobic trifunctional enzyme subunit-alpha (see paper)
100% identity, 99% coverage: 1:719/729 of query aligns to 1:719/719 of 6tnmA

query
sites
6tnmA

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Q

Q

R

R

M

M

Q

Q

K

K

D

D

Y

Y

R

R

D

D

A

A

I

I

D

D

A

A

L

L

F

F

D

D

A

A

N

N

R

R

F

F

G

G

Q

Q

K
|
K

N

N

G

G

L

L

G

G

F

F

W

W

R

R

Y

Y

K

K

E

E

D

D

S

S

K

K

G

G

K

K

P

P

K

K

K

K

E

E

E

E

D

D

A

A

A

A

V

V

E

E

D

D

L

L

L

L

A

A

E

E

V

V

S

S

Q

Q

P

P

K

K

R

R

D

D

F

F

S

S

E

E

E

E

E

E

I

I

I

I

A

A

R

R

M

M

M

M

I

I

P

P

M

M

V

V

N

N

E

E

V

V

V

V

R

R

C

C

L

L

E

E

E

E

G

G

I

I

I

I

A

A

T

T

P

P

A

A

E

E

A

A

D

D

M

M

A

A

L

L

V

V

Y

Y

G

G

L

L

G

G

F

F

P

P

P

P

F

F

H

H

G

G

G

G

A

A

F

F

R

R

W

W

L

L

D

D

T

T

L

L

G

G

S

S

A

A

K

K

Y

Y

L

L

D

D

M

M

A

A

Q

Q

Q

Q

Y

Y

Q

Q

H

H

L

L

G

G

P

P

L

L

Y

Y

E

E

V

V

P

P

E

E

G

G

L

L

R

R

N

N

K

K

A

A

R

R

H

H

N

N

E

E

P

P

Y

Y

Y

Y

P

P

P

P

V

V

E

E

P

P

active site: A68 (= A68), F73 (= F73), G116 (= G116), E119 (= E119), P138 (= P138), E139 (= E139), G147 (= G147), N271 (= N271), S429 (= S429), H450 (= H450), E462 (= E462), N500 (= N500)
binding adenosine-5'-triphosphate: D343 (= D343), I344 (= I344), V400 (= V400), V401 (= V401), V406 (= V406), K584 (= K584)

1wdlA Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form ii (native4) (see paper)
57% identity, 98% coverage: 1:714/729 of query aligns to 1:714/715 of 1wdlA

query
sites
1wdlA

M

M

L

I

Y

Y

K

E

G

G

D

K

T

A

L

I

Y

T

L

V

D

T

W

A

L

L

E

E

D

S

G

G

I

I

A

V

E

E

L

L

V

K

F

F

D

D

A

L

P

K

G

G

-

E

S

S

V

V

N

N

K

K

L

F

D

N

T

R

A

L

T

T

V

L

A

N

S

E

L

L

G

R

E

Q

A

A

I

V

G

D

V

A

L

I

E

K

Q

A

Q

D

S

A

D

S

L

V

K

K

G

G

L

V

L

I

L

V

R

S

S

S

N

G

K

K

A

D

A

V

F

F

I

I

V

V

G

G

A
|
A

D

D

I

I

T

T

E

E

F

F

L

V

S

E

L

N

F

F

L

K

V

L

P

P

E

D

E

A

Q

E

L

L

S

I

Q

A

W

G

L
x
N

H

L

F

E

A

A

N
|
N

S

K

V

I

F

F

N

S

R

D

L

F

E

E

D

D

L

L

P

N

V

V

P

P

T

T

I

V

A

A

A

A

V

I

N

N

G

G

Y

I

A

A

L

L

G

G

G
|
G

G

G

C

L

E
|
E

C

M

V

C

L

L

A

A

T

A

D

D

Y

F

R

R

L

V

A

M

T

A

P

D

D

S

L

A

R

K

I

I

G

G

L

L

P
|
P

E
|
E

T

V

K

K

L

L

G

G

I

I

M

Y

P
|
P

G
|
G

F

F

G

G

G

G

S

T

V

V

R

R

M

L

P

P

R

R

M

L

L

I

G

G

A

V

D

D

S

N

A

A

L

V

E

E

I

W

I

I

A

A

A

S

G

G

K

K

D

E

V

N

G

R

A

A

D

E

Q

D

A

A

L

L

K

K

I

V

G

S

L

A

V

V

D

D

G

A

V

V

V

V

K

T

A

A

E

D

K

K

L

L

V

G

E

A

G

A

A

A

K

L

A

D

V

L

L

I

R

K

Q

R

A

A

I

I

N

S

G

G

D

E

L

L

D

D

W

Y

K

K

A

A

K

K

R

R

Q

Q

P

P

K

K

L

L

E

E

P

K

L

L

K

K

L

L

S

N

K

A

I

I

E

E

A

Q

T

M

M

M

S

A

F

F

T

E

I

T

A

A

K

K

G

G

M

F

V

V

A

A

Q

G

T

Q

A

A

G

G

K

P

H

N

Y

Y

P

P

A

A

P

P

I

V

T

E

A

A

V

I

K

K

T

T

I

I

E

Q

A

K

A

A

A

A

R

N

F

F

G

G

R

R

E

D

E

K

A

A

L

L

N

E

L

V

E

E

N

A

K

A

S

G

F

F

V

A

P

K

L

L

A

A

H

K

T

T

N

S

E

A

A

S

R

N

A

C

L

L

V

I

G

G

I

L

F

F

L

L

N

N

D

D

Q

Q

Y

E

V

L

K

K

G

K

K

K

A

A

K

K

K

V

L

Y

T

D

K

K

D

I

V

A

E

K

T

D

P

V

K

K

Q

Q

A

A

A

A

V

V

L

L

G
|
G

A
|
A

G

G

I
|
I

M
|
M

G

G

G

G

G

G

I

I

A

A

Y

Y

Q

Q

S

S

A

A

W

S

K

K

G

G

V

T

P

P

V

I

V

L

M

M

K

K

D
|
D

I
|
I

N

N

D

E

K

H

S

G

L

I

T

E

L

Q

G

G

M

L

T

A

E

E

A

A

A

A

K

K

L

L

L

L

N

V

K

G

Q

R

L

V

E

D

R

K

G

G

K

R

I

M

D

T

G

P

L

A

K

K

L

M

A

A

G

E

V

V

I

L

S

N

T

G

I

I

H

R

P

P

T

T

L

L

D

S

Y

Y

A

G

G

D

F

F

D

G

R

N

V

V

D

D

I

L

V

V

V

V

E

E

A
|
A

V
|
V

V
|
V

E
|
E

N

N

P

P

K

K

V

V

K
|
K

K

Q

A

A

V
|
V

L

L

A

A

E

E

T

V

E

E

Q

N

K

H

V

V

R

R

Q

E

D

D

T

A

V

I

L

L

A

A

S

S

N
|
N

T
|
T

S
|
S

T

T

I

I

P

S

I

I

S

S

E

L

L

L

A

A

N

K

A

A

L

L

E

K

R

R

P

P

E

E

N

N

F

F

C

V

G

G

M

M

H
|
H

F

F

F

F

N

N

P

P

V

V

H

H

R

M

M

M

P

P

L

L

V

V

E
|
E

I

V

I

I

R

R

G

G

E

E

K

K

S

S

S

S

D

D

E

L

T

A

I

V

A

A

K

T

V

T

V

V

A

A

W

Y

A

A

S

K

K

K

M

M

G

G

K

K

T

N

P

P

I

I

V

V

V

V

N

N

D

D

C

C

P

P

G

G

F

F

F

L

V

V

N
|
N

R

R

V

V

L

L

F

F

P

P

Y

Y

F

F

A

G

G

G

F

F

S

A

Q

K

L

L

L

V

R

S

D

A

G

G

A

V

D

D

F

F

R

V

K

R

I

I

D

D

K

K

V

V

M

M

E

E

K

K

Q

-

F

F

G

G

W

W

P

P

M

M

G

G

P

P

A

A

Y

Y

L

L

L

M

D

D

V

V

V

V

G

G

I

I

D

D

T

T

A

G

H

H

H

H

A

G

Q

R

A

D

V

V

M

M

A

A

A

E

G

G

F

F

P

P

Q

D

R

R

M

M

Q

K

K

D

D

D

Y

R

R

R

D

S

A

A

I

I

D

D

A

A

L

L

F

Y

D

E

A

A

N

K

R

R

F

L

G

G

Q

Q

K

K

N

N

G

G

L

K

G

G

F

F

W

Y

R

A

Y

Y

K

E

E

A

D

D

S

K

K

K

G

G

K

K

P

Q

K

K

K

K

E

L

E

V

D

D

A

S

A

S

V

V

E

L

D

E

L

V

L

L

A

K

E

P

V

I

S

V

Q

Y

P

E

K

Q

R

R

D

D

F

V

S

T

E

D

E

E

E

D

I

I

I

I

A

N

R

W

M

M

M

M

I

I

P

P

M

L

V

C

N

L

E

E

V

T

V

V

R

R

C

C

L

L

E

E

E

D

G

G

I

I

I

V

A

E

T

T

P

A

A

A

E

E

A

A

D

D

M

M

A

G

L

L

V

V

Y

Y

G

G

L

I

G

G

F

F

P

P

P

L

F

F

H

R

G

G

G

G

A

A

F

L

R

R

W

Y

L

I

D

D

T

S

L

I

G

G

S

V

A

A

K

E

Y

F

L

V

D

A

M

L

A

A

Q

D

Q

Q

Y

Y

Q

A

H

E

L

L

G

G

P

A

L

L

Y

Y

E

H

V

P

P

T

E

A

G

K

L

L

R

R

N

E

K

M

A

A

R

K

H

N

N

G

E

Q

P

S

Y

F

Y

F

active site: A69 (= A68), N89 (≠ L88), N93 (= N92), G117 (= G116), E120 (= E119), P139 (= P138), E140 (= E139), P147 (= P146), G148 (= G147), S430 (= S429), H451 (= H450), E463 (= E462), N501 (= N500)
binding nicotinamide-adenine-dinucleotide: G321 (= G320), A322 (= A321), I324 (= I323), M325 (= M324), D344 (= D343), I345 (= I344), A400 (= A399), V401 (= V400), V402 (= V401), E403 (= E402), K408 (= K407), V411 (= V410), N428 (= N427), T429 (= T428), S430 (= S429)

P28793 Fatty acid oxidation complex subunit alpha; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Pseudomonas fragi (see paper)
57% identity, 98% coverage: 1:714/729 of query aligns to 1:714/715 of P28793

query
sites
P28793

M

M

L

I

Y

Y

K

E

G

G

D

K

T

A

L

I

Y

T

L

V

D

T

W

A

L

L

E

E

D

S

G

G

I

I

A

V

E

E

L

L

V

K

F

F

D

D

A

L

P

K

G

G

-

E

S

S

V

V

N

N

K

K

L

F

D

N

T

R

A

L

T

T

V

L

A

N

S

E

L

L

G

R

E

Q

A

A

I

V

G

D

V

A

L

I

E

K

Q

A

Q

D

S

A

D

S

L

V

K

K

G

G

L

V

L

I

L

V

R

S

S

S

N

G

K

K

A

D

A

V

F

F

I

I

V

V

G

G

A

A

D

D

I

I

T

T

E

E

F

F

L

V

S

E

L

N

F

F

L

K

V

L

P

P

E

D

E

A

Q

E

L

L

S

I

Q

A

W

G

L

N

H

L

F

E

A

A

N

N

S

K

V

I

F

F

N

S

R

D

L

F

E

E

D

D

L

L

P

N

V

V

P

P

T

T

I

V

A

A

A

A

V

I

N

N

G

G

Y

I

A

A

L

L

G

G

G

G

G

G

C

L

E

E

C

M

V

C

L

L

A

A

T

A

D

D

Y

F

R

R

L

V

A

M

T

A

P

D

D

S

L

A

R

K

I

I

G

G

L

L

P

P

E

E

T

V

K

K

L

L

G

G

I

I

M

Y

P

P

G

G

F

F

G

G

G

G

S

T

V

V

R

R

M

L

P

P

R

R

M

L

L

I

G

G

A

V

D

D

S

N

A

A

L

V

E

E

I

W

I

I

A

A

A

S

G

G

K

K

D

E

V

N

G

R

A

A

D

E

Q

D

A

A

L

L

K

K

I

V

G

S

L

A

V

V

D

D

G

A

V

V

V

V

K

T

A

A

E

D

K

K

L

L

V

G

E

A

G

A

A

A

K

L

A

D

V

L

L

I

R

K

Q

R

A

A

I

I

N

S

G

G

D

E

L

L

D

D

W

Y

K

K

A

A

K

K

R

R

Q

Q

P

P

K

K

L

L

E

E

P

K

L

L

K

K

L

L

S

N

K

A

I

I

E

E

A

Q

T

M

M

M

S

A

F

F

T

E

I

T

A

A

K

K

G

G

M

F

V

V

A

A

Q

G

T

Q

A

A

G

G

K

P

H

N

Y

Y

P

P

A

A

P

P

I

V

T

E

A

A

V

I

K

K

T

T

I

I

E

Q

A

K

A

A

A

A

R

N

F

F

G

G

R

R

E

D

E

K

A

A

L

L

N

E

L

V

E

E

N

A

K

A

S

G

F

F

V

A

P

K

L

L

A

A

H

K

T

T

N

S

E

A

A

S

R

N

A

C

L

L

V

I

G

G

I

L

F

F

L

L

N

N

D
|
D

Q

Q

Y

E

V

L

K

K

G

K

K

K

A

A

K

K

K

V

L

Y

T

D

K

K

D

I

V

A

E

K

T

D

P

V

K

K

Q

Q

A

A

A

A

V

V

L

L

G

G

A

A

G

G

I

I

M
|
M

G

G

G

G

G

G

I

I

A

A

Y

Y

Q

Q

S

S

A

A

W

S

K

K

G

G

V

T

P

P

V

I

V

L

M

M

K

K

D
|
D

I

I

N

N

D

E

K

H

S

G

L

I

T

E

L

Q

G

G

M

L

T

A

E

E

A

A

A

A

K

K

L

L

L

L

N

V

K

G

Q

R

L

V

E

D

R

K

G

G

K

R

I

M

D

T

G

P

L

A

K

K

L

M

A

A

G

E

V

V

I

L

S

N

T

G

I

I

H

R

P

P

T

T

L

L

D

S

Y

Y

A

G

G

D

F

F

D

G

R

N

V

V

D

D

I

L

V

V

V

V

E

E

A

A

V
|
V

V
|
V

E
|
E

N

N

P

P

K

K

V

V

K
|
K

K

Q

A

A

V

V

L

L

A

A

E

E

T

V

E

E

Q

N

K

H

V

V

R

R

Q

E

D

D

T

A

V

I

L

L

A

A

S

S

N

N

T

T

S
|
S

T

T

I

I

P

S

I

I

S

S

E

L

L

L

A

A

N

K

A

A

L

L

E

K

R

R

P

P

E

E

N

N

F

F

C

V

G

G

M

M

H

H

F

F

F

F

N
|
N

P

P

V

V

H

H

R

M

M

M

P

P

L

L

V

V

E

E

I

V

I

I

R

R

G

G

E

E

K

K

S

S

S

S

D

D

E

L

T

A

I

V

A

A

K

T

V

T

V

V

A

A

W

Y

A

A

S

K

K

K

M

M

G

G

K

K

T

N

P

P

I

I

V

V

V

V

N

N

D

D

C

C

P

P

G

G

F

F

F

L

V

V

N
|
N

R

R

V

V

L

L

F

F

P

P

Y

Y

F

F

A

G

G

G

F

F

S

A

Q

K

L

L

L

V

R

S

D

A

G

G

A

V

D

D

F

F

R

V

K

R

I

I

D

D

K

K

V

V

M

M

E

E

K

K

Q

-

F

F

G

G

W

W

P

P

M

M

G

G

P

P

A

A

Y

Y

L

L

L

M

D

D

V

V

V

V

G

G

I

I

D

D

T

T

A

G

H

H

H

H

A

G

Q

R

A

D

V

V

M

M

A

A

A

E

G

G

F

F

P

P

Q

D

R

R

M

M

Q

K

K

D

D

D

Y

R

R

R

D

S

A

A

I

I

D

D

A

A

L

L

F

Y

D

E

A

A

N

K

R

R

F

L

G

G

Q

Q

K

K

N

N

G

G

L

K

G

G

F

F

W

Y

R

A

Y

Y

K

E

E

A

D

D

S

K

K

K

G

G

K

K

P

Q

K

K

K

K

E

L

E

V

D

D

A

S

A

S

V

V

E

L

D

E

L

V

L

L

A

K

E

P

V

I

S

V

Q

Y

P

E

K

Q

R

R

D

D

F

V

S

T

E

D

E

E

E

D

I

I

I

I

A

N

R

W

M

M

M

M

I

I

P

P

M

L

V

C

N

L

E

E

V

T

V

V

R

R

C

C

L

L

E

E

E

D

G

G

I

I

I

V

A

E

T

T

P

A

A

A

E

E

A

A

D

D

M

M

A

G

L

L

V

V

Y
|
Y

G

G

L

I

G

G

F

F

P

P

P

L

F

F

H

R

G

G

G

G

A

A

F

L

R

R

W

Y

L

I

D

D

T

S

L

I

G

G

S

V

A

A

K

E

Y

F

L

V

D

A

M

L

A

A

Q

D

Q

Q

Y

Y

Q

A

H

E

L

L

G

G

P

A

L

L

Y

Y

E

H

V

P

P

T

E

A

G

K

L

L

R

R

N

E

K

M

A

A

R

K

H

N

N

G

E

Q

P

S

Y

F

Y

F

D297 (= D296) binding
M325 (= M324) binding
D344 (= D343) binding
VVE 401:403 (= VVE 400:402) binding
K408 (= K407) binding
S430 (= S429) binding
N454 (= N453) binding
N501 (= N500) binding
Y660 (= Y660) binding

1wdmA Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form i (native3) (see paper)
56% identity, 98% coverage: 1:714/729 of query aligns to 1:706/707 of 1wdmA

query
sites
1wdmA

M

M

L

I

Y

Y

K

E

G

G

D

K

T

A

L

I

Y

T

L

V

D

T

W

A

L

L

E

E

D

S

G

G

I

I

A

V

E

E

L

L

V

K

F

F

D

D

A

L

P

K

G

G

-

E

S

S

V

V

N

N

K

K

L

F

D

N

T

R

A

L

T

T

V

L

A

N

S

E

L

L

G

R

E

Q

A

A

I

V

G

D

V

A

L

I

E

K

Q

A

Q

D

S

A

D

S

L

V

K

K

G

G

L

V

L

I

L

V

R

S

S

S

N

G

K

K

A

D

A

V

F

F

I

I

V

V

G

G

A
|
A

D

D

I

I

T

T

E

E

F

F

L

V

S

E

L

N

F

F

L

K

V

L

P

P

E

D

E

A

Q

E

L

L

S

I

Q

A

W

G

L
x
N

H

L

F

E

A

A

N
|
N

S

K

V

I

F

F

N

S

R

D

L

F

E

E

D

D

L

L

P

N

V

V

P

P

T

T

I

V

A

A

A

A

V

I

N

N

G

G

Y

I

A

A

L

L

G

G

G
|
G

G

G

C

L

E
|
E

C

M

V

C

L

L

A

A

T

A

D

D

Y

F

R

R

L

V

A

M

T

A

P

D

D

S

L

A

R

K

I

I

G

G

L

L

P
|
P

E
|
E

T

V

K
|
K

L

L

G

G

I

I

M

Y

P
|
P

G
|
G

F

F

G

G

G

G

S

T

V

V

R

R

M

L

P

P

R

R

M

L

L

I

G

G

A

V

D

D

S

N

A

A

L

V

E

E

I

W

I

I

A

A

A

S

G

G

K

K

D

E

V

N

G

R

A

A

D

E

Q

D

A

A

L

L

K

K

I

V

G

S

L

A

V

V

D

D

G

A

V

V

V

V

K

T

A

A

E

D

K

K

L

L

V

G

E

A

G

A

A

A

K

L

A

D

V

L

L

I

R

K

Q

R

A

A

I

I

N

S

G

G

D

E

L

L

D

D

W

Y

K

K

A

A

K

K

R

R

Q

Q

P

P

K

K

L

L

E

E

P

K

L

L

K

K

L

L

S

N

K

A

I

I

E

E

A

Q

T

M

M

M

S

A

F

F

T

E

I

T

A

A

K

K

G

G

M

F

V

V

A

A

Q

G

T

Q

A

A

G

G

K

P

H

N

Y

Y

P

P

A

A

P

P

I

V

T

E

A

A

V

I

K

K

T

T

I

I

E

Q

A

K

A

A

A

A

R

N

F

F

G

G

R

R

E

D

E

K

A

A

L

L

N

E

L

V

E

E

N

A

K

A

S

G

F

F

V

A

P

K

L

L

A

A

H

K

T

T

N

S

E

A

A

S

R

N

A

C

L

L

V

I

G

G

I

L

F

F

L

L

N

N

D
|
D

Q

Q

Y

E

V

L

K

K

G

K

K

K

A

A

K

K

K

V

L

Y

T

D

K

K

D

I

V

A

E

K

T

D

P

V

K

K

Q

Q

A

A

A

A

V

V

L

L

G
|
G

A
|
A

G

G

I
|
I

M
|
M

G

G

G

G

G

G

I

I

A

A

Y

Y

Q

Q

S

S

A

A

W

S

K

K

G

G

V

T

P

P

V

I

V

L

M

M

K
|
K

D
|
D

I
|
I

N

N

D

E

K

H

S

G

L

I

T

E

L

Q

G

G

M

L

T

A

E

E

A

A

A

A

K

K

L

L

L

L

N

V

K

G

Q

R

L

V

E

D

R

K

G

G

K

R

I

M

D

T

G

P

L

A

K

K

L

M

A

A

G

E

V

V

I

L

S

N

T

G

I

I

H

R

P

P

T

T

L

L

D

S

Y

Y

A

G

G

D

F

F

D

G

R

N

V

V

D

D

I

L

V

V

V

V

E

E

A
|
A

V
|
V

V

V

E
|
E

N

N

P

P

K

K

V

V

K
|
K

K

Q

A

A

V

V

L

L

A

A

E

E

T

V

E

E

Q

N

K

H

V

V

R

R

Q

E

D

D

T

A

V

I

L

L

A

A

S

S

N
|
N

T
|
T

S
|
S

T

T

I

I

P

S

I

I

S

S

E

L

L

L

A

A

N

K

A

A

L

L

E

K

R

R

P

P

E

E

N

N

F

F

C

V

G

G

M

M

H
|
H

F
|
F

F

F

N
|
N

P

P

V

V

H

H

R

M

M
|
M

P

P

L

L

V

V

E
|
E

I

V

I

I

R

R

G

G

E

E

K

K

S

S

S

S

D

D

E

L

T

A

I

V

A

A

K

T

V

T

V

V

A

A

W

Y

A

A

S

K

K

K

M

M

G

G

K

K

T

N

P

P

I

I

V

V

V

V

N

N

D

D

C

C

P

P

G

G

F

F

F

L

V

V

N
|
N

R

R

V

V

L

L

F

F

P

P

Y

Y

F

F

A

G

G

G

F

F

S

A

Q

K

L

L

L

V

R

S

D

A

G

G

A

V

D

D

F

F

R

V

K

R

I

I

D

D

K

K

V

V

M

M

E

E

K

K

Q

-

F

F

G

G

W

W

P
|
P

M
|
M

G

G

P

P

A

A

Y

Y

L

L

L

M

D

D

V

V

V
|
V

G

G

I

I

D

D

T

T

A

G

H

H

H

H

A

G

Q

R

A

D

V

V

M

M

A

A

A

E

G

G

F

F

P

P

Q

D

R

R

M

M

Q

K

K

D

D

D

Y

R

R

R

D

S

A

A

I

I

D

D

A

A

L

L

F

Y

D

E

A

A

N

K

R

R

F

L

G

G

Q

Q

K

K

N

N

G

G

L

K

G

G

F

F

W

Y

R

A

Y

Y

K

-

E

-

D

-

S

-

K

-

G

-

K

-

P

-

K

K

K

K

E

L

E

V

D

D

A

S

A

S

V

V

E

L

D

E

L

V

L

L

A

K

E

P

V

I

S

V

Q

Y

P

E

K

Q

R

R

D

D

F

V

S

T

E

D

E

E

E

D

I

I

I

I

A

N

R

W

M

M

M

M

I

I

P

P

M

L

V

C

N

L

E

E

V

T

V

V

R

R

C

C

L

L

E

E

E

D

G

G

I

I

I

V

A

E

T

T

P

A

A

A

E

E

A

A

D

D

M

M

A

G

L

L

V
|
V

Y
|
Y

G

G

L

I

G
|
G

F

F

P

P

P
x
L

F

F

H

R

G

G

G

G

A

A

F

L

R

R

W

Y

L

I

D

D

T

S

L

I

G

G

S

V

A

A

K

E

Y

F

L

V

D

A

M

L

A

A

Q

D

Q

Q

Y

Y

Q

A

H

E

L

L

G

G

P

A

L

L

Y

Y

E

H

V

P

P

T

E

A

G

K

L

L

R

R

N

E

K

M

A

A

R

K

H

N

N

G

E

Q

P

S

Y

F

Y

F

active site: A69 (= A68), N89 (≠ L88), N93 (= N92), G117 (= G116), E120 (= E119), P139 (= P138), E140 (= E139), P147 (= P146), G148 (= G147), S430 (= S429), H451 (= H450), E463 (= E462), N501 (= N500)
binding acetyl coenzyme *a: K142 (= K141), D297 (= D296), M459 (= M458), N501 (= N500), P534 (= P534), M535 (= M535), V544 (= V544), V651 (= V659), Y652 (= Y660), G655 (= G663), L658 (≠ P666)
binding nicotinamide-adenine-dinucleotide: G321 (= G320), A322 (= A321), I324 (= I323), M325 (= M324), K343 (= K342), D344 (= D343), I345 (= I344), A400 (= A399), V401 (= V400), E403 (= E402), K408 (= K407), N428 (= N427), T429 (= T428), S430 (= S429), F452 (= F451), N454 (= N453)

P40939 Trifunctional enzyme subunit alpha, mitochondrial; 78 kDa gastrin-binding protein; Monolysocardiolipin acyltransferase; TP-alpha; EC 2.3.1.-; EC 4.2.1.17; EC 1.1.1.211 from Homo sapiens (Human) (see 5 papers)
35% identity, 93% coverage: 17:691/729 of query aligns to 49:737/763 of P40939

query
sites
P40939

I

V

A

A

E

V

L

V

V

R

F

I

D

N

A

S

P

P

G

N

S

S

-

K

V

V

N

N

K

T

L

L

D

S

T

K

A

E

T

L

V

H

A

S

S

E

L

F

G

S

E

E

A

V

I

M

G

N

V

E

L

I

E

W

Q

A

Q

S

S

D

D

Q

L

I

K

R

G

S

L

A

L

V

L

L

R

I

S

S

N

S

K

K

-

P

A

G

A

C

F

F

I

I

V

A

G

G

A

A

D

D

I

I

T

N

E

M

F

L

L

A

S

A

L

C

F

K

L

T

V

L

P

Q

E

E

-

V

E

T

Q

Q

L

L

S

S

Q

Q

W

E

L

-

H

-

F

-

A

A

N

Q

S

R

V

I

F

V

N

E

R

K

L

L

E

E

D

K

L

S

P

T

V

K

P

P

T

I

I

V

A

A

A

A

V

I

N

N

G

G

Y

S

A

C

L

L

G

G

G

G

G

G

C

L

E

E

C

V

V

A

L

I

A

S

T

C

D

Q

Y

Y

R

R

L

I

A

A

T

T

P

K

D

D

L

R

R

K

-

T

-

V

I

L

G

G

L

T

P

P

E

E

T

V

K

L

L

L

G

G

I

A

M

L

P

P

G

G

F

A

G

G

G

G

S

T

V

Q

R

R

M

L

P

P

R

K

M

M

L

V

G

G

A

V

D

P

S

A

A

A

L

L

E

D

I

M

I

M

A

L

A

T

G

G

K

R

D

S

V

I

G

R

A

A

D

D

Q

R

A

A

L

K

K

K

I

M

G

G

L

L

V

V

D

D

G

Q

V

L

V

V

K

E

-

P

-

L

-

G

-

P

-

G

-

L

-

K

-

P

-

P

A

E

E

E

K

R

L

T

V

I

E

E

G

Y

A

L

K

E

A

E

V

V

L

A

R

I

Q

T

A

F

I

A

N

K

G

G

D

L

L

A

D

D

W

K

K

K

A

I

-

S

-

P

K

K

R

R

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A

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K

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D

D

M

R

A

L

Q

K

Q

K

Y

Y

Q

E

V282 (vs. gap) to D: in MTPD; mild phenotype with slowly progressive myopathy and sensorimotor polyneuropathy; dbSNP:rs137852773
I305 (≠ V255) to N: in MTPD; mild phenotype with slowly progressive myopathy and sensorimotor polyneuropathy; dbSNP:rs137852774
L342 (≠ I292) to P: in LCHAD deficiency; dbSNP:rs137852772
E510 (= E462) active site, For hydroxyacyl-coenzyme A dehydrogenase activity; to Q: in AFLP and LCHAD deficiency; loss of long-chain-3-hydroxyacyl-CoA dehydrogenase activity; dbSNP:rs137852769

6yswA E. Coli anaerobic trifunctional enzyme subunit-alpha in complex with coenzyme a
35% identity, 93% coverage: 15:689/729 of query aligns to 11:677/707 of 6yswA

query
sites
6yswA

D

D

G

N

I

I

A

A

E

V

L

I

V

T

F

I

D

D

A

V

P

P

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-
x
E

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x
M

N

N

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x
T

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L

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A

A

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A

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A

A

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G

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L

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F

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V

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S

N

A

K

K

A

P

-

D

A

N

F

F

I

I

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x
A

G

G

A
|
A

D
|
D

I
|
I

T
x
N

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M

F
x
I

L

G

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N

L

C

F

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L

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V

A

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Q

E

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A

E

E

Q

A

L

L

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x
A

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W

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H

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F

-

A

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N
x
Q

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L

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A

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A

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I

I

A

A

A

A

V

I

N

H

G

G

Y

A

A

C

L

L

G

G

G
|
G

G

G

C

L

E
|
E

C

L

V

A

L

L

A

A

T

C

D

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Y

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A

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-

D

-

D

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P

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R

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I

L

G

G

L

L

P
|
P

E
|
E

T

V

K

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L
|
L

G

G

I

L

M

L

P

P

G
|
G

F

S

G

G

G

G

S

T

V

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A

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G

G

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E

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A

G

L

Y

N
x
D

L

A

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E

N

A