SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing 17910 FitnessBrowser__Keio:17910 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P0A9C5 Glutamine synthetase; GS; Glutamate--ammonia ligase; Glutamine synthetase I beta; GSI beta; EC 6.3.1.2 from Escherichia coli (strain K12) (see 3 papers)
100% identity, 100% coverage: 1:469/469 of query aligns to 1:469/469 of P0A9C5

query
sites
P0A9C5

M
|
M

S

S

A

A

E

E

H

H

V

V

L

L

T

T

M

M

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L

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N

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E

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H

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E

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V

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K

F

F

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V

D

D

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L

R

R

F

F

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D

T

T

K

K

G

G

K

K

E

E

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Q

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H

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T

I

I

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P

A

A

H

H

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Q

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V

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N

A

A

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E

F

F

F

F

E

E

E

E

G

G

K

K

M

M

F

F

D

D

G

G

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S

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S

I

I

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G

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G

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K

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G

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E

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D

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M

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L

M

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D

A

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A

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F

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A

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F

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M

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K

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P

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D

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M

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H

M

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V

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N

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L

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F

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A

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G

D

D

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Y

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G

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Y

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L

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E

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A

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V

M1 (= M1) modified: Initiator methionine, Removed
Y398 (= Y398) modified: O-AMP-tyrosine

P0A1P6 Glutamine synthetase; GS; Glutamate--ammonia ligase; Glutamine synthetase I beta; GSI beta; EC 6.3.1.2 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
98% identity, 100% coverage: 1:469/469 of query aligns to 1:469/469 of P0A1P6

query
sites
P0A1P6

M

M

S

S

A

A

E

E

H

H

V

V

L

L

T

T

M

M

L

L

N

N

E

E

H

H

E

E

V

V

K

K

F

F

V

V

D

D

L

L

R

R

F

F

T

T

D

D

T

T

K

K

G

G

K

K

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E

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Q

H

H

V

V

T

T

I

I

P

P

A

A

H

H

Q

Q

V

V

N

N

A

A

E

E

F

F

F

F

E

E

E

E

G

G

K

K

M

M

F

F

D

D

G

G

S

S

S

S

I

I

G

G

G

G

W

W

K

K

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G

I

I

N

N

E

E

S

S

D

D

M

M

V

V

L

L

M

M

P

P

D

D

A

A

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S

T

T

A

A

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V

I

I

D

D

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P

F

F

F

F

A

A

D

D

S

S

T

T

L

L

I

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I

I

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R

C

C

D

D

I

I

L

L

E

E

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P

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G

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T

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L

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Q

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G

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Y

D

D

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R

D

D

P

P

R

R

S

S

I

I

A

A

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R

R

A

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D

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T

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G

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I

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A

D

D

T

T

V

V

L

L

F

F

G

G

P

P

E
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E

P

P

E
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E

F

F

F

F

L

L

F

F

D

D

D

D

I

I

R

R

F

F

G

G

S

A

S

S

I

I

S

S

G

G

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S

H

H

V

V

A

A

I

I

D

D

D

D

I

I

E

E

G

G

A

A

W

W

N

N

S

S

S

S

T

T

Q

K

Y

Y

E

E

G

G

G

G

N

N

K

K

G

G

H

H

R

R

P

P

A

G

V

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K

K

G

G

G

G

Y

Y

F

F

P

P

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V

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P

P

P

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V

D

D

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S

A

A

Q

Q

D

D

I

I

R

R

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S

E

E

M

M

C

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L

L

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V

M

M

E

E

Q

Q

M

M

G

G

L

L

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V

V

V

E
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E

A

A

H

H

H

H

H

H

E
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E

V

V

A

A

T

T

A

A

G

G

Q

Q

N

N

E
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E

V

V

A

A

T

T

R

R

F

F

N

N

T

T

M

M

T

T

K

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K

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A

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Y

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Y

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A

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H

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F

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M

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P

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K

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P

M

M

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F

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G

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D

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N

G
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G

S

S

G

G

M

M

H
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H

C

C

H
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H

M
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M

S
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S

L

L

S

A

K

K

N

N

G

G

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T

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L

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F

A

S

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G

D

D

K

K

Y

Y

A

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G

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I

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K

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H

A

A

K

K

A

A

I

I

N

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A

A

L

L

A

A

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N

P

P

T

T

T

T

N

N

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Y

Y

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L

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V

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P

G

G

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Y

E

E

A

A

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P

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M

M

L

L

A

A

Y

Y

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S

A

A

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R

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N

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S

A

A

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S

I

I

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R

I

I

P

P

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V

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P

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K

A

A

R

R

R

R

I

I

E
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E

V

V

R
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R

F

F

P

P

D

D

P

P

A

A

A

A

N

N

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P

Y

Y

L

L

C

C

F

F

A

A

A

A

L

L

L

L

M

M

A

A

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G

L

L

D

D

G

G

I

I

K

K

N

N

K

K

I

I

H

H

P

P

G

G

E

E

A

A

M

M

D

D

K

K

N

N

L

L

Y

Y

D

D

L

L

P

P

P

P

E

E

E

E

A

A

K

K

E

E

I

I

P

P

Q

Q

V

V

A

A

G

G

S

S

L

L

E

E

E

E

A

A

L

L

N

N

E

A

L

L

D

D

L

L

D

D

R

R

E

E

F

F

L

L

K

K

A

A

G

G

G

G

V

V

F

F

T

T

D

D

E

E

A

A

I

I

D

D

A

A

Y

Y

I

I

A

A

L

L

R

R

R

R

E

E

E

E

D

D

D

D

R

R

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V

R

R

M

M

T

T

P

P

H

H

P

P

V

V

E

E

F

F

E

E

L

L

Y

Y

Y

Y

S

S

V

V

E130 (= E130) binding
E132 (= E132) binding
E208 (= E208) binding
E213 (= E213) binding
E221 (= E221) binding
NG 265:266 (= NG 265:266) binding
H270 (= H270) binding
HMS 272:274 (= HMS 272:274) binding
R322 (= R322) binding
E358 (= E358) binding
R360 (= R360) binding

1fpyA Crystal structure of glutamine synthetase from salmonella typhimurium with inhibitor phosphinothricin (see paper)
98% identity, 100% coverage: 2:469/469 of query aligns to 1:468/468 of 1fpyA

query
sites
1fpyA

S

S

A

A

E

E

H

H

V

V

L

L

T

T

M

M

L

L

N

N

E

E

H

H

E

E

V

V

K

K

F

F

V

V

D

D

L

L

R

R

F

F

T

T

D

D

T

T

K

K

G

G

K

K

E

E

Q

Q

H

H

V

V

T

T

I

I

P

P

A

A

H

H

Q

Q

V

V

N

N

A

A

E

E

F

F

F

F

E

E

E

E

G

G

K

K

M

M

F

F

D

D

G

G

S

S

S

S

I

I

G

G

G

G

W

W

K

K

G

G

I

I

N

N

E

E

S

S

D

D

M

M

V

V

L

L

M

M

P

P

D

D

A

A

S

S

T

T

A

A

V

V

I

I

D

D

P

P

F

F

F

F

A

A

D

D

S

S

T

T

L

L

I

I

I

I

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R

C

C

D

D

I

I

L

L

E

E

P

P

G

G

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T

L

L

Q

Q

G

G

Y

Y

D

D

R

R

D

D

P

P

R

R

S

S

I

I

A

A

K

K

R

R

A

A

E

E

D

D

Y

Y

L

L

R

R

S

A

T

T

G

G

I

I

A

A

D

D

T

T

V

V

L
|
L

F

F

G
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G

P

P

E
|
E

P

P

E
|
E

F

F

F

F

L

L

F

F

D

D

D

D

I

I

R

R

F

F

G

G

S

A

S

S

I

I

S

S

G

G

S

S

H

H

V

V

A

A

I

I

D

D

D

D

I

I

E

E

G

G

A

A

W

W

N

N

S

S

S

S

T

T

Q

K

Y

Y

E

E

G

G

G

G

N

N

K

K

G

G

H

H

R

R

P

P

A

G

V

V

K

K

G

G

G

G

Y

Y

F

F

P

P

V

V

P

P

P

P

V

V

D

D

S

S

A

A

Q

Q

D

D

I

I

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R

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S

E

E

M

M

C

C

L

L

V

V

M

M

E

E

Q

Q

M

M

G

G

L

L

V

V

V

V

E
|
E

A

A

H

H

H

H

H

H

E
|
E

V

V

A

A

T

T

A

A

G

G

Q

Q

N

N

E
|
E

V

V

A

A

T
|
T

R
|
R

F
|
F

N

N

T

T

M

M

T

T

K

K

K

K

A

A

D

D

E

E

I

I

Q

Q

I

I

Y

Y

K

K

Y

Y

V

V

V

V

H

H

N

N

V

V

A

A

H

H

R

R

F

F

G

G

K

K

T

T

A

A

T

T

F

F

M

M

P

P

K

K

P

P

M

M

F

F

G

G

D

D

N

N

G
|
G

S
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S

G
|
G

M

M

H
|
H

C

C

H
|
H

M

M

S
|
S

L

L

S

A

K

K

N

N

G

G

V

T

N

N

L

L

F

F

A

S

G

G

D

D

K

K

Y

Y

A

A

G

G

L

L

S

S

E

E

Q

Q

A

A

L

L

Y

Y

Y

Y

I

I

G

G

G

G

V

V

I

I

K

K

H

H

A

A

K

K

A

A

I

I

N

N

A

A

L

L

A

A

N

N

P

P

T

T

T

T

N

N

S

S

Y

Y

K

K

R
|
R

L

L

V

V

P

P

G

G

Y

Y

E
|
E

A

A

P

P

V

V

M

M

L

L

A

A

Y

Y

S

S

A

A

R

R

N

N

R

R

S

S

A

A

S

S

I

I

R

R

I

I

P

P

V

V

V

V

S

A

S

S

P

P

K

K

A
|
A

R

R

R
|
R

I

I

E
|
E

V

V

R
|
R

F

F

P

P

D

D

P

P

A

A

A

A

N

N

P

P

Y

Y

L

L

C

C

F

F

A

A

A

A

L

L

L

L

M

M

A

A

G

G

L

L

D

D

G

G

I

I

K

K

N

N

K

K

I

I

H

H

P

P

G

G

E

E

A

P

M

M

D

D

K

K

N

N

L

L

Y

Y

D

D

L

L

P

P

P

P

E

E

E

E

A

A

K

K

E

E

I

I

P

P

Q

Q

V

V

A

A

G

G

S

S

L

L

E

E

E

E

A

A

L

L

N

N

E

A

L

L

D

D

L

L

D

D

R

R

E

E

F

F

L

L

K

K

A

A

G

G

G

G

V

V

F

F

T

T

D

D

E

E

A

A

I

I

D

D

A

A

Y

Y

I

I

A

A

L

L

R

R

R

R

E

E

E

E

D

D

D

D

R

R

V

V

R

R

M

M

T

T

P

P

H

H

P

P

V

V

E

E

F

F

E

E

L

L

Y

Y

Y

Y

S

S

V

V

binding adenosine-5'-diphosphate: L125 (= L126), G127 (= G128), E129 (= E130), E207 (= E208), T223 (= T224), R224 (= R225), F225 (= F226), H271 (= H272), S273 (= S274), A353 (= A354), R355 (= R356), E357 (= E358)
binding manganese (ii) ion: E129 (= E130), E131 (= E132), E212 (= E213), E220 (= E221), H269 (= H270), E357 (= E358)
binding phosphinothricin: E131 (= E132), E212 (= E213), G265 (= G266), S266 (= S267), G267 (= G268), H269 (= H270), R321 (= R322), E327 (= E328), R359 (= R360)

1f1hA Crystal structure of glutamine synthetase from salmonella typhimurium with thallium ions (see paper)
98% identity, 100% coverage: 2:469/469 of query aligns to 1:468/468 of 1f1hA

query
sites
1f1hA

S

S

A

A

E

E

H

H

V

V

L

L

T

T

M

M

L

L

N

N

E

E

H

H

E

E

V

V

K

K

F

F

V

V

D

D

L

L

R

R

F

F

T

T

D

D

T

T

K

K

G

G

K

K

E

E

Q

Q

H

H

V

V

T

T

I

I

P

P

A

A

H

H

Q

Q

V

V

N

N

A

A

E

E

F

F

F

F

E

E

E

E

G

G

K

K

M

M

F

F

D

D

G

G

S

S

S

S

I

I

G

G

G

G

W

W

K

K

G

G

I

I

N

N

E

E

S

S

D

D

M

M

V

V

L

L

M

M

P

P

D

D

A

A

S

S

T

T

A

A

V

V

I

I

D

D

P

P

F

F

F

F

A

A

D

D

S

S

T

T

L

L

I

I

I

I

R

R

C

C

D

D

I

I

L

L

E

E

P

P

G

G

T

T

L

L

Q

Q

G

G

Y

Y

D

D

R

R

D

D

P

P

R

R

S

S

I

I

A

A

K

K

R

R

A

A

E

E

D

D

Y

Y

L

L

R

R

S

A

T

T

G

G

I

I

A

A

D

D

T

T

V

V

L

L

F

F

G
|
G

P

P

E
|
E

P

P

E
|
E

F

F

F

F

L

L

F

F

D

D

D

D

I

I

R

R

F

F

G

G

S

A

S

S

I

I

S

S

G

G

S

S

H

H

V

V

A

A

I

I

D

D

D

D

I

I

E

E

G

G

A

A

W

W

N

N

S

S

S

S

T

T

Q

K

Y

Y

E

E

G

G

G

G

N

N

K

K

G

G

H

H

R

R

P

P

A

G

V

V

K

K

G

G

G

G

Y

Y

F

F

P

P

V

V

P

P

P

P

V

V

D

D

S

S

A

A

Q

Q

D

D

I

I

R

R

S

S

E

E

M

M

C

C

L

L

V

V

M

M

E

E

Q

Q

M

M

G

G

L

L

V

V

V

V

E
|
E

A

A

H

H

H
|
H

H

H

E
|
E

V

V

A

A

T

T

A

A

G

G

Q

Q

N

N

E
|
E

V

V

A

A

T
|
T

R
|
R

F
|
F

N

N

T

T

M

M

T

T

K

K

K

K

A

A

D

D

E

E

I

I

Q

Q

I

I

Y

Y

K

K

Y

Y

V

V

V

V

H

H

N

N

V

V

A

A

H

H

R

R

F

F

G

G

K

K

T

T

A

A

T

T

F

F

M

M

P

P

K

K

P

P

M

M

F

F

G

G

D

D

N

N

G

G

S

S

G

G

M

M

H
|
H

C

C

H
|
H

M

M

S
|
S

L

L

S

A

K

K

N

N

G

G

V

T

N

N

L

L

F

F

A

S

G

G

D

D

K

K

Y

Y

A

A

G

G

L

L

S

S

E

E

Q

Q

A

A

L

L

Y

Y

Y

Y

I

I

G

G

G

G

V

V

I

I

K

K

H

H

A

A

K

K

A

A

I

I

N

N

A

A

L

L

A

A

N

N

P

P

T

T

T

T

N

N

S

S

Y

Y

K

K

R

R

L

L

V

V

P

P

G

G

Y

Y

E

E

A

A

P

P

V

V

M

M

L

L

A

A

Y

Y

S

S

A

A

R

R

N

N

R

R

S

S

A

A

S

S

I

I

R

R

I

I

P

P

V

V

V

V

S

A

S

S

P

P

K

K

A
|
A

R

R

R
|
R

I

I

E
|
E

V

V

R

R

F

F

P

P

D

D

P

P

A

A

A

A

N

N

P

P

Y

Y

L

L

C

C

F

F

A

A

A

A

L

L

L

L

M

M

A

A

G

G

L

L

D

D

G

G

I

I

K

K

N

N

K

K

I

I

H

H

P

P

G

G

E

E

A

P

M

M

D

D

K

K

N

N

L

L

Y

Y

D

D

L

L

P

P

P

P

E

E

E

E

A

A

K

K

E

E

I

I

P

P

Q

Q

V

V

A

A

G

G

S

S

L

L

E

E

E

E

A

A

L

L

N

N

E

A

L

L

D

D

L

L

D

D

R

R

E

E

F

F

L

L

K

K

A

A

G

G

G

G

V

V

F

F

T

T

D

D

E

E

A

A

I

I

D

D

A

A

Y

Y

I

I

A

A

L

L

R

R

R

R

E

E

E

E

D

D

D

D

R

R

V

V

R

R

M

M

T

T

P

P

H

H

P

P

V

V

E

E

F

F

E

E

L

L

Y

Y

Y

Y

S

S

V

V

binding adenosine-5'-diphosphate: G127 (= G128), E129 (= E130), E207 (= E208), H210 (= H211), E220 (= E221), T223 (= T224), R224 (= R225), F225 (= F226), H271 (= H272), S273 (= S274), A353 (= A354), R355 (= R356)
binding manganese (ii) ion: E129 (= E130), E131 (= E132), E212 (= E213), E220 (= E221), H269 (= H270), E357 (= E358)

2lgsA Feedback inhibition of fully unadenylylated glutamine synthetase from salmonella typhimurium by glycine, alanine, and serine (see paper)
93% identity, 100% coverage: 2:469/469 of query aligns to 1:445/445 of 2lgsA

query
sites
2lgsA

S

S

A

A

E

E

H

H

V

V

L

L

T

T

M

M

L

L

N

N

E

E

H

H

E

E

V

V

K

K

F

F

V

V

D

D

L

L

R

R

F

F

T

T

D

D

T

T

K

K

G

G

K

K

E

E

Q

Q

H

H

V

V

T

T

I

I

P

P

A

A

H

H

Q

Q

V

V

N

N

A

A

E

E

F

F

F

F

E

E

E

E

G

G

K

K

M

M

F

F

D

D

G

G

S

S

S

S

I

I

G

G

G

G

W

W

K

-

G

-

I

-

N

-

E

-

S

-

D

D

M

M

V

V

L

L

M

M

P

P

D

D

A

A

S

S

T

T

A

A

V

V

I

I

D

D

P

P

F

F

F

F

A

A

D

D

S

S

T

T

L

L

I

I

I

I

R

R

C

C

D

D

I

I

L

L

E

E

P

P

G

G

T

T

L

L

Q

Q

G

G

Y

Y

D

D

R

R

D

D

P

P

R

R

S

S

I

I

A

A

K

K

R

R

A

A

E

E

D

D

Y

Y

L

L

R

R

S

A

T

T

G

G

I

I

A

A

D

D

T

T

V

V

L

L

F

F

G

G

P

P

E
|
E

P

P

E
|
E

F

F

F

F

L

L

F

F

D

D

D

D

I

I

R

R

F

F

G

G

S

A

S

S

I

I

S

S

G

G

S

S

H

H

V

V

A

A

I

I

D

D

D

D

I

I

E

E

G

G

A

A

W

W

N

N

S

S

S

S

T

T

Q

K

Y

Y

E

E

G

G

G

G

N

N

K

K

G

G

H

H

R

R

P

P

A

G

V

V

K

K

G

G

G

G

Y

Y

F

F

P

P

V

V

P

P

P

P

V

V

D

D

S

S

A

A

Q

Q

D

D

I

I

R

R

S

S

E

E

M

M

C

C

L

L

V

V

M

M

E

E

Q

Q

M

M

G

G

L

L

V

V

V

V

E

E

A

A

H

H

H

H

H

H

E
|
E

V

V

A

A

T

T

A

A

G

G

Q

Q

N

N

E
|
E

V

V

A

A

T

T

R

R

F

F

N

N

T

T

M

M

T

T

K

K

K

K

A

A

D

D

E

E

I

I

Q

Q

I

I

Y

Y

K

K

Y

Y

V

V

V

V

H

H

N

N

V

V

A

A

H

H

R

R

F

F

G

G

K

K

T

T

A

A

T

T

F

F

M

M

P

P

K

K

P

P

M

M

F

F

G

G

D

D

N
|
N

G
|
G

S

S

G
|
G

M

M

H
|
H

C

C

H

H

M

M

S

S

L

L

S

A

K

K

N

N

G

G

V

T

N

N

L

L

F

F

A

S

G

G

D

D

K

K

Y

Y

A

A

G

G

L

L

S

S

E

E

Q

Q

A

A

L

L

Y

Y

Y

Y

I

I

G

G

G

G

V

V

I

I

K

K

H

H

A

A

K

K

A

A

I

I

N

N

A

A

L

L

A

A

N

N

P

P

T

T

T

T

N

N

S

S

Y

Y

K

K

R
|
R

L

L

V

V

P

P

G

-

Y

-

E

-

A

-

P

P

V

V

M

M

L

L

A

A

Y

Y

S

S

A

A

R

R

N

N

R
|
R

S

S

A

A

S

S

I

I

R

R

I

I

P

P

V

V

V

V

S

A

S

S

P

P

K

K

A

A

R

R

R

R

I

I

E
|
E

V

V

R
|
R

F

F

P

P

D

D

P

P

A

A

A

A

N

N

P

P

Y

Y

L

L

C

C

F

F

A

A

A

A

L

L

L

L

M

M

A

A

G

G

L

L

D

D

G

G

I

I

K

K

N

N

K

K

I

I

H

H

P

P

G

G

E

E

A

P

M

M

D

D

K

-

N

-

L

-

Y

-

D

-

L

-

P

-

P

-

E

-

E

-

A

-

K

-

E

-

I

I

P

P

Q

Q

V

V

A

A

G

G

S

S

L

L

E

E

E

E

A

A

L

L

N

N

E

A

L

L

D

D

L

L

D

D

R

R

E

E

F

F

L

L

K

K

A

A

G

G

G

G

V

V

F

F

T

T

D

D

E

E

A

A

I

I

D

D

A

A

Y

Y

I

I

A

A

L

L

R

R

R

R

E

E

E

E

D

D

D

D

R

R

V

V

R

R

M

M

T

T

P

P

H

H

P

P

V

V

E

E

F

F

E

E

L

L

Y

Y

Y

Y

S

S

V

V

binding glutamic acid: E125 (= E132), N258 (= N265), G259 (= G266), G261 (= G268), H263 (= H270), R315 (= R322), R329 (= R340), R349 (= R360)
binding manganese (ii) ion: E123 (= E130), E125 (= E132), E206 (= E213), E214 (= E221), H263 (= H270), E347 (= E358)

1lgrA Interactions of nucleotides with fully unadenylylated glutamine synthetase from salmonella typhimurium (see paper)
93% identity, 100% coverage: 2:469/469 of query aligns to 1:445/445 of 1lgrA

query
sites
1lgrA

S

S

A

A

E

E

H

H

V

V

L

L

T

T

M

M

L

L

N

N

E

E

H

H

E

E

V

V

K

K

F

F

V

V

D

D

L

L

R

R

F

F

T

T

D

D

T

T

K

K

G

G

K

K

E

E

Q

Q

H

H

V

V

T

T

I

I

P

P

A

A

H

H

Q

Q

V

V

N

N

A

A

E

E

F

F

F

F

E

E

E

E

G

G

K

K

M

M

F

F

D

D

G

G

S

S

S

S

I

I

G

G

G

G

W

W

K

-

G

-

I

-

N

-

E

-

S

-

D

D

M

M

V

V

L

L

M

M

P

P

D

D

A

A

S

S

T

T

A

A

V

V

I

I

D

D

P

P

F

F

F

F

A

A

D

D

S

S

T

T

L

L

I

I

I

I

R

R

C

C

D

D

I

I

L

L

E

E

P

P

G

G

T

T

L

L

Q

Q

G

G

Y

Y

D

D

R

R

D

D

P

P

R

R

S

S

I

I

A

A

K

K

R

R

A

A

E

E

D

D

Y

Y

L

L

R

R

S

A

T

T

G

G

I

I

A

A

D

D

T

T

V

V

L
|
L

F

F

G
|
G

P

P

E
|
E

P

P

E
|
E

F

F

F

F

L

L

F

F

D

D

D

D

I

I

R

R

F

F

G

G

S

A

S

S

I

I

S

S

G

G

S

S

H

H

V

V

A

A

I

I

D

D

D

D

I

I

E

E

G

G

A

A

W

W

N

N

S

S

S

S

T

T

Q

K

Y

Y

E

E

G

G

G

G

N

N

K

K

G

G

H

H

R

R

P

P

A

G

V

V

K

K

G

G

G

G

Y

Y

F

F

P

P

V

V

P

P

P

P

V

V

D

D

S

S

A

A

Q

Q

D

D

I

I

R

R

S

S

E

E

M

M

C

C

L

L

V

V

M

M

E

E

Q

Q

M

M

G

G

L

L

V

V

V

V

E
|
E

A

A

H

H

H

H

H

H

E
|
E

V

V

A

A

T

T

A

A

G

G

Q

Q

N

N

E
|
E

V

V

A

A

T
|
T

R

R

F
|
F

N

N

T

T

M

M

T

T

K

K

K

K

A

A

D

D

E

E

I

I

Q

Q

I

I

Y

Y

K

K

Y

Y

V

V

V

V

H

H

N

N

V

V

A

A

H

H

R

R

F

F

G

G

K

K

T

T

A

A

T

T

F

F

M

M

P

P

K

K

P

P

M

M

F

F

G

G

D

D

N

N

G

G

S

S

G

G

M

M

H
|
H

C

C

H
|
H

M
|
M

S
|
S

L

L

S

A

K

K

N

N

G

G

V

T

N

N

L

L

F

F

A

S

G

G

D

D

K

K

Y

Y

A

A

G

G

L

L

S

S

E

E

Q

Q

A

A

L

L

Y

Y

Y

Y

I

I

G

G

G

G

V

V

I

I

K

K

H

H

A

A

K

K

A

A

I

I

N

N

A

A

L

L

A

A

N

N

P

P

T

T

T

T

N

N

S

S

Y

Y

K

K

R

R

L

L

V

V

P

P

G

-

Y

-

E

-

A

-

P

P

V

V

M

M

L

L

A

A

Y

Y

S

S

A

A

R

R

N

N

R

R

S

S

A

A

S

S

I

I

R

R

I

I

P

P

V

V

V

V

S

A

S

S

P

P

K

K

A

A

R

R

R
|
R

I

I

E
|
E

V

V

R

R

F

F

P

P

D

D

P

P

A

A

A

A

N

N

P

P

Y

Y

L

L

C

C

F

F

A

A

A

A

L

L

L

L

M

M

A

A

G

G

L

L

D

D

G

G

I

I

K

K

N

N

K

K

I

I

H

H

P

P

G

G

E

E

A

P

M

M

D

D

K

-

N

-

L

-

Y

-

D

-

L

-

P

-

P

-

E

-

E

-

A

-

K

-

E

-

I

I

P

P

Q

Q

V

V

A

A

G

G

S

S

L

L

E

E

E

E

A

A

L

L

N

N

E

A

L

L

D

D

L

L

D

D

R

R

E

E

F

F

L

L

K

K

A

A

G

G

G

G

V

V

F

F

T

T

D

D

E

E

A

A

I

I

D

D

A

A

Y

Y

I

I

A

A

L

L

R

R

R

R

E

E

E

E

D

D

D

D

R

R

V

V

R

R

M

M

T

T

P

P

H

H

P

P

V

V

E

E

F

F

E

E

L

L

Y

Y

Y

Y

S

S

V

V

binding adenosine monophosphate: L119 (= L126), G121 (= G128), E201 (= E208), T217 (= T224), F219 (= F226), H265 (= H272), M266 (= M273), S267 (= S274), R345 (= R356)
binding manganese (ii) ion: E123 (= E130), E125 (= E132), E206 (= E213), E214 (= E221), H263 (= H270), E347 (= E358)

P77961 Glutamine synthetase; GS; Glutamate--ammonia ligase; Glutamine synthetase I beta; GSI beta; EC 6.3.1.2 from Synechocystis sp. (strain PCC 6803 / Kazusa)
56% identity, 100% coverage: 2:469/469 of query aligns to 4:473/473 of P77961

query
sites
P77961

S

T

A

P

E

Q

H

E

V

V

L

L

T

K

M

W

L

I

N

Q

E

D

H

E

E

N

V

I

K

K

F

I

V

I

D

D

L

L

R

K

F

F

T

I

D

D

T

T

K

P

G

G

K

I

E

W

Q

Q

H

H

V

C

T

S

I

F

P

Y

A

Y

H

D

Q

Q

V

L

N

D

A

E

E

N

F

S

F

F

E

T

E

E

G

G

K

I

M

P

F

F

D

D

G

G

S

S

S

S

I

I

G

R

G

G

W

W

K

K

G

A

I

I

N

N

E

E

S

S

D

D

M

M

V

C

L

M

M

V

P

P

D

D

A

P

S

N

T

T

A

A

V

T

I

I

D

D

P

P

F

F

F

C

A

K

D

E

S

P

T

T

L

L

I

S

I

M

R

I

C

C

D

S

I

I

L

K

E

E

P

P

G

R

T

T

L

G

Q

E

G

W

Y

Y

D

N

R

R

D

D

P

P

R

R

S

T

I

I

A

A

K

A

R

K

A

A

E

V

D

E

Y

Y

L

L

R

R

S

G

T

T

G

G

I

I

A

A

D

D

T

T

V

V

L

Y

F

F

G

G

P

P

E

E

P

A

E
|
E

F

F

F

F

L

L

F

F

D

D

D

D

I

I

R

R

F

F

G

G

S

Q

S

T

I

E

S

N

G

S

S

S

H

Y

V

Y

A

F

I

A

D

D

D

S

I

V

E

E

G

G

A

R

W

W

N

N

S

T

S

G

T

R

Q

E

Y

E

E

E

G

G

G

G

N

N

K

L

G

G

H

Y

R

K

P

P

A

G

V

Y

K

K

G

Q

G

G

Y

Y

F

F

P

P

V

V

P

A

P

P

V

T

D

D

S

T

A

A

Q

Q

D

D

I

I

R

R

S

T

E

E

M

M

C

L

L

L

V

T

M

M

E

A

Q

G

M

L

G

C

L

V

V

P

V

I

E

E

A

K

H

H

H

H

H

H

E
|
E

V

V

A

A

T

S

A

G

G

G

Q

Q

N

N

E
|
E

V

L

A

G

T

I

R

K

F

F

N

D

T

K

M

L

T

V

K

N

K

S

A

A

D

D

E

N

I

L

Q

M

I

I

Y

Y

K

K

Y

Y

V

V

V

I

H

K

N

N

V

V

A

A

H

K

R

K

F

Y

G

G

K

K

T

T

A

V

T

T

F

F

M

M

P

P

K

K

P

P

M

I

F

F

G

N

D

D

N

N

G

G

S

S

G

G

M

M

H

H

C

V

H

H

M

Q

S

S

L

L

S

W

K

K

N

D

G

G

V

Q

N

P

L

L

F

F

A

A

G

G

D

D

K

K

Y

Y

A

A

G

G

L

F

S

S

E

Q

Q

M

A

G

L

L

Y

W

Y

Y

I

I

G

G

G

G

V

I

I

L

K

K

H

H

A

A

K

P

A

A

I

L

N

L

A

A

L

F

A

T

N

N

P

P

T

T

T

T

N

N

S

S

Y

Y

K

K

R

R

L

L

V

V

P

P

G

G

Y

F

E

E

A

A

P

P

V

V

M

N

L

L

A

A

Y

Y

S

S

A

Q

R

G

N

N

R

R

S

S

A

A

S

S

I

V

R

R

I

I

P

P

V

L

V

S

-

G

S

G

S

N

P

P

K

K

A

A

R

K

R

R

I

L

E
|
E

V

F

R

R

F

C

P

P

D

D

P

A

A

T

A

S

N

N

P

P

Y

Y

L

L

C

A

F

F

A

A

A

A

L

M

L

L

M

C

A

A

G

G

L

I

D

D

G

G

I

I

K

K

N

N

K

Q

I

I

H

D

P

P

G

G

E

E

A

P

M

L

D

D

K

V

N

D

L

I

Y

Y

D

D

L

L

P

S

P

P

E

E

E

E

A

L

K

A

E

K

I

I

P

P

Q

S

V

T

A

P

G

G

S

S

L

L

E

E

E

A

A

A

L

L

N

E

E

A

L

L

D

E

L

K

D

D

R

H

E

E

F

F

L

L

K

T

A

G

G

T

G

G

V

V

F

F

T

S

D

P

E

D

A

F

I

V

D

E

A

S

Y

W

I

I

A

E

L

Y

R

K

R

L

E

D

-

N

E

E

D

V

D

N

R

P

V

M

R

R

M

L

T

R

P

P

H

H

P

P

V

Y

E

E

F

F

E

S

L

L

Y

Y

Y

Y

S

D

V

C

E134 (= E132) binding
E215 (= E213) binding
E223 (= E221) binding
E361 (= E358) binding

3ng0A Crystal structure of glutamine synthetase from synechocystis sp. Pcc 6803
55% identity, 100% coverage: 2:469/469 of query aligns to 2:465/465 of 3ng0A

query
sites
3ng0A

S

T

A

P

E

Q

H

E

V

V

L

L

T

K

M

W

L

I

N

Q

E

D

H

E

E

N

V

I

K

K

F

I

V

I

D

D

L

L

R

K

F

F

T

I

D

D

T

T

K

P

G

G

K

I

E

W

Q

Q

H

H

V

C

T

S

I

F

P

Y

A

Y

H

D

Q

Q

V

L

N

D

A

E

E

N

F

S

F

F

E

T

E

E

G

G

K

I

M

P

F

F

D
|
D

G

G

S

S

S

S

I

I

G

R

G

G

W

W

K

K

G

A

I

I

N

N

E

E

S

S

D

D

M

M

V

C

L

M

M

V

P

P

D

D

A

P

S

N

T

T

A

A

V

T

I

I

D

D

P

P

F

F

F

C

A

K

D

E

S

P

T

T

L

L

I

S

I

M

R

I

C

C

D

S

I

I

L

K

E

E

P

P

G

R

T

T

L

G

Q

E

G

W

Y

Y

D

N

R

R

D

D

P

P

R

R

S

T

I

I

A

A

K

A

R

K

A

A

E

A

D

E

Y

Y

L

L

R

R

S

G

T

T

G

G

I

I

A

A

D

D

T

T

V

V

L
x
Y

F

F

G
|
G

P

P

E
|
E

P

A

E
|
E

F

F

F

F

L

L

F

F

D

D

D

D

I

I

R

R

F

F

G

G

S

Q

S

T

I

E

S

N

G

S

S

S

H

Y

V

Y

A

F

I

A

D

D

D

S

I

V

E

E

G

G

A

R

W

W

N

N

S

T

S

G

T

R

Q

E

Y

E

E

E

G

G

G

G

N

N

K

L

G

G

H

Y

R

K

P

P

A

G

V

Y

K

K

G

Q

G

G

Y

Y

F

F

P

P

V

V

P

A

P

P

V

T

D

D

S

T

A

A

Q

Q

D

D

I

I

R

R

S

T

E

E

M

M

C

L

L

L

V

T

M

M

E

A

Q

A

M

F

G

G

L

V

V

P

V

I

E
|
E

A
x
K

H

H

H

H

H

H

E
|
E

V

V

A

A

T

S

A

G

G

G

Q

Q

N

N

E
|
E

V

L

A

G

T
x
I

R
x
K

F
|
F

N

D

T

K

M

L

T

V

K

N

K

S

A

A

D

D

E

N

I

L

Q

M

I

I

Y

Y

K

K

Y

Y

V

V

V

I

H

K

N

N

V

V

A

A

H

K

R

K

F

Y

G

G

K

K

T

T

A

V

T

T

F

F

M

M

P

P

K

K

P

P

M

I

F

F

G

N

D

D

N

N

G

G

S

S

G

G

M

M

H
|
H

C

V

H
|
H

M
x
Q

S
|
S

L

L

S
x
W

K

K

N

D

G

G

V

Q

N

P

L

L

F

F

A

A

G

G

D

D

K

K

Y

Y

A

A

G

G

L

F

S

S

E

Q

Q

M

A

G

L

L

Y

W

Y

Y

I

I

G

G

G

G

V

I

I

L

K

K

H

H

A

A

K

P

A

A

I

L

N

L

A

A

L

F

A

T

N

N

P

P

T

T

T

T

N

N

S

S

Y

Y

K

K

R

R

L

L

V

V

P

P

G

G

Y

F

E

E

A

A

P

P

V

V

M

N

L

L

A

A

Y

Y

S

S

A

Q

R

G

N

N

R
|
R

S

S

A

A

S

S

I

V

R
|
R

I

I

P

P

V

L

V

S

-

G

S

G

S

N

P

P

K
|
K

A
|
A

R

K

R
|
R

I

L

E
|
E

V

F

R
|
R

F

C

P

P

D

D

P

A

A

T

A

S

N

N

P

P

Y

Y

L

L

C

A

F

F

A

A

A

A

L

M

L

L

M

C

A

A

G

G

L

I

D

D

G

G

I

I

K

K

N

N

K

Q

I

I

H

D

P

P

G

G

E

E

A

P

M

L

D

D

K

V

N

D

L

I

Y

-

D

-

L

-

P

-

P

-

E

-

E

E

A

L

K

A

E

K

I

I

P

P

Q

S

V

T

A

P

G

G

S

S

L

L

E

E

E

A

A

A

L

L

N

E

E

A

L

L

D

E

L

K

D

D

R

H

E

E

F

F

L

L

K

T

A

G

G

T

G

G

V

V

F

F

T

S

D

P

E

D

A

F

I

V

D

E

A

S

Y

W

I

I

A

E

L

Y

R

K

R

L

E

D

-

N

E

E

D

V

D

N

R

P

V

M

R

R

M

L

T

R

P

P

H

H

P

P

V

Y

E

E

F

F

E

S

L

L

Y

Y

Y

Y

S

D

V

C

active site: D51 (= D51), E130 (= E130), E132 (= E132), E213 (= E213), E221 (= E221), H270 (= H270), R340 (= R340), E359 (= E358), R361 (= R360)
binding phosphoaminophosphonic acid-adenylate ester: Y126 (≠ L126), G128 (= G128), E130 (= E130), E208 (= E208), K209 (≠ A209), I224 (≠ T224), K225 (≠ R225), F226 (= F226), H272 (= H272), Q273 (≠ M273), S274 (= S274), W276 (≠ S276), R340 (= R340), R345 (= R345), K354 (= K353), A355 (= A354), R357 (= R356), E359 (= E358)
binding manganese (ii) ion: E130 (= E130), E130 (= E130), E132 (= E132), E213 (= E213), E221 (= E221), E221 (= E221), H270 (= H270), E359 (= E358), R361 (= R360)

4acfA Crystal structure of mycobacterium tuberculosis glutamine synthetase in complex with imidazopyridine inhibitor ((4-(6-bromo-3- (butylamino)imidazo(1,2-a)pyridin-2-yl)phenoxy) acetic acid) and l- methionine-s-sulfoximine phosphate.
51% identity, 100% coverage: 2:469/469 of query aligns to 2:475/475 of 4acfA

query
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active site: D51 (= D51), E130 (= E130), E132 (= E132), E216 (= E213), E224 (= E221), H273 (= H270), R344 (= R340), E363 (= E358), R365 (= R360)
binding {4-[6-bromo-3-(butylamino)imidazo[1,2-a]pyridin-2-yl]phenoxy}acetic acid: Y126 (≠ L126), F229 (= F226), H275 (= H272), Q276 (≠ M273), S277 (= S274), W279 (≠ S276), N356 (≠ S351), K358 (= K353), A359 (= A354), R361 (= R356)
binding magnesium ion: E130 (= E130), E130 (= E130), E132 (= E132), E216 (= E213), E224 (= E221), E224 (= E221), H273 (= H270), E363 (= E358)
binding l-methionine-s-sulfoximine phosphate: E130 (= E130), E132 (= E132), Y183 (= Y180), E216 (= E213), E224 (= E221), N268 (= N265), G269 (= G266), S270 (= S267), G271 (= G268), H273 (= H270), R326 (= R322), Y331 (= Y327), E332 (= E328), R344 (= R340), R365 (= R360)

3zxvA Crystal structure of mycobacterium tuberculosis glutamine synthetase in complex with tri-substituted imidazole inhibitor (4-(2-tert-butyl- 4-(6-methoxynaphthalen-2-yl)-1h-imidazol-5-yl)pyridin-2-amine) and l- methionine-s-sulfoximine phosphate (see paper)
51% identity, 100% coverage: 2:469/469 of query aligns to 2:475/475 of 3zxvA

query
sites
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