SitesBLAST

R257 (= R284) mutation to C: Sodium-independent binding affinity for proline.
C281 (≠ T312) mutation to S: Does not affect proline uptake activity. Confers resistance to N-ethylmaleimide. Na(+)-dependent proline binding activity is similar to wild-type carrier.
C344 (≠ G374) mutation to S: Small decrease in proline uptake activity. Confers resistance to N-ethylmaleimide. Exhibits low Na(+)-dependent proline binding.
C349 (≠ G379) mutation to S: Does not affect proline uptake activity. Sensitive to N-ethylmaleimide. Na(+)-dependent proline binding activity is similar to wild-type carrier.
R376 (≠ K406) mutation R->E,Q: No change in activity.; mutation to K: Loss of activity.

Q92911 Sodium/iodide cotransporter; Na(+)/I(-) cotransporter; Natrium iodide transporter; Sodium-iodide symporter; Na(+)/I(-) symporter; Solute carrier family 5 member 5 from Homo sapiens (Human) (see 3 papers)
25% identity, 33% coverage: 38:218/549 of query aligns to 19:201/643 of Q92911

query
sites
Q92911

M

V

F

F

L

A

I

L

F

M

V

L

F

V

T

S

L

T

G

G

I

I

T

G

Y

L

W

W

-

V

-

G

-

L

A

A

S

R

K

G

R

G

V

Q

R

R

S

S

R

A

S

E

D

D

Y

F

T

T

A

G

G

G

G

R

N

R

I

L

T

A

G

A

F

L

Q

P

N

V

G

G

L

L

A

S

I

L

A

S

G

A

D

S

Y

F

M

M

S

S

A

A

A

V

S

Q

F

V

L

L

G

G

I

V

S

P

A

S

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E

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A

F

Y

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S

Y

G

G

Y

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D

K

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Y

M

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C

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L

G

G

F

Q

L

L

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L

G

N

W

S

P

V

I

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I

T

L
x
A

F

L

L

L

I

F

A

M

E

P

R

V

L

F

R

Y

N

R

L

L

G

G

R

L

Y

T

T

S

F

T

A

Y

D

E

V

Y

A

L

S

E

Y

M

R

R

L

F

K

S

Q

-

G

-

P

-

I

-

R

R

I

A

L

V

S

R

A

L

C

C

G

G

S

T

L

L

V

Q

V

-

A

-

L

-

Y

Y

L

I

I

V

A

A

Q

T

M

M

V

L

G

Y

A

T

G

G

K

I

L

V

I

I

-

Y

-

A

-

P

-

A

-

L

-

I

-

L

E

N

L

Q

L

V

F

T

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G

L

L

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D

Y

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A

A

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C

M

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M

F

Y

Y

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T

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A

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G

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M

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K

A

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T

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W

W

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I

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I

F

K

Q

A

V

V

V

L

V

L

M

L

L

F

S

G

G

A102 (≠ L118) natural variant: A -> P

Sites not aligning to the query:

226 mutation H->A,D,E,K: Significant loss of iodide transport activity but no effect on its localization to the cell membrane.
237 D→A: Loss of localization to the cell membrane, significant loss of iodide transport activity but no effect on homodimerization.
242 Required for homodimerization; Y→A: Loss of localization to the cell membrane, significant loss of iodide transport activity but no effect on homodimerization. Reduced homodimerization; when associated with A-471. Loss of iodide transport activity; when associated with F-535.
243 Required for homodimerization; T→A: Loss of localization to the cell membrane, significant loss of iodide transport activity but no effect on homodimerization. Reduced homodimerization; when associated with A-471.
471 Required for homodimerization; Q→A: No effect on localization to the cell membrane, iodide transport activity and homodimerization. Significant loss of homodimerization; when associated with A-242 or A243.
525 A→F: Loss of localization to the cell membrane, significant loss of iodide transport activity but no effect on homodimerization. Loss of iodide transport activity; when associated with A-242.
536 T → Q: requires 2 nucleotide substitutions
556 S → Q: requires 2 nucleotide substitutions

5nv9A Substrate-bound outward-open state of a na+-coupled sialic acid symporter reveals a novel na+-site (see paper)
22% identity, 34% coverage: 54:239/549 of query aligns to 25:209/480 of 5nv9A

query
sites
5nv9A

S

S

K

K

R

R

V

Q

R

K

S

T

R

A

S

D

D

D

Y

Y

Y

F

T

R

A

G

G

G

N

R

I

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T

P

G

G

F

W

Q

A

N

A

G

G

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V

A

S

I

V

A

F

G
x
A

D
x
T

Y
x
T

M
x
L

S
|
S

A

S

A
x
I

S
x
T

F

F

L

M

G

S

I

I

S

P

A

A

L

K

V

A

F

Y

T

T

S

S

G

D

Y

W

D

T

G

F

L

I

I

I

Y
x
G

S
x
Q

L

Y

G

L

F

A

L

I

V

A

G

I

W

L

P

P

I

L

I

V

L

F

F

Y

L

F

I

Y

A

I

E

P

R

F

L

F

R

R

N

K

L

L

G

-

R

-

Y

-

T

-

F

-

A

K

D

I

V

T

A

S

S

A

Y

Y

R

E

L

Y

K

L

Q

E

G

A

P

R

I

F

R

D

I

V

L

R

S

S

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R

C

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F

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A

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S

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L

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S

V

F

A

M

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Y

F

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H

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A

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Q
x
R

M

V

V

A

G

I

A

I

G

T

K

Y

L

L

I

T

E

V

L

L

-

A

-

L

-

R

-

P

L

F

F

M

G

G

L

I

N

D

Y

P

H

V

I

V

A

L

V

I

V

V

L

L

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G

S

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L

L

M

C

M

I

Y

Y

V

T

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W

F

M

G

G

M

I

L

E

A

G

T
x
V

T

I

W

W

V

T

Q
x
D

I

V

I

I

K

Q

A

G

V

L

L

L

L

S

F

G

G

G

A

A

S

V

F

L

M

I

A

F

F

I

M

M

V

I

M

C

K

F

H

K

V

V

G

D

F

G

S

G

F

I

N

S

N

E

L

I

F

F

S

T

binding sodium ion: A52 (≠ G81), T53 (≠ D82), L55 (≠ M84), S56 (= S85), V174 (≠ T204), D178 (≠ Q208)
binding N-acetyl-beta-neuraminic acid: T54 (≠ Y83), L55 (≠ M84), S56 (= S85), I58 (≠ A87), T59 (≠ S88), G77 (≠ Y106), Q78 (≠ S107), R131 (≠ Q165)

Sites not aligning to the query:

binding sodium ion: 335, 338, 338, 339, 341, 342
binding N-acetyl-beta-neuraminic acid: 239, 277

7slaA Cryoem structure of sglt1 at 3.15 angstrom resolution (see paper)
20% identity, 53% coverage: 173:461/549 of query aligns to 138:454/585 of 7slaA

query
sites
7slaA

I

I

E

N

L

L

L

A

F

L

G

G

L

W

N

N

Y

L

H

Y

I

L

A

S

V

I

L

L

V

L

G

L

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A

L

I

M

T

M

A

M

L

Y

Y

V

T

L

I

F

T

G

G

M

L

L

A

A

A

T

V

T

I

W

Y

V

T

Q

D

I

T

I

L

K

Q

A

T

V

L

L

I

L

M

L

L

F

I

G

G

A

A

S

L

F

I

M

L

A

-

F

-

M

-

V

-

M

-

K

-

H

-

V

M

G

G

F

F

S

A

F

F

N

H

N

E

L

V

-

G

F

Y

S

D

E

A

A

F

M

M

A

E

V

K

H

Y

P

M

K

K

G

A

V

I

D

P

I

T

M

I

K

V

P

S

G

D

G

G

-

N

-

T

-

F

-

Q

-

E

-

K

-

C

-

Y

-

T

-

P

-

R

-

A

-

D

-

S

-

F

-

H

L

I

V

F

K

R

D

D

P

P

I

L

S

T

A

G

L

D

S

L

L

P

G

W

L

P

G

G

L

F

M

I

F

F

G

G

T

L

A

T

G

-

L

-

P

-

H

-

I

I

L

L

M

A

R

L

F

W

F

Y

T

W

V

C

S

T

D

D

A

Q

-

V

-

I

-

V

-

Q

-

R

R

C

E

L

A

A

R

A

K

K

S

N

V

M

F
x
S

Y

H

A

V

T

K

G

G

-

G

-

C

-

I

F

L

M

A

G

G

Y
|
Y

F

L

Y

K

I

L

L

L

T

P

F

M

I

F

I

I

G

M

-

V

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M

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P

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G

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M

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I

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R

-

I

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L

F

F

G

P

A

D

I

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M

V

L

A

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C

G

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A

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N

P

P

S

E

E

Y

C

K

E

D

K

A

Y

A

C

G

G

H

T

L

K

I

V

G

G

G

C

N

T

N

N

M

I

A

A

A

Y

V

P

H

T

L

L

A

V

N

V

A

E

V

L

G

M

G

P

N

N

L

G

F

L

L

R

G

G

F

L

I

M

S

L

A

A

V

V

A

M

F

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A

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A

I

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L

M

A

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S

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N

A

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G

A

A

S

S

T

A

L

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H

M

D

D

L

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Y

Y

A

A

N

K

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F

-

K

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K

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R

A

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K

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E

E

L

L

M

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Q

N

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A

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F

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M

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G

D

L

Y

A

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F

Q

A

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A

S

S

Y

C

L

N

A

F

P

P

P

I

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A

-

V

I

F

L

L

S

A

M

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Y

F

W

W

S

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K

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L

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N

T

E

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Q

G

G

A

A

binding cholesterol hemisuccinate: S277 (≠ F299), Y288 (= Y307)

Sites not aligning to the query:

binding cholesterol hemisuccinate: 36, 554, 558, 561

7sl8A Cryoem structure of sglt1 at 3.4 a resolution (see paper)
20% identity, 53% coverage: 173:461/549 of query aligns to 137:453/582 of 7sl8A

query
sites
7sl8A

I

I

E

N

L

L

L

A

F

L

G

G

L

W

N

N

Y

L

H

Y

I

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A

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V

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G

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M

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M

A

M

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Y

Y

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T

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F

T

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G

M

L

L

A

A

A

T

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T

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Y

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Q

D

I

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I

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K

Q

A

T

V

L

L

I

L

M

L

L

F

I

G

G

A

A

S

L

F

I

M

L

A

-

F

-

M

-

V

-

M

-

K

-

H

-

V

M

G

G

F

F

S

A

F

F

N

H

N

E

L

V

-

G

F

Y

S

D

E

A

A

F

M

M

A

E

V

K

H

Y

P

M

K

K

G

A

V

I

D

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I

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M

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G

D

G

G

-

N

-

T

-

F

-

Q

-

E

-

K

-

C

-

Y

-

T

-

P

-

R

-

A

-

D

-

S

-

F

-

H

L

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F

K

R

D

D

P

P

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A

G

L

D

S

L

L

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G

W

L

P

G

G

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M

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F

G

G

T

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A

T

G

-

L

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P

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H

-

I

I

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L

M

A

R

L

F

W

F

Y

T

W

V

C

S

T

D

D

A

Q

-

V

-

I

-

V

-

Q

-

R

R

C

E

L

A

A

R

A

K

K

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N

V

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F

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Y

H

A

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T

K

G
|
G

-

G

-

C

-

I

F

L

M

A

G

G

Y
|
Y

F

L

Y

K

I

L

L

L

T

P

F

M

I

F

I

I

G

M

-

V

-

M

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P

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G

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M

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R

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I

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L

F

F

G

P

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D

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A

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C

G

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A

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N

P

P

S

E

E

Y

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K

E

D

K

A

Y

A

C

G

G

H

T

L

K

I

V

G

G

G

C

N

T

N

N

M

I

A

A

A

Y

V

P

H

T

L

L

A

V

N

V

A

E

V

L

G

M

G

P

N

N

L

G

F

L

L

R

G

G

F

L

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M

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L

A

A

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V

A

M

F

L

A

A

T

A

I

L

L

M

A

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S

V

L

A

T

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S

L

I

T

F

L

N

A

S

G

A

A

S

S

T

A

L

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F

S

T

H

M

D

D

L

I

Y

Y

A

A

N

K

V

V

F

-

K

R

K

K

G

R

A

A

T

S

E

E

R

K

E

E

E

L

L

M

R

I

V

V

S

G

K

R

I

L

T

F

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V

L

L

I

F

L

L

G

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V

V

I

V

A

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I

I

I

A

L

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G

I

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P

L

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F

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E

Q

N

S

Q

A

N

Q

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S

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F

Q

M

L

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F

G

D

L

Y

A

I

F

Q

A

S

I

V

A

S

S

Y

C

L

N

A

F

P

P

P

I

V

-

A

-

V

I

F

L

L

S

A

M

I

Y

F

W

W

S

K

K

R

L

V

T

N

T

E

R

Q

G

G

A

A

binding cholesterol: G280 (= G303), Y287 (= Y307)

Sites not aligning to the query:

binding cholesterol: 35, 551, 554, 555, 558

P13866 Sodium/glucose cotransporter 1; Na(+)/glucose cotransporter 1; High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1 from Homo sapiens (Human) (see 6 papers)
20% identity, 53% coverage: 173:461/549 of query aligns to 169:485/664 of P13866

query
sites
P13866

I

I

E

N

L

L

L

A

F

L

G

G

L

L

N

N

Y

L

H

Y

I

L

A

A

V

I

V

F

L

L

V

L

G

L

V

A

L

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M

T

M

A

M

L

Y
|
Y

V
x
T

L
x
I

F
x
T

G
|
G

M
x
L

L
x
A

A
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A

T
x
V

T
x
I

W
x
Y

V
x
T

Q
x
D

I
x
T

I
x
L

K
x
Q

A
x
T

V
|
V

L
x
I

L
x
M

L
|
L

F
x
V

G
|
G

A
x
S

S
x
L

F
x
I

M
x
L

A
x
T

F
x
G

M
x
F

V
x
A

M
x
F

K
x
H

H
x
E

V
|
V

G
|
G

F

-

S
x
G

F
x
Y

N
x
D

N
x
A

L
x
F

F
x
M

S
x
E

E
x
K

A
x
Y

M
|
M

A
x
K

V
x
A

H
x
I

P
|
P

K
x
T

G
x
I

V
|
V

-
x
S

-
x
D

-
x
G

-
x
N

-
x
T

-
x
F

-
x
Q

-
x
E

D
x
K

I
x
C

M
x
Y

K
x
T

P
|
P

G
x
R

G
x
A

-
x
D

-
x
S

-
x
F

-
x
H

L
x
I

V
x
F

K
x
R

D
|
D

P
|
P

I
x
L

S
x
T

A
x
G

L
x
D

S
x
L

L
x
P

G
x
W

L
x
P

G
|
G

L
x
F

M
x
I

F
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F

G
|
G

T
x
M

A
x
S

G

-

L

-

P

-

H

-

I
|
I

L
|
L

M
x
T

R
x
L

F
x
W

F
x
Y

T
x
W

V
x
C

S
x
T

D
|
D

A
x
Q

R
x
V

E
x
I

A
x
V

R
x
Q

-
x
R

-
x
C

-
x
L

-
x
S

-
x
A

K
|
K

S
x
N

V
x
M

F
x
S

Y
x
H

A
x
V

T
x
K

G
|
G

-
x
G

-
x
C

-
x
I

F
x
L

M
x
C

G
|
G

Y
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Y

F
x
L

Y
x
K

I
x
L

L
x
M

T
x
P

F
x
M

I
x
F

I
|
I

-
x
M

-
x
V

-
x
M

-
x
P

G
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G

F
x
M

G
x
I

A
x
S

I
x
R

M
x
I

L
|
L

V
x
Y

G
x
T

A
x
E

N
x
K

-
x
I

-
x
A

-
x
C

-
x
V

-
x
P

P
x
S

E
|
E

Y
x
C

K
x
E

D
x
K

A
x
Y

A
x
C

G
|
G

H
x
T

L
x
K

I
x
V

G
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G

G
x
C

N
x
T

N
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N

M
x
I

A
|
A

A
x
Y

V
x
P

H
x
T

L
|
L

A
x
V

N
x
V

A
x
E

V
x
L

G
x
M

G
x
P

N
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N

L
x
G

F
x
L

L
x
R

G
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G

F
x
L

I
x
M

S
x
L

A
x
S

V
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V

A
x
M

F
x
L

A
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A

T
x
S

I
x
L

L
x
M

A
x
S

V
x
S

V
x
L

A
x
T

G
x
S

L
x
I

T
x
F

L
x
N

A
x
S

G
x
A

A
x
S

S
x
T

A
x
L

V
x
F

S
x
T

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x
M

D
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D

L
x
I

Y
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Y

A
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A

N
x
K

V
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V

F

-

K
x
R

K
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K

G
x
R

A
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A

T
x
S

E
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E

R
x
K

E
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E

E
x
L

L
x
M

R
x
I

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x
A

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x
G

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x
R

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x
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x
F

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x
I

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L

I
x
V

L
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L

G
x
I

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x
G

I
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I

A
x
S

I
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I

I
x
A

L
x
W

G
x
V

V
x
P

L
x
I

F
x
V

E
x
Q

N
x
S

Q
x
A

N
x
Q

I
x
S

A
x
G

F
x
Q

M
x
L

V
x
F

G
x
D

L
x
Y

A
x
I

F
x
Q

A
x
S

I
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I

A
x
T

A
x
S

S
x
Y

C
x
L

N
x
G

F
x
P

P
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P

I
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I

-
x
A

-
x
V

I
x
F

L
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L

S
x
A

M
x
I

Y
x
F

W
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W

S
x
K

K
x
R

L
x
V

T
x
N

T
x
E

R
x
P

G
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G

A
|
A

D204 (≠ Q208) mutation to A: Loss of activity.
N248 (vs. gap) modified: carbohydrate, N-linked (GlcNAc...) asparagine; mutation to Q: Loss of N-glycosylation.
C255 (≠ I251) modified: Disulfide link with 511
W276 (≠ G268) to L: in GGM; about 95% reduction in activity
T287 (≠ M283) mutation to A: Acquires D-mannose, D-fructose and L-sorbose transporter activity; when associated with L-83 and C-290.; mutation to N: Loss of D-glucose transporter activity. Has strict selectivity for D-galactose.; mutation T->S,A: Has normal D-glucose and D-galactose transporter activity.
Y290 (≠ F286) mutation to C: Loss of D-galactose transporter activity. Has strict selectivity for D-glucose. Acquires D-mannose, D-fructose and L-sorbose transporter activity; when associated with A-287 and L-83.
W291 (≠ T287) mutation to A: Loss of D-glucose transporter activity.
C292 (≠ V288) to Y: in GGM; loss of activity; mutation to A: Has no effect on water permeability.
Q295 (≠ A291) to R: in GGM; loss of activity
R300 (vs. gap) to S: in GGM; loss of activity
A304 (vs. gap) to V: in GGM; impairs trafficking to the plasma membrane
K321 (≠ Y309) mutation to Q: Acquires D-mannose and D-allose transporter activity comparable to glucose and galactose.
C345 (vs. gap) modified: Disulfide link with 351
C351 (≠ Y329) modified: Disulfide link with 345
C355 (≠ A333) modified: Disulfide link with 361
C361 (≠ G339) modified: Disulfide link with 355
N363 (= N341) mutation to A: Loss of water permeation.
L369 (= L347) to S: in GGM; loss of activity
R379 (≠ L357) to Q: in GGM; loss of activity
A388 (= A366) to V: in GGM; loss of activity
S396 (≠ G374) mutation to A: Loss of activity.
F405 (≠ V383) to S: in GGM; loss of activity
A411 (= A389) to T: in GGM; slightly decreased activity; dbSNP:rs17683430
G426 (≠ S405) to R: in GGM; loss of activity
Q451 (≠ F430) mutation to A: Strong reduction in water permeation.
L452 (≠ M431) mutation to A: Loss of water permeation.
D454 (≠ G433) mutation to A: Has no effect on water permeation.
Q457 (≠ F436) mutation to A: Loss of D-glucose transporter activity.; mutation to C: Strong reduction in D-glucose transporter activity.
T460 (≠ A439) mutation to A: Loss of D-glucose transporter activity.
V470 (vs. gap) to N: in GGM; requires 2 nucleotide substitutions; about 90% reduction in activity

Sites not aligning to the query:

51 N → S: in GGM; slightly decreased activity; dbSNP:rs17683011
67 W→A: Strong reduction in D-glucose transporter activity.
77 S→A: Loss of activity.
83 H→L: Acquires D-mannose, D-fructose and L-sorbose transporter activity; when associated with A-287 and C-290.; H→Q: Loss of D-glucose transporter activity.
135 R → W: in GGM; loss of activity
159 S → P: in GGM; loss of activity
166 A → T: in GGM; about 90% reduction in activity
191:664 natural variant: Missing (in GGM; loss of activity)
379:664 natural variant: Missing (in GGM; loss of activity)
499 R → H: in GGM; impairs trafficking to the plasma membrane; decreases the sugar affinity
511 modified: Disulfide link with 255
517 modified: Disulfide link with 522
522 modified: Disulfide link with 517
615 H → Q: in GGM; slightly decreased activity
641 W→A: Slightly reduced D-glucose transporter activity.
660:661 HA→WG: Loss of D-glucose transporter activity.

7wmvA Structure of human sglt1-map17 complex bound with lx2761 (see paper)
20% identity, 54% coverage: 164:461/549 of query aligns to 143:468/602 of 7wmvA

query
sites
7wmvA

A

A

Q

D

M

I

V

F

G

S

A

G

G

A

K

I

L

F

I

I

E

N

L

L

L

A

F

L

G

G

L

L

N

N

Y

L

H

Y

I

L

A

A

V

I

V

F

L

L

V

L

G

L

V

A

L

I

M

T

M

A

M

L

Y

Y

V

T

L

I

F

T

G

G

M

L

L

A

A

A

T

V

T

I

W

Y

V

T

Q

D

I

T

I

L

K

Q

A

T

V

V

L

I

L

M

L

L

F

V

G

G

A

S

S

L

F

I

M

L

A

T

F

G

M

F

V

A

M

F

K

H

H

E

V

V

G

G

F

-

S

G

F

Y

N

D

N

A

L

F

F

M

S

E

E

K

A

Y

M

M

A

K

V

A

H

I

P

P

K

T

G

I

V

V

-

S

-

D

-

G

-

N

-

T

-

F

-

Q

-

E

D

K

I

C

M

Y

K

T

P

P

G

R

G

A

-

D

-

S

-

F

-

H

L

I

V

F

K

R

D

D

P

P

I

L

S

T

A

G

L
x
D

S
x
L

L

P

G

W

L

P

G

G

L

F

M

I

F

F

G

G

T
x
M

A

S

G

-

L

-

P

-

H

-

I

I

L
|
L

M
x
T

R

L

F

W

F
x
Y

T
x
W

V

C

S

T

D

D

A

Q

R

V

E

I

A

V

R

Q

-

R

-

C

-

L

-

S

-

A

K

K

S

N

V

M

F

S

Y

H

A

V

T

K

G

G

-

G

-

C

-

I

F

L

M

C

G

G

Y

Y

F

L

Y
x
K

I

L

L

M

T

P

F

M

I

F

I

I

-

M

-

V

-

M

-

P

G

G

F

M

G

I

A

S

I

R

M

I

L

L

V

Y

G

T

A

E

N

K

-

I

-

A

-

C

-

V

-

P

P

S

E

E

Y

C

K

E

D

K

A

Y

A

C

G

G

H

T

L

K

I

V

G

G

G

C

N

T

N

N

M

I

A

A

A

Y

V

P

H

T

L

L

A

V

N

V

A

E

V

L

G

M

G

P

N

N

L

G

F

L

L

R

G

G

F

L

I

M

S

L

A

S

V

V

A

M

F

L

A

A

T

S

I

L

L

M

A

S

V

S

V

L

A

T

G

S

L

I

T

F

L

N

A

S

G

A

A

S

S

T

A

L

V

F

S

T

H

M

D

D

L

I

Y

Y

A

A

N

K

V

V

F

-

K

R

K

K

G

R

A

A

T

S

E

E

R

K

E

E

E

L

L

M

R

I

V

A

S

G

K

R

I

L

T

F

V

I

L

L

I

V

L

L

G

I

V

G

I

I

A

S

I

I

I

A

L

W

G

V

V

P

L

I

F

V

E

Q

N

S

Q

A

N

Q

I

S

A

G

F

Q

M

L

V
x
F

G
x
D

L

Y

A

I

F
x
Q

A

S

I

I

A

T

A

S

S

Y

C

L

N

G

F

P

P

P

I

I

-

A

-

V

I

F

L

L

S

A

M

I

Y

F

W

W

S

K

K

R

L

V

T

N

T

E

R

P

G

G

A

A

binding N-[2-(dimethylamino)ethyl]-2-methyl-2-[4-[4-[[2-methyl-5-[(2S,3R,4R,5S,6R)-6-methylsulfanyl-3,4,5-tris(oxidanyl)oxan-2-yl]phenyl]methyl]phenyl]butanoylamino]propanamide: D256 (≠ L265), L257 (≠ S266), M266 (≠ T275), L269 (= L282), T270 (≠ M283), Y273 (≠ F286), W274 (≠ T287), K304 (≠ Y309), F436 (≠ V432), D437 (≠ G433), Q440 (≠ F436)

Sites not aligning to the query:

binding N-[2-(dimethylamino)ethyl]-2-methyl-2-[4-[4-[[2-methyl-5-[(2S,3R,4R,5S,6R)-6-methylsulfanyl-3,4,5-tris(oxidanyl)oxan-2-yl]phenyl]methyl]phenyl]butanoylamino]propanamide: 61, 66, 70, 81, 84, 85, 88, 508

Query Sequence

>18095 FitnessBrowser__Keio:18095
MKRVLTALAATLPFAANAADAISGAVERQPTNWQAIIMFLIFVVFTLGITYWASKRVRSR
SDYYTAGGNITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSLGFLVGWPIILFL
IAERLRNLGRYTFADVASYRLKQGPIRILSACGSLVVVALYLIAQMVGAGKLIELLFGLN
YHIAVVLVGVLMMMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFSE
AMAVHPKGVDIMKPGGLVKDPISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFY
ATGFMGYFYILTFIIGFGAIMLVGANPEYKDAAGHLIGGNNMAAVHLANAVGGNLFLGFI
SAVAFATILAVVAGLTLAGASAVSHDLYANVFKKGATEREELRVSKITVLILGVIAIILG
VLFENQNIAFMVGLAFAIAASCNFPIILLSMYWSKLTTRGAMMGGWLGLITAVVLMILGP
TIWVQILGHEKAIFPYEYPALFSITVAFLGIWFFSATDNSAEGARERELFRAQFIRSQTG
FGVEQGRAH

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory