SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing 1936904 FitnessBrowser__Keio:1936904 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

7qh2C Cryo-em structure of ldh-etfab complex from acetobacterium woodii (see paper)
31% identity, 47% coverage: 18:180/350 of query aligns to 64:226/467 of 7qh2C

query
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7qh2C

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binding flavin-adenine dinucleotide: V73 (≠ I27), G75 (= G29), S76 (= S30), G77 (≠ N31), T78 (≠ S32), G79 (≠ A34), L80 (≠ F35), A83 (≠ R38), C84 (≠ P39), P137 (= P89), G138 (= G93), E139 (= E94), A142 (= A96), T143 (= T97), G146 (= G100), N147 (≠ M101), S149 (≠ A103), T150 (≠ C104), A152 (≠ L106), G153 (≠ A107), E203 (≠ Y157), G204 (= G158), I209 (≠ L163)

Sites not aligning to the query:

8jdsA Crystal structure of mldhd in complex with pyruvate (see paper)
25% identity, 46% coverage: 53:213/350 of query aligns to 96:257/456 of 8jdsA

query
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binding flavin-adenine dinucleotide: P132 (= P89), G133 (= G93), A134 (≠ E94), G140 (= G100), M141 (= M101), A143 (= A103), T144 (≠ C104), A146 (≠ L106), S147 (≠ A107), E200 (≠ Y157), G201 (= G158), I206 (≠ L163)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 32, 68, 70, 71, 72, 73, 74, 78, 79, 90, 323, 414, 415, 451
binding manganese (ii) ion: 370, 377, 414
binding pyruvic acid: 319, 370, 377, 415

8jdrA Crystal structure of h405a mldhd in complex with d-2-hydroxy-3-methyl- valeric acid (see paper)
25% identity, 46% coverage: 53:213/350 of query aligns to 96:257/456 of 8jdrA

query
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binding flavin-adenine dinucleotide: P132 (= P89), G133 (= G93), A134 (≠ E94), G140 (= G100), M141 (= M101), A143 (= A103), T144 (≠ C104), A146 (≠ L106), S147 (≠ A107), E200 (≠ Y157), G201 (= G158), I206 (≠ L163)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 68, 70, 71, 72, 73, 74, 78, 79, 90, 324, 370, 414, 451
binding (2R,3S)-3-methyl-2-oxidanyl-pentanoic acid: 319, 323, 415

8jdqA Crystal structure of h405a mldhd in complex with d-2-hydroxyisocaproic acid (see paper)
25% identity, 46% coverage: 53:213/350 of query aligns to 96:257/456 of 8jdqA

query
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8jdqA

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binding flavin-adenine dinucleotide: P132 (= P89), G133 (= G93), A134 (≠ E94), G140 (= G100), M141 (= M101), A143 (= A103), T144 (≠ C104), A146 (≠ L106), S147 (≠ A107), E200 (≠ Y157), G201 (= G158), I206 (≠ L163)

Sites not aligning to the query:

binding (2R)-2-hydroxy-4-methylpentanoic acid: 319, 323, 370, 415
binding flavin-adenine dinucleotide: 68, 70, 71, 72, 73, 74, 78, 79, 90, 370, 414, 451

8jdoA Crystal structure of h405a mldhd in complex with d-2-hydroxyhexanoic acid (see paper)
25% identity, 46% coverage: 53:213/350 of query aligns to 96:257/456 of 8jdoA

query
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binding flavin-adenine dinucleotide: P132 (= P89), G133 (= G93), A134 (≠ E94), G140 (= G100), M141 (= M101), A143 (= A103), T144 (≠ C104), A146 (≠ L106), S147 (≠ A107), E200 (≠ Y157), G201 (= G158), I206 (≠ L163)

Sites not aligning to the query:

binding (2R)-2-hydroxyhexanoic acid: 319, 323, 415
binding flavin-adenine dinucleotide: 68, 70, 71, 72, 73, 74, 78, 79, 90, 324, 370, 414, 451

8jdnA Crystal structure of h405a mldhd in complex with d-2-hydroxyvaleric acid (see paper)
25% identity, 46% coverage: 53:213/350 of query aligns to 96:257/456 of 8jdnA

query
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8jdnA

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binding flavin-adenine dinucleotide: P132 (= P89), G133 (= G93), A134 (≠ E94), G140 (= G100), M141 (= M101), A143 (= A103), T144 (≠ C104), A146 (≠ L106), S147 (≠ A107), E200 (≠ Y157), G201 (= G158), I206 (≠ L163)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 68, 70, 71, 72, 73, 74, 78, 79, 90, 370, 414, 451
binding (2R)-2-oxidanylpentanoic acid: 319, 323, 415

8jdgA Crystal structure of h405a mldhd in complex with d-2-hydroxybutanoic acid (see paper)
25% identity, 46% coverage: 53:213/350 of query aligns to 96:257/456 of 8jdgA

query
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8jdgA

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G

G

P

T

R

N

R

A

P

V

W

R

S

Y

G

G

S

T

V

M

R

R

D

D

F

N

V

V

L

I

G

N

T

L

R

E

I

V

I

V

T

L

G

P

A

D

G

G

K

R

H

L

L

L

R

H

F

T

G

A

G

G

-

R

-

G

-

R

E

H

V

Y

M

R

K

K

N

S

V

A

A

A

G

G

Y

Y

D

N

L

L

S

T

R

G

L

L

M

F

V

V

G

G

S

S

Y
x
E

G
|
G

C

T

L

L

G

G

V

I

L
x
I

T

T

E

S

I

T

S

T

M

L

K

R

V

L

L

H

P

P

R

A

P

P

R

E

A

A

S

T

L

V

S

A

L

A

R

T

R

C

E

A

I

F

-

P

S

S

L

V

Q

Q

E

A

A

A

M

V

S

D

E

S

I

T

A

V

E

Q

W

I

Q

L

L

Q

Q

A

P

A

L

V

P

P

I

V

S

A

G

R

L

I

C

E

Y

F

F

L

D

D

N

D

A

V

L

M

binding flavin-adenine dinucleotide: P132 (= P89), G133 (= G93), A134 (≠ E94), G140 (= G100), M141 (= M101), A143 (= A103), T144 (≠ C104), A146 (≠ L106), S147 (≠ A107), E200 (≠ Y157), G201 (= G158), I206 (≠ L163)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 68, 70, 71, 72, 73, 74, 78, 79, 90, 370, 414, 451
binding (2R)-2-oxidanylbutanoic acid: 319, 415

8jdbA Crystal structure of h405a mldhd in complex with d-2-hydroxyoctanoic acid (see paper)
25% identity, 46% coverage: 53:213/350 of query aligns to 96:257/456 of 8jdbA

query
sites
8jdbA

I

I

V

T

N

E

Y

L

D

N

P

T

T

E

E

D

L

F

V

S

I

V

T

V

A

V

R

E

V

P

G

G

T

V

P

T

L

R

V

K

T

A

I

L

E

N

A

T

A

H

L

L

E

R

S

D

A

S

G

G

Q

L

M

W

L

F

P

P

C

V

E

D

P
|
P

P

-

H

-

Y

-

G
|
G

E
x
A

E

D

A

A

T

S

W

L

G

C

G
|
G

M
|
M

V

A

A
|
A

C
x
T

G

G

L
x
A

A
x
S

G

G

P

T

R

N

R

A

P

V

W

R

S

Y

G

G

S

T

V

M

R

R

D

D

F

N

V

V

L

I

G

N

T

L

R

E

I

V

I

V

T

L

G

P

A

D

G

G

K

R

H

L

L

L

R

H

F

T

G

A

G

G

-

R

-

G

-

R

E

H

V

Y

M

R

K

K

N

S

V

A

A

A

G

G

Y

Y

D

N

L

L

S

T

R

G

L

L

M

F

V

V

G

G

S

S

Y
x
E

G
|
G

C

T

L

L

G

G

V

I

L
x
I

T

T

E

S

I

T

S

T

M

L

K

R

V

L

L

H

P

P

R

A

P

P

R

E

A

A

S

T

L

V

S

A

L

A

R

T

R

C

E

A

I

F

-

P

S

S

L

V

Q

Q

E

A

A

A

M

V

S

D

E

S

I

T

A

V

E

Q

W

I

Q

L

L

Q

Q

A

P

A

L

V

P

P

I

V

S

A

G

R

L

I

C

E

Y

F

F

L

D

D

N

D

A

V

L

M

binding flavin-adenine dinucleotide: P132 (= P89), G133 (= G93), A134 (≠ E94), G140 (= G100), M141 (= M101), A143 (= A103), T144 (≠ C104), A146 (≠ L106), S147 (≠ A107), E200 (≠ Y157), G201 (= G158), I206 (≠ L163)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 68, 70, 71, 72, 73, 74, 78, 79, 90, 324, 370, 414, 451
binding (2R)-2-oxidanyloctanoic acid: 75, 319, 323, 415

8jdvA Crystal structure of mldhd in complex with 2-ketohexanoic acid (see paper)
25% identity, 46% coverage: 53:213/350 of query aligns to 96:257/454 of 8jdvA

query
sites
8jdvA

I

I

V

T

N

E

Y

L

D

N

P

T

T

E

E

D

L

F

V

S

I

V

T

V

A

V

R

E

V

P

G

G

T

V

P

T

L

R

V

K

T

A

I

L

E

N

A

T

A

H

L

L

E

R

S

D

A

S

G

G

Q

L

M

W

L

F

P

P

C

V

E

D

P
|
P

P

-

H

-

Y

-

G
|
G

E
x
A

E

D

A

A

T

S

W

L

G

C

G
|
G

M
|
M

V

A

A
|
A

C
x
T

G

G

L
x
A

A
x
S

G

G

P

T

R

N

R

A

P

V

W

R

S

Y

G

G

S

T

V

M

R

R

D

D

F

N

V

V

L

I

G

N

T

L

R

E

I

V

I

V

T

L

G

P

A

D

G

G

K

R

H

L

L

L

R

H

F

T

G

A

G

G

-

R

-

G

-

R

E

H

V

Y

M

R

K

K

N

S

V

A

A

A

G

G

Y

Y

D

N

L

L

S

T

R

G

L

L

M

F

V

V

G

G

S

S

Y
x
E

G
|
G

C

T

L

L

G

G

V

I

L
x
I

T

T

E

S

I

T

S

T

M

L

K

R

V

L

L

H

P

P

R

A

P

P

R

E

A

A

S

T

L

V

S

A

L

A

R

T

R

C

E

A

I

F

-

P

S

S

L

V

Q

Q

E

A

A

A

M

V

S

D

E

S

I

T

A

V

E

Q

W

I

Q

L

L

Q

Q

A

P

A

L

V

P

P

I

V

S

A

G

R

L

I

C

E

Y

F

F

L

D

D

N

D

A

V

L

M

binding flavin-adenine dinucleotide: P132 (= P89), G133 (= G93), A134 (≠ E94), G140 (= G100), M141 (= M101), A143 (= A103), T144 (≠ C104), A146 (≠ L106), S147 (≠ A107), E200 (≠ Y157), G201 (= G158), I206 (≠ L163)

Sites not aligning to the query:

binding 2-Ketohexanoic acid: 75, 317, 321, 368, 375, 413
binding flavin-adenine dinucleotide: 68, 70, 71, 72, 73, 74, 78, 79, 90, 321, 322, 412, 413, 449
binding manganese (ii) ion: 368, 375, 412

8jdtA Crystal structure of mldhd in complex with 2-ketobutanoic acid (see paper)
25% identity, 46% coverage: 53:213/350 of query aligns to 96:257/455 of 8jdtA

query
sites
8jdtA

I

I

V

T

N

E

Y

L

D

N

P

T

T

E

E

D

L

F

V

S

I

V

T

V

A

V

R

E

V

P

G

G

T

V

P

T

L

R

V

K

T

A

I

L

E

N

A

T

A

H

L

L

E

R

S

D

A

S

G

G

Q

L

M

W

L

F

P

P

C

V

E

D

P
|
P

P

-

H

-

Y

-

G
|
G

E
x
A

E

D

A

A

T

S

W

L

G

C

G
|
G

M
|
M

V

A

A
|
A

C
x
T

G

G

L
x
A

A
x
S

G

G

P

T

R

N

R

A

P

V

W

R

S

Y

G

G

S

T

V

M

R

R

D

D

F

N

V

V

L

I

G

N

T

L

R

E

I

V

I

V

T

L

G

P

A

D

G

G

K

R

H

L

L

L

R

H

F

T

G

A

G

G

-

R

-

G

-

R

E

H

V

Y

M

R

K

K

N

S

V

A

A

A

G

G

Y

Y

D

N

L

L

S

T

R

G

L

L

M

F

V

V

G

G

S

S

Y
x
E

G
|
G

C

T

L

L

G

G

V

I

L
x
I

T

T

E

S

I

T

S

T

M

L

K

R

V

L

L

H

P

P

R

A

P

P

R

E

A

A

S

T

L

V

S

A

L

A

R

T

R

C

E

A

I

F

-

P

S

S

L

V

Q

Q

E

A

A

A

M

V

S

D

E

S

I

T

A

V

E

Q

W

I

Q

L

L

Q

Q

A

P

A

L

V

P

P

I

V

S

A

G

R

L

I

C

E

Y

F

F

L

D

D

N

D

A

V

L

M

binding flavin-adenine dinucleotide: P132 (= P89), G133 (= G93), A134 (≠ E94), G140 (= G100), M141 (= M101), A143 (= A103), T144 (≠ C104), A146 (≠ L106), S147 (≠ A107), E200 (≠ Y157), G201 (= G158), I206 (≠ L163)

Sites not aligning to the query:

binding 2-ketobutyric acid: 318, 369, 376, 414
binding flavin-adenine dinucleotide: 68, 70, 71, 72, 73, 74, 78, 79, 90, 322, 413, 414, 450
binding manganese (ii) ion: 369, 376, 413

8jdpA Crystal structure of h405a mldhd in complex with d-2-hydroxyisovaleric acid (see paper)
25% identity, 46% coverage: 53:213/350 of query aligns to 96:257/455 of 8jdpA

query
sites
8jdpA

I

I

V

T

N

E

Y

L

D

N

P

T

T

E

E

D

L

F

V

S

I

V

T

V

A

V

R

E

V

P

G

G

T

V

P

T

L

R

V

K

T

A

I

L

E

N

A

T

A

H

L

L

E

R

S

D

A

S

G

G

Q

L

M

W

L

F

P

P

C

V

E

D

P
|
P

P

-

H

-

Y

-

G
|
G

E
x
A

E

D

A

A

T

S

W

L

G

C

G
|
G

M
|
M

V

A

A
|
A

C
x
T

G

G

L
x
A

A
x
S

G

G

P

T

R

N

R

A

P

V

W

R

S

Y

G

G

S

T

V

M

R

R

D

D

F

N

V

V

L

I

G

N

T

L

R

E

I

V

I

V

T

L

G

P

A

D

G

G

K

R

H

L

L

L

R

H

F

T

G

A

G

G

-

R

-

G

-

R

E

H

V

Y

M

R

K

K

N

S

V

A

A

A

G

G

Y

Y

D

N

L

L

S

T

R

G

L

L

M

F

V

V

G

G

S

S

Y
x
E

G
|
G

C

T

L

L

G

G

V

I

L
x
I

T

T

E

S

I

T

S

T

M

L

K

R

V

L

L

H

P

P

R

A

P

P

R

E

A

A

S

T

L

V

S

A

L

A

R

T

R

C

E

A

I

F

-

P

S

S

L

V

Q

Q

E

A

A

A

M

V

S

D

E

S

I

T

A

V

E

Q

W

I

Q

L

L

Q

Q

A

P

A

L

V

P

P

I

V

S

A

G

R

L

I

C

E

Y

F

F

L

D

D

N

D

A

V

L

M

binding flavin-adenine dinucleotide: P132 (= P89), G133 (= G93), A134 (≠ E94), G140 (= G100), M141 (= M101), A143 (= A103), T144 (≠ C104), A146 (≠ L106), S147 (≠ A107), E200 (≠ Y157), G201 (= G158), I206 (≠ L163)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 68, 70, 71, 72, 73, 74, 78, 79, 90, 369, 413, 450
binding deaminohydroxyvaline: 319, 414

8jdeA Crystal structure of mldhd in complex with d-lactate (see paper)
25% identity, 46% coverage: 53:213/350 of query aligns to 96:257/455 of 8jdeA

query
sites
8jdeA

I

I

V

T

N

E

Y

L

D

N

P

T

T

E

E

D

L

F

V

S

I

V

T

V

A

V

R

E

V

P

G

G

T

V

P

T

L

R

V

K

T

A

I

L

E

N

A

T

A

H

L

L

E

R

S

D

A

S

G

G

Q

L

M

W

L

F

P

P

C

V

E

D

P
|
P

P

-

H

-

Y

-

G
|
G

E
x
A

E

D

A

A

T

S

W

L

G

C

G
|
G

M
|
M

V

A

A
|
A

C
x
T

G

G

L
x
A

A
x
S

G

G

P

T

R

N

R

A

P

V

W

R

S

Y

G

G

S

T

V

M

R

R

D

D

F

N

V

V

L

I

G

N

T

L

R

E

I

V

I

V

T

L

G

P

A

D

G

G

K

R

H

L

L

L

R

H

F

T

G

A

G

G

-

R

-

G

-

R

E

H

V

Y

M

R

K

K

N

S

V

A

A

A

G

G

Y

Y

D

N

L

L

S

T

R

G

L

L

M

F

V

V

G

G

S

S

Y
x
E

G
|
G

C

T

L

L

G

G

V

I

L
x
I

T

T

E

S

I

T

S

T

M

L

K

R

V

L

L

H

P

P

R

A

P

P

R

E

A

A

S

T

L

V

S

A

L

A

R

T

R

C

E

A

I

F

-

P

S

S

L

V

Q

Q

E

A

A

A

M

V

S

D

E

S

I

T

A

V

E

Q

W

I

Q

L

L

Q

Q

A

P

A

L

V

P

P

I

V

S

A

G

R

L

I

C

E

Y

F

F

L

D

D

N

D

A

V

L

M

binding flavin-adenine dinucleotide: P132 (= P89), G133 (= G93), A134 (≠ E94), G140 (= G100), M141 (= M101), A143 (= A103), T144 (≠ C104), A146 (≠ L106), S147 (≠ A107), E200 (≠ Y157), G201 (= G158), I206 (≠ L163)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 68, 70, 71, 72, 73, 74, 78, 79, 90, 322, 413, 414, 450
binding lactic acid: 318, 369, 376, 414
binding manganese (ii) ion: 369, 376, 413

8jdxA Crystal structure of mldhd in complex with 2-ketoisovaleric acid (see paper)
25% identity, 46% coverage: 53:213/350 of query aligns to 96:257/455 of 8jdxA

query
sites
8jdxA

I

I

V

T

N

E

Y

L

D

N

P

T

T

E

E

D

L

F

V

S

I

V

T

V

A

V

R

E

V

P

G

G

T

V

P

T

L

R

V

K

T

A

I

L

E

N

A

T

A

H

L

L

E

R

S

D

A

S

G

G

Q

L

M

W

L

F

P

P

C

V

E

D

P
|
P

P

-

H

-

Y

-

G
|
G

E
x
A

E

D

A

A

T

S

W

L

G

C

G
|
G

M
|
M

V

A

A
|
A

C
x
T

G

G

L
x
A

A
x
S

G

G

P

T

R

N

R

A

P

V

W

R

S

Y

G

G

S

T

V

M

R

R

D

D

F

N

V

V

L

I

G

N

T

L

R

E

I

V

I

V

T

L

G

P

A

D

G

G

K

R

H

L

L

L

R

H

F

T

G

A

G

G

-

R

-

G

-

R

E

H

V

Y

M

R

K

K

N

S

V

A

A

A

G

G

Y

Y

D

N

L

L

S

T

R

G

L

L

M

F

V

V

G

G

S

S

Y
x
E

G
|
G

C

T

L

L

G

G

V

I

L
x
I

T

T

E

S

I

T

S

T

M

L

K

R

V

L

L

H

P

P

R

A

P

P

R

E

A

A

S

T

L

V

S

A

L

A

R

T

R

C

E

A

I

F

-

P

S

S

L

V

Q

Q

E

A

A

A

M

V

S

D

E

S

I

T

A

V

E

Q

W

I

Q

L

L

Q

Q

A

P

A

L

V

P

P

I

V

S

A

G

R

L

I

C

E

Y

F

F

L

D

D

N

D

A

V

L

M

binding flavin-adenine dinucleotide: P132 (= P89), G133 (= G93), A134 (≠ E94), G140 (= G100), M141 (= M101), A143 (= A103), T144 (≠ C104), A146 (≠ L106), S147 (≠ A107), E200 (≠ Y157), G201 (= G158), I206 (≠ L163)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 32, 68, 70, 71, 72, 73, 74, 78, 79, 90, 322, 413, 414, 450
binding 3-methyl-2-oxobutanoic acid: 318, 369, 376, 414
binding manganese (ii) ion: 369, 376, 413

8jduA Crystal structure of mldhd in complex with 2-ketovaleric acid (see paper)
25% identity, 46% coverage: 53:213/350 of query aligns to 96:257/455 of 8jduA

query
sites
8jduA

I

I

V

T

N

E

Y

L

D

N

P

T

T

E

E

D

L

F

V

S

I

V

T

V

A

V

R

E

V

P

G

G

T

V

P

T

L

R

V

K

T

A

I

L

E

N

A

T

A

H

L

L

E

R

S

D

A

S

G

G

Q

L

M

W

L

F

P

P

C

V

E

D

P
|
P

P

-

H

-

Y

-

G
|
G

E
x
A

E

D

A

A

T

S

W

L

G

C

G
|
G

M
|
M

V

A

A
|
A

C
x
T

G

G

L
x
A

A
x
S

G

G

P

T

R

N

R

A

P

V

W

R

S

Y

G

G

S

T

V

M

R

R

D

D

F

N

V

V

L

I

G

N

T

L

R

E

I

V

I

V

T

L

G

P

A

D

G

G

K

R

H

L

L

L

R

H

F

T

G

A

G

G

-

R

-

G

-

R

E

H

V

Y

M

R

K

K

N

S

V

A

A

A

G

G

Y

Y

D

N

L

L

S

T

R

G

L

L

M

F

V

V

G

G

S

S

Y
x
E

G
|
G

C

T

L

L

G

G

V

I

L
x
I

T

T

E

S

I

T

S

T

M

L

K

R

V

L

L

H

P

P

R

A

P

P

R

E

A

A

S

T

L

V

S

A

L

A

R

T

R

C

E

A

I

F

-

P

S

S

L

V

Q

Q

E

A

A

A

M

V

S

D

E

S

I

T

A

V

E

Q

W

I

Q

L

L

Q

Q

A

P

A

L

V

P

P

I

V

S

A

G

R

L

I

C

E

Y

F

F

L

D

D

N

D

A

V

L

M

binding flavin-adenine dinucleotide: P132 (= P89), G133 (= G93), A134 (≠ E94), G140 (= G100), M141 (= M101), A143 (= A103), T144 (≠ C104), A146 (≠ L106), S147 (≠ A107), E200 (≠ Y157), G201 (= G158), I206 (≠ L163)

Sites not aligning to the query:

binding 2-oxopentanoic acid: 318, 322, 369, 376, 414
binding flavin-adenine dinucleotide: 68, 70, 71, 72, 73, 74, 78, 79, 90, 322, 413, 450
binding manganese (ii) ion: 369, 376, 413

8jdzA Crystal structure of mldhd in complex with 2-keto-3-methylvaleric acid (see paper)
25% identity, 46% coverage: 53:213/350 of query aligns to 96:257/454 of 8jdzA

query
sites
8jdzA

I

I

V

T

N

E

Y

L

D

N

P

T

T

E

E

D

L

F

V

S

I

V

T

V

A

V

R

E

V

P

G

G

T

V

P

T

L

R

V

K

T

A

I

L

E

N

A

T

A

H

L

L

E

R

S

D

A

S

G

G

Q

L

M

W

L

F

P

P

C

V

E

D

P
|
P

P

-

H

-

Y

-

G
|
G

E
x
A

E

D

A

A

T

S

W

L

G

C

G
|
G

M
|
M

V

A

A
|
A

C
x
T

G

G

L
x
A

A
x
S

G

G

P

T

R

N

R

A

P

V

W

R

S

Y

G

G

S

T

V

M

R

R

D

D

F

N

V

V

L

I

G

N

T

L

R

E

I

V

I

V

T

L

G

P

A

D

G

G

K

R

H

L

L

L

R

H

F

T

G

A

G

G

-

R

-

G

-

R

E

H

V

Y

M

R

K

K

N

S

V

A

A

A

G

G

Y

Y

D

N

L

L

S

T

R

G

L

L

M

F

V

V

G

G

S

S

Y
x
E

G
|
G

C

T

L

L

G

G

V

I

L
x
I

T

T

E

S

I

T

S

T

M

L

K

R

V

L

L

H

P

P

R

A

P

P

R

E

A

A

S

T

L

V

S

A

L

A

R

T

R

C

E

A

I

F

-

P

S

S

L

V

Q

Q

E

A

A

A

M

V

S

D

E

S

I

T

A

V

E

Q

W

I

Q

L

L

Q

Q

A

P

A

L

V

P

P

I

V

S

A

G

R

L

I

C

E

Y

F

F

L

D

D

N

D

A

V

L

M

binding flavin-adenine dinucleotide: P132 (= P89), G133 (= G93), A134 (≠ E94), G140 (= G100), M141 (= M101), A143 (= A103), T144 (≠ C104), A146 (≠ L106), S147 (≠ A107), E200 (≠ Y157), G201 (= G158), I206 (≠ L163)

Sites not aligning to the query:

binding (3S)-3-methyl-2-oxopentanoic acid: 318, 322, 369, 376, 413
binding flavin-adenine dinucleotide: 32, 68, 70, 71, 72, 73, 74, 78, 79, 90, 322, 412, 413, 449
binding manganese (ii) ion: 369, 376, 412

8jdyA Crystal structure of mldhd in complex with 2-ketoisocaproic acid (see paper)
25% identity, 46% coverage: 53:213/350 of query aligns to 96:257/454 of 8jdyA

query
sites
8jdyA

I

I

V

T

N

E

Y

L

D

N

P

T

T

E

E

D

L

F

V

S

I

V

T

V

A

V

R

E

V

P

G

G

T

V

P

T

L

R

V

K

T

A

I

L

E

N

A

T

A

H

L

L

E

R

S

D

A

S

G

G

Q

L

M

W

L

F

P

P

C

V

E

D

P
|
P

P

-

H

-

Y

-

G
|
G

E
x
A

E

D

A

A

T

S

W

L

G

C

G
|
G

M
|
M

V

A

A
|
A

C
x
T

G

G

L
x
A

A
x
S

G

G

P

T

R

N

R

A

P

V

W

R

S

Y

G

G

S

T

V

M

R

R

D

D

F

N

V

V

L

I

G

N

T

L

R

E

I

V

I

V

T

L

G

P

A

D

G

G

K

R

H

L

L

L

R

H

F

T

G

A

G

G

-

R

-

G

-

R

E

H

V

Y

M

R

K

K

N

S

V

A

A

A

G

G

Y

Y

D

N

L

L

S

T

R

G

L

L

M

F

V

V

G

G

S

S

Y
x
E

G
|
G

C

T

L

L

G

G

V

I

L
x
I

T

T

E

S

I

T

S

T

M

L

K

R

V

L

L

H

P

P

R

A

P

P

R

E

A

A

S

T

L

V

S

A

L

A

R

T

R

C

E

A

I

F

-

P

S

S

L

V

Q

Q

E

A

A

A

M

V

S

D

E

S

I

T

A

V

E

Q

W

I

Q

L

L

Q

Q

A

P

A

L

V

P

P

I

V

S

A

G

R

L

I

C

E

Y

F

F

L

D

D

N

D

A

V

L

M

binding flavin-adenine dinucleotide: P132 (= P89), G133 (= G93), A134 (≠ E94), G140 (= G100), M141 (= M101), A143 (= A103), T144 (≠ C104), A146 (≠ L106), S147 (≠ A107), E200 (≠ Y157), G201 (= G158), I206 (≠ L163)

Sites not aligning to the query:

binding 2-oxo-4-methylpentanoic acid: 318, 322, 336, 369, 376, 413
binding flavin-adenine dinucleotide: 68, 70, 71, 72, 73, 74, 78, 79, 90, 412, 449
binding manganese (ii) ion: 369, 376, 412

3pm9A Crystal structure of a putative dehydrogenase (rpa1076) from rhodopseudomonas palustris cga009 at 2.57 a resolution
27% identity, 48% coverage: 10:176/350 of query aligns to 55:219/465 of 3pm9A

query
sites
3pm9A

A

A

L

I

L

C

E

K

Q

L

V

A

N

N

Q

E

A

A

I

-

S

-

D

-

K

R

T

V

P

A

L

L

V

V

I
x
P

Q
|
Q

G
|
G

S
x
G

N
|
N

S
x
T

K
x
G

A
x
L

F

V

L

G

G
|
G

R
x
Q

-

T

P

P

V

H

T

N

G

G

Q

E

T

V

-

V

L

I

D

S

V
x
L

R

K

C

R

H

M

R

D

G

K

I

I

V

R

N

E

Y

I

D

D

P

T

T

S

E

S

L

N

V

T

I

I

T

T

A

V

R

E

V

A

G

G

T

A

P

I

L

L

V

Q

T

R

I

V

E

Q

A

E

A

K

L

A

E

A

S

E

A

V

G

D

Q

R

M

L

L

F

P

P

C

L

E

S

P
x
L

P
x
G

H
x
A

Y

Q

G

G

E

S

E

-

A
x
C

T
|
T

W

I

G
|
G

G
|
G

M

N

V

L

A
x
S

C
x
T

G

N

L
x
A

A
x
G

G

G

P

T

R

A

R

A

P

L

W

A

S

Y

G

G

S
x
L

V

A

R

R

D

D

F

M

V

A

L

L

G

G

T

V

R

E

I

V

I

V

T

L

G

A

A

D

G

G

K

R

H

V

L

M

R

N

F

L

G

L

G

S

E

K

V

L

M

K

K

K

N

D

V

N

A

T

G

G

Y

Y

D

D

L

L

S

R

R

D

L

L

M

F

V

I

G

G

S

A

Y
x
E

G
|
G

C

T

L

L

G

G

V
x
I

L
x
I

T

T

E

A

I

A

S

T

M

L

K

K

V

L

L

F

P

P

R

K

P

P

R

R

A

A

active site: A149 (≠ L106), L159 (≠ S116)
binding flavin-adenine dinucleotide: P69 (≠ I27), Q70 (= Q28), G71 (= G29), G72 (≠ S30), N73 (= N31), T74 (≠ S32), G75 (≠ K33), L76 (≠ A34), G79 (= G37), Q80 (≠ R38), L91 (≠ V47), L133 (≠ P89), G134 (≠ P90), A135 (≠ H91), C139 (≠ A96), T140 (= T97), G142 (= G99), G143 (= G100), S146 (≠ A103), T147 (≠ C104), A149 (≠ L106), G150 (≠ A107), E200 (≠ Y157), G201 (= G158), I205 (≠ V162), I206 (≠ L163)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 423

P9WIT1 Uncharacterized FAD-linked oxidoreductase Rv2280; EC 1.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
29% identity, 50% coverage: 38:211/350 of query aligns to 80:253/459 of P9WIT1

query
sites
P9WIT1

R

R

P

P

V

V

T

E

G

G

Q

G

T

L

L

L

D

-

V

I

R

S

C

F

H

D

R

R

-

M

-

N

G

K

I

V

V

L

N

E

Y

V

D

D

P

T

T

A

E

N

L

Q

V

V

I

A

T

V

A

V

R

Q

V

P

G

G

T

V

P

A

L

L

V

T

T

D

I

L

E

D

A

A

A

A

L

T

E

A

S

D

A

T

G

G

Q

L

M

R

L

Y

P

T

C

V

E

Y

P

P

P

-

H

-

Y

-

G

G

E

E

-

L

E

S

A

S

T

S

W

V

G

G

G

G

M

N

V

V

A

G

C

T

G

N

L

A

A

G

G

G

P

M

R

R

R

A

P

V

W

K

S

Y

G

G

S

V

V

A

R

R

D

H

F

N

V

V

L

L

G

G

T

L

R

Q

I

A

I

V

T

L

G

P

A

T

G

G

K

E

H

I

L

I

R

R

F

T

G

G

G

G

E

R

V

M

M

A

K

K

N

V

V

S

A

T

G

G

Y

Y

D

D

L

L

S

T

R

Q

L

L

M

I

V

I

G

G

S

S

Y

E

G

G

C

T

L

L

G

A

V

L

L

V

T

T

E

E

I

V

S

I

M

V

K

K

V

L

L

H

P

P

R

R

P

L

R

D

A

H

S

N

L

A

S

S

L

V

R

L

R

A

E

P

I

F

S

A

-

D

L

F

Q

D

E

Q

A

V

M

M

S

A

E

A

I

V

A

P

E

K

W

I

Q

L

L

A

Q

S

P

G

L

L

P

A

I

P

S

D

G

I

L

L

C

E

Y

Y

F

I

D

D

N

N

Sites not aligning to the query:

354 modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)

6lpxA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with 2-oxoglutarate (2-og) (see paper)
28% identity, 35% coverage: 53:176/350 of query aligns to 103:225/466 of 6lpxA

query
sites
6lpxA

I

V

V

L

N

S

Y

F

D

H

P

S

T

V

E

S

L

G

V

I

I

L

T

V

A

C

R

Q

V

A

G

G

T

C

P

V

L

L

V

E

T

E

I

L

E

S

A

R

A

Y

L

V

E

E

S

E

A

R

G

D

Q

F

M

I

L

M

P

P

C

L

E

D

P
x
L

P
x
G

H
x
A

Y

K

G

G

E

S

E

-

A
x
C

T

H

W

I

G

G

G
|
G

M
x
N

V

V

A
|
A

C
x
T

G

N

L

A

A

G

G
|
G

P

L

R

R

R

F

P

L

W

R

S

Y

G

G

S

S

V

L

R

H

D

G

F

T

V

V

L

L

G

G

T

L

R

E

I

V

I

V

T

L

G

A

A

D

G

G

K

T

H

V

L

L

R

D

F

C

G

L

G

T

E

S

V

L

M

R

K

K

N

D

V

N

A

T

G

G

Y

Y

D

D

L

L

S

K

R

Q

L

L

M

F

V

I

G

G

S

S

Y

E

G
|
G

C

T

L

L

G

G

V

I

L
x
I

T

T

E

T

I

V

S

S

M

I

K

L

V

C

L

P

P

P

R

K

P

P

R

R

A

A

binding flavin-adenine dinucleotide: L139 (≠ P89), G140 (≠ P90), A141 (≠ H91), C145 (≠ A96), G149 (= G100), N150 (≠ M101), A152 (= A103), T153 (≠ C104), G157 (= G108), G207 (= G158), I212 (≠ L163)

Sites not aligning to the query:

binding 2-oxoglutaric acid: 333, 337, 348, 379, 381, 388, 423
binding flavin-adenine dinucleotide: 39, 75, 76, 77, 78, 79, 80, 81, 82, 85, 86, 422, 459
binding zinc ion: 381, 388, 422

6lpuA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with l-2-hydroxyglutarate (l-2-hg) (see paper)
28% identity, 35% coverage: 53:176/350 of query aligns to 103:225/466 of 6lpuA

query
sites
6lpuA

I

V

V

L

N

S

Y

F

D

H

P

S

T

V

E

S

L

G

V

I

I

L

T

V

A

C

R

Q

V

A

G

G

T

C

P

V

L

L

V

E

T

E

I

L

E

S

A

R

A

Y

L

V

E

E

S

E

A

R

G

D

Q

F

M

I

L

M

P

P

C

L

E

D

P
x
L

P
x
G

H
x
A

Y

K

G

G

E

S

E

-

A
x
C

T
x
H

W

I

G
|
G

G
|
G

M
x
N

V

V

A
|
A

C
x
T

G

N

L
x
A

A

G

G

G

P

L

R

R

R

F

P

L

W

R

S

Y

G

G

S

S

V

L

R

H

D

G

F

T

V

V

L

L

G

G

T

L

R

E

I

V

I

V

T

L

G

A

A

D

G

G

K

T

H

V

L

L

R

D

F

C

G

L

G

T

E

S

V

L

M

R

K

K

N

D

V

N

A

T

G

G

Y

Y

D

D

L

L

S

K

R

Q

L

L

M

F

V

I

G

G

S

S

Y
x
E

G
|
G

C

T

L

L

G

G

V
x
I

L
x
I

T

T

E

T

I

V

S

S

M

I

K

L

V

C

L

P

P

P

R

K

P

P

R

R

A

A

binding flavin-adenine dinucleotide: L139 (≠ P89), G140 (≠ P90), A141 (≠ H91), C145 (≠ A96), H146 (≠ T97), G148 (= G99), G149 (= G100), N150 (≠ M101), A152 (= A103), T153 (≠ C104), A155 (≠ L106), E206 (≠ Y157), G207 (= G158), I211 (≠ V162), I212 (≠ L163)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 39, 75, 77, 78, 79, 80, 81, 85, 86, 422, 459
binding (2s)-2-hydroxypentanedioic acid: 333, 337, 348, 379, 381, 388, 423
binding zinc ion: 381, 388, 422

Query Sequence

>1936904 FitnessBrowser__Keio:1936904
MLRECDYSQALLEQVNQAISDKTPLVIQGSNSKAFLGRPVTGQTLDVRCHRGIVNYDPTE
LVITARVGTPLVTIEAALESAGQMLPCEPPHYGEEATWGGMVACGLAGPRRPWSGSVRDF
VLGTRIITGAGKHLRFGGEVMKNVAGYDLSRLMVGSYGCLGVLTEISMKVLPRPRASLSL
RREISLQEAMSEIAEWQLQPLPISGLCYFDNALWIRLEGGEGSVKAARELLGGEEVAGQF
WQQLREQQLPFFSLPGTLWRISLPSDAPMMDLPGEQLIDWGGALRWLKSTAEDNQIHRIA
RNAGGHATRFSAGDGGFAPLSAPLFRYHQQLKQQLDPCGVFNPGRMYAEL

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory