Comparing 1936938 FitnessBrowser__Keio:1936938 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1h16A Pyruvate formate-lyase (e.Coli) in complex with pyruvate and coa (see paper)
80% identity, 98% coverage: 13:764/764 of query aligns to 8:759/759 of 1h16A
P09373 Formate acetyltransferase 1; Pyruvate formate-lyase 1; EC 2.3.1.54 from Escherichia coli (strain K12) (see 4 papers)
80% identity, 98% coverage: 13:764/764 of query aligns to 9:760/760 of P09373
Sites not aligning to the query:
1cm5A Crystal structure of c418a,c419a mutant of pfl from e.Coli (see paper)
79% identity, 98% coverage: 13:764/764 of query aligns to 8:759/759 of 1cm5A
1r9dA Glycerol bound form of the b12-independent glycerol dehydratase from clostridium butyricum (see paper)
27% identity, 70% coverage: 229:759/764 of query aligns to 235:782/786 of 1r9dA
Sites not aligning to the query:
2f3oA Crystal structure of a glycyl radical enzyme from archaeoglobus fulgidus (see paper)
25% identity, 80% coverage: 146:758/764 of query aligns to 118:768/773 of 2f3oA
6vxeA Crystal structure of hydroxyproline dehydratase (hypd) from clostridioides difficile with substrate trans-4-hydroxy-l-proline bound (see paper)
22% identity, 87% coverage: 99:759/764 of query aligns to 67:785/789 of 6vxeA
A0A031WDE4 Trans-4-hydroxy-L-proline dehydratase; Glycyl radical enzyme; Hyp dehydratase; EC 4.2.1.172 from Clostridioides difficile (Peptoclostridium difficile) (see paper)
22% identity, 87% coverage: 99:759/764 of query aligns to 67:785/789 of A0A031WDE4
6nd3A Wild-type choline tma lyase in complex with betaine aldehyde (see paper)
25% identity, 71% coverage: 220:760/764 of query aligns to 229:791/795 of 6nd3A
Sites not aligning to the query:
5fawB T502a mutant of choline tma-lyase (see paper)
24% identity, 71% coverage: 220:764/764 of query aligns to 240:806/806 of 5fawB
Sites not aligning to the query:
6vueA Wild-type choline tma lyase in complex with 1-methyl-1,2,3,6- tetrahydropyridin-3-ol (see paper)
24% identity, 71% coverage: 220:764/764 of query aligns to 237:803/803 of 6vueA
Sites not aligning to the query:
Q30W70 Choline trimethylamine-lyase; Choline TMA-lyase; Choline utilization protein C; Glycyl radical enzyme CutC; GRE CutC; EC 4.3.99.4 from Oleidesulfovibrio alaskensis (strain ATCC BAA-1058 / DSM 17464 / G20) (Desulfovibrio alaskensis) (see 2 papers)
25% identity, 71% coverage: 220:760/764 of query aligns to 280:842/846 of Q30W70
Sites not aligning to the query:
7e7lA The crystal structure of arylacetate decarboxylase from olsenella scatoligenes.
23% identity, 66% coverage: 252:759/764 of query aligns to 231:767/770 of 7e7lA
Sites not aligning to the query:
7vuaA Anaerobic hydroxyproline degradation involving c-n cleavage by a glycyl radical enzyme (see paper)
24% identity, 67% coverage: 252:764/764 of query aligns to 248:785/785 of 7vuaA
5a0uH Structure of cutc choline lyase choline bound form from klebsiella pneumoniae. (see paper)
24% identity, 70% coverage: 225:762/764 of query aligns to 234:793/795 of 5a0uH
Sites not aligning to the query:
6lonA Crystal structure of hpsg (see paper)
25% identity, 66% coverage: 252:759/764 of query aligns to 260:799/804 of 6lonA
Sites not aligning to the query:
E5Y7I4 (2S)-3-sulfopropanediol sulfolyase; (S)-DHPS sulfolyase; EC 4.4.1.41 from Bilophila wadsworthia (strain 3_1_6) (see paper)
25% identity, 66% coverage: 252:759/764 of query aligns to 280:819/824 of E5Y7I4
Sites not aligning to the query:
P68066 Autonomous glycyl radical cofactor from Escherichia coli (strain K12) (see paper)
77% identity, 8% coverage: 701:764/764 of query aligns to 64:127/127 of P68066
Sites not aligning to the query:
7kq3A Structure of isethionate sulfite-lyase from bilophila wadsworthia with substrate isethionate bound (see paper)
24% identity, 67% coverage: 250:759/764 of query aligns to 279:820/825 of 7kq3A
Sites not aligning to the query:
Q727N1 Isethionate sulfite-lyase; C-S lyase IseG; Glycyl radical enzyme IseG; GRE IseG; EC 4.4.1.38 from Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough) (see paper)
25% identity, 68% coverage: 237:759/764 of query aligns to 269:823/828 of Q727N1
Sites not aligning to the query:
5ymrB The crystal structure of iseg (see paper)
25% identity, 68% coverage: 237:759/764 of query aligns to 239:793/798 of 5ymrB
Sites not aligning to the query:
>1936938 FitnessBrowser__Keio:1936938
MKVDIDTSDKLYADAWLGFKGTDWKNEINVRDFIQHNYTPYEGDESFLAEATPATTELWE
KVMEGIRIENATHAPVDFDTNIATTITAHDAGYINQPLEKIVGLQTDAPLKRALHPFGGI
NMIKSSFHAYGREMDSEFEYLFTDLRKTHNQGVFDVYSPDMLRCRKSGVLTGLPDGYGRG
RIIGDYRRVALYGISYLVRERELQFADLQSRLEKGEDLEATIRLREELAEHRHALLQIQE
MAAKYGFDISRPAQNAQEAVQWLYFAYLAAVKSQNGGAMSLGRTASFLDIYIERDFKAGV
LNEQQAQELIDHFIMKIRMVRFLRTPEFDSLFSGDPIWATEVIGGMGLDGRTLVTKNSFR
YLHTLHTMGPAPEPNLTILWSEELPIAFKKYAAQVSIVTSSLQYENDDLMRTDFNSDDYA
IACCVSPMVIGKQMQFFGARANLAKTLLYAINGGVDEKLKIQVGPKTAPLMDDVLDYDKV
MDSLDHFMDWLAVQYISALNIIHYMHDKYSYEASLMALHDRDVYRTMACGIAGLSVATDS
LSAIKYARVKPIRDENGLAVDFEIDGEYPQYGNNDERVDSIACDLVERFMKKIKALPTYR
NAVPTQSILTITSNVVYGQKTGNTPDGRRAGTPFAPGANPMHGRDRKGAVASLTSVAKLP
FTYAKDGISYTFSIVPAALGKEDPVRKTNLVGLLDGYFHHEADVEGGQHLNVNVMNREML
LDAIEHPEKYPNLTIRVSGYAVRFNALTREQQQDVISRTFTQAL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory