Comparing 1937093 b4478 galactonate dehydratase (NCBI) to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q6BF17 D-galactonate dehydratase; GalD; EC 4.2.1.6 from Escherichia coli (strain K12)
100% identity, 100% coverage: 1:382/382 of query aligns to 1:382/382 of Q6BF17
3rraB Crystal structure of enolase prk14017 (target efi-500653) from ralstonia pickettii 12j with magnesium bound
81% identity, 100% coverage: 1:382/382 of query aligns to 2:375/379 of 3rraB
3gy1B Crystal structure of putative mandelate racemase/muconate lactonizing protein from clostridium beijerinckii ncimb 8052
32% identity, 94% coverage: 3:360/382 of query aligns to 7:363/388 of 3gy1B
A6M2W4 D-galactonate dehydratase family member Cbei_4837 from Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum) (see paper)
32% identity, 94% coverage: 3:360/382 of query aligns to 6:377/399 of A6M2W4
4e4fB Crystal structure of enolase pc1_0802 (target efi-502240) from pectobacterium carotovorum subsp. Carotovorum pc1
32% identity, 100% coverage: 1:382/382 of query aligns to 2:381/381 of 4e4fB
B3PDB1 D-galactonate dehydratase family member RspA; D-mannonate dehydratase; Starvation sensing protein RspA homolog; EC 4.2.1.-; EC 4.2.1.8 from Cellvibrio japonicus (strain Ueda107) (Pseudomonas fluorescens subsp. cellulosa) (see paper)
31% identity, 96% coverage: 18:382/382 of query aligns to 20:402/402 of B3PDB1
Q8FHC7 D-galactonate dehydratase family member RspA; D-mannonate dehydratase; Starvation sensing protein RspA homolog; EC 4.2.1.-; EC 4.2.1.8 from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) (see paper)
30% identity, 100% coverage: 1:382/382 of query aligns to 12:415/415 of Q8FHC7
4il2B Crystal structure of d-mannonate dehydratase (rspa) from e. Coli cft073 (efi target efi-501585)
30% identity, 100% coverage: 1:382/382 of query aligns to 1:404/404 of 4il2B
3v3wA Crystal structure of an enolase from the soil bacterium cellvibrio japonicus (target efi-502161) with bound mg and glycerol
31% identity, 96% coverage: 18:382/382 of query aligns to 20:397/397 of 3v3wA
4gmeC Crystal structure of mannonate dehydratase (target efi-502209) from caulobacter crescentus cb15 complexed with magnesium and d-mannonate
31% identity, 97% coverage: 14:382/382 of query aligns to 17:403/403 of 4gmeC
4gmeA Crystal structure of mannonate dehydratase (target efi-502209) from caulobacter crescentus cb15 complexed with magnesium and d-mannonate
31% identity, 97% coverage: 14:382/382 of query aligns to 17:403/403 of 4gmeA
Q9AAR4 D-mannonate dehydratase CC0532; ManD; EC 4.2.1.8 from Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus) (see paper)
31% identity, 97% coverage: 14:382/382 of query aligns to 17:403/403 of Q9AAR4
4hnlA Crystal structure of enolase egbg_01401 (target efi-502226) from enterococcus gallinarum eg2
31% identity, 94% coverage: 3:360/382 of query aligns to 8:379/401 of 4hnlA
Sites not aligning to the query:
C8ZZN2 D-galactonate dehydratase family member EGBG_01401 from Enterococcus gallinarum (strain EG2) (see paper)
31% identity, 94% coverage: 3:360/382 of query aligns to 6:377/399 of C8ZZN2
C6D9S0 D-galactonate dehydratase family member PC1_0802; D-mannonate dehydratase; EC 4.2.1.-; EC 4.2.1.8 from Pectobacterium carotovorum subsp. carotovorum (strain PC1) (see paper)
30% identity, 100% coverage: 1:382/382 of query aligns to 1:404/404 of C6D9S0
3rgtA Crystal structure of d-mannonate dehydratase from chromohalobacter salexigens complexed with d-arabinohydroxamate
32% identity, 96% coverage: 18:382/382 of query aligns to 20:383/383 of 3rgtA
4k1wA Crystal structure of the a314p mutant of mannonate dehydratase from novosphingobium aromaticivorans complexed with mg and d-mannonate
32% identity, 100% coverage: 1:382/382 of query aligns to 11:395/395 of 4k1wA
3p93C Crystal structure of d-mannonate dehydratase from chromohalobacter salexigens complexed with mg,d-mannonate and 2-keto-3-deoxy-d- gluconate
31% identity, 96% coverage: 18:382/382 of query aligns to 20:384/384 of 3p93C
3p93A Crystal structure of d-mannonate dehydratase from chromohalobacter salexigens complexed with mg,d-mannonate and 2-keto-3-deoxy-d- gluconate
31% identity, 96% coverage: 18:382/382 of query aligns to 20:384/384 of 3p93A
A5KUH4 D-galactonate dehydratase family member VSWAT3_13707 from Vibrionales bacterium (strain SWAT-3) (see paper)
31% identity, 89% coverage: 20:360/382 of query aligns to 26:377/399 of A5KUH4
>1937093 b4478 galactonate dehydratase (NCBI)
MKITKITTYRLPPRWMFLKIETDEGVVGWGEPVIEGRARTVEAAVHELGDYLIGQDPSRI
NDLWQVMYRAGFYRGGPILMSAIAGIDQALWDIKGKVLNAPVWQLMGGLVRDKIKAYSWV
GGDRPADVIDGIKTLREIGFDTFKLNGCEELGLIDNSRAVDAAVNTVAQIREAFGNQIEF
GLDFHGRVSAPMAKVLIKELEPYRPLFIEEPVLAEQAEYYPKLAAQTHIPLAAGERMFSR
FDFKRVLEAGGISILQPDLSHAGGITECYKIAGMAEAYDVTLAPHCPLGPIALAACLHID
FVSYNAVLQEQSMGIHYNKGAELLDFVKNKEDFSMVGGFFKPLTKPGLGVEIDEAKVIEF
SKNAPDWRNPLWRHEDNSVAEW
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory