Comparing 1937120 FitnessBrowser__Keio:1937120 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 12 hits to proteins with known functional sites (download)
P9WKJ5 Dihydroxy-acid dehydratase; DAD; EC 4.2.1.9 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
39% identity, 98% coverage: 3:608/616 of query aligns to 18:573/575 of P9WKJ5
6ovtA Crystal structure of ilvd from mycobacterium tuberculosis (see paper)
39% identity, 98% coverage: 3:608/616 of query aligns to 5:560/562 of 6ovtA
Q9LIR4 Dihydroxy-acid dehydratase, chloroplastic; AthDHAD; DAD; EC 4.2.1.9 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
38% identity, 99% coverage: 3:611/616 of query aligns to 55:608/608 of Q9LIR4
8hs0A The mutant structure of dhad v178w
38% identity, 99% coverage: 3:611/616 of query aligns to 17:570/570 of 8hs0A
8ej0A Crystal structure of fe-s cluster-dependent dehydratase from paralcaligenes ureilyticus in complex with mg
31% identity, 90% coverage: 19:574/616 of query aligns to 19:526/568 of 8ej0A
8epzA Crystal structure of fe-s cluster-dependent dehydratase from paralcaligenes ureilyticus in complex with mn
31% identity, 90% coverage: 19:574/616 of query aligns to 20:527/569 of 8epzA
B5ZZ34 L-arabinonate dehydratase; ArDHT; D-fuconate dehydratase; Galactonate dehydratase; L-arabonate dehydratase; EC 4.2.1.25; EC 4.2.1.67; EC 4.2.1.6 from Rhizobium leguminosarum bv. trifolii (strain WSM2304) (see 2 papers)
31% identity, 94% coverage: 33:610/616 of query aligns to 43:564/579 of B5ZZ34
5j85A Ser480ala mutant of l-arabinonate dehydratase (see paper)
31% identity, 93% coverage: 33:607/616 of query aligns to 40:558/576 of 5j85A
Q1JUQ1 L-arabonate dehydratase; L-arabinonate dehydratase; EC 4.2.1.25 from Azospirillum brasilense (see paper)
30% identity, 92% coverage: 2:568/616 of query aligns to 6:529/583 of Q1JUQ1
7m3kA Crystal structure of galactonate dehydratase from brucella melitensis biovar abortus 2308
29% identity, 88% coverage: 33:576/616 of query aligns to 37:543/587 of 7m3kA
5oynA Crystal structure of d-xylonate dehydratase in holo-form (see paper)
29% identity, 87% coverage: 33:570/616 of query aligns to 42:541/589 of 5oynA
Q9A9Z2 D-xylonate dehydratase; XyDHT; Gluconate dehydratase; EC 4.2.1.82; EC 4.2.1.39 from Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus) (see 2 papers)
29% identity, 87% coverage: 33:570/616 of query aligns to 48:547/595 of Q9A9Z2
>1937120 FitnessBrowser__Keio:1937120
MPKYRSATTTHGRNMAGARALWRATGMTDADFGKPIIAVVNSFTQFVPGHVHLRDLGKLV
AEQIEAAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
NCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDQIIKLDLVDAMIQGADPKVSDSQ
SDQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGKRIV
ELTKRYYEQNDESALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMSD
IDKLSRKVPQLCKVAPSTQKYHMEDVHRAGGVIGILGELDRAGLLNRDVKNVLGLTLPQT
LEQYDVMLTQDDAVKNMFRAGPAGIRTTQAFSQDCRWDTLDDDRANGCIRSLEHAYSKDG
GLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVAGDVVVIRY
EGPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGSIGL
IEDGDLIAIDIPNRGIQLQVSDAELAARREAQDARGDKAWTPKNRERQVSFALRAYASLA
TSADKGAVRDKSKLGG
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory