SitesBLAST
Comparing 200442 FitnessBrowser__MR1:200442 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 3 hits to proteins with known functional sites (download)
5i39A High resolution structure of l-amino acid deaminase from proteus vulgaris with the deletion of the specific insertion sequence (see paper)
22% identity, 84% coverage: 36:401/435 of query aligns to 25:374/383 of 5i39A
- active site: F66 (≠ N77), Q69 (≠ E80), A70 (≠ L81), Q248 (= Q276), P267 (≠ D295)
- binding flavin-adenine dinucleotide: V30 (= V41), G31 (= G42), G33 (= G44), I34 (≠ F45), L35 (≠ S46), V53 (≠ L64), E54 (= E65), K55 (≠ A66), Q62 (≠ A73), S63 (= S74), F66 (≠ N77), Y67 (≠ G78), Q69 (≠ E80), A196 (= A215), A197 (= A216), G226 (= G243), G227 (≠ N244), W229 (≠ Y246), Q248 (= Q276), Q250 (≠ K278), G321 (= G347), M323 (≠ I349), T348 (≠ A375), G349 (= G376), W350 (≠ H377), G351 (= G378), M352 (≠ V379), T353 (≠ N380)
1y56B Crystal structure of l-proline dehydrogenase from p.Horikoshii (see paper)
23% identity, 79% coverage: 53:395/435 of query aligns to 22:353/374 of 1y56B
- active site: F44 (≠ G75), G47 (= G78), T48 (≠ G79), H224 (vs. gap), P239 (= P282), G305 (= G347), M338 (≠ N380)
- binding flavin-adenine dinucleotide: I33 (≠ L64), E34 (= E65), K35 (≠ A66), S42 (≠ A73), T43 (≠ S74), R45 (= R76), C46 (≠ N77), G47 (= G78), G49 (≠ E80), E170 (≠ A215), V171 (≠ A216), T200 (≠ G243), N201 (= N244), W203 (≠ Y246), G305 (= G347), Y306 (≠ M348), Y307 (≠ I349), G334 (= G376), H335 (= H377), G336 (= G378), F337 (≠ V379), M338 (≠ N380)
- binding flavin mononucleotide: F44 (≠ G75), R45 (= R76), I260 (≠ D302), R301 (≠ Y343), W303 (= W345)
Sites not aligning to the query:
5hxwA L-amino acid deaminase from proteus vulgaris (see paper)
22% identity, 84% coverage: 36:401/435 of query aligns to 17:424/433 of 5hxwA
- active site: F58 (≠ N77), Q61 (≠ E80), A62 (≠ L81), Q240 (vs. gap), V284 (≠ C277), F288 (≠ I281)
- binding cetyl-trimethyl-ammonium: G291 (≠ N284), Y294 (≠ F287), N310 (≠ D302), E311 (≠ R303), F317 (≠ G309), M318 (≠ L310), S320 (≠ C311), M373 (≠ I349), E379 (≠ R355), G399 (= G376), W400 (≠ H377)
- binding flavin-adenine dinucleotide: V22 (= V41), G23 (= G42), G25 (= G44), I26 (≠ F45), L27 (≠ S46), E46 (= E65), K47 (≠ A66), E53 (≠ G72), Q54 (≠ A73), S55 (= S74), R57 (= R76), F58 (≠ N77), Y59 (≠ G78), G60 (= G79), Q61 (≠ E80), A188 (= A215), A189 (= A216), G218 (= G243), G219 (≠ N244), W221 (≠ Y246), Q240 (vs. gap), Q242 (vs. gap), F331 (vs. gap), G371 (= G347), M373 (≠ I349), T398 (≠ A375), G399 (= G376), W400 (≠ H377), G401 (= G378), M402 (≠ V379), T403 (≠ N380)
Query Sequence
>200442 FitnessBrowser__MR1:200442
MPTKPPVHSEQYPHSYYLDTAKEIYAHPQLEGSITADVCIVGGGFSGINTAIELRQRGLS
VVLLEAKRMGWGASGRNGGELIRGIGHDPAQFINEIGQEGVSAIQQMGFEAVDIVRNRIQ
THQIDCDLQMGYCDLAVKPRHMIELQEEFESLKSLGYKHEIKLLAQSQLGNVIGSDFYQG
ALVDMGSGHLHPLNLALGEARVARELGAQLFEYSAAEKIIQGDKPKVLTAKGEVTCQYLV
LAGNAYIGHKLNSYIGGKVLPAGSYLLATEPLTQQQCKNIIPQNMAFADMRIALDYFHLS
ADRRLLFGGLCTYSGKDPKDIEAALRPNLEKVFPQLKGVRIDYEWGGMIGIGANRMPQIG
RLPDASNIFFAQAYAGHGVNATHMAAKLLAEAICQQAGHFDVFAKIKHMTFPGGPTFRSP
MLAAGMLYHRFKDLF
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory