Comparing 200476 FitnessBrowser__MR1:200476 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5g1nE Aspartate transcarbamoylase domain of human cad bound to pala (see paper)
45% identity, 92% coverage: 6:318/339 of query aligns to 5:305/307 of 5g1nE
1ml4A The pala-liganded aspartate transcarbamoylase catalytic subunit from pyrococcus abyssi (see paper)
43% identity, 93% coverage: 4:319/339 of query aligns to 2:306/307 of 1ml4A
P27708 Multifunctional protein CAD; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Homo sapiens (Human) (see 7 papers)
44% identity, 94% coverage: 1:318/339 of query aligns to 1918:2223/2225 of P27708
Sites not aligning to the query:
P08955 Multifunctional protein CAD; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Mesocricetus auratus (Golden hamster) (see paper)
44% identity, 94% coverage: 1:318/339 of query aligns to 1918:2223/2225 of P08955
Sites not aligning to the query:
P20054 Multifunctional protein pyr1-3; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Dictyostelium discoideum (Social amoeba)
43% identity, 94% coverage: 2:318/339 of query aligns to 1918:2222/2225 of P20054
Sites not aligning to the query:
P07259 Multifunctional protein URA2; Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase; CPSase-ATCase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
43% identity, 94% coverage: 2:320/339 of query aligns to 1906:2213/2214 of P07259
Sites not aligning to the query:
4eknB Structure of the catalytic chain of methanococcus jannaschii aspartate transcarbamoylase in a hexagonal crystal form (see paper)
43% identity, 91% coverage: 7:313/339 of query aligns to 2:296/304 of 4eknB
5g1pA Aspartate transcarbamoylase domain of human cad bound to carbamoyl phosphate (see paper)
44% identity, 92% coverage: 6:318/339 of query aligns to 2:290/292 of 5g1pA
Q09794 Multifunctional protein ura1; Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase; CPSase-ATCase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
44% identity, 93% coverage: 4:318/339 of query aligns to 1934:2238/2244 of Q09794
Sites not aligning to the query:
P05990 Multifunctional protein r; Protein rudimentary; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Drosophila melanogaster (Fruit fly) (see 2 papers)
42% identity, 92% coverage: 6:318/339 of query aligns to 1917:2218/2224 of P05990
Sites not aligning to the query:
8bplA Aspartate transcarbamoylase mutant (n2045c, r2238c) from chaetomium thermophilum cad-like bound to carbamoyl phosphate (see paper)
43% identity, 93% coverage: 2:317/339 of query aligns to 11:315/316 of 8bplA
2at1A Crystal structures of phosphonoacetamide ligated t and phosphonoacetamide and malonate ligated r states of aspartate carbamoyltransferase at 2.8-angstroms resolution and neutral ph (see paper)
40% identity, 94% coverage: 2:320/339 of query aligns to 2:307/310 of 2at1A
1at1A Crystal structures of phosphonoacetamide ligated t and phosphonoacetamide and malonate ligated r states of aspartate carbamoyltransferase at 2.8-angstroms resolution and neutral p H (see paper)
40% identity, 94% coverage: 2:320/339 of query aligns to 2:307/310 of 1at1A
6ys6B Arabidopsis aspartate transcarbamoylase complex with pala (see paper)
41% identity, 93% coverage: 4:317/339 of query aligns to 4:309/312 of 6ys6B
6ypoA Arabidopsis aspartate transcarbamoylase bound to ump (see paper)
41% identity, 93% coverage: 4:317/339 of query aligns to 4:309/312 of 6ypoA
2hseA Structure of d236a e. Coli aspartate transcarbamoylase in the presence of phosphonoacetamide and l-aspartate at 2.60 a resolution
40% identity, 94% coverage: 2:320/339 of query aligns to 2:307/310 of 2hseA
2a0fA Structure of d236a mutant e. Coli aspartate transcarbamoylase in presence of phosphonoacetamide at 2.90 a resolution (see paper)
40% identity, 94% coverage: 2:320/339 of query aligns to 2:307/310 of 2a0fA
P0A786 Aspartate carbamoyltransferase catalytic subunit; Aspartate transcarbamylase; ATCase; EC 2.1.3.2 from Escherichia coli (strain K12) (see 4 papers)
40% identity, 94% coverage: 2:320/339 of query aligns to 3:308/311 of P0A786
Sites not aligning to the query:
P49077 Aspartate carbamoyltransferase, chloroplastic; Aspartate transcarbamylase; ATCase; EC 2.1.3.2 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
41% identity, 94% coverage: 1:317/339 of query aligns to 79:387/390 of P49077
2ipoA E. Coli aspartate transcarbamoylase complexed with n-phosphonacetyl-l- asparagine (see paper)
40% identity, 94% coverage: 2:320/339 of query aligns to 2:307/310 of 2ipoA
>200476 FitnessBrowser__MR1:200476
MNQFEGSHILSVNQLDLDSIQTIFNVAHRMMPYALREKRTKVLEGAILGNLFFEPSTRTR
VSFGCAFNLLGGHVRETTGMASSSLSKGESLYDTARVLSTYSDVIAMRHPDSYSVKEFAE
GSRVPVINGGDGSNEHPTQALLDLFTIQKELGHASRGIDGMHIAMVGDLKFGRTVHSLSR
LLCMYKNISFTLISPTELAMPDYVISDIENAGHSIKITDQLEGHLDKADILYLTRIQEER
FPSQEEANKYRGKFRLNRSIYTQHCKSNTVIMHPLPRDSRAQANELDNDLNSHPNLAIFR
QADNGLLIRMALFALTLGVDSQLEKYECPVNWYSRKADR
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory