Comparing 201228 FitnessBrowser__MR1:201228 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q9S5G5 Histidine biosynthesis bifunctional protein HisB; EC 3.1.3.15; EC 4.2.1.19 from Escherichia coli O157:H7 (see paper)
61% identity, 98% coverage: 9:363/363 of query aligns to 1:355/355 of Q9S5G5
2fpsB Crystal structure of the n-terminal domain of e.Coli hisb- apo ca model. (see paper)
59% identity, 45% coverage: 11:173/363 of query aligns to 1:163/163 of 2fpsB
2fpuB Crystal structure of the n-terminal domain of e.Coli hisb- complex with histidinol (see paper)
59% identity, 45% coverage: 11:173/363 of query aligns to 1:160/160 of 2fpuB
2fprA Crystal structure the n-terminal domain of e. Coli hisb. Apo mg model. (see paper)
60% identity, 44% coverage: 10:170/363 of query aligns to 1:155/156 of 2fprA
P34047 Imidazoleglycerol-phosphate dehydratase 1, chloroplastic; IGPD 1; Protein HISTIDINE BIOSYNTHESIS 5A; EC 4.2.1.19 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
48% identity, 52% coverage: 174:363/363 of query aligns to 73:267/270 of P34047
O23346 Imidazoleglycerol-phosphate dehydratase 2, chloroplastic; IGPD 2; Protein HISTIDINE BIOSYNTHESIS 5B; EC 4.2.1.19 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
47% identity, 56% coverage: 159:363/363 of query aligns to 59:269/272 of O23346
6fwhA Acanthamoeba igpd in complex with r-c348 to 1.7a resolution (see paper)
47% identity, 52% coverage: 175:363/363 of query aligns to 3:195/196 of 6fwhA
6fwhL Acanthamoeba igpd in complex with r-c348 to 1.7a resolution (see paper)
47% identity, 52% coverage: 175:363/363 of query aligns to 2:194/195 of 6fwhL
5el9A A. Thaliana igpd2 in complex with the triazole-phosphonate inhibitor, (s)-c348, to 1.1a resolution (see paper)
48% identity, 52% coverage: 175:363/363 of query aligns to 3:196/199 of 5el9A
5ekwA A. Thaliana igpd2 in complex with the racemate of the triazole- phosphonate inhibitor, c348 (see paper)
48% identity, 52% coverage: 175:361/363 of query aligns to 3:194/194 of 5ekwA
2f1dA X-ray structure of imidazoleglycerol-phosphate dehydratase (see paper)
48% identity, 49% coverage: 174:352/363 of query aligns to 1:181/183 of 2f1dA
7oj5A Cryo-em structure of medicago truncatula hisn5 protein
48% identity, 49% coverage: 174:352/363 of query aligns to 1:181/184 of 7oj5A
4qnkA The structure of wt a. Thaliana igpd2 in complex with mn2+ and phosphate (see paper)
48% identity, 49% coverage: 174:350/363 of query aligns to 2:180/185 of 4qnkA
4mu1A The structure of wt a. Thaliana igpd2 in complex with mn2+, imidazole, and sulfate at 1.5 a resolution (see paper)
48% identity, 49% coverage: 174:350/363 of query aligns to 2:180/185 of 4mu1A
4mu0A The structure of wt a. Thaliana igpd2 in complex with mn2+ and 1,2,4- triazole at 1.3 a resolution (see paper)
48% identity, 49% coverage: 174:350/363 of query aligns to 2:180/185 of 4mu0A
4mu3A The form a structure of an e21q catalytic mutant of a. Thaliana igpd2 in complex with mn2+ and a mixture of its substrate, 2r3s-igp, and an inhibitor, 2s3s-igp, to 1.12 a resolution (see paper)
48% identity, 48% coverage: 175:350/363 of query aligns to 3:180/186 of 4mu3A
6ezmU Imidazoleglycerol-phosphate dehydratase from saccharomyces cerevisiae (see paper)
42% identity, 52% coverage: 175:363/363 of query aligns to 2:212/212 of 6ezmU
P40374 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
42% identity, 52% coverage: 175:363/363 of query aligns to 2:216/216 of P40374
P06633 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
41% identity, 52% coverage: 175:363/363 of query aligns to 4:219/220 of P06633
P9WML9 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
43% identity, 49% coverage: 185:363/363 of query aligns to 21:210/210 of P9WML9
>201228 FitnessBrowser__MR1:201228
MNPVFTPNVAQKILFIDRDGTLIEEPVTDKQVDNLAKLVFEPQVIPALLRLQKAGFRLVM
VSNQDGLGTPSFPQEDFDAPHNMMMQILSSQGVKFEDVLICPHFNDENCSCRKPKLGLVK
DFLTQGFIDFTQSAVIGDRHTDVELGNAMGIISFQYQRGSLGWNAIADALLNKGRSATVV
RTTKETDIRVTVDLDNASKGTINTGIGFFDHMLDQIATHGNFKMEVNVDGDLEIDDHHSV
EDTALAIGDALRQALGDKRGIARFGFSLPMDEAKGECLLDLSGRPFIKFAAQFEREKVGE
MATEMVPHFFRSFADGLRCTLHVAAEGDNDHHKVEALFKVLGRALRQAVKVEGDVLPSSK
GVL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory