SitesBLAST
Comparing 201429 FitnessBrowser__MR1:201429 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see paper)
42% identity, 98% coverage: 2:564/572 of query aligns to 89:654/664 of P09114
- P191 (= P104) mutation to A: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with L-568.
- W568 (= W484) mutation to L: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with A-191.
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
41% identity, 98% coverage: 2:564/572 of query aligns to 92:657/667 of P09342
- C161 (≠ V71) modified: Disulfide link with 307
- P194 (= P104) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
- C307 (≠ A217) modified: Disulfide link with 161
6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
42% identity, 99% coverage: 4:571/572 of query aligns to 12:583/597 of 6demA
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (≠ S29), I38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), K228 (≠ Q225), M264 (= M260), V291 (≠ T287), V407 (= V395), L432 (= L420), G433 (= G421), M435 (= M423), D460 (= D448), N487 (= N475), E489 (≠ F477), Q490 (≠ L478), M492 (= M480), V493 (= V481), W496 (= W484), L518 (≠ I507), N523 (≠ G512), V524 (≠ H513)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (= M260), D289 (= D285), R290 (= R286), M492 (= M480), W496 (= W484), A567 (≠ R557)
- binding flavin-adenine dinucleotide: R161 (= R153), G217 (= G214), A218 (≠ G215), G219 (= G216), N222 (≠ I219), T244 (= T240), L245 (= L241), Q246 (≠ M242), L262 (= L258), G284 (= G280), A285 (≠ V281), R286 (= R282), D288 (= D284), R290 (= R286), V291 (≠ T287), E317 (≠ D304), I318 (= I305), N322 (≠ S309), D336 (≠ S323), V337 (≠ A324), M412 (= M400), G430 (= G418)
- binding magnesium ion: D460 (= D448), N487 (= N475), E489 (≠ F477)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V395), G408 (= G396), Q409 (= Q397), H410 (= H398), M435 (= M423), G459 (= G447), D460 (= D448), A461 (≠ G449), S462 (= S450), M465 (= M453), N487 (= N475), E489 (≠ F477), Q490 (≠ L478), G491 (= G479), M492 (= M480), V493 (= V481)
6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
42% identity, 99% coverage: 4:571/572 of query aligns to 12:583/597 of 6delA
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (≠ S29), I38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), K228 (≠ Q225), M264 (= M260), V291 (≠ T287), V407 (= V395), L432 (= L420), G433 (= G421), M435 (= M423), D460 (= D448), N487 (= N475), E489 (≠ F477), Q490 (≠ L478), M492 (= M480), V493 (= V481), W496 (= W484), L518 (≠ I507), N523 (≠ G512), V524 (≠ H513)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (= D285), R290 (= R286), W496 (= W484)
- binding flavin-adenine dinucleotide: R161 (= R153), G217 (= G214), A218 (≠ G215), G219 (= G216), N222 (≠ I219), T244 (= T240), L245 (= L241), Q246 (≠ M242), L262 (= L258), G284 (= G280), A285 (≠ V281), R286 (= R282), D288 (= D284), R290 (= R286), V291 (≠ T287), E317 (≠ D304), I318 (= I305), N322 (≠ S309), D336 (≠ S323), V337 (≠ A324), M412 (= M400), G430 (= G418)
- binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (= V395), G408 (= G396), Q409 (= Q397), H410 (= H398), G433 (= G421), M435 (= M423), G459 (= G447), D460 (= D448), A461 (≠ G449), S462 (= S450), M465 (= M453), N487 (= N475), E489 (≠ F477), Q490 (≠ L478), G491 (= G479), M492 (= M480), V493 (= V481)
- binding magnesium ion: D460 (= D448), N487 (= N475), E489 (≠ F477)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V395), G408 (= G396), Q409 (= Q397), H410 (= H398), G433 (= G421), M435 (= M423), G459 (= G447), D460 (= D448), A461 (≠ G449), S462 (= S450), M465 (= M453), N487 (= N475), E489 (≠ F477), Q490 (≠ L478), G491 (= G479), M492 (= M480), V493 (= V481)
6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl (see paper)
42% identity, 99% coverage: 4:571/572 of query aligns to 14:585/599 of 6denA
- active site: Y35 (= Y25), G37 (= G27), G38 (= G28), A39 (≠ S29), I40 (≠ V30), E61 (= E51), T84 (= T74), F123 (= F113), Q124 (= Q114), E125 (= E115), K173 (= K163), K230 (≠ Q225), M266 (= M260), V293 (≠ T287), V409 (= V395), L434 (= L420), G435 (= G421), M437 (= M423), D462 (= D448), N489 (= N475), E491 (≠ F477), Q492 (≠ L478), M494 (= M480), V495 (= V481), W498 (= W484), L520 (≠ I507), N525 (≠ G512), V526 (≠ H513)
- binding flavin-adenine dinucleotide: R163 (= R153), G219 (= G214), A220 (≠ G215), G221 (= G216), N224 (≠ I219), T246 (= T240), L247 (= L241), Q248 (≠ M242), L264 (= L258), G286 (= G280), A287 (≠ V281), R288 (= R282), D290 (= D284), R292 (= R286), V293 (≠ T287), E319 (≠ D304), I320 (= I305), N324 (≠ S309), D338 (≠ S323), V339 (≠ A324), M414 (= M400), G432 (= G418)
- binding ethyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M266 (= M260), D291 (= D285), R292 (= R286), W498 (= W484)
- binding magnesium ion: D462 (= D448), N489 (= N475), E491 (≠ F477)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V409 (= V395), G410 (= G396), Q411 (= Q397), H412 (= H398), G435 (= G421), M437 (= M423), G461 (= G447), D462 (= D448), A463 (≠ G449), S464 (= S450), N489 (= N475), E491 (≠ F477), Q492 (≠ L478), G493 (= G479), M494 (= M480), V495 (= V481)
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
42% identity, 99% coverage: 4:571/572 of query aligns to 10:579/593 of 6deoA
- active site: Y31 (= Y25), G33 (= G27), G34 (= G28), A35 (≠ S29), I36 (≠ V30), E57 (= E51), T80 (= T74), F119 (= F113), Q120 (= Q114), E121 (= E115), K169 (= K163), K224 (≠ Q225), M260 (= M260), V287 (≠ T287), V403 (= V395), L428 (= L420), G429 (= G421), M431 (= M423), D456 (= D448), N483 (= N475), E485 (≠ F477), Q486 (≠ L478), M488 (= M480), V489 (= V481), W492 (= W484), L514 (≠ I507), N519 (≠ G512), V520 (≠ H513)
- binding flavin-adenine dinucleotide: R159 (= R153), G213 (= G214), A214 (≠ G215), G215 (= G216), N218 (≠ I219), T240 (= T240), L241 (= L241), Q242 (≠ M242), L258 (= L258), G280 (= G280), A281 (≠ V281), R282 (= R282), D284 (= D284), R286 (= R286), V287 (≠ T287), E313 (≠ D304), I314 (= I305), N318 (≠ S309), D332 (≠ S323), V333 (≠ A324), M408 (= M400), G426 (= G418)
- binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (= M260), D285 (= D285), R286 (= R286), M488 (= M480), W492 (= W484)
- binding magnesium ion: D456 (= D448), N483 (= N475), E485 (≠ F477)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (= V395), G404 (= G396), Q405 (= Q397), H406 (= H398), G429 (= G421), M431 (= M423), G455 (= G447), D456 (= D448), A457 (≠ G449), S458 (= S450), M461 (= M453), N483 (= N475), E485 (≠ F477), Q486 (≠ L478), G487 (= G479), M488 (= M480), V489 (= V481)
6deqA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
42% identity, 99% coverage: 4:571/572 of query aligns to 14:587/601 of 6deqA
- active site: Y35 (= Y25), G37 (= G27), G38 (= G28), A39 (≠ S29), I40 (≠ V30), E61 (= E51), T84 (= T74), F123 (= F113), Q124 (= Q114), E125 (= E115), K173 (= K163), K232 (≠ Q225), M268 (= M260), V295 (≠ T287), V411 (= V395), L436 (= L420), G437 (= G421), M439 (= M423), D464 (= D448), N491 (= N475), E493 (≠ F477), Q494 (≠ L478), M496 (= M480), V497 (= V481), W500 (= W484), L522 (≠ I507), N527 (≠ G512), V528 (≠ H513)
- binding flavin-adenine dinucleotide: R163 (= R153), G221 (= G214), A222 (≠ G215), G223 (= G216), N226 (≠ I219), T248 (= T240), L249 (= L241), Q250 (≠ M242), L266 (= L258), G288 (= G280), A289 (≠ V281), R290 (= R282), D292 (= D284), R294 (= R286), V295 (≠ T287), E321 (≠ D304), I322 (= I305), D340 (≠ S323), V341 (≠ A324), M416 (= M400), G434 (= G418)
- binding magnesium ion: D464 (= D448), N491 (= N475), E493 (≠ F477)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M268 (= M260), R294 (= R286), M496 (= M480), V497 (= V481), W500 (= W484), A571 (≠ R557)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V411 (= V395), G412 (= G396), Q413 (= Q397), H414 (= H398), M439 (= M423), G463 (= G447), D464 (= D448), A465 (≠ G449), S466 (= S450), N491 (= N475), E493 (≠ F477), Q494 (≠ L478), G495 (= G479), M496 (= M480), V497 (= V481)
6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone (see paper)
42% identity, 99% coverage: 4:571/572 of query aligns to 12:584/598 of 6desA
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (≠ S29), I38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), K229 (≠ Q225), M265 (= M260), V292 (≠ T287), V408 (= V395), L433 (= L420), G434 (= G421), M436 (= M423), D461 (= D448), N488 (= N475), E490 (≠ F477), Q491 (≠ L478), M493 (= M480), V494 (= V481), W497 (= W484), L519 (≠ I507), N524 (≠ G512), V525 (≠ H513)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: M265 (= M260), D290 (= D285), R291 (= R286), W497 (= W484)
- binding flavin-adenine dinucleotide: R161 (= R153), G218 (= G214), A219 (≠ G215), G220 (= G216), N223 (≠ I219), T245 (= T240), L246 (= L241), Q247 (≠ M242), L263 (= L258), G285 (= G280), A286 (≠ V281), R287 (= R282), D289 (= D284), R291 (= R286), V292 (≠ T287), E318 (≠ D304), I319 (= I305), N323 (≠ S309), D337 (≠ S323), V338 (≠ A324), Q412 (= Q399), M413 (= M400), G431 (= G418)
- binding magnesium ion: D461 (= D448), N488 (= N475), E490 (≠ F477)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V395), G409 (= G396), Q410 (= Q397), H411 (= H398), G434 (= G421), M436 (= M423), G460 (= G447), D461 (= D448), A462 (≠ G449), S463 (= S450), N488 (= N475), E490 (≠ F477), Q491 (≠ L478), G492 (= G479), M493 (= M480), V494 (= V481)
6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl (see paper)
42% identity, 99% coverage: 4:571/572 of query aligns to 12:584/598 of 6depA
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (≠ S29), I38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), K229 (≠ Q225), M265 (= M260), V292 (≠ T287), V408 (= V395), L433 (= L420), G434 (= G421), M436 (= M423), D461 (= D448), N488 (= N475), E490 (≠ F477), Q491 (≠ L478), M493 (= M480), V494 (= V481), W497 (= W484), L519 (≠ I507), N524 (≠ G512), V525 (≠ H513)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D290 (= D285), R291 (= R286), M493 (= M480), W497 (= W484)
- binding flavin-adenine dinucleotide: R161 (= R153), G218 (= G214), A219 (≠ G215), G220 (= G216), N223 (≠ I219), T245 (= T240), L246 (= L241), Q247 (≠ M242), L263 (= L258), G264 (= G259), G285 (= G280), A286 (≠ V281), R287 (= R282), D289 (= D284), R291 (= R286), V292 (≠ T287), E318 (≠ D304), I319 (= I305), N323 (≠ S309), D337 (≠ S323), V338 (≠ A324), M413 (= M400), G431 (= G418)
- binding magnesium ion: D461 (= D448), N488 (= N475), E490 (≠ F477)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V408 (= V395), G409 (= G396), Q410 (= Q397), H411 (= H398), G434 (= G421), M436 (= M423), G460 (= G447), D461 (= D448), A462 (≠ G449), S463 (= S450), M466 (= M453), N488 (= N475), E490 (≠ F477), Q491 (≠ L478), G492 (= G479), M493 (= M480), V494 (= V481)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V395), G409 (= G396), Q410 (= Q397), H411 (= H398), G434 (= G421), M436 (= M423), G460 (= G447), D461 (= D448), A462 (≠ G449), S463 (= S450), M466 (= M453), N488 (= N475), E490 (≠ F477), Q491 (≠ L478), G492 (= G479), M493 (= M480), V494 (= V481)
6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam (see paper)
42% identity, 99% coverage: 4:571/572 of query aligns to 14:586/600 of 6derA
- active site: Y35 (= Y25), G37 (= G27), G38 (= G28), A39 (≠ S29), I40 (≠ V30), E61 (= E51), T84 (= T74), F123 (= F113), Q124 (= Q114), E125 (= E115), K173 (= K163), K231 (≠ Q225), M267 (= M260), V294 (≠ T287), V410 (= V395), L435 (= L420), G436 (= G421), M438 (= M423), D463 (= D448), N490 (= N475), E492 (≠ F477), Q493 (≠ L478), M495 (= M480), V496 (= V481), W499 (= W484), L521 (≠ I507), N526 (≠ G512), V527 (≠ H513)
- binding flavin-adenine dinucleotide: R163 (= R153), G220 (= G214), A221 (≠ G215), G222 (= G216), N225 (≠ I219), T247 (= T240), L248 (= L241), Q249 (≠ M242), L265 (= L258), H268 (= H261), G287 (= G280), A288 (≠ V281), R289 (= R282), D291 (= D284), R293 (= R286), V294 (≠ T287), E320 (≠ D304), I321 (= I305), N325 (≠ S309), G338 (= G322), D339 (≠ S323), V340 (≠ A324), Q414 (= Q399), M415 (= M400), G433 (= G418)
- binding Metosulam: R293 (= R286), M495 (= M480), W499 (= W484), A570 (≠ R557)
- binding magnesium ion: D463 (= D448), N490 (= N475), E492 (≠ F477)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V410 (= V395), G411 (= G396), Q412 (= Q397), H413 (= H398), G436 (= G421), M438 (= M423), G462 (= G447), D463 (= D448), A464 (≠ G449), S465 (= S450), N490 (= N475), E492 (≠ F477), Q493 (≠ L478), G494 (= G479), M495 (= M480), V496 (= V481)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V410 (= V395), G411 (= G396), Q412 (= Q397), H413 (= H398), G436 (= G421), M438 (= M423), G462 (= G447), D463 (= D448), A464 (≠ G449), S465 (= S450), M468 (= M453), N490 (= N475), E492 (≠ F477), Q493 (≠ L478), G494 (= G479), V496 (= V481)
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
40% identity, 98% coverage: 6:564/572 of query aligns to 99:660/670 of P17597
- A122 (≠ S29) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (≠ L31) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E51) binding
- S186 (= S93) binding
- P197 (= P104) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ N106) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q114) binding
- K220 (= K127) binding
- R246 (= R153) binding ; binding
- K256 (= K163) binding
- G308 (= G215) binding
- TL 331:332 (= TL 240:241) binding
- C340 (≠ G249) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (= LGMH 258:261) binding
- GVRFD 371:375 (= GVRFD 280:284) binding
- DR 376:377 (= DR 285:286) binding
- DI 395:396 (= DI 304:305) binding
- DV 414:415 (≠ SA 323:324) binding
- QH 487:488 (= QH 397:398) binding
- GG 508:509 (= GG 418:419) binding
- GAM 511:513 (≠ GTM 421:423) binding
- D538 (= D448) binding
- DGS 538:540 (= DGS 448:450) binding
- N565 (= N475) binding
- NQHLGM 565:570 (≠ NRFLGM 475:480) binding
- H567 (≠ F477) binding
- W574 (= W484) binding ; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
- S653 (≠ R557) binding ; mutation to A: No effect on catalytic activity or sensitivity to herbicides.; mutation to F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; mutation to N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; mutation to T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
5k2oA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
40% identity, 98% coverage: 6:564/572 of query aligns to 14:575/585 of 5k2oA
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (≠ S29), S38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), M266 (= M260), V293 (≠ T287), V400 (= V395), G426 (= G421), M428 (= M423), D453 (= D448), N480 (= N475), H482 (≠ F477), L483 (= L478), M485 (= M480), V486 (= V481), W489 (= W484), H558 (≠ E547)
- binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: M266 (= M260), R292 (= R286), W489 (= W484), S568 (≠ R557)
- binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G214), G223 (= G215), G224 (= G216), T246 (= T240), L247 (= L241), M248 (= M242), L264 (= L258), G286 (= G280), R288 (= R282), D290 (= D284), V293 (≠ T287), D310 (= D304), I311 (= I305), D329 (≠ S323), V330 (≠ A324), Q404 (= Q399), M405 (= M400), G423 (= G418)
- binding magnesium ion: D453 (= D448), N480 (= N475), H482 (≠ F477)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V395), G401 (= G396), Q402 (= Q397), H403 (= H398), M428 (= M423), D453 (= D448), G454 (= G449), S455 (= S450), N480 (= N475), H482 (≠ F477), L483 (= L478), G484 (= G479), M485 (= M480), V486 (= V481)
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
40% identity, 98% coverage: 6:564/572 of query aligns to 14:575/583 of 5k3sA
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (≠ S29), S38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), M266 (= M260), V293 (≠ T287), V400 (= V395), G426 (= G421), M428 (= M423), D453 (= D448), N480 (= N475), H482 (≠ F477), L483 (= L478), M485 (= M480), V486 (= V481), W489 (= W484), H558 (≠ E547)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (= R286), M485 (= M480), W489 (= W484), G569 (= G558)
- binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G214), G223 (= G215), G224 (= G216), T246 (= T240), L247 (= L241), M248 (= M242), L264 (= L258), M266 (= M260), G286 (= G280), R288 (= R282), D290 (= D284), V293 (≠ T287), D310 (= D304), I311 (= I305), D329 (≠ S323), V330 (≠ A324), M405 (= M400), G423 (= G418)
- binding magnesium ion: D453 (= D448), N480 (= N475), H482 (≠ F477)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V395), G401 (= G396), Q402 (= Q397), H403 (= H398), G426 (= G421), M428 (= M423), D453 (= D448), G454 (= G449), S455 (= S450), N480 (= N475), H482 (≠ F477), L483 (= L478), G484 (= G479), M485 (= M480), V486 (= V481)
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
40% identity, 98% coverage: 6:564/572 of query aligns to 14:575/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V395), G401 (= G396), Q402 (= Q397), H403 (= H398), G426 (= G421), M428 (= M423), G452 (= G447), D453 (= D448), G454 (= G449), S455 (= S450), M458 (= M453), N480 (= N475), H482 (≠ F477), L483 (= L478), G484 (= G479), M485 (= M480), V486 (= V481)
- binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G214), G223 (= G215), G224 (= G216), T246 (= T240), L247 (= L241), M248 (= M242), L264 (= L258), M266 (= M260), H267 (= H261), G286 (= G280), V287 (= V281), R288 (= R282), D290 (= D284), R292 (= R286), V293 (≠ T287), D310 (= D304), I311 (= I305), D329 (≠ S323), V330 (≠ A324), M405 (= M400), G423 (= G418)
- binding magnesium ion: F370 (≠ Y365), D453 (= D448), M458 (= M453), Q461 (= Q456), N480 (= N475), H482 (≠ F477), K533 (≠ P521)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (= M260), R292 (= R286), M485 (= M480), W489 (= W484), S568 (≠ R557)
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
40% identity, 98% coverage: 6:564/572 of query aligns to 14:575/582 of 5wj1A
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (≠ S29), S38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), M266 (= M260), V293 (≠ T287), V400 (= V395), G426 (= G421), M428 (= M423), D453 (= D448), N480 (= N475), H482 (≠ F477), L483 (= L478), M485 (= M480), V486 (= V481), W489 (= W484), H558 (≠ E547)
- binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G214), G223 (= G215), G224 (= G216), T246 (= T240), L247 (= L241), M248 (= M242), M263 (= M257), L264 (= L258), G286 (= G280), R288 (= R282), V293 (≠ T287), D310 (= D304), I311 (= I305), D329 (≠ S323), V330 (≠ A324), M405 (= M400), G423 (= G418), G424 (= G419)
- binding magnesium ion: D453 (= D448), N480 (= N475), H482 (≠ F477)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (= M260), D291 (= D285), R292 (= R286), M485 (= M480), W489 (= W484), S568 (≠ R557)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V395), G401 (= G396), Q402 (= Q397), H403 (= H398), M428 (= M423), D453 (= D448), G454 (= G449), S455 (= S450), M458 (= M453), N480 (= N475), H482 (≠ F477), L483 (= L478), G484 (= G479), M485 (= M480), V486 (= V481)
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
40% identity, 98% coverage: 6:564/572 of query aligns to 14:575/582 of 5k6tA
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (≠ S29), S38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), M266 (= M260), V293 (≠ T287), V400 (= V395), G426 (= G421), M428 (= M423), D453 (= D448), N480 (= N475), H482 (≠ F477), L483 (= L478), M485 (= M480), V486 (= V481), W489 (= W484), H558 (≠ E547)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (= H261), R292 (= R286), M485 (= M480), W489 (= W484), S568 (≠ R557)
- binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G214), G223 (= G215), G224 (= G216), T246 (= T240), L247 (= L241), M248 (= M242), L264 (= L258), G286 (= G280), R288 (= R282), D290 (= D284), R292 (= R286), V293 (≠ T287), D310 (= D304), I311 (= I305), D329 (≠ S323), V330 (≠ A324), Q404 (= Q399), M405 (= M400), G423 (= G418)
- binding magnesium ion: D453 (= D448), N480 (= N475), H482 (≠ F477)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V395), G401 (= G396), Q402 (= Q397), H403 (= H398), G426 (= G421), M428 (= M423), G452 (= G447), G454 (= G449), S455 (= S450), N480 (= N475), H482 (≠ F477), L483 (= L478), G484 (= G479)
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
40% identity, 98% coverage: 6:564/572 of query aligns to 14:575/582 of 5k6rA
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (≠ S29), S38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), M266 (= M260), V293 (≠ T287), V400 (= V395), G426 (= G421), M428 (= M423), D453 (= D448), N480 (= N475), H482 (≠ F477), L483 (= L478), M485 (= M480), V486 (= V481), W489 (= W484), H558 (≠ E547)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (= R286), W489 (= W484), S568 (≠ R557)
- binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G214), G223 (= G215), G224 (= G216), T246 (= T240), L247 (= L241), M248 (= M242), L264 (= L258), M266 (= M260), G286 (= G280), R288 (= R282), R292 (= R286), V293 (≠ T287), D310 (= D304), I311 (= I305), G328 (= G322), D329 (≠ S323), V330 (≠ A324), M405 (= M400), G423 (= G418)
- binding magnesium ion: D453 (= D448), N480 (= N475), H482 (≠ F477)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V395), G401 (= G396), Q402 (= Q397), H403 (= H398), G426 (= G421), M428 (= M423), D453 (= D448), G454 (= G449), S455 (= S450), M458 (= M453), N480 (= N475), H482 (≠ F477), L483 (= L478), G484 (= G479), M485 (= M480), V486 (= V481)
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
40% identity, 98% coverage: 6:564/572 of query aligns to 14:575/582 of 1z8nA
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (≠ S29), S38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), M266 (= M260), V293 (≠ T287), V400 (= V395), G426 (= G421), M428 (= M423), D453 (= D448), N480 (= N475), H482 (≠ F477), L483 (= L478), M485 (= M480), V486 (= V481), W489 (= W484), H558 (≠ E547)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K127), R161 (= R153), Y191 (= Y185), R194 (vs. gap), D291 (= D285), R292 (= R286), D312 (= D306), W489 (= W484), G569 (= G558)
- binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G214), G224 (= G216), T246 (= T240), L247 (= L241), M248 (= M242), L264 (= L258), G265 (= G259), M266 (= M260), H267 (= H261), G286 (= G280), V287 (= V281), R288 (= R282), D290 (= D284), R292 (= R286), V293 (≠ T287), D310 (= D304), I311 (= I305), D329 (≠ S323), V330 (≠ A324), M405 (= M400), G423 (= G418), G424 (= G419)
- binding magnesium ion: D453 (= D448), N480 (= N475)
- binding thiamine diphosphate: V400 (= V395), G401 (= G396), Q402 (= Q397), H403 (= H398), G426 (= G421), M428 (= M423), G452 (= G447), G454 (= G449), S455 (= S450), N480 (= N475), H482 (≠ F477), L483 (= L478), G484 (= G479), M485 (= M480), V486 (= V481)
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
40% identity, 98% coverage: 6:564/572 of query aligns to 14:575/582 of 1yi1A
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (≠ S29), S38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), M266 (= M260), V293 (≠ T287), V400 (= V395), G426 (= G421), M428 (= M423), D453 (= D448), N480 (= N475), H482 (≠ F477), L483 (= L478), M485 (= M480), V486 (= V481), W489 (= W484), H558 (≠ E547)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (= D285), R292 (= R286), W489 (= W484), S568 (≠ R557)
- binding flavin-adenine dinucleotide: R161 (= R153), G223 (= G215), G224 (= G216), T246 (= T240), L247 (= L241), M248 (= M242), M263 (= M257), L264 (= L258), G265 (= G259), M266 (= M260), H267 (= H261), G286 (= G280), V287 (= V281), R288 (= R282), D290 (= D284), V293 (≠ T287), D310 (= D304), I311 (= I305), D329 (≠ S323), V330 (≠ A324), M405 (= M400), G423 (= G418), G424 (= G419)
- binding magnesium ion: D453 (= D448), N480 (= N475), H482 (≠ F477)
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
40% identity, 98% coverage: 6:564/572 of query aligns to 14:575/582 of 1yi0A
- active site: Y33 (= Y25), G35 (= G27), G36 (= G28), A37 (≠ S29), S38 (≠ V30), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (= K163), M266 (= M260), V293 (≠ T287), V400 (= V395), G426 (= G421), M428 (= M423), D453 (= D448), N480 (= N475), H482 (≠ F477), L483 (= L478), M485 (= M480), V486 (= V481), W489 (= W484), H558 (≠ E547)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D285), R292 (= R286), W489 (= W484), S568 (≠ R557)
- binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G214), G223 (= G215), G224 (= G216), T246 (= T240), L247 (= L241), M248 (= M242), L264 (= L258), G265 (= G259), M266 (= M260), H267 (= H261), G286 (= G280), V287 (= V281), R288 (= R282), D290 (= D284), R292 (= R286), V293 (≠ T287), D310 (= D304), I311 (= I305), G328 (= G322), D329 (≠ S323), V330 (≠ A324), M405 (= M400), G423 (= G418), G424 (= G419)
- binding magnesium ion: D453 (= D448), N480 (= N475), H482 (≠ F477)
Query Sequence
>201429 FitnessBrowser__MR1:201429
MEKLSGASMIVRSLIDEGVKHIFGYPGGSVLDIYDALHLIPGIEHILVRHEQAAVHMADG
YARATGKVGVVLVTSGPGATNAITGIATAYMDSIPLVVLSGQVPSNLIGNDAFQECDMIG
ISRPVVKHSFLVQDPTQIPEIIKKAFYIASTGRPGPVVVDLPKDCLNPALLHDYIYPESI
KMRSYNPTTSGHKGQIRRGLQALLAAKKPVLYVGGGAIISGSEKQILTLAEKLNIPVIST
LMGLGAFPGTHKNSLGMLGMHGRYEANMAMHNCDLIFGIGVRFDDRTTNNIEKYCPNATI
LHIDIDPSSISKTVRVDIPIVGSADIVLDSILALLDEASETNDFVAINQWWQEITTWRNR
QCLAYDKESNRIKPQQVIETLYKLTNGEAYVASDVGQHQMFAALYYPFDKPRRWINSGGL
GTMGFGLPAAMGVKMAMPDETVVCVTGDGSIQMNIQELSTALQYDTPVKIINLNNRFLGM
VKQWQDMIYSGRHSHSYMDSVPNFAKIAEAYGHVGMTISDPAELESKMAEALAMKDRLVF
IDIMVDETEHVYPMLIRGGAMNEMWLSKTEKC
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory