Comparing 201612 FitnessBrowser__MR1:201612 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
7t1qA Crystal structure of the succinyl-diaminopimelate desuccinylase (dape) from acinetobacter baumannii in complex with succinic acid
70% identity, 94% coverage: 24:384/384 of query aligns to 16:376/377 of 7t1qA
7lgpB Dape enzyme from shigella flexneri
63% identity, 98% coverage: 7:383/384 of query aligns to 1:376/377 of 7lgpB
5vo3A Crystal structure of dape in complex with the products (succinic acid and diaminopimelic acid) (see paper)
59% identity, 99% coverage: 5:383/384 of query aligns to 1:379/380 of 5vo3A
P44514 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 3 papers)
60% identity, 97% coverage: 13:383/384 of query aligns to 5:375/377 of P44514
4pqaA Crystal structure of succinyl-diaminopimelate desuccinylase from neisseria meningitidis mc58 in complex with the inhibitor captopril (see paper)
61% identity, 96% coverage: 15:383/384 of query aligns to 7:375/375 of 4pqaA
4o23A Crystal structure of mono-zinc form of succinyl diaminopimelate desuccinylase from neisseria meningitidis mc58 (see paper)
61% identity, 96% coverage: 15:383/384 of query aligns to 7:375/376 of 4o23A
4op4B Crystal structure of the catalytic domain of dape protein from v.Cholerea in the zn bound form (see paper)
75% identity, 46% coverage: 12:188/384 of query aligns to 4:180/265 of 4op4B
Sites not aligning to the query:
4h2kA Crystal structure of the catalytic domain of succinyl-diaminopimelate desuccinylase from haemophilus influenzae (see paper)
64% identity, 46% coverage: 13:188/384 of query aligns to 7:182/258 of 4h2kA
Sites not aligning to the query:
7rsfA Acetylornithine deacetylase from escherichia coli
30% identity, 66% coverage: 12:266/384 of query aligns to 4:261/380 of 7rsfA
7uoiA Crystallographic structure of dape from enterococcus faecium
25% identity, 85% coverage: 58:384/384 of query aligns to 56:383/383 of 7uoiA
3pfoA Crystal structure of a putative acetylornithine deacetylase (rpa2325) from rhodopseudomonas palustris cga009 at 1.90 a resolution
29% identity, 49% coverage: 67:253/384 of query aligns to 96:281/426 of 3pfoA
Sites not aligning to the query:
Q03154 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Homo sapiens (Human) (see 6 papers)
24% identity, 73% coverage: 74:355/384 of query aligns to 79:368/408 of Q03154
Sites not aligning to the query:
2pokA Crystal structure of a m20 family metallo peptidase from streptococcus pneumoniae
26% identity, 50% coverage: 15:205/384 of query aligns to 25:222/458 of 2pokA
Sites not aligning to the query:
3dljA Crystal structure of human carnosine dipeptidase 1
43% identity, 19% coverage: 71:144/384 of query aligns to 97:170/471 of 3dljA
Sites not aligning to the query:
Q96KN2 Beta-Ala-His dipeptidase; CNDP dipeptidase 1; Carnosine dipeptidase 1; Glutamate carboxypeptidase-like protein 2; Serum carnosinase; EC 3.4.13.20 from Homo sapiens (Human) (see 4 papers)
43% identity, 19% coverage: 71:144/384 of query aligns to 128:201/507 of Q96KN2
Sites not aligning to the query:
P37111 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Sus scrofa (Pig) (see paper)
24% identity, 73% coverage: 75:355/384 of query aligns to 80:367/407 of P37111
Sites not aligning to the query:
Q8C165 N-fatty-acyl-amino acid synthase/hydrolase PM20D1; Peptidase M20 domain-containing protein 1; PM20D1; EC 3.5.1.114; EC 3.5.1.14 from Mus musculus (Mouse) (see paper)
29% identity, 36% coverage: 70:206/384 of query aligns to 120:262/503 of Q8C165
Sites not aligning to the query:
4mmoA The crystal structure of a m20 family metallo-carboxypeptidase sso-cp2 from sulfolobus solfataricus
25% identity, 38% coverage: 20:164/384 of query aligns to 11:155/437 of 4mmoA
Sites not aligning to the query:
Q96KP4 Cytosolic non-specific dipeptidase; CNDP dipeptidase 2; Glutamate carboxypeptidase-like protein 1; Peptidase A; Threonyl dipeptidase; EC 3.4.13.18 from Homo sapiens (Human)
36% identity, 19% coverage: 71:143/384 of query aligns to 95:167/475 of Q96KP4
Sites not aligning to the query:
Q9D1A2 Cytosolic non-specific dipeptidase; CNDP dipeptidase 2; Glutamate carboxypeptidase-like protein 1; Threonyl dipeptidase; EC 3.4.13.18 from Mus musculus (Mouse) (see 2 papers)
34% identity, 19% coverage: 71:143/384 of query aligns to 95:167/475 of Q9D1A2
Sites not aligning to the query:
>201612 FitnessBrowser__MR1:201612
MTDAAHSSQTGPVTELTKALIARPSVTPLDEGCQTLMAERLAAIGFNIEAMVFEDTTNMW
ARRGNTGPVFCFAGHTDVVPTGDLSRWHTPPFEPTIIDGYLYGRGAADMKGSLAAMVVAT
ERFVAKHPNHPGSIAFLITSDEEGPFINGTTRVIDTLEARNEKITWALVGEPSSTLKLGD
VVKNGRRGSLTANLTVKGVQGHVAYPHLADNPIHKAAPFLAELSQTHWDNGNAFFPPTSM
QIANINGGTGASNVIPGALEVMFNFRYSTEVTAEILIERVETLLTAHELDYDIRWTFNGL
PFLTGEGPLLDATRHAIRQVTGYDTDPQTTGGTSDGRFIAPTGAKVLELGPVNATIHKVN
ECVKVDDLEQLALCYEVILEQLLC
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory