Comparing 202142 FitnessBrowser__MR1:202142 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 17 hits to proteins with known functional sites (download)
P00900 Anthranilate synthase component 2; AS; ASII; Anthranilate synthase, GATase component; Anthranilate synthase, glutamine amidotransferase component; EC 4.1.3.27 from Serratia marcescens (see 3 papers)
56% identity, 93% coverage: 3:189/202 of query aligns to 4:189/193 of P00900
Sites not aligning to the query:
1i7qB Anthranilate synthase from s. Marcescens (see paper)
56% identity, 93% coverage: 3:189/202 of query aligns to 3:188/192 of 1i7qB
P00903 Aminodeoxychorismate synthase component 2; ADC synthase; ADCS; 4-amino-4-deoxychorismate synthase component 2; Aminodeoxychorismate synthase, glutamine amidotransferase component; EC 2.6.1.85 from Escherichia coli (strain K12) (see paper)
48% identity, 92% coverage: 3:187/202 of query aligns to 2:185/187 of P00903
Q42565 Anthranilate synthase beta subunit 1, chloroplastic; Anthranilate synthase component 2-1; Anthranilate synthase, glutamine amidotransferase component 2-1; Protein TRYPTOPHAN BIOSYNTHESIS 4; Protein WEAK ETHYLENE INSENSITIVE 7; EC 4.1.3.27 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
40% identity, 90% coverage: 3:183/202 of query aligns to 75:260/276 of Q42565
8hx8A Crystal structure of 4-amino-4-deoxychorismate synthase from streptomyces venezuelae co-crystallized with chorismate (see paper)
39% identity, 92% coverage: 1:185/202 of query aligns to 4:186/673 of 8hx8A
Sites not aligning to the query:
2ywcA Crystal structure of gmp synthetase from thermus thermophilus in complex with xmp
31% identity, 91% coverage: 5:187/202 of query aligns to 4:181/475 of 2ywcA
Sites not aligning to the query:
8hx9A Crystal structure of 4-amino-4-deoxychorismate synthase from streptomyces venezuelae with chorismate (see paper)
31% identity, 92% coverage: 1:185/202 of query aligns to 3:143/632 of 8hx9A
Sites not aligning to the query:
7yc6A Crystal structure of d110p mutant of gatase subunit of methanocaldococcus jannaschii gmp synthetase
27% identity, 91% coverage: 3:185/202 of query aligns to 2:173/183 of 7yc6A
Q9LVW7 Carbamoyl phosphate synthase small chain, chloroplastic; Carbamoyl phosphate synthetase glutamine chain; Protein VENOSA 6; EC 6.3.5.5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
33% identity, 51% coverage: 15:118/202 of query aligns to 254:352/430 of Q9LVW7
Sites not aligning to the query:
1gpmA Escherichia coli gmp synthetase complexed with amp and pyrophosphate (see paper)
26% identity, 95% coverage: 2:192/202 of query aligns to 7:201/501 of 1gpmA
Sites not aligning to the query:
5tw7F Crystal structure of a gmp synthase (glutamine-hydrolyzing) from neisseria gonorrhoeae
31% identity, 68% coverage: 49:185/202 of query aligns to 47:186/490 of 5tw7F
Sites not aligning to the query:
P49915 GMP synthase [glutamine-hydrolyzing]; GMP synthetase; Glutamine amidotransferase; EC 6.3.5.2 from Homo sapiens (Human) (see paper)
28% identity, 71% coverage: 44:187/202 of query aligns to 64:207/693 of P49915
Sites not aligning to the query:
P05990 Multifunctional protein r; Protein rudimentary; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Drosophila melanogaster (Fruit fly) (see 2 papers)
29% identity, 60% coverage: 51:172/202 of query aligns to 234:355/2224 of P05990
Sites not aligning to the query:
Q18990 Multifunctional protein pyr-1; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Caenorhabditis elegans (see 3 papers)
29% identity, 63% coverage: 46:172/202 of query aligns to 215:341/2198 of Q18990
Sites not aligning to the query:
2vxoB Human gmp synthetase in complex with xmp (see paper)
29% identity, 71% coverage: 44:187/202 of query aligns to 42:182/658 of 2vxoB
Sites not aligning to the query:
P0A6F1 Carbamoyl phosphate synthase small chain; Carbamoyl phosphate synthetase glutamine chain; EC 6.3.5.5 from Escherichia coli (strain K12) (see paper)
27% identity, 79% coverage: 15:173/202 of query aligns to 204:356/382 of P0A6F1
Sites not aligning to the query:
1ce8B Carbamoyl phosphate synthetase from escherichis coli with complexed with the allosteric ligand imp (see paper)
27% identity, 79% coverage: 15:173/202 of query aligns to 203:355/379 of 1ce8B
Sites not aligning to the query:
>202142 FitnessBrowser__MR1:202142
MKLYLLDNFDSFTYNLVDQFRSLGCEVVIYRNDVAADYIADKLLAETAPTALVLSPGPGA
PHEAGSMMELIDKVAGKVPMLGICLGHQAMVEYYGGKVERAPFVVHGKASPTFHNGTGVF
ANLPSPLPVARYHSLVATKVPNCLDVIATTDDMPMAILHAKHRAVGFQFHPESILTTLGS
TLLTQTLVYLTQAMTSRHAGAK
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory