Comparing 202144 FitnessBrowser__MR1:202144 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1piiA Three-dimensional structure of the bifunctional enzyme phosphoribosylanthranilate isomerase: indoleglycerolphosphate synthase from escherichia coli refined at 2.0 angstroms resolution (see paper)
48% identity, 98% coverage: 10:468/469 of query aligns to 4:450/452 of 1piiA
7etxA Crystal structure of bifunctional indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpc) from corynebacterium glutamicum (see paper)
41% identity, 98% coverage: 9:469/469 of query aligns to 5:462/472 of 7etxA
7etyA Crystal structure of bifunctional indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpc) from corynebacterium glutamicum in complex with reduced 1-(o-carboxyphenylamino)-1- deoxyribulose 5-phosphate (rcdrp) (see paper)
41% identity, 98% coverage: 9:469/469 of query aligns to 3:460/470 of 7etyA
1jcmP Trpc stability mutant containing an engineered disulphide bridge and in complex with a cdrp-related substrate (see paper)
54% identity, 54% coverage: 10:263/469 of query aligns to 4:259/259 of 1jcmP
6y88B Igps (indole-3-glycerol phosphate synthase) from pseudomonas aeruginosa in complex with substrate inhibitor rcdrp (see paper)
39% identity, 53% coverage: 9:258/469 of query aligns to 4:264/265 of 6y88B
6y88G Igps (indole-3-glycerol phosphate synthase) from pseudomonas aeruginosa in complex with substrate inhibitor rcdrp (see paper)
40% identity, 49% coverage: 28:258/469 of query aligns to 22:251/253 of 6y88G
1vc4B Crystal structure of indole-3-glycerol phosphate synthase (trpc) from thermus thermophilus at 1.8 a resolution (see paper)
35% identity, 53% coverage: 9:257/469 of query aligns to 10:253/254 of 1vc4B
1lbfA Crystal structure of indole-3-glycerol phosphate syntase (igps)with reduced 1-(o-caboxyphenylamino)-1-deoxyribulose 5-phosphate (rcdrp) (see paper)
38% identity, 41% coverage: 55:244/469 of query aligns to 48:236/247 of 1lbfA
Sites not aligning to the query:
1jukA Indole-3-glycerolphosphate synthase from sulfolobus solfataricus in a trigonal crystal form (see paper)
38% identity, 41% coverage: 55:244/469 of query aligns to 48:236/247 of 1jukA
1igsA Indole-3-glycerolphosphate synthase from sulfolobus solfataricus at 2.0 a resolution (see paper)
38% identity, 41% coverage: 55:244/469 of query aligns to 48:236/247 of 1igsA
1a53A Complex of indole-3-glycerolphosphate synthase from sulfolobus solfataricus with indole-3-glycerolphosphate at 2.0 a resolution (see paper)
38% identity, 41% coverage: 55:244/469 of query aligns to 48:236/247 of 1a53A
3t44A Crystal structure of mycobacterium tuberculosis indole glycerol phosphate synthase (igps) in complex with indole glycerol phosphate (igp) amd anthranilate
35% identity, 46% coverage: 43:257/469 of query aligns to 39:255/259 of 3t44A
3t55A Crystal structure of mycobacterium tuberculosis indole glycerol phosphate synthase (igps) in complex with phenoxymethyl benzoic acid (pmba)
35% identity, 46% coverage: 43:257/469 of query aligns to 39:255/258 of 3t55A
3t78A Crystal structure of mycobacterium tuberculosis indole glycerol phosphate synthase (igps) in complex with 5-fluoroanthranilate
35% identity, 46% coverage: 43:257/469 of query aligns to 39:253/257 of 3t78A
4iwwA Computational design of an unnatural amino acid metalloprotein with atomic level accuracy (see paper)
35% identity, 41% coverage: 55:244/469 of query aligns to 48:236/247 of 4iwwA
5k7jA Structure of designed zinc binding protein ze2 bound to zn2+ (see paper)
35% identity, 41% coverage: 55:244/469 of query aligns to 48:229/240 of 5k7jA
1nsjA Crystal structure of phosphoribosyl anthranilate isomerase from thermotoga maritima (see paper)
32% identity, 43% coverage: 262:461/469 of query aligns to 5:196/205 of 1nsjA
3uxdA Designed protein ke59 r1 7/10h with dichlorobenzotriazole (dbt) (see paper)
34% identity, 40% coverage: 59:244/469 of query aligns to 52:236/247 of 3uxdA
3t40A Crystal structure of mycobacterium tuberculosis indole glycerol phosphate synthase (igps) complex with n-2-carboxyphenyl glycine (cpg)
32% identity, 47% coverage: 43:264/469 of query aligns to 39:249/251 of 3t40A
4ou1A Crystal structure of a computationally designed retro-aldolase covalently bound to folding probe 1 [(6-methoxynaphthalen-2-yl) (oxiran-2-yl)methanol] (see paper)
32% identity, 41% coverage: 55:244/469 of query aligns to 48:236/247 of 4ou1A
>202144 FitnessBrowser__MR1:202144
MQTSTTQANVLTRIVDTKAAHIAALKLRFPEASLVPKVSDRSLFAALKAPKAGYILECKK
ASPSKGLIRKDFDVEAIASIYTKYAAGISVLTDEQFFQGDMDYIPKVRAKVSQPILCKDF
FVDEYQVKLAAHQGADAILLMLSVLDDERYQQLASEAAKYQLDVLTEISNEEELKRAIAL
NAPIIGINNRNLRDLSTDLATTEALAPHIGSDRVVISESGIYTNDQVRRLSPLVDGFLVG
SSIMAEEDIDLACRKLIFGHNKVCGLTRLEDIEAAANAGAVYAGLIFAEKSPRALTKDAA
KQLVEQYRAAKLPAIEFVGVFVNNTPKLIASIAKACDLAAVQLHGSETELEITELSQLLQ
QAGLKTHIWKAVSVDATSGELGAMPKGVQRYLFDSKNNAGFGGTGQPFNWHLPLAHKAKA
LLAGGLNAANAANANAQGFYGLDFNSGLETAPGIKSAEQIQTAFAQLRL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory