SitesBLAST
Comparing 202205 SO3088 fatty oxidation complex, alpha subunit (NCBI ptt file) to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
6yswA E. Coli anaerobic trifunctional enzyme subunit-alpha in complex with coenzyme a
58% identity, 99% coverage: 7:707/707 of query aligns to 4:703/707 of 6yswA
- active site: A66 (= A69), I71 (≠ L74), A84 (≠ S87), Q88 (≠ H91), G112 (= G115), E115 (= E118), P136 (= P139), E137 (= E140), G145 (= G148), D264 (≠ E270), S422 (= S429), H443 (= H450), E455 (= E462), N493 (= N500)
- binding coenzyme a: E23 (= E26), M25 (= M28), A66 (= A69), D67 (= D70), I68 (= I71), P136 (= P139), E137 (= E140), L140 (= L143), T290 (= T296), K293 (= K299)
P40939 Trifunctional enzyme subunit alpha, mitochondrial; 78 kDa gastrin-binding protein; Monolysocardiolipin acyltransferase; TP-alpha; EC 2.3.1.-; EC 4.2.1.17; EC 1.1.1.211 from Homo sapiens (Human) (see 5 papers)
44% identity, 98% coverage: 16:707/707 of query aligns to 49:761/763 of P40939
- V282 (≠ I231) to D: in MTPD1; mild phenotype with slowly progressive myopathy and sensorimotor polyneuropathy; dbSNP:rs137852773
- I305 (= I254) to N: in MTPD1; mild phenotype with slowly progressive myopathy and sensorimotor polyneuropathy; dbSNP:rs137852774
- L342 (≠ I291) to P: in LCHAD deficiency; dbSNP:rs137852772
- E510 (= E462) active site, For hydroxyacyl-coenzyme A dehydrogenase activity; to Q: in AFLP and LCHAD deficiency; loss of long-chain-3-hydroxyacyl-CoA dehydrogenase activity; dbSNP:rs137852769
1wdlA Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form ii (native4) (see paper)
39% identity, 100% coverage: 4:707/707 of query aligns to 5:714/715 of 1wdlA
- active site: A69 (= A69), N89 (≠ D82), N93 (≠ H91), G117 (= G115), E120 (= E118), P139 (= P139), E140 (= E140), P147 (= P147), G148 (= G148), S430 (= S429), H451 (= H450), E463 (= E462), N501 (= N500)
- binding nicotinamide-adenine-dinucleotide: A322 (≠ G320), I324 (≠ L322), M325 (= M323), D344 (= D343), I345 (= I344), A400 (= A399), V401 (= V400), E403 (= E402), N428 (= N427), T429 (= T428), S430 (= S429)
P28793 Fatty acid oxidation complex subunit alpha; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Pseudomonas fragi (see paper)
39% identity, 100% coverage: 4:707/707 of query aligns to 5:714/715 of P28793
1wdmA Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form i (native3) (see paper)
38% identity, 100% coverage: 4:707/707 of query aligns to 5:706/707 of 1wdmA
- active site: A69 (= A69), N89 (≠ D82), N93 (≠ H91), G117 (= G115), E120 (= E118), P139 (= P139), E140 (= E140), P147 (= P147), G148 (= G148), S430 (= S429), H451 (= H450), E463 (= E462), N501 (= N500)
- binding acetyl coenzyme *a: K142 (≠ Q142), D297 (≠ T295), M459 (= M458), N501 (= N500), P534 (= P533), Y652 (≠ F652), L658 (≠ P658)
- binding nicotinamide-adenine-dinucleotide: G321 (= G319), A322 (≠ G320), I324 (≠ L322), M325 (= M323), D344 (= D343), V401 (= V400), E403 (= E402), N428 (= N427), S430 (= S429), N454 (≠ S453)
6tnmA E. Coli aerobic trifunctional enzyme subunit-alpha (see paper)
37% identity, 100% coverage: 4:707/707 of query aligns to 5:714/719 of 6tnmA
- active site: A68 (= A69), F73 (≠ L74), G116 (= G115), E119 (= E118), P138 (= P139), E139 (= E140), G147 (= G148), N271 (≠ E270), S429 (= S429), H450 (= H450), E462 (= E462), N500 (= N500)
- binding adenosine-5'-triphosphate: D343 (= D343), I344 (= I344), V400 (= V400), V401 (≠ F401), V406 (≠ L406), K584 (= K581)
P21177 Fatty acid oxidation complex subunit alpha; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Escherichia coli (strain K12) (see 2 papers)
37% identity, 100% coverage: 4:707/707 of query aligns to 5:714/729 of P21177
- G116 (= G115) mutation to F: Absence of both enoyl-CoA hydratase and 3-hydroxyacyl-CoA epimerase activities. Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase is only slightly affected.
- G322 (= G321) mutation to A: 10-fold increase in KM for NADH.
- H450 (= H450) active site, For 3-hydroxyacyl-CoA dehydrogenase activity; mutation H->A,Q: Almost complete loss of 3-hydroxyacyl-CoA dehydrogenase activity.
6iunB Crystal structure of enoyl-coa hydratase (ech) from ralstonia eutropha h16 in complex with NAD
34% identity, 98% coverage: 13:706/707 of query aligns to 7:690/692 of 6iunB
- active site: A60 (= A69), F65 (≠ L74), E73 (≠ Q88), H77 (= H91), G101 (= G115), E104 (= E118), E124 (= E140), G132 (= G148), K248 (≠ E270), S407 (= S429), H428 (= H450), E440 (= E462), N478 (= N500)
- binding nicotinamide-adenine-dinucleotide: G300 (= G321), T301 (≠ L322), M302 (= M323), E321 (≠ D343), T322 (≠ I344), Y365 (= Y387), A377 (= A399), V378 (= V400), E380 (= E402), V384 (≠ L406), V388 (≠ M410), N405 (= N427), S407 (= S429)
7o4uA Structure of the alpha subunit of mycobacterium tuberculosis beta- oxidation trifunctional enzyme in complex with oxidized nicotinamide adenine dinucleotide (see paper)
33% identity, 98% coverage: 5:696/707 of query aligns to 2:709/711 of 7o4uA
8oqsB Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-83
33% identity, 98% coverage: 5:696/707 of query aligns to 19:733/735 of 8oqsB
- binding 4-phenylbenzenesulfonic acid: M45 (≠ L31), I50 (vs. gap), G82 (= G68), G83 (≠ A69), D84 (= D70), T87 (≠ S72), T87 (≠ S72), M88 (= M73), M88 (= M73), A91 (= A76), D95 (≠ T79), D98 (= D82), V99 (≠ A83), T102 (≠ L86), T102 (≠ L86), E134 (= E118), E156 (= E140), L159 (= L143), F302 (= F276), F302 (= F276), F319 (= F293), S456 (= S429), T457 (≠ S430), M485 (= M458), P486 (= P459), G523 (= G496), S527 (≠ N500), N535 (= N508), P560 (= P533), M575 (≠ G548), I578 (= I551), I578 (= I551), I682 (= I651), M683 (≠ F652), G686 (= G655)
Sites not aligning to the query:
4b3iA Crystal structure of mycobacterium tuberculosis fatty acid beta-oxidation complex with coenzymea bound at the hydratase active sites (see paper)
33% identity, 98% coverage: 5:696/707 of query aligns to 15:729/731 of 4b3iA
- active site: G79 (≠ A69), E100 (≠ Q88), R104 (≠ V92), G127 (= G115), E130 (= E118), P151 (= P139), E152 (= E140), G160 (= G148), S452 (= S429), H473 (= H450), E485 (= E462), S523 (≠ N500)
- binding adenosine-5'-diphosphate: Q640 (≠ R622), P641 (≠ C623), P642 (≠ V624), L643 (≠ V625), Q644 (= Q626)
- binding coenzyme a: T38 (≠ M28), V40 (≠ T30), A77 (= A67), G79 (≠ A69), D80 (= D70), V81 (≠ I71), E152 (= E140), F315 (= F293), Q319 (≠ E297)
8pf8A Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-72
33% identity, 98% coverage: 5:696/707 of query aligns to 13:727/729 of 8pf8A
- binding [2-methyl-5-(trifluoromethyl)pyrazol-3-yl]boronic acid: G76 (= G68), F169 (≠ V159), N173 (≠ T163), S177 (≠ D166), I193 (≠ M182), F313 (= F293)
- binding bis[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]-bis(oxidanyl)boranuide: M39 (≠ L31), N40 (≠ K32), E41 (≠ A33), T81 (≠ S72), D92 (= D82), V93 (≠ A83)
- binding [(2~{R})-2,3-bis(oxidanyl)propoxy]-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]borinic acid: M39 (≠ L31), G77 (≠ A69), D78 (= D70), M82 (= M73), V93 (≠ A83)
- binding (2~{R})-3-bis[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]boranyloxypropane-1,2-diol: T152 (≠ Q142), R184 (≠ Q173), A311 (≠ I291), F312 (= F292), I673 (= I648)
Sites not aligning to the query:
8oquA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-92
33% identity, 98% coverage: 5:696/707 of query aligns to 14:728/730 of 8oquA
- binding 4-chloranylbenzenesulfonic acid: M40 (≠ L31), N41 (≠ K32), E42 (≠ A33), G77 (= G68), G78 (≠ A69), D79 (= D70), V80 (≠ I71), D90 (≠ T79), V94 (≠ A83), L124 (= L113), G125 (= G114), P150 (= P139), E151 (= E140)
8oqtA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-91
33% identity, 98% coverage: 5:696/707 of query aligns to 13:727/729 of 8oqtA
- binding 4-bromanylbenzenesulfonic acid: E41 (≠ A33), G76 (= G68), G77 (≠ A69), D78 (= D70), V79 (≠ I71), M82 (= M73), D89 (≠ T79), V93 (≠ A83), T96 (≠ L86), T96 (≠ L86), P149 (= P139), E150 (= E140)
Sites not aligning to the query:
8oqnA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-53
33% identity, 98% coverage: 5:696/707 of query aligns to 13:727/729 of 8oqnA
- binding 1-benzyl-1H-pyrazole-4-carboxylic acid: M39 (≠ L31), M82 (= M73), E150 (= E140), Q172 (≠ T162), F175 (≠ L165), V176 (vs. gap), Q181 (≠ T170), T241 (vs. gap), F254 (≠ A235), N257 (≠ Q238), Q261 (≠ K242), L262 (≠ T243), P266 (vs. gap), P268 (= P248), Q282 (≠ A262), V283 (≠ K263), G302 (≠ S282), Q303 (≠ K283), V304 (≠ E284), S521 (≠ N500), G525 (≠ A504)
8opvA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with resveratrol (fragment-b-h11)
33% identity, 98% coverage: 5:696/707 of query aligns to 13:727/729 of 8opvA
- binding resveratrol: M39 (≠ L31), A75 (= A67), G76 (= G68), M82 (= M73), E128 (= E118), P149 (= P139), E150 (= E140), T152 (≠ Q142), L153 (= L143), R184 (≠ Q173), F296 (= F276)
8opuA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with sulfamethoxazole (fragment-b-e1)
33% identity, 98% coverage: 5:696/707 of query aligns to 13:727/729 of 8opuA
8oqoA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-49
33% identity, 98% coverage: 5:696/707 of query aligns to 12:726/727 of 8oqoA
8oqlA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-1
33% identity, 98% coverage: 5:696/707 of query aligns to 12:726/728 of 8oqlA
- binding Hexafluorophosphate anion: V37 (≠ T30), N39 (≠ K32), G75 (= G68), D77 (= D70), M81 (= M73), V92 (≠ A83), T95 (≠ L86), P148 (= P139), E149 (= E140), L152 (= L143), Q180 (≠ T170), Q260 (≠ K242), K362 (= K342), D363 (= D343), V364 (≠ I344), V430 (≠ M410), D476 (≠ E456), K477 (= K457), M478 (= M458), P479 (= P459), K506 (= K486)
- binding formamide: V78 (≠ I71), K79 (vs. gap)
8oqrA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-80
33% identity, 98% coverage: 5:696/707 of query aligns to 13:727/728 of 8oqrA
- binding 4-cyanobenzenesulfonic acid: G76 (= G68), G77 (≠ A69), T81 (≠ S72), M82 (= M73), M82 (= M73), A85 (= A76), D89 (≠ T79), T96 (≠ L86), L123 (= L113), G124 (= G114), P149 (= P139), E150 (= E140), S366 (≠ N345), L367 (≠ E346), E368 (≠ K347), A420 (= A399), V421 (= V400), F422 (= F401)
Query Sequence
>202205 SO3088 fatty oxidation complex, alpha subunit (NCBI ptt file)
MAVGKTFNLTRREDGIAILTMDVPGETMNTLKAEFGPEISEILSEIKRDSSIRGLVLISG
KKDSFVAGADISMLDACQTAGDAKALSQQGHVVFNELEALNIPVVAAIHGACLGGGLELA
LACHQRVCSDDGKTMLGVPEVQLGLLPGGGGTQRLPRLVGITTALDMMLTGKQIRPKQAL
KMGLVNDVVPQTILLQTAVEMALAGKQIAKPVKKSLVNQLLEGTGFGRNIIFDQAAKQVA
KKTQGNYPAPAKIIDCVRQGIAKGMQKGLEVEASHFAELVVSKESEALRSIFFATTEMKK
ETGAEGATPRKVKKAVILGGGLMGGGIASVTTTKAKIPARVKDINEKGLSNALSYAYKLL
DKGVKRRHMTPAARDNLMALMTTTTEYKGVKDADIVVEAVFEDLALKHQMVKDIERECGE
HTIFASNTSSLPIGQIAQAASRPENVIGLHYFSPVEKMPLVEVIAHAKTSPETIATTVAF
ARKQGKTPIVVQDGAGFYVNRILALYMNEAAQLLLEGQSVEHLDKALVKFGFPVGPITLL
DEVGIDVGAKISPILEKELGERFKAPAAFDKLLSDDRKGRKNGKGFYQYGAASKKKAVDE
TVYGVLGIKPGVDKEMSAVAERCVVQMLNEAVRCLDAGIIASPRDGDIGAIFGIGFPPFL
GGPFHYIDTLGADNLVKILERYQTQYGDRFEPCQRLKAMAAEKARFF
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory