SitesBLAST
Comparing 202370 FitnessBrowser__MR1:202370 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
35% identity, 97% coverage: 1:565/581 of query aligns to 1:573/596 of 1t9dA
- active site: Y29 (= Y28), G31 (= G30), G32 (= G31), A33 (≠ T32), I34 (= I33), E55 (= E53), T78 (= T76), F117 (= F121), Q118 (= Q122), E119 (= E123), K167 (≠ M171), R227 (= R232), M263 (≠ H265), V290 (≠ Q292), V406 (= V397), L431 (≠ H423), G432 (= G424), M434 (= M426), D459 (= D451), N486 (= N478), E488 (≠ R480), Q489 (≠ L481), M491 (≠ L483), V492 (= V484), W495 (≠ F487), L517 (≠ I509), G522 (= G514), L523 (≠ I515), K556 (≠ T548)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G31), A33 (≠ T32), V107 (= V105), P108 (≠ G106), F117 (= F121), K167 (≠ M171), M263 (≠ H265), D288 (≠ V290), R289 (= R291), W495 (≠ F487)
- binding flavin-adenine dinucleotide: R157 (= R161), G216 (= G219), A217 (≠ N220), G218 (= G221), N221 (≠ S224), T243 (≠ S245), L244 (= L246), Q245 (≠ L247), M260 (≠ F262), L261 (≠ H263), H264 (≠ T266), G283 (= G285), A284 (≠ S286), R285 (= R287), D287 (= D289), R289 (= R291), V290 (≠ Q292), E316 (≠ D310), V317 (≠ L311), N321 (≠ D312), G334 (≠ K325), D335 (≠ A326), A336 (≠ V327), Q410 (= Q401), M411 (≠ H402), G429 (≠ A421), G430 (= G422)
- binding magnesium ion: D459 (= D451), N486 (= N478), E488 (≠ R480)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E53), P81 (= P79), Q118 (= Q122), G432 (= G424), M434 (= M426), M464 (= M456)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
35% identity, 97% coverage: 1:565/581 of query aligns to 2:574/597 of 1t9aA
- active site: Y30 (= Y28), G32 (= G30), G33 (= G31), A34 (≠ T32), I35 (= I33), E56 (= E53), T79 (= T76), F118 (= F121), Q119 (= Q122), E120 (= E123), K168 (≠ M171), R228 (= R232), M264 (≠ H265), V291 (≠ Q292), V407 (= V397), L432 (≠ H423), G433 (= G424), M435 (= M426), D460 (= D451), N487 (= N478), E489 (≠ R480), Q490 (≠ L481), M492 (≠ L483), V493 (= V484), W496 (≠ F487), L518 (≠ I509), G523 (= G514), L524 (≠ I515), K557 (≠ T548)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (= G31), V108 (= V105), P109 (≠ G106), F118 (= F121), K168 (≠ M171), M264 (≠ H265), D289 (≠ V290), R290 (= R291), M492 (≠ L483), V493 (= V484), W496 (≠ F487)
- binding flavin-adenine dinucleotide: R158 (= R161), G217 (= G219), A218 (≠ N220), G219 (= G221), N222 (≠ S224), T244 (≠ S245), L245 (= L246), Q246 (≠ L247), L262 (≠ H263), M264 (≠ H265), H265 (≠ T266), G284 (= G285), A285 (≠ S286), R286 (= R287), D288 (= D289), R290 (= R291), V291 (≠ Q292), E317 (≠ D310), V318 (≠ L311), N322 (≠ D312), G335 (≠ K325), D336 (≠ A326), A337 (≠ V327), Q411 (= Q401), M412 (≠ H402), G430 (≠ A421), G431 (= G422)
- binding magnesium ion: D460 (= D451), N487 (= N478), E489 (≠ R480)
- binding propyl trihydrogen diphosphate: V407 (= V397), G408 (= G398), Q409 (≠ A399), H410 (= H400), M435 (= M426), G459 (= G450), D460 (= D451), A461 (≠ G452), S462 (= S453), N487 (= N478), E489 (≠ R480), Q490 (≠ L481), G491 (= G482), M492 (≠ L483)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G424), M435 (= M426), M465 (= M456)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
35% identity, 97% coverage: 1:565/581 of query aligns to 1:573/596 of 1t9cA
- active site: Y29 (= Y28), G31 (= G30), G32 (= G31), A33 (≠ T32), I34 (= I33), E55 (= E53), T78 (= T76), F117 (= F121), Q118 (= Q122), E119 (= E123), K167 (≠ M171), R227 (= R232), M263 (≠ H265), V290 (≠ Q292), V406 (= V397), L431 (≠ H423), G432 (= G424), M434 (= M426), D459 (= D451), N486 (= N478), E488 (≠ R480), Q489 (≠ L481), M491 (≠ L483), V492 (= V484), W495 (≠ F487), L517 (≠ I509), G522 (= G514), L523 (≠ I515), K556 (≠ T548)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G31), V107 (= V105), P108 (≠ G106), F117 (= F121), K167 (≠ M171), D288 (≠ V290), R289 (= R291), W495 (≠ F487)
- binding flavin-adenine dinucleotide: R157 (= R161), G216 (= G219), A217 (≠ N220), G218 (= G221), N221 (≠ S224), T243 (≠ S245), L244 (= L246), Q245 (≠ L247), L261 (≠ H263), M263 (≠ H265), H264 (≠ T266), G283 (= G285), A284 (≠ S286), R285 (= R287), D287 (= D289), R289 (= R291), V290 (≠ Q292), E316 (≠ D310), V317 (≠ L311), N321 (≠ D312), G334 (≠ K325), D335 (≠ A326), A336 (≠ V327), M411 (≠ H402), G429 (≠ A421), G430 (= G422)
- binding magnesium ion: D459 (= D451), N486 (= N478), E488 (≠ R480)
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
34% identity, 97% coverage: 1:565/581 of query aligns to 3:576/599 of 1n0hA
- active site: Y31 (= Y28), G33 (= G30), G34 (= G31), A35 (≠ T32), I36 (= I33), E57 (= E53), T80 (= T76), F119 (= F121), Q120 (= Q122), E121 (= E123), K169 (≠ M171), R230 (= R232), M266 (≠ H265), V293 (≠ Q292), V409 (= V397), L434 (≠ H423), G435 (= G424), M437 (= M426), D462 (= D451), N489 (= N478), E491 (≠ R480), Q492 (≠ L481), M494 (≠ L483), V495 (= V484), W498 (≠ F487), L520 (≠ I509), G525 (= G514), L526 (≠ I515), K559 (≠ T548)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (= V397), G410 (= G398), Q411 (≠ A399), H412 (= H400), G435 (= G424), M437 (= M426), G461 (= G450), D462 (= D451), A463 (≠ G452), S464 (= S453), M467 (= M456), N489 (= N478), E491 (≠ R480), Q492 (≠ L481), G493 (= G482), V495 (= V484)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (= G31), A35 (≠ T32), V109 (= V105), P110 (≠ G106), F119 (= F121), K169 (≠ M171), M266 (≠ H265), D291 (≠ V290), R292 (= R291), V495 (= V484), W498 (≠ F487)
- binding flavin-adenine dinucleotide: R159 (= R161), G219 (= G219), A220 (≠ N220), G221 (= G221), N224 (≠ S224), T246 (≠ S245), L247 (= L246), Q248 (≠ L247), L264 (≠ H263), G265 (= G264), M266 (≠ H265), H267 (≠ T266), G286 (= G285), A287 (≠ S286), R288 (= R287), D290 (= D289), R292 (= R291), V293 (≠ Q292), E319 (≠ D310), V320 (≠ L311), N324 (≠ D312), G337 (≠ K325), D338 (≠ A326), A339 (≠ V327), M414 (≠ H402), G432 (≠ A421), G433 (= G422)
- binding magnesium ion: D462 (= D451), N489 (= N478), E491 (≠ R480)
- binding thiamine diphosphate: Y31 (= Y28), E57 (= E53), P83 (= P79)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
34% identity, 97% coverage: 1:565/581 of query aligns to 1:572/595 of 1t9bB
- active site: Y29 (= Y28), G31 (= G30), G32 (= G31), A33 (≠ T32), I34 (= I33), E55 (= E53), T78 (= T76), F117 (= F121), Q118 (= Q122), E119 (= E123), K167 (≠ M171), R226 (= R232), M262 (≠ H265), V289 (≠ Q292), V405 (= V397), L430 (≠ H423), G431 (= G424), M433 (= M426), D458 (= D451), N485 (= N478), E487 (≠ R480), Q488 (≠ L481), M490 (≠ L483), V491 (= V484), W494 (≠ F487), L516 (≠ I509), G521 (= G514), L522 (≠ I515), K555 (≠ T548)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V105), P108 (≠ G106), D287 (≠ V290), R288 (= R291), M490 (≠ L483), W494 (≠ F487)
- binding flavin-adenine dinucleotide: R157 (= R161), G215 (= G219), A216 (≠ N220), G217 (= G221), N220 (≠ S224), T242 (≠ S245), L243 (= L246), Q244 (≠ L247), M259 (≠ F262), L260 (≠ H263), M262 (≠ H265), H263 (≠ T266), G282 (= G285), A283 (≠ S286), R284 (= R287), D286 (= D289), R288 (= R291), V289 (≠ Q292), E315 (≠ D310), V316 (≠ L311), N320 (≠ D312), G333 (≠ K325), D334 (≠ A326), A335 (≠ V327), Q409 (= Q401), M410 (≠ H402), G428 (≠ A421), G429 (= G422)
- binding magnesium ion: D458 (= D451), N485 (= N478), E487 (≠ R480)
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
34% identity, 97% coverage: 1:565/581 of query aligns to 5:584/607 of 6u9dB
- active site: Y33 (= Y28), G35 (= G30), G36 (= G31), A37 (≠ T32), I38 (= I33), E59 (= E53), T82 (= T76), F121 (= F121), Q122 (= Q122), E123 (= E123), K171 (≠ M171), M274 (≠ H265), V301 (≠ Q292), V417 (= V397), G443 (= G424), M445 (= M426), D470 (= D451), N497 (= N478), E499 (≠ R480), Q500 (≠ L481), M502 (≠ L483), V503 (= V484), W506 (≠ F487)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (= G31), V111 (= V105), P112 (≠ G106), F121 (= F121), K171 (≠ M171), D299 (≠ V290), R300 (= R291), M502 (≠ L483), W506 (≠ F487)
- binding flavin-adenine dinucleotide: R161 (= R161), A228 (≠ N220), G229 (= G221), N232 (≠ S224), T254 (≠ S245), L255 (= L246), Q256 (≠ L247), L272 (≠ H263), M274 (≠ H265), G294 (= G285), R296 (= R287), D298 (= D289), R300 (= R291), V301 (≠ Q292), E327 (≠ D310), V328 (≠ L311), N332 (≠ D312), D346 (≠ A326), A347 (≠ V327), M422 (≠ H402), G440 (≠ A421), G441 (= G422)
- binding magnesium ion: D470 (= D451), N497 (= N478)
- binding thiamine diphosphate: E59 (= E53), P85 (= P79), V417 (= V397), G418 (= G398), Q419 (≠ A399), H420 (= H400), G443 (= G424), M445 (= M426), A471 (≠ G452), S472 (= S453), N497 (= N478), E499 (≠ R480), Q500 (≠ L481), G501 (= G482), M502 (≠ L483), V503 (= V484)
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
34% identity, 97% coverage: 1:565/581 of query aligns to 85:664/687 of P07342
- R241 (= R161) binding
- 355:376 (vs. 266:287, 32% identical) binding
- 407:426 (vs. 310:326, 15% identical) binding
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
34% identity, 97% coverage: 1:565/581 of query aligns to 1:568/591 of 5wkcA
- active site: Y29 (= Y28), G31 (= G30), G32 (= G31), A33 (≠ T32), I34 (= I33), E55 (= E53), T78 (= T76), F117 (= F121), Q118 (= Q122), E119 (= E123), K167 (≠ M171), R222 (= R232), M258 (≠ H265), V285 (≠ Q292), V401 (= V397), L426 (≠ H423), G427 (= G424), M429 (= M426), D454 (= D451), N481 (= N478), E483 (≠ R480), Q484 (≠ L481), M486 (≠ L483), V487 (= V484), W490 (≠ F487), L512 (≠ I509), G517 (= G514), L518 (≠ I515), K551 (≠ T548)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (= V397), G402 (= G398), Q403 (≠ A399), H404 (= H400), G427 (= G424), M429 (= M426), G453 (= G450), D454 (= D451), A455 (≠ G452), S456 (= S453), M459 (= M456), N481 (= N478), E483 (≠ R480), Q484 (≠ L481), G485 (= G482), M486 (≠ L483), V487 (= V484)
- binding ethaneperoxoic acid: G32 (= G31), Q118 (= Q122)
- binding flavin-adenine dinucleotide: R157 (= R161), G211 (= G219), A212 (≠ N220), G213 (= G221), N216 (≠ S224), T238 (≠ S245), L239 (= L246), Q240 (≠ L247), L256 (≠ H263), M258 (≠ H265), G278 (= G285), A279 (≠ S286), R280 (= R287), R284 (= R291), V285 (≠ Q292), E311 (≠ D310), V312 (≠ L311), N316 (≠ D312), D330 (≠ A326), A331 (≠ V327), M406 (≠ H402), G424 (≠ A421)
- binding magnesium ion: D454 (= D451), N481 (= N478), E483 (≠ R480)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (= G31), A33 (≠ T32), V107 (= V105), F117 (= F121), K167 (≠ M171), M258 (≠ H265), R284 (= R291), M486 (≠ L483), W490 (≠ F487)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (= P29), E55 (= E53)
1t9bA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
34% identity, 97% coverage: 1:565/581 of query aligns to 1:560/583 of 1t9bA
- active site: Y29 (= Y28), G31 (= G30), G32 (= G31), A33 (≠ T32), I34 (= I33), E55 (= E53), T78 (= T76), F117 (= F121), Q118 (= Q122), E119 (= E123), K167 (≠ M171), R214 (= R232), M250 (≠ H265), V277 (≠ Q292), V393 (= V397), L418 (≠ H423), G419 (= G424), M421 (= M426), D446 (= D451), N473 (= N478), E475 (≠ R480), Q476 (≠ L481), M478 (≠ L483), V479 (= V484), W482 (≠ F487), L504 (≠ I509), G509 (= G514), L510 (≠ I515), K543 (≠ T548)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V105), P108 (≠ G106), F117 (= F121), D275 (≠ V290), R276 (= R291), M478 (≠ L483), W482 (≠ F487)
- binding flavin-adenine dinucleotide: R157 (= R161), G203 (= G219), A204 (≠ N220), G205 (= G221), N208 (≠ S224), T230 (≠ S245), L231 (= L246), Q232 (≠ L247), M247 (≠ F262), L248 (≠ H263), M250 (≠ H265), H251 (≠ T266), G270 (= G285), A271 (≠ S286), R272 (= R287), D274 (= D289), R276 (= R291), V277 (≠ Q292), E303 (≠ D310), V304 (≠ L311), N308 (≠ D312), D322 (≠ A326), A323 (≠ V327), Q397 (= Q401), M398 (≠ H402), G416 (≠ A421), G417 (= G422)
- binding magnesium ion: D446 (= D451), N473 (= N478), E475 (≠ R480)
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
34% identity, 94% coverage: 15:563/581 of query aligns to 18:568/593 of 6deoA
- active site: Y31 (= Y28), G33 (= G30), G34 (= G31), A35 (≠ T32), I36 (= I33), E57 (= E53), T80 (= T76), F119 (= F121), Q120 (= Q122), E121 (= E123), K169 (≠ M171), K224 (≠ A226), M260 (≠ H265), V287 (≠ Q292), V403 (= V397), L428 (≠ H423), G429 (= G424), M431 (= M426), D456 (= D451), N483 (= N478), E485 (≠ R480), Q486 (≠ L481), M488 (≠ L483), V489 (= V484), W492 (≠ F487), L514 (≠ I509), N519 (≠ G514), V520 (≠ I515)
- binding flavin-adenine dinucleotide: R159 (= R161), G213 (= G219), A214 (≠ N220), G215 (= G221), N218 (≠ S224), T240 (≠ S245), L241 (= L246), Q242 (≠ L247), L258 (≠ H263), G280 (= G285), A281 (≠ S286), R282 (= R287), D284 (= D289), R286 (= R291), V287 (≠ Q292), E313 (≠ R308), I314 (≠ V309), N318 (≠ D312), D332 (≠ A326), V333 (= V327), M408 (≠ H402), G426 (≠ A421)
- binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (≠ H265), D285 (≠ V290), R286 (= R291), M488 (≠ L483), W492 (≠ F487)
- binding magnesium ion: D456 (= D451), N483 (= N478), E485 (≠ R480)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (= V397), G404 (= G398), Q405 (≠ A399), H406 (= H400), G429 (= G424), M431 (= M426), G455 (= G450), D456 (= D451), A457 (≠ G452), S458 (= S453), M461 (= M456), N483 (= N478), E485 (≠ R480), Q486 (≠ L481), G487 (= G482), M488 (≠ L483), V489 (= V484)
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
34% identity, 95% coverage: 15:565/581 of query aligns to 15:559/582 of 1t9dB
- active site: Y28 (= Y28), G30 (= G30), G31 (= G31), A32 (≠ T32), I33 (= I33), E54 (= E53), T77 (= T76), F116 (= F121), Q117 (= Q122), E118 (= E123), K166 (≠ M171), R213 (= R232), M249 (≠ H265), V276 (≠ Q292), V392 (= V397), L417 (≠ H423), G418 (= G424), M420 (= M426), D445 (= D451), N472 (= N478), E474 (≠ R480), Q475 (≠ L481), M477 (≠ L483), V478 (= V484), W481 (≠ F487), L503 (≠ I509), G508 (= G514), L509 (≠ I515), K542 (≠ T548)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G31 (= G31), A32 (≠ T32), V106 (= V105), P107 (≠ G106), F116 (= F121), K166 (≠ M171), M249 (≠ H265), D274 (≠ V290), R275 (= R291), W481 (≠ F487)
- binding flavin-adenine dinucleotide: R156 (= R161), G202 (= G219), A203 (≠ N220), G204 (= G221), N207 (≠ S224), T229 (≠ S245), L230 (= L246), Q231 (≠ L247), L247 (≠ H263), M249 (≠ H265), H250 (≠ T266), G269 (= G285), A270 (≠ S286), R271 (= R287), D273 (= D289), R275 (= R291), V276 (≠ Q292), E302 (≠ D310), V303 (≠ L311), N307 (≠ D312), G320 (≠ K325), D321 (≠ A326), A322 (≠ V327), Q396 (= Q401), M397 (≠ H402), G415 (≠ A421), G416 (= G422)
- binding magnesium ion: D445 (= D451), N472 (= N478), E474 (≠ R480)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E54 (= E53), P80 (= P79), G418 (= G424), M420 (= M426), M450 (= M456)
6deqA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
34% identity, 94% coverage: 15:563/581 of query aligns to 22:576/601 of 6deqA
- active site: Y35 (= Y28), G37 (= G30), G38 (= G31), A39 (≠ T32), I40 (= I33), E61 (= E53), T84 (= T76), F123 (= F121), Q124 (= Q122), E125 (= E123), K173 (≠ M171), K232 (≠ A226), M268 (≠ H265), V295 (≠ Q292), V411 (= V397), L436 (≠ H423), G437 (= G424), M439 (= M426), D464 (= D451), N491 (= N478), E493 (≠ R480), Q494 (≠ L481), M496 (≠ L483), V497 (= V484), W500 (≠ F487), L522 (≠ I509), N527 (≠ G514), V528 (≠ I515)
- binding flavin-adenine dinucleotide: R163 (= R161), G221 (= G219), A222 (≠ N220), G223 (= G221), N226 (≠ S224), T248 (≠ S245), L249 (= L246), Q250 (≠ L247), L266 (≠ H263), G288 (= G285), A289 (≠ S286), R290 (= R287), D292 (= D289), R294 (= R291), V295 (≠ Q292), E321 (≠ R308), I322 (≠ V309), D340 (≠ A326), V341 (= V327), M416 (≠ H402), G434 (≠ A421)
- binding magnesium ion: D464 (= D451), N491 (= N478), E493 (≠ R480)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M268 (≠ H265), R294 (= R291), M496 (≠ L483), V497 (= V484), W500 (≠ F487), A571 (≠ G558)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V411 (= V397), G412 (= G398), Q413 (≠ A399), H414 (= H400), M439 (= M426), G463 (= G450), D464 (= D451), A465 (≠ G452), S466 (= S453), N491 (= N478), E493 (≠ R480), Q494 (≠ L481), G495 (= G482), M496 (≠ L483), V497 (= V484)
6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone (see paper)
34% identity, 94% coverage: 15:563/581 of query aligns to 20:573/598 of 6desA
- active site: Y33 (= Y28), G35 (= G30), G36 (= G31), A37 (≠ T32), I38 (= I33), E59 (= E53), T82 (= T76), F121 (= F121), Q122 (= Q122), E123 (= E123), K171 (≠ M171), K229 (≠ A226), M265 (≠ H265), V292 (≠ Q292), V408 (= V397), L433 (≠ H423), G434 (= G424), M436 (= M426), D461 (= D451), N488 (= N478), E490 (≠ R480), Q491 (≠ L481), M493 (≠ L483), V494 (= V484), W497 (≠ F487), L519 (≠ I509), N524 (≠ G514), V525 (≠ I515)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: M265 (≠ H265), D290 (≠ V290), R291 (= R291), W497 (≠ F487)
- binding flavin-adenine dinucleotide: R161 (= R161), G218 (= G219), A219 (≠ N220), G220 (= G221), N223 (≠ S224), T245 (≠ S245), L246 (= L246), Q247 (≠ L247), L263 (≠ H263), G285 (= G285), A286 (≠ S286), R287 (= R287), D289 (= D289), R291 (= R291), V292 (≠ Q292), E318 (≠ R308), I319 (≠ V309), N323 (≠ D312), D337 (≠ A326), V338 (= V327), Q412 (= Q401), M413 (≠ H402), G431 (≠ A421)
- binding magnesium ion: D461 (= D451), N488 (= N478), E490 (≠ R480)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V397), G409 (= G398), Q410 (≠ A399), H411 (= H400), G434 (= G424), M436 (= M426), G460 (= G450), D461 (= D451), A462 (≠ G452), S463 (= S453), N488 (= N478), E490 (≠ R480), Q491 (≠ L481), G492 (= G482), M493 (≠ L483), V494 (= V484)
6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl (see paper)
34% identity, 94% coverage: 15:563/581 of query aligns to 20:573/598 of 6depA
- active site: Y33 (= Y28), G35 (= G30), G36 (= G31), A37 (≠ T32), I38 (= I33), E59 (= E53), T82 (= T76), F121 (= F121), Q122 (= Q122), E123 (= E123), K171 (≠ M171), K229 (≠ A226), M265 (≠ H265), V292 (≠ Q292), V408 (= V397), L433 (≠ H423), G434 (= G424), M436 (= M426), D461 (= D451), N488 (= N478), E490 (≠ R480), Q491 (≠ L481), M493 (≠ L483), V494 (= V484), W497 (≠ F487), L519 (≠ I509), N524 (≠ G514), V525 (≠ I515)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D290 (≠ V290), R291 (= R291), M493 (≠ L483), W497 (≠ F487)
- binding flavin-adenine dinucleotide: R161 (= R161), G218 (= G219), A219 (≠ N220), G220 (= G221), N223 (≠ S224), T245 (≠ S245), L246 (= L246), Q247 (≠ L247), L263 (≠ H263), G264 (= G264), G285 (= G285), A286 (≠ S286), R287 (= R287), D289 (= D289), R291 (= R291), V292 (≠ Q292), E318 (≠ R308), I319 (≠ V309), N323 (≠ D312), D337 (≠ A326), V338 (= V327), M413 (≠ H402), G431 (≠ A421)
- binding magnesium ion: D461 (= D451), N488 (= N478), E490 (≠ R480)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V408 (= V397), G409 (= G398), Q410 (≠ A399), H411 (= H400), G434 (= G424), M436 (= M426), G460 (= G450), D461 (= D451), A462 (≠ G452), S463 (= S453), M466 (= M456), N488 (= N478), E490 (≠ R480), Q491 (≠ L481), G492 (= G482), M493 (≠ L483), V494 (= V484)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V397), G409 (= G398), Q410 (≠ A399), H411 (= H400), G434 (= G424), M436 (= M426), G460 (= G450), D461 (= D451), A462 (≠ G452), S463 (= S453), M466 (= M456), N488 (= N478), E490 (≠ R480), Q491 (≠ L481), G492 (= G482), M493 (≠ L483), V494 (= V484)
6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl (see paper)
33% identity, 94% coverage: 15:563/581 of query aligns to 22:574/599 of 6denA
- active site: Y35 (= Y28), G37 (= G30), G38 (= G31), A39 (≠ T32), I40 (= I33), E61 (= E53), T84 (= T76), F123 (= F121), Q124 (= Q122), E125 (= E123), K173 (≠ M171), K230 (≠ A226), M266 (≠ H265), V293 (≠ Q292), V409 (= V397), L434 (≠ H423), G435 (= G424), M437 (= M426), D462 (= D451), N489 (= N478), E491 (≠ R480), Q492 (≠ L481), M494 (≠ L483), V495 (= V484), W498 (≠ F487), L520 (≠ I509), N525 (≠ G514), V526 (≠ I515)
- binding flavin-adenine dinucleotide: R163 (= R161), G219 (= G219), A220 (≠ N220), G221 (= G221), N224 (≠ S224), T246 (≠ S245), L247 (= L246), Q248 (≠ L247), L264 (≠ H263), G286 (= G285), A287 (≠ S286), R288 (= R287), D290 (= D289), R292 (= R291), V293 (≠ Q292), E319 (≠ R308), I320 (≠ V309), N324 (≠ D312), D338 (≠ A326), V339 (= V327), M414 (≠ H402), G432 (≠ A421)
- binding ethyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M266 (≠ H265), D291 (≠ V290), R292 (= R291), W498 (≠ F487)
- binding magnesium ion: D462 (= D451), N489 (= N478), E491 (≠ R480)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V409 (= V397), G410 (= G398), Q411 (≠ A399), H412 (= H400), G435 (= G424), M437 (= M426), G461 (= G450), D462 (= D451), A463 (≠ G452), S464 (= S453), N489 (= N478), E491 (≠ R480), Q492 (≠ L481), G493 (= G482), M494 (≠ L483), V495 (= V484)
6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
33% identity, 94% coverage: 15:563/581 of query aligns to 20:572/597 of 6demA
- active site: Y33 (= Y28), G35 (= G30), G36 (= G31), A37 (≠ T32), I38 (= I33), E59 (= E53), T82 (= T76), F121 (= F121), Q122 (= Q122), E123 (= E123), K171 (≠ M171), K228 (≠ A226), M264 (≠ H265), V291 (≠ Q292), V407 (= V397), L432 (≠ H423), G433 (= G424), M435 (= M426), D460 (= D451), N487 (= N478), E489 (≠ R480), Q490 (≠ L481), M492 (≠ L483), V493 (= V484), W496 (≠ F487), L518 (≠ I509), N523 (≠ G514), V524 (≠ I515)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (≠ H265), D289 (≠ V290), R290 (= R291), M492 (≠ L483), W496 (≠ F487), A567 (≠ G558)
- binding flavin-adenine dinucleotide: R161 (= R161), G217 (= G219), A218 (≠ N220), G219 (= G221), N222 (≠ S224), T244 (≠ S245), L245 (= L246), Q246 (≠ L247), L262 (≠ H263), G284 (= G285), A285 (≠ S286), R286 (= R287), D288 (= D289), R290 (= R291), V291 (≠ Q292), E317 (≠ R308), I318 (≠ V309), N322 (≠ D312), D336 (≠ A326), V337 (= V327), M412 (≠ H402), G430 (≠ A421)
- binding magnesium ion: D460 (= D451), N487 (= N478), E489 (≠ R480)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V397), G408 (= G398), Q409 (≠ A399), H410 (= H400), M435 (= M426), G459 (= G450), D460 (= D451), A461 (≠ G452), S462 (= S453), M465 (= M456), N487 (= N478), E489 (≠ R480), Q490 (≠ L481), G491 (= G482), M492 (≠ L483), V493 (= V484)
6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
33% identity, 94% coverage: 15:563/581 of query aligns to 20:572/597 of 6delA
- active site: Y33 (= Y28), G35 (= G30), G36 (= G31), A37 (≠ T32), I38 (= I33), E59 (= E53), T82 (= T76), F121 (= F121), Q122 (= Q122), E123 (= E123), K171 (≠ M171), K228 (≠ A226), M264 (≠ H265), V291 (≠ Q292), V407 (= V397), L432 (≠ H423), G433 (= G424), M435 (= M426), D460 (= D451), N487 (= N478), E489 (≠ R480), Q490 (≠ L481), M492 (≠ L483), V493 (= V484), W496 (≠ F487), L518 (≠ I509), N523 (≠ G514), V524 (≠ I515)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (≠ V290), R290 (= R291), W496 (≠ F487)
- binding flavin-adenine dinucleotide: R161 (= R161), G217 (= G219), A218 (≠ N220), G219 (= G221), N222 (≠ S224), T244 (≠ S245), L245 (= L246), Q246 (≠ L247), L262 (≠ H263), G284 (= G285), A285 (≠ S286), R286 (= R287), D288 (= D289), R290 (= R291), V291 (≠ Q292), E317 (≠ R308), I318 (≠ V309), N322 (≠ D312), D336 (≠ A326), V337 (= V327), M412 (≠ H402), G430 (≠ A421)
- binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (= V397), G408 (= G398), Q409 (≠ A399), H410 (= H400), G433 (= G424), M435 (= M426), G459 (= G450), D460 (= D451), A461 (≠ G452), S462 (= S453), M465 (= M456), N487 (= N478), E489 (≠ R480), Q490 (≠ L481), G491 (= G482), M492 (≠ L483), V493 (= V484)
- binding magnesium ion: D460 (= D451), N487 (= N478), E489 (≠ R480)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V397), G408 (= G398), Q409 (≠ A399), H410 (= H400), G433 (= G424), M435 (= M426), G459 (= G450), D460 (= D451), A461 (≠ G452), S462 (= S453), M465 (= M456), N487 (= N478), E489 (≠ R480), Q490 (≠ L481), G491 (= G482), M492 (≠ L483), V493 (= V484)
6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam (see paper)
34% identity, 94% coverage: 15:563/581 of query aligns to 22:575/600 of 6derA
- active site: Y35 (= Y28), G37 (= G30), G38 (= G31), A39 (≠ T32), I40 (= I33), E61 (= E53), T84 (= T76), F123 (= F121), Q124 (= Q122), E125 (= E123), K173 (≠ M171), K231 (≠ A226), M267 (≠ H265), V294 (≠ Q292), V410 (= V397), L435 (≠ H423), G436 (= G424), M438 (= M426), D463 (= D451), N490 (= N478), E492 (≠ R480), Q493 (≠ L481), M495 (≠ L483), V496 (= V484), W499 (≠ F487), L521 (≠ I509), N526 (≠ G514), V527 (≠ I515)
- binding flavin-adenine dinucleotide: R163 (= R161), G220 (= G219), A221 (≠ N220), G222 (= G221), N225 (≠ S224), T247 (≠ S245), L248 (= L246), Q249 (≠ L247), L265 (≠ H263), H268 (≠ T266), G287 (= G285), A288 (≠ S286), R289 (= R287), D291 (= D289), R293 (= R291), V294 (≠ Q292), E320 (≠ R308), I321 (≠ V309), N325 (≠ D312), G338 (≠ K325), D339 (≠ A326), V340 (= V327), Q414 (= Q401), M415 (≠ H402), G433 (≠ A421)
- binding Metosulam: R293 (= R291), M495 (≠ L483), W499 (≠ F487), A570 (≠ G558)
- binding magnesium ion: D463 (= D451), N490 (= N478), E492 (≠ R480)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V410 (= V397), G411 (= G398), Q412 (≠ A399), H413 (= H400), G436 (= G424), M438 (= M426), G462 (= G450), D463 (= D451), A464 (≠ G452), S465 (= S453), N490 (= N478), E492 (≠ R480), Q493 (≠ L481), G494 (= G482), M495 (≠ L483), V496 (= V484)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V410 (= V397), G411 (= G398), Q412 (≠ A399), H413 (= H400), G436 (= G424), M438 (= M426), G462 (= G450), D463 (= D451), A464 (≠ G452), S465 (= S453), M468 (= M456), N490 (= N478), E492 (≠ R480), Q493 (≠ L481), G494 (= G482), V496 (= V484)
6dekA Crystal structure of candida albicans acetohydroxyacid synthase catalytic subunit (see paper)
34% identity, 94% coverage: 15:563/581 of query aligns to 21:570/595 of 6dekA
- active site: Y34 (= Y28), G36 (= G30), G37 (= G31), A38 (≠ T32), I39 (= I33), E60 (= E53), T83 (= T76), Q118 (= Q122), E119 (= E123), K167 (≠ M171), K226 (≠ A226), M262 (≠ H265), V289 (≠ Q292), V405 (= V397), L430 (≠ H423), G431 (= G424), M433 (= M426), D458 (= D451), N485 (= N478), E487 (≠ R480), Q488 (≠ L481), M490 (≠ L483), V491 (= V484), W494 (≠ F487), L516 (≠ I509), N521 (≠ G514), V522 (≠ I515)
- binding flavin-adenine dinucleotide: R157 (= R161), G215 (= G219), A216 (≠ N220), G217 (= G221), N220 (≠ S224), T242 (≠ S245), L243 (= L246), Q244 (≠ L247), L260 (≠ H263), M262 (≠ H265), G282 (= G285), A283 (≠ S286), R284 (= R287), D286 (= D289), R288 (= R291), V289 (≠ Q292), E315 (≠ R308), I316 (≠ V309), N320 (≠ D312), D334 (≠ A326), V335 (= V327), M410 (≠ H402), G428 (≠ A421)
- binding magnesium ion: D458 (= D451), N485 (= N478), E487 (≠ R480)
- binding thiamine diphosphate: V405 (= V397), G406 (= G398), Q407 (≠ A399), H408 (= H400), M433 (= M426), G457 (= G450), D458 (= D451), A459 (≠ G452), S460 (= S453), N485 (= N478), E487 (≠ R480), Q488 (≠ L481), G489 (= G482), M490 (≠ L483), V491 (= V484)
7egvA Acetolactate synthase from trichoderma harzianum with inhibitor harzianic acid (see paper)
33% identity, 94% coverage: 15:559/581 of query aligns to 15:561/590 of 7egvA
- active site: Y28 (= Y28), G30 (= G30), G31 (= G31), A32 (≠ T32), I33 (= I33), E54 (= E53), T77 (= T76), F116 (= F121), Q117 (= Q122), K166 (≠ M171), E220 (≠ D229), M256 (≠ H265), V283 (≠ Q292), V400 (= V397), L425 (≠ H423), G426 (= G424), M428 (= M426), Q483 (≠ L481), M485 (≠ L483), V486 (= V484), W489 (≠ F487), L511 (≠ I509), G516 (= G514), I517 (= I515)
- binding flavin-adenine dinucleotide: R156 (= R161), G209 (= G219), Q210 (≠ N220), G211 (= G221), T236 (≠ S245), L237 (= L246), H238 (≠ L247), G276 (= G285), S277 (= S286), R278 (= R287), D280 (= D289), R282 (= R291), V283 (≠ Q292), E309 (≠ D310), I310 (≠ L311), D328 (≠ E330), V329 (≠ L331), M405 (≠ H402), G423 (≠ A421), G424 (= G422)
- binding (2S)-3-methyl-2-[[(2S,4R)-1-methyl-4-[(2E,4E)-octa-2,4-dienoyl]-3,5-bis(oxidanylidene)pyrrolidin-2-yl]methyl]-2-oxidanyl-butanoic acid: F493 (≠ N491), Y494 (≠ W492)
- binding magnesium ion: D453 (= D451), N480 (= N478), E482 (≠ R480)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: P29 (= P29), E54 (= E53), Q117 (= Q122), V400 (= V397), G401 (= G398), Q402 (≠ A399), H403 (= H400), G426 (= G424), M428 (= M426), D453 (= D451), A454 (≠ G452), S455 (= S453), E482 (≠ R480), Q483 (≠ L481), G484 (= G482), M485 (≠ L483), V486 (= V484)
Query Sequence
>202370 FitnessBrowser__MR1:202370
MSTSPITVVADAIIEFLAHQGIKAFHNYPGGTIAPLLDACKRFGVTVYTSRNEQGAGYAA
LAQGKLTQLPGIVAVTSGPGVTNVLTPVADAYFDGIPMLVFTGQVGTGDLTGQKRVRQSG
FQEVDTPSLMKPITKGQFQPKNSEELYAILPIAWQLALEGRKGPVSIDLPMDVQRSAAIK
SIKVPEIVTYPVNRTELGTFIDELINAIDHSQKPVIICGNGMTSPALVDAIRTLRNYWPA
PVSHSLLGVGVLDTDDSGSLGFHGHTGSQLAGKAIAECDLLLVLGSRLDVRQTGTLKTAF
ASNAKIFRVDLDIGELTDSRIAHHKAVQAELEQFFDALHPKFAQLSPPNLSSWHNTISQW
KAQLAWPYPDYPGIAPKLLLEKLSNSLPENTIVTTGVGAHQHWVARHFRFALPHRQLFTS
AGHGTMGYDLPTAIGAAIHSPESTILCIAGDGSFQMNIQELGVIKELGLKIKILVLDNHR
LGLVSQFQLMNWETDTACGNKQSPNFALIAQGYGIKALHCSDSAKLEQTLAEFIETDESI
LLHIEIATQHDVLPMLLGGQTTDKMWPYFDMQGNPRDPSNV
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory