Comparing 202608 SO3507 conserved hypothetical protein (NCBI ptt file) to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 6 hits to proteins with known functional sites (download)
2e2oA Crystal structure of sulfolobus tokodaii hexokinase in complex with glucose (see paper)
32% identity, 79% coverage: 11:246/300 of query aligns to 3:238/299 of 2e2oA
2e2pA Crystal structure of sulfolobus tokodaii hexokinase in complex with adp (see paper)
32% identity, 79% coverage: 11:246/300 of query aligns to 3:238/298 of 2e2pA
Sites not aligning to the query:
2e2qA Crystal structure of sulfolobus tokodaii hexokinase in complex with xylose, mg2+, and adp (see paper)
32% identity, 79% coverage: 11:246/300 of query aligns to 3:238/297 of 2e2qA
Sites not aligning to the query:
Q9UJ70 N-acetyl-D-glucosamine kinase; N-acetylglucosamine kinase; GlcNAc kinase; Muramyl dipeptide kinase; N-acetyl-D-mannosamine kinase; EC 2.7.1.59; EC 2.7.1.-; EC 2.7.1.60 from Homo sapiens (Human) (see 5 papers)
25% identity, 81% coverage: 11:254/300 of query aligns to 4:258/344 of Q9UJ70
Sites not aligning to the query:
2ch6A Crystal structure of human n-acetylglucosamine kinase in complex with adp and glucose (see paper)
25% identity, 81% coverage: 11:254/300 of query aligns to 3:257/343 of 2ch6A
Sites not aligning to the query:
P81799 N-acetyl-D-glucosamine kinase; N-acetylglucosamine kinase; GlcNAc kinase; Muramyl dipeptide kinase; N-acetyl-D-mannosamine kinase; EC 2.7.1.59; EC 2.7.1.-; EC 2.7.1.60 from Rattus norvegicus (Rat) (see paper)
26% identity, 81% coverage: 11:254/300 of query aligns to 4:258/343 of P81799
Sites not aligning to the query:
>202608 SO3507 conserved hypothetical protein (NCBI ptt file)
MGLVQTNDQQLFIGVDGGGSKCRATIYTADGTVLGTGVAGRANPLHGLAQTFESIEASAH
QALLDAGMKATDSHLLVAGLGLAGVNVPRLYQDVVNWQHPFAAMYVTTDLHTACIGAHRG
ADGAVIITGTGSCGYAHVGDASLSIGGHGFALGDKGSGAWLGLKAAEHVLLALDGFATPT
ALTEMLLSHLGVKDALGIVEHLAGKSSSCYAQLARNVLDCANAGDQVAIAIVQEGADYIS
EMARKLFMLNPVRFSMIGGLAEPLQAWLGSDVVAKISETLAPPELGAMYYAQQQFNSATV
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory