SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing 206067 MicrobesOnline__882:206067 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P07821 Iron(3+)-hydroxamate import ATP-binding protein FhuC; Ferric hydroxamate uptake protein C; Ferrichrome transport ATP-binding protein FhuC; Iron(III)-hydroxamate import ATP-binding protein FhuC; EC 7.2.2.16 from Escherichia coli (strain K12) (see 2 papers)
38% identity, 86% coverage: 16:249/271 of query aligns to 26:260/265 of P07821

query
sites
P07821

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K50 (= K40) mutation to Q: Lack of activity.
D172 (= D162) mutation to E: Lack of activity.
E173 (= E163) mutation to A: Lack of activity.

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
31% identity, 83% coverage: 1:225/271 of query aligns to 2:224/241 of 4u00A

query
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binding adenosine-5'-diphosphate: F12 (≠ Y11), V17 (= V16), S37 (≠ N36), G38 (= G37), S39 (= S38), G40 (= G39), K41 (= K40), S42 (≠ T41), T43 (= T42)

P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
31% identity, 79% coverage: 4:216/271 of query aligns to 12:224/233 of P75957

query
sites
P75957

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G42 (= G34) mutation to D: Loss of lipoprotein release when overexpressed.

7arlD Lolcde in complex with lipoprotein and adp (see paper)
31% identity, 79% coverage: 4:216/271 of query aligns to 9:221/222 of 7arlD

query
sites
7arlD

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binding adenosine-5'-diphosphate: G42 (= G37), G44 (= G39), K45 (= K40), S46 (≠ T41)

7mdyC Lolcde nucleotide-bound
31% identity, 79% coverage: 4:216/271 of query aligns to 9:221/226 of 7mdyC

query
sites
7mdyC

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binding adp orthovanadate: Y12 (≠ L7), G42 (= G37), S43 (= S38), G44 (= G39), K45 (= K40), S46 (≠ T41), T47 (= T42), Q91 (= Q82), H138 (≠ R133), E142 (≠ T137), S144 (= S139), G145 (= G140), G146 (= G141), E168 (= E163), N172 (≠ G167), H201 (= H195)
binding magnesium ion: S46 (≠ T41), Q91 (= Q82)

7v8iD Lolcd(e171q)e with bound amppnp in nanodiscs (see paper)
31% identity, 79% coverage: 4:216/271 of query aligns to 11:223/229 of 7v8iD

query
sites
7v8iD

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Y

-

P

-

H

-

T

-

G

-

P

P

L

L

-

L

-

I

-

G

R

K

G

K

Y

K

T

P

A

A

V

E

D

I

H

N

D

S

A

R

A

A

A

L

A

E

A

M

L

L

A

K

A

A

T

V

G

G

T

L

A

D

H

H

L
x
R

A

A

R

N

R
x
H

S

R

A

P

A

S

T
x
E

L

L

S
|
S

G

G

G
|
G

E
|
E

L

R

Q

Q

R

R

V

V

L

A

V

I

A

A

R

R

A

A

L

L

A

V

Q

N

D

N

T

P

D

R

T

L

L

V

L

L

L

A

D

D

E

Q

V

P

T

T

A

G

G

N

L

L

D

D

V

A

A

R

R

N

M

A

V

D

E

S

V

I

F

F

D

Q

L

L

A

G

Q

E

R

L

H

N

R

R

-

L

H

Q

G

G

L

T

R

A

I

F

V

L

A

V

I

T

H
|
H

D

D

I

L

N

Q

L

L

A

A

A

K

L

-

Y

R

C

M

T

S

R

R

L

Q

V

L

F

E

L

M

K

R

S

D

G

G

R

R

V

L

V

T

binding phosphoaminophosphonic acid-adenylate ester: V23 (= V16), S43 (≠ N36), G44 (= G37), G46 (= G39), K47 (= K40), S48 (≠ T41), T49 (= T42), Q93 (= Q82), R137 (≠ L130), H140 (≠ R133), E144 (≠ T137), S146 (= S139), G148 (= G141), E149 (= E142), H203 (= H195)
binding magnesium ion: S48 (≠ T41), Q93 (= Q82)

3c4jA Abc protein artp in complex with atp-gamma-s
29% identity, 83% coverage: 1:226/271 of query aligns to 3:227/242 of 3c4jA

query
sites
3c4jA

M

M

M

I

E

D

C

V

R

H

A

Q

L

L

H

K

A

K

G

S

Y
x
F

A

G

Q

S

T

L

E

E

V
|
V

L

L

H

K

G

G

I

I

D

N

L

V

R

H

I

I

A

R

Q

E

D

G

E

E

L

V

V

V

G

V

L

V

L

I

G

G

P

P

N
x
S

G
|
G

S
|
S

G
|
G

K
|
K

T
x
S

T
|
T

L

F

L

L

L

R

A

C

L

L

S

N

G

L

V

L

L

E

P

D

A

F

R

D

G

E

G

G

D

E

V

I

L

I

D

D

G

G

T

I

P

N

L

L

A

K

A

A

M

K

A

D

P

T

R

N

E

L

R

N

A

K

R

V

R

R

-

E

I

V

A

G

T

M

V

V

P

F

Q

Q

R

R

P

F

E

N

V

L

I

F

P

P

D

H

V

M

D

T

A

V

F

L

S

N

L

N

V

I

L

T

M

L

G

A

R

-

Y

-

P

-

H

-

T

-

G

-

P

P

L

M

R

K

G

V

Y

R

T

K

A

W

V

P

D

R

H

E

D

K

A

A

A

E

A

A

A

K

A

A

L

M

A

E

A

L

T

L

G

D

T

K

A

V

H

G

L

L

A

K

R

D

R

K

S

A

A

H

A

A

-

Y

-

P

-

D

T

S

L

L

S

S

G

G

E

Q

L

A

Q

Q

R

R

V

V

L

A

V

I

A

A

R

R

A

A

L

L

A

A

Q

M

D

E

T

P

D

K

T

I

L

M

L

L

L

F

D

D

E

E

V

P

T

T

A

S

G

A

L

L

D

D

V

P

A

E

R

M

M

V

V

G

E

E

V

V

F

L

D

S

L

V

L

M

A

K

Q

Q

R

L

H

A

R

N

H

E

G

G

L

M

R

T

I

M

V

V

A

V

I

T

H

H

D

E

I

M

N

G

L

F

A

A

A

R

L

E

Y

V

C

G

T

D

R

R

L

V

V

L

F

F

L

M

K

D

S

G

G

G

R

Y

V

I

L

E

D

E

G

G

P

K

V

P

A

E

Q

D

V

L

F

F

D

D

binding phosphothiophosphoric acid-adenylate ester: F13 (≠ Y11), V18 (= V16), S38 (≠ N36), G39 (= G37), S40 (= S38), G41 (= G39), K42 (= K40), S43 (≠ T41), T44 (= T42)

3c41J Abc protein artp in complex with amp-pnp/mg2+
29% identity, 83% coverage: 1:226/271 of query aligns to 3:227/242 of 3c41J

query
sites
3c41J

M

M

M

I

E

D

C

V

R

H

A

Q

L

L

H

K

A

K

G

S

Y
x
F

A

G

Q

S

T

L

E

E

V
|
V

L

L

H

K

G

G

I

I

D

N

L

V

R

H

I

I

A

R

Q

E

D

G

E

E

L

V

V

V

G

V

L

V

L

I

G

G

P

P

N
x
S

G
|
G

S

S

G
|
G

K
|
K

T
x
S

T
|
T

L

F

L

L

L

R

A

C

L

L

S

N

G

L

V

L

L

E

P

D

A

F

R

D

G

E

G

G

D

E

V

I

L

I

D

D

G

G

T

I

P

N

L

L

A

K

A

A

M

K

A

D

P

T

R

N

E

L

R

N

A

K

R

V

R

R

-

E

I

V

A

G

T

M

V

V

P

F

Q

Q

R

R

P

F

E

N

V

L

I

F

P

P

D

H

V

M

D

T

A

V

F

L

S

N

L

N

V

I

L

T

M

L

G

A

R

-

Y

-

P

-

H

-

T

-

G

-

P

P

L

M

R

K

G

V

Y

R

T

K

A

W

V

P

D

R

H

E

D

K

A

A

A

E

A

A

A

K

A

A

L

M

A

E

A

L

T

L

G

D

T

K

A

V

H

G

L

L

A

K

R

D

R

K

S

A

A

H

A

A

-

Y

-

P

-

D

T

S

L

L

S

S

G

G

E

Q

L

A

Q

Q

R

R

V

V

L

A

V

I

A

A

R

R

A

A

L

L

A

A

Q

M

D

E

T

P

D

K

T

I

L

M

L

L

L

F

D
|
D

E

E

V

P

T

T

A

S

G

A

L

L

D

D

V

P

A

E

R

M

M

V

V

G

E

E

V

V

F

L

D

S

L

V

L

M

A

K

Q

Q

R

L

H

A

R

N

H

E

G

G

L

M

R

T

I

M

V

V

A

V

I

T

H

H

D

E

I

M

N

G

L

F

A

A

A

R

L

E

Y

V

C

G

T

D

R

R

L

V

V

L

F

F

L

M

K

D

S

G

G

G

R

Y

V

I

L

E

D

E

G

G

P

K

V

P

A

E

Q

D

V

L

F

F

D

D

binding phosphoaminophosphonic acid-adenylate ester: F13 (≠ Y11), V18 (= V16), S38 (≠ N36), G39 (= G37), G41 (= G39), K42 (= K40), S43 (≠ T41), T44 (= T42)
binding magnesium ion: S43 (≠ T41), D163 (= D162)

2olkA Abc protein artp in complex with adp-beta-s
29% identity, 83% coverage: 1:226/271 of query aligns to 3:227/242 of 2olkA

query
sites
2olkA

M

M

M

I

E

D

C

V

R

H

A

Q

L

L

H

K

A

K

G

S

Y
x
F

A

G

Q

S

T

L

E

E

V
|
V

L

L

H

K

G

G

I

I

D

N

L

V

R

H

I

I

A

R

Q

E

D

G

E

E

L

V

V

V

G

V

L

V

L

I

G

G

P

P

N
x
S

G
|
G

S
|
S

G
|
G

K
|
K

T
x
S

T
|
T

L

F

L

L

L

R

A

C

L

L

S

N

G

L

V

L

L

E

P

D

A

F

R

D

G

E

G

G

D

E

V

I

L

I

D

D

G

G

T

I

P

N

L

L

A

K

A

A

M

K

A

D

P

T

R

N

E

L

R

N

A

K

R

V

R

R

-

E

I

V

A

G

T

M

V

V

P

F

Q

Q

R

R

P

F

E

N

V

L

I

F

P

P

D

H

V

M

D

T

A

V

F

L

S

N

L

N

V

I

L

T

M

L

G

A

R

-

Y

-

P

-

H

-

T

-

G

-

P

P

L

M

R

K

G

V

Y

R

T

K

A

W

V

P

D

R

H

E

D

K

A

A

A

E

A

A

A

K

A

A

L

M

A

E

A

L

T

L

G

D

T

K

A

V

H

G

L

L

A

K

R

D

R

K

S

A

A

H

A

A

-

Y

-

P

-

D

T

S

L

L

S

S

G

G

E

Q

L

A

Q

Q

R

R

V

V

L

A

V

I

A

A

R

R

A

A

L

L

A

A

Q

M

D

E

T

P

D

K

T

I

L

M

L

L

L

F

D

D

E

E

V

P

T

T

A

S

G

A

L

L

D

D

V

P

A

E

R

M

M

V

V

G

E

E

V

V

F

L

D

S

L

V

L

M

A

K

Q

Q

R

L

H

A

R

N

H

E

G

G

L

M

R

T

I

M

V

V

A

V

I

T

H

H

D

E

I

M

N

G

L

F

A

A

A

R

L

E

Y

V

C

G

T

D

R

R

L

V

V

L

F

F

L

M

K

D

S

G

G

G

R

Y

V

I

L

E

D

E

G

G

P

K

V

P

A

E

Q

D

V

L

F

F

D

D

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (≠ Y11), V18 (= V16), S38 (≠ N36), G39 (= G37), S40 (= S38), G41 (= G39), K42 (= K40), S43 (≠ T41), T44 (= T42)

2oljA Abc protein artp in complex with adp/mg2+
29% identity, 83% coverage: 1:226/271 of query aligns to 3:227/242 of 2oljA

query
sites
2oljA

M

M

M

I

E

D

C

V

R

H

A

Q

L

L

H

K

A

K

G

S

Y
x
F

A

G

Q

S

T

L

E

E

V
|
V

L

L

H

K

G

G

I

I

D

N

L

V

R

H

I

I

A

R

Q

E

D

G

E

E

L

V

V

V

G

V

L

V

L

I

G

G

P

P

N
x
S

G
|
G

S
|
S

G
|
G

K
|
K

T
x
S

T
|
T

L

F

L

L

L

R

A

C

L

L

S

N

G

L

V

L

L

E

P

D

A

F

R

D

G

E

G

G

D

E

V

I

L

I

D

D

G

G

T

I

P

N

L

L

A

K

A

A

M

K

A

D

P

T

R

N

E

L

R

N

A

K

R

V

R

R

-

E

I

V

A

G

T

M

V

V

P

F

Q

Q

R

R

P

F

E

N

V

L

I

F

P

P

D

H

V

M

D

T

A

V

F

L

S

N

L

N

V

I

L

T

M

L

G

A

R

-

Y

-

P

-

H

-

T

-

G

-

P

P

L

M

R

K

G

V

Y

R

T

K

A

W

V

P

D

R

H

E

D

K

A

A

A

E

A

A

A

K

A

A

L

M

A

E

A

L

T

L

G

D

T

K

A

V

H

G

L

L

A

K

R

D

R

K

S

A

A

H

A

A

-

Y

-

P

-

D

T

S

L

L

S

S

G

G

E

Q

L

A

Q

Q

R

R

V

V

L

A

V

I

A

A

R

R

A

A

L

L

A

A

Q

M

D

E

T

P

D

K

T

I

L

M

L

L

L

F

D

D

E

E

V

P

T

T

A

S

G

A

L

L

D

D

V

P

A

E

R

M

M

V

V

G

E

E

V

V

F

L

D

S

L

V

L

M

A

K

Q

Q

R

L

H

A

R

N

H

E

G

G

L

M

R

T

I

M

V

V

A

V

I

T

H

H

D

E

I

M

N

G

L

F

A

A

A

R

L

E

Y

V

C

G

T

D

R

R

L

V

V

L

F

F

L

M

K

D

S

G

G

G

R

Y

V

I

L

E

D

E

G

G

P

K

V

P

A

E

Q

D

V

L

F

F

D

D

binding adenosine-5'-diphosphate: F13 (≠ Y11), V18 (= V16), S38 (≠ N36), G39 (= G37), S40 (= S38), G41 (= G39), K42 (= K40), S43 (≠ T41), T44 (= T42)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
27% identity, 83% coverage: 1:225/271 of query aligns to 1:224/240 of 4ymuJ

query
sites
4ymuJ

M

M

M

I

E

F

C

V

R

N

A

D

L

V

H

Y

A

K

G

N

Y
x
F

A

G

Q

S

T

L

E

E

V
|
V

L

L

H

K

G

G

I

V

D

T

L

L

R

K

I

V

A

N

Q

K

D

G

E

E

L

V

V

V

G

V

L

I

G

G

P

P

N
x
S

G
|
G

S
|
S

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

R

A

C

L

I

S

N

G

L

V

L

L

E

P

E

A

P

R

T

G

K

G

G

D

E

V

V

L

F

L

I

D

D

G

G

T

V

P

K

L

I

-

N

A

G

A

K

M

V

A

N

P

I

R

N

E

K

R

V

A

R

R

Q

R

K

I

V

A

G

T

M

V

V

P

F

Q

Q

R

H

P

F

E

N

V

L

I

F

P

P

D

H

V

L

D

T

A

A

F

I

S

E

L

N

V

I

L

T

M

L

G

A

R

-

Y

-

P

-

H

-

T

-

G

-

P

P

L

V

R

K

G

V

Y

K

T

K

A

M

V

N

D

K

H

K

D

E

A

A

A

E

A

L

A

A

-

V

-

D

-

L

L

L

A

A

A

K

T

V

G

G

T

L

A

L

H

D

L

K

A

K

R

D

R

Q

S

Y

A

P

A

I

T

K

L

L

S

S

G

G

E

Q

L

K

Q

Q

R

R

V

L

L

A

V

I

A

A

R

R

A

A

L

L

A

A

Q

M

D

Q

T

P

D

E

T

V

L

M

L

L

L

F

D

D

E
|
E

V

P

T

T

A

S

G

A

L

L

D

D

V

P

A

E

R

M

M

V

V

K

E

E

V

V

F

L

D

N

L

V

L

M

A

K

Q

Q

R

L

H

A

R

N

H

E

G

G

L

M

R

T

I

M

V

V

A

V

I

T

H
|
H

D

E

I

M

N

G

L

F

A

A

A

R

L

E

Y

V

C

G

T

D

R

R

L

V

V

I

F

F

L

M

K

D

S

D

G

G

R

V

V

I

V

V

L

E

D

E

G

G

P

T

V

P

A

E

Q

E

V

I

F

F

binding adenosine-5'-triphosphate: F11 (≠ Y11), V16 (= V16), S36 (≠ N36), G37 (= G37), S38 (= S38), G39 (= G39), K40 (= K40), S41 (≠ T41), T42 (= T42), E162 (= E163), H194 (= H195)
binding magnesium ion: S41 (≠ T41), E162 (= E163)

1ji0A Crystal structure analysis of the abc transporter from thermotoga maritima
27% identity, 86% coverage: 1:234/271 of query aligns to 6:236/240 of 1ji0A

query
sites
1ji0A

M

V

M

L

E

E

C

V

R

Q

A

S

L

L

H

H

A

V

G

Y

Y
|
Y

A

G

Q

A

T

I

E

H

V

A

L

I

H

K

G

G

I

I

D

D

L

L

R

K

I

V

A

P

Q

R

D

G

E

Q

L

I

V

V

G

T

L

L

L

I

G

G

P

A

N

N

G
|
G

S

A

G
|
G

K
|
K

T
|
T

L

T

L

L

L

S

A

A

L

I

S

A

G

G

V

L

L

V

P

R

A

A

R

Q

G

K

G

G

D

K

V

I

L

I

L

F

D

N

G

G

T

Q

P

D

L

I

A

T

A

N

M

-

A

K

P

P

R

A

E

H

R

V

A

I

R

N

R

R

-

M

-

G

I

I

A

A

T

L

V

V

P

P

Q
x
E

R

G

P

R

E

R

V

I

I

F

P

P

D

E

V

L

D

T

A

V

F

Y

S

E

L

N

V

L

L

M

M

M

G

G

R

A

Y

Y

P

N

H

R

T

-

G

-

P

-

L

-

R

K

G

D

Y

K

T

E

A

G

V

I

D

K

H

R

D

D

A

L

A

E

A

W

A

I

A

F

L

S

A

L

A

F

T

P

G

R

T

L

A

K

H

E

L

R

A

L

R

K

R

Q

S

L

A

G

T

T

L

L

S

S

G

G

E

E

L

Q

Q

Q

R

M

V

L

L

A

V

I

A

G

R

R

A

A

L

L

A

M

Q

S

D

R

T

P

D

K

T

L

L

L

L

M

D

D

E
|
E

V

P

T

S

A

L

G

G

L

L

D

A

V

P

A

I

R

L

M

V

V

S

E

E

V

V

F

F

D

E

L

V

L

I

A

Q

Q

K

R

I

H

N

R

Q

H

E

G

G

L

T

R

T

I

I

V

L

A

-

A

L

I

V

H

E

D

Q

I

N

N

A

L

L

A

G

A

A

L

L

Y

K

C

V

T

A

R

H

L

Y

V

G

F

Y

-

V

L

L

K

E

S

T

G

G

R

Q

V

I

V

V

L

L

D

E

G

G

P

K

V

A

A

S

Q

E

V

L

F

L

D

D

E

N

Q

E

A

M

L

V

S

R

A

K

I

A

Y

Y

binding adenosine-5'-triphosphate: Y16 (= Y11), G42 (= G37), G44 (= G39), K45 (= K40), T46 (= T41), T47 (= T42), E88 (≠ Q82), E165 (= E163)

6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
25% identity, 86% coverage: 1:234/271 of query aligns to 2:233/240 of 6mjpA

query
sites
6mjpA

M

I

M

L

E

K

C

A

R

Q

A

H

L

L

H

A

A

K

G

S

Y

Y

A

K

Q

K

T

R

E

K

V

V

L

V

H

S

G

D

I

V

D

S

L

L

R

Q

I

V

A

E

Q

S

D

G

E

Q

L

I

V

V

G

G

L

L

G

G

P

P

N

N

G

G

S

A

G

G

K

K

T

T

L

S

L

F

L

Y

A

M

L

I

S

V

G

G

V

L

L

V

P

A

A

R

R

D

G

E

G

G

D

T

V

I

L

T

L

I

D

D

G

D

T

N

P

D

L

I

A

S

A

I

M

L

A

P

P

M

R

H

E

S

R

R

A

S

R

R

R

M

-

G

I

I

A

G

T

Y

V

L

P

P

Q

Q

R

E

P

A

E

S

V

I

I

F

P

R

D

K

V

L

-

S

-

V

-

E

D

D

A

N

F

I

S

M

L

A

V

V

L

L

M

Q

G

T

R

R

Y

E

P

E

H

L

T

T

G

H

P
x
E

L

E

R

R

G

-

Y

-

T

-

A

-

V

-

D

-

H

Q

D
|
D

A

K

A

L

A

E

A

D

A

L

L

L

A

E

T

F

G

H

T

I

A

Q

H

H

L

I

A

R

R

K

R

S

S

A

A

G

A

M

T

A

L

L

S

S

G

G

E

E

L

R

Q

R

R

R

V

V

L

E

V

I

A

A

R

R

A

A

L

L

A

A

Q

A

D

N

T

P

D

Q

T

F

L

I

L

L

D

D

E

Q

V

P

T

F

A

A

G

G

L

V

D

D

V

P

A

I

R

S

M

V

V

I

E

D

V

I

F

K

D

K

L

I

A

E

Q

H

R

L

H

R

R

D

H

R

G

G

L

L

R

G

I

V

V

L

A

I

A

T

I

D

H

H

D

N

I

V

N

R

L

E

A

T

A

L

L

D

Y

V

C

C

T

E

R

K

L

A

V

Y

F

I

L

V

K

S

S

Q

G

G

R

R

V

L

V

I

L

A

D

E

G

G

P

T

V

P

A

Q

Q

D

V

V

F

L

D

N

E

N

Q

E

A

Q

L

V

S

K

A

Q

I

V

Y

Y

binding calcium ion: E111 (≠ P106), D115 (= D116)

2pclA Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
34% identity, 77% coverage: 15:224/271 of query aligns to 17:223/223 of 2pclA

query
sites
2pclA

E

E

V

I

L

L

H

K

G

G

I

I

D

S

L

L

R

S

I

V

A

K

Q

K

D

G

E

E

L

F

V

V

G

S

L

I

G

G

P

A

N

S

G

G

S

S

G

G

K

K

T

S

T

T

L

L

L

Y

A

I

L

L

S

-

G

G

V

L

L

L

P

D

A

A

-

P

R

T

G

E

G

G

D

K

V

V

L

F

L

L

D

E

G

G

T

K

P

E

L

V

A

D

A

Y

M

T

A

N

P

E

R

K

E

E

-

L

-

S

-

L

R

R

A

N

R

R

R

K

I

L

A

G

T

F

V

V

P

F

Q

Q

R

F

P

H

E

Y

V

L

I

I

P

P

D

E

V

L

D

T

A

A

F

L

S

E

L

N

V

V

L

I

-

V

-

P

-

M

-

L

-

K

M

M

G

G

R

K

Y

P

P

K

H

K

T

E

G

A

P

K

L

E

R

R

G

G

Y

-

T

-

A

-

V

-

D

-

H

-

D

-

A

-

A

E

A

Y

A

L

L

L

A

S

A

E

T

L

G

G

T

L

A

G

H

D

L

K

A

L

R

S

R

R

S

K

A

P

A

Y

T

E

L

L

S

S

G

G

E

E

L

Q

Q

Q

R

R

V

V

L

A

V

I

A

A

R

R

A

A

L

L

A

A

Q

N

D

E

T

P

D

I

T

L

L

L

L

F

L

A

D

D

E
|
E

V
x
P

T
|
T

A

G

G

N

L

L

D

D

V

S

A

A

R

N

M

T

V

K

E

R

V

V

F

M

D

D

L

I

L

F

A

L

Q

K

R

I

H

N

R

E

H

G

G

G

L

T

R

S

I

I

V

V

A

M

A

V

I
x
T

H

H

D

E

I

R

N

E

L

L

A

A

A

E

L

L

Y

-

C

T

T

H

R

R

L

T

V

L

F

E

L

M

K

K

S

D

G

G

R

K

V

V

L

-

D

-

G

G

P

E

V

I

A

T

Q

R

V

V

binding magnesium ion: E165 (= E163), P166 (≠ V164), T167 (= T165), T196 (≠ I194)

5x40A Structure of a cbio dimer bound with amppcp (see paper)
34% identity, 79% coverage: 15:229/271 of query aligns to 19:232/280 of 5x40A

query
sites
5x40A

E

K

V
x
A

L

L

H

D

G

D

I

L

D

S

L

L

R

A

I

V

A

P

Q

K

D

G

E

E

L

S

V

L

G

A

L

I

L

L

G

G

P

P

N
|
N

G
|
G

S

A

G
|
G

K
|
K

T
x
S

T
|
T

L

L

A

H

L

L

S

N

G

G

V

T

L

L

P

R

A

P

R

Q

G

S

G

G

D

R

V

V

L

L

D

G

G

G

T

T

P

-

L

-

A

A

A

T

M

G

A

H

P

S

R

R

E

K

-

D

-

L

-

T

-

G

R

W

A

R

R

R

I

V

A

G

T

L

V

V

P

L

Q
|
Q

R

D

P

A

E

D

V

-

I

-

P

-

D

-

V

-

D

D

A

Q

F

L

S

F

L

A

V

T

L

T

M

V

G

F

R

E

Y

D

P

V

H

S

T

F

G

G

P

P

L

L

R

N

-

L

G

G

Y

L

T

S

A

E

V

A

D

E

H

A

D

R

A

A

-

R

A

V

A

E

A

A

L

L

A

A

T

L

G

S

T

I

A

S

H

D

L

L

A

R

R

D

R

R

S

P

A

T

A
x
H

T
x
M

L
|
L

S
|
S

G

G

G
|
G

E
x
Q

L

K

Q

R

R

R

V

V

L

A

V

I

A

A

R

G

A

A

L

V

A

A

Q

M

D

R

T

P

D

E

T

V

L

L

D

D

E
x
Q

V

P

T

T

A

A

G

G

L

L

D

D

V

L

A

A

R

G

M

T

V

E

E

Q

V

L

F

L

D

T

L

L

A

R

Q

G

R

L

H

R

R

A

H

A

G

G

L

M

R

T

I

L

V

V

A

F

A

S

I

T

H
|
H

D

D

I

V

N

E

L

L

A

A

L

A

Y

L

C

A

T

D

R

R

L

V

V

A

F

L

L

F

K

R

S

T

G

G

R

R

V

V

V

L

L

A

D

E

G

G

P

A

V

A

A

E

Q

A

V

V

F

L

D

S

E

D

Q

R

A

A

binding phosphomethylphosphonic acid adenylate ester: A20 (≠ V16), N40 (= N36), G41 (= G37), G43 (= G39), K44 (= K40), S45 (≠ T41), T46 (= T42), Q88 (= Q82), H139 (≠ A136), M140 (≠ T137), L141 (= L138), S142 (= S139), G144 (= G141), Q145 (≠ E142), Q166 (≠ E163), H198 (= H195)
binding magnesium ion: S45 (≠ T41), Q88 (= Q82)

Sites not aligning to the query:

binding phosphomethylphosphonic acid adenylate ester: 14, 18

6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
27% identity, 86% coverage: 2:234/271 of query aligns to 3:233/234 of 6b89A

query
sites
6b89A

M

L

E

T

C

A

R

K

A

N

L

L

H

A

A

K

G

A

Y
|
Y

A

K

Q

G

T
x
R

E

R

V
|
V

L

V

H

E

G

D

I

V

D

S

L

L

R

T

I

V

A

N

Q

S

D

G

E

E

L

I

V

V

G

G

L

L

G

G

P

P

N
|
N

G
|
G

S

A

G
|
G

K
|
K

T
|
T

L

T

L

F

L

Y

A

M

L

V

S

V

G

G

V

I

L

V

P

P

A

R

R

D

G

A

G

G

D

N

V

I

L

I

D

D

G

D

T

D

P

D

L

I

A

S

A

L

M

L

A

P

P
x
L

R
x
H

E

A

R

R

A

A

R

R

-

G

I

I

A

G

T

Y

V

L

P
|
P

Q
|
Q

R

E

P
x
A

E
x
S

V

I

I
x
F

P
x
R

D
x
R

V
x
L

-

S

-

V

-

Y

D

D

A

N

F

L

S

M

L

A

V
|
V

L

L

M

Q

G

I

R

R

Y

D

P

D

H

L

T

S

G

A

P

E

L

Q

R

R

G

-

Y

-

T

-

A

-

V

-

D

-

H

E

D

D

A

R

A

A

A

N

A

E

A

L

L

M

A

E

T

F

G

H

T

I

A

E

H

H

L

L

A

R

R

D

R

S

S

M

A

G

A
x
Q

T

S

L

L

S

S

G

G

E

E

L

R

Q

R

R

R

V

V

L

E

V

I

A

A

R
|
R

A

A

L

L

A

A

Q

A

D

N

T

P

D

K

T

F

L

I

L

L

D

D

E

E

V

P

T

F

A

A

G

G

L

V

D

D

V

P

A

I

R

S

M

V

V

I

E

D

V

I

F

K

D

R

L

I

A

E

Q

H

R

L

H

R

R

D

H

S

G

G

L

L

R

G

I

V

V

L

A

I

A

T

I

D

H

H

D

N

I

V

N

R

L

E

A

T

A

L

L

A

Y

V

C

C

T

E

R

R

L

A

V

Y

F

I

L

V

K

S

S

Q

G

G

R

H

V

L

V

I

L

A

D

H

G

G

P

T

V

P

A

T

Q

E

V

I

F

L

D

Q

E

D

Q

E

A

H

L

V

S

K

A

R

I

V

Y

Y

binding adenosine-5'-diphosphate: Y12 (= Y11), R15 (≠ T14), V17 (= V16), N37 (= N36), G38 (= G37), G40 (= G39), K41 (= K40), T42 (= T41), T43 (= T42)
binding magnesium ion: T42 (= T41), Q84 (= Q82)
binding novobiocin: L71 (≠ P70), H72 (≠ R71), P83 (= P81), A86 (≠ P84), S87 (≠ E85), F89 (≠ I87), R90 (≠ P88), R91 (≠ D89), L92 (≠ V90), V101 (= V96), Q135 (≠ A136), R149 (= R150)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
27% identity, 86% coverage: 2:234/271 of query aligns to 3:233/234 of 4p31A

query
sites
4p31A

M

L

E

T

C

A

R

K

A

N

L

L

H

A

A

K

G

A

Y
|
Y

A

K

Q

G

T
x
R

E

R

V
|
V

L

V

H

E

G

D

I

V

D

S

L

L

R

T

I

V

A

N

Q

S

D

G

E

E

L

I

V

V

G

G

L

L

G

G

P

P

N

N

G
|
G

S

A

G
|
G

K
|
K

T
|
T

L

T

L

F

L

Y

A

M

L

V

S

V

G

G

V

I

L

V

P

P

A

R

R

D

G

A

G

G

D

N

V

I

L

I

D

D

G

D

T

D

P

D

L

I

A

S

A

L

M

L

A

P

P

L

R

H

E

A

R

R

A

A

R

R

-

G

I

I

A

G

T

Y

V

L

P

P

Q
|
Q

R

E

P

A

E

S

V

I

I

F

P

R

D

R

V

L

-

S

-

V

-

Y

D

D

A

N

F

L

S

M

L

A

V

V

L

L

M

Q

G

I

R

R

Y

D

P

D

H

L

T

S

G

A

P

E

L

Q

R

R

G

-

Y

-

T

-

A

-

V

-

D

-

H

E

D

D

A

R

A

A

A

N

A

E

A

L

L

M

A

E

T

F

G

H

T

I

A

E

H

H

L

L

A

R

R

D

R

S

S

M

A

G

A

Q

T

S

L

L

S

S

G

G

E

E

L

R

Q

R

R

R

V

V

L

E

V

I

A

A

R

R

A

A

L

L

A

A

Q

A

D

N

T

P

D

K

T

F

L

I

L

L

D

D

E

E

V

P

T

F

A

A

G

G

L

V

D

D

V

P

A

I

R

S

M

V

V

I

E

D

V

I

F

K

D

R

L

I

A

E

Q

H

R

L

H

R

R

D

H

S

G

G

L

L

R

G

I

V

V

L

A

I

A

T

I

D

H

H

D

N

I

V

N

R

L

E

A

T

A

L

L

A

Y

V

C

C

T

E

R

R

L

A

V

Y

F

I

L

V

K

S

S

Q

G

G

R

H

V

L

V

I

L

A

D

H

G

G

P

T

V

P

A

T

Q

E

V

I

F

L

D

Q

E

D

Q

E

A

H

L

V

S

K

A

R

I

V

Y

Y

binding adenosine-5'-diphosphate: Y12 (= Y11), R15 (≠ T14), V17 (= V16), G38 (= G37), G40 (= G39), K41 (= K40), T42 (= T41), T43 (= T42)
binding magnesium ion: T42 (= T41), Q84 (= Q82)

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
27% identity, 86% coverage: 2:234/271 of query aligns to 3:233/233 of 6b8bA

query
sites
6b8bA

M

L

E

T

C

A

R

K

A

N

L

L

H

A

A

K

G

A

Y
|
Y

A

K

Q

G

T
x
R

E

R

V
|
V

L

V

H

E

G

D

I

V

D

S

L

L

R

T

I

V

A

N

Q

S

D

G

E

E

L

I

V

V

G

G

L

L

G

G

P

P

N

N

G
|
G

S

A

G
|
G

K
|
K

T
|
T

L

T

L

F

L

Y

A

M

L

V

S

V

G

G

V

I

L

V

P

P

A

R

R

D

G

A

G

G

D

N

V

I

L

I

D

D

G

D

T

D

P

D

L

I

A

S

A

L

M

L

A

P

P

L

R

H

E

A

R

R

A

A

R

R

-

G

I

I

A

G

T

Y

V

L

P

P

Q

Q

R

E

P

A

E

S

V

I

I
x
F

P
x
R

D
x
R

V

L

-

S

-

V

-

Y

D

D

A

N

F

L

S

M

L

A

V

V

L

L

M

Q

G

I

R

R

Y

D

P

D

H

L

T

S

G

A

P

E

L

Q

R

R

G

-

Y

-

T

-

A

-

V

-

D

-

H

E

D

D

A

R

A

A

A

N

A

E

A

L

L

M

A

E

T

F

G

H

T

I

A

E

H

H

L

L

A

R

R

D

R

S

S

M

A

G

A

Q

T

S

L

L

S

S

G

G

E

E

L

R

Q

R

R

R

V

V

L

E

V

I

A

A

R

R

A

A

L

L

A

A

Q

A

D

N

T

P

D

K

T

F

L

I

L

L

D

D

E

E

V

P

T

F

A

A

G

G

L

V

D

D

V

P

A

I

R

S

M

V

V

I

E

D

V

I

F

K

D

R

L

I

A

E

Q

H

R

L

H

R

R

D

H

S

G

G

L

L

R

G

I

V

V

L

A

I

A

T

I

D

H

H

D

N

I

V

N

R

L

E

A

T

A

L

L

A

Y

V

C

C

T

E

R

R

L

A

V

Y

F

I

L

V

K

S

S

Q

G

G

R

H

V

L

V

I

L

A

D

H

G

G

P

T

V

P

A

T

Q

E

V

I

F

L

D

Q

E

D

Q

E

A

H

L

V

S

K

A

R

I

V

Y

Y

binding adenosine-5'-diphosphate: Y12 (= Y11), R15 (≠ T14), V17 (= V16), G38 (= G37), G40 (= G39), K41 (= K40), T42 (= T41), T43 (= T42)
binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (≠ I87), R90 (≠ P88), R91 (≠ D89)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
27% identity, 86% coverage: 2:234/271 of query aligns to 3:233/235 of 6mhzA

query
sites
6mhzA

M

L

E

T

C

A

R

K

A

N

L

L

H

A

A

K

G

A

Y
|
Y

A

K

Q

G

T

R

E

R

V

V

L

V

H

E

G

D

I

V

D

S

L

L

R

T

I

V

A

N

Q

S

D

G

E

E

L

I

V

V

G

G

L

L

G

G

P

P

N
|
N

G
|
G

S

A

G
|
G

K
|
K

T
|
T

L

T

L

F

L

Y

A

M

L

V

S

V

G

G

V

I

L

V

P

P

A

R

R

D

G

A

G

G

D

N

V

I

L

I

D

D

G

D

T

D

P

D

L

I

A

S

A

L

M

L

A

P

P

L

R

H

E

A

R

R

A

A

R

R

-

G

I

I

A

G

T

Y

V

L

P

P

Q
|
Q

R

E

P

A

E

S

V

I

I

F

P

R

D

R

V

L

-

S

-

V

-

Y

D

D

A

N

F

L

S

M

L

A

V

V

L

L

M

Q

G

I

R

R

Y

D

P

D

H

L

T

S

G

A

P

E

L

Q

R

R

G

-

Y

-

T

-

A

-

V

-

D

-

H

E

D

D

A

R

A

A

A

N

A

E

A

L

L

M

A

E

T

F

G

H

T

I

A

E

H

H

L

L

A

R

R

D

R

S

S

M

A

G

A

Q

T
x
S

L

L

S
|
S

G
|
G

E

E

L

R

Q

R

R

R

V

V

L

E

V

I

A

A

R

R

A

A

L

L

A

A

Q

A

D

N

T

P

D

K

T

F

L

I

L

L

D

D

E
|
E

V

P

T

F

A

A

G
|
G

L

V

D

D

V

P

A

I

R

S

M

V

V

I

E

D

V

I

F

K

D

R

L

I

A

E

Q

H

R

L

H

R

R

D

H

S

G

G

L

L

R

G

I

V

V

L

A

I

A

T

I

D

H
|
H

D

N

I

V

N

R

L

E

A

T

A

L

L

A

Y

V

C

C

T

E

R

R

L

A

V

Y

F

I

L

V

K

S

S

Q

G

G

R

H

V

L

V

I

L

A

D

H

G

G

P

T

V

P

A

T

Q

E

V

I

F

L

D

Q

E

D

Q

E

A

H

L

V

S

K

A

R

I

V

Y

Y

binding adp orthovanadate: Y12 (= Y11), N37 (= N36), G38 (= G37), G40 (= G39), K41 (= K40), T42 (= T41), T43 (= T42), Q84 (= Q82), S136 (≠ T137), S138 (= S139), G139 (= G140), G140 (= G141), E162 (= E163), G166 (= G167), H194 (= H195)

P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 3 papers)
32% identity, 79% coverage: 15:227/271 of query aligns to 31:238/378 of P69874

query
sites
P69874

E

E

V

V

L

I

H

P

G

Q

I

L

D

D

L

L

R

T

I

I

A

N

Q

N

D

G

E

E

L
x
F

V

L

G

T

L

L

G

G

P

P

N

S

G

G

S
x
C

G

G

K

K

T

T

L

V

L
|
L

L

R

A

L

L

I

S

A

G

G

V

L

L

E

P

T

A

V

R

D

G

S

G

G