SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing 207852 FitnessBrowser__DvH:207852 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

2zyjA Crystal structure of lysn, alpha-aminoadipate aminotransferase (complexed with n-(5'-phosphopyridoxyl)-l-glutamate), from thermus thermophilus hb27 (see paper)
45% identity, 99% coverage: 3:387/388 of query aligns to 10:395/397 of 2zyjA

query
sites
2zyjA

I

F

A

G

K

K

R

G

M

A

D

G

N

R

V

I

Q

Q

R

A

S

S

Y

T

I
|
I

R
|
R

E

E

I

L

L

L

K

K

V

L

T

T

A

Q

R

R

P

P

D

G

I

I

I

L

S

S

F

F

A

A

G
|
G

L

L

P

P

H

A

P

P

D

E

S

L

F

F

P

P

V

K

Q

E

G

E

V

A

A

A

E

E

A

A

A

R

V

I

L

L

A

R

E

E

S

K

G

G

S

E

E

V

A

A

L

L

Q

Q

Y

Y

S

S

T

P

T

T

E

E

G

G

Y

Y

L

A

P

P

L

L

R

R

E

A

W

F

I

V

S

A

A

-

R

-

Y

-

A

-

R

-

Q

E

G

W

I

I

E

G

V

V

S

R

P

P

D

E

E

E

I

V

L

L

I

I

T

T

G
|
G

S
|
S

Q
|
Q

Q

Q

A

A

L

L

D

D

L

L

V

V

A

G

K

K

T

V

T

F

I

L

D

D

R

E

G

G

A

S

P

P

V

V

V

L

I

L

E

E

R

A

P

P

G

S

Y
|
Y

L

M

G

G

A

A

I

I

Q

Q

C

A

F

F

S

R

F

L

Y

Q

G

G

A

P

Q

R

F

F

R

L

T

T

V

V

D

P

L

A

T

G

P

E

L

E

G

G

V

P

D

D

V

L

E

D

A

A

L

L

R

E

E

V

A

L

K

K

G

R

A

E

-

R

-

P

R

R

L

F

F

L

Y

Y

A

L

V

I

P

P

S

S

F

F

Q

Q

N
|
N

P

P

S

T

G

G

I

G

T

L

Y

T

D

P

E

L

P

P

T

A

R

R

R

K

E

R

V

L

A

L

A

Q

I

M

M

V

A

M

E

E

T

R

G

G

C

L

M

V

L

V

V

V

E

E

D
|
D

N

D

P

A

Y
|
Y

G

R

E

E

L

L

R

Y

F

F

M

-

G

G

T

E

P

A

V

R

A

L

P

P

-

S

-

L

-

F

-

E

I

L

R

A

K

R

W

E

A

A

E

G

S

Y

P

P

S

G

V

V

L

I

-

Y

L

L

G

G

S
|
S

F

F

S
|
S

K
|
K

V

V

V

L

S

S

P

P

G

G

L

L

R
|
R

I

V

G

A

W

F

A

A

C

V

A

A

P

H

A

P

E

E

L

A

M

L

R

Q

H

K

M

L

V

V

T

Q

A

A

K

K

Q

Q

A

G

S

A

D

D

L

L

H

H

T

T

P

P

M

M

F

L

T

N

Q

Q

R

M

L

L

L

V

H

H

R

E

F

L

L

L

V

K

D

E

N

G

D

-

V

F

D

S

E

E

H

R

I

L

A

E

S

R

I

V

R

R

K

R

R

V

Y

Y

G

R

A

E

Q

K

R

A

Q

Q

C

A

M

M

M

L

D

H

A

A

I

L

R

D

K

R

H

E

F

V

P

P

E

K

C

E

V

V

T

R

V

Y

T

T

E

R

P

P

E

K

G

G

M

M

F

F

L

V

W

W

C

M

G

E

L

L

P

P

E

K

G

G

V

L

T

S

S

A

E

E

H

G

L

L

F

F

H

R

K

R

A

A

I

L

E

E

R

E

K

N

V

V

A

A

F

F

V

V

P

P

G

G

C

G

P

P

F

F

Y

F

V

A

D

N

-

G

G

G

T

G

D

E

T

N

G

T

F

L

R
|
R

L

L

N

S

F

Y

S

A

N

T

A

L

S

D

Q

R

D

E

D

G

I

I

V

A

E

E

G

G

I

V

A

R

R

R

L

L

G

G

A

R

C

A

L

L

T

K

E

G

E

L

L

L

A

A

binding N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-glutamic acid: I22 (= I15), R23 (= R16), G39 (= G32), G40 (= G33), G99 (= G97), S100 (= S98), Q101 (= Q99), Y125 (= Y123), N174 (= N170), D202 (= D198), Y205 (= Y201), S235 (= S227), S237 (= S229), K238 (= K230), R245 (= R237), R368 (= R360)

Q72LL6 2-aminoadipate transaminase; 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT; EC 2.6.1.39 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 2 papers)
45% identity, 99% coverage: 3:387/388 of query aligns to 10:395/397 of Q72LL6

query
sites
Q72LL6

I

F

A

G

K

K

R

G

M

A

D

G

N

R

V

I

Q

Q

R

A

S
|
S

Y

T

I

I

R
|
R

E

E

I

L

L

L

K

K

V

L

T

T

A

Q

R

R

P

P

D

G

I

I

I

L

S

S

F

F

A

A

G

G

G
|
G

L

L

P

P

H

A

P

P

D

E

S

L

F

F

P

P

V

K

Q

E

G

E

V

A

A

A

E

E

A

A

A

R

V

I

L

L

A

R

E

E

S

K

G

G

S

E

E

V

A

A

L

L

Q

Q

Y
|
Y

S

S

T

P

T

T

E

E

G

G

Y

Y

L

A

P

P

L

L

R

R

E

A

W

F

I

V

S

A

A

-

R

-

Y

-

A

-

R

-

Q

E

G

W

I

I

E

G

V

V

S

R

P

P

D

E

E

E

I

V

L

L

I

I

T

T

G

G

S

S

Q

Q

A

A

L

L

D

D

L

L

V

V

A

G

K

K

T

V

T

F

I

L

D

D

R

E

G

G

A

S

P

P

V

V

V

L

I

L

E

E

R

A

P

P

G

S

Y

Y

L

M

G

G

A

A

I

I

Q

Q

C

A

F

F

S

R

F

L

Y

Q

G

G

A

P

Q

R

F

F

R

L

T

T

V

V

D

P

L

A

T

G

P

E

L

E

G

G

V

P

D

D

V

L

E

D

A

A

L

L

R

E

E

V

A

L

K

K

G

R

A

E

-

R

-

P

R

R

L

F

F

L

Y

Y

A

L

V

I

P

P

S

S

F

F

Q

Q

N
|
N

P

P

S

T

G

G

I

G

T

L

Y

T

D

P

E

L

P

P

T

A

R

R

R

K

E

R

V

L

A

L

A

Q

I

M

M

V

A

M

E

E

T

R

G

G

C

L

M

V

L

V

V

V

E

E

D

D

N

D

P

A

Y

Y

G

R

E

E

L

L

R

Y

F

F

M

-

G

G

T

E

P

A

V

R

A

L

P

P

-

S

-

L

-

F

-

E

I

L

R

A

K

R

W

E

A

A

E

G

S

Y

P

P

S

G

V

V

L

I

-

Y

L

L

G

G

S

S

F

F

S

S

K

K

V

V

V

L

S

S

P

P

G

G

L

L

R
|
R

I

V

G

A

W

F

A

A

C

V

A

A

P

H

A

P

E

E

L

A

M

L

R

Q

H

K

M

L

V

V

T

Q

A

A

K

K

Q

Q

A

G

S

A

D

D

L

L

H

H

T

T

P

P

M

M

F

L

T

N

Q

Q

R

M

L

L

L

V

H

H

R

E

F

L

L

L

V

K

D

E

N

G

D

-

V

F

D

S

E

E

H

R

I

L

A

E

S

R

I

V

R

R

K

R

R

V

Y

Y

G

R

A

E

Q

K

R

A

Q

Q

C

A

M

M

M

L

D

H

A

A

I

L

R

D

K

R

H

E

F

V

P

P

E

K

C

E

V

V

T

R

V

Y

T

T

E

R

P

P

E

K

G

G

M

M

F

F

L

V

W

W

C

M

G

E

L

L

P

P

E

K

G

G

V

L

T

S

S

A

E

E

H

G

L

L

F

F

H

R

K

R

A

A

I

L

E

E

R

E

K

N

V

V

A

A

F

F

V

V

P

P

G

G

C

G

P

P

F

F

Y

F

V

A

D

N

-

G

G

G

T

G

D

E

T

N

G

T

F

L

R
|
R

L

L

N

S

F

Y

S

A

N

T

A

L

S

D

Q

R

D

E

D

G

I

I

V

A

E

E

G

G

I

V

A

R

R

R

L

L

G

G

A

R

C

A

L

L

T

K

E

G

E

L

L

L

A

A

S20 (= S13) mutation to E: Strongly decreases the affinity for AAA and Glu. A mild decrease of affinity is observed for 2-oxoglutarate. Increases the affinity for leucine and 2-oxoisocaproate.
R23 (= R16) mutation to A: Strongly decreases the affinity for AAA and Glu. A mild decrease of affinity is observed for 2-oxoglutarate which has the same chain length as Glu, but differs by the presence of a 2-oxo group which is not recognized by R-23. Increases the affinity for leucine and 2-oxoisocaproate due to the absence of gamma-carboxyl group.; mutation to Q: Strongly decreases the affinity for AAA and Glu. A mild decrease of affinity is observed for 2-oxoglutarate which has the same chain length as Glu, but differs by the presence of a 2-oxo group which is not recognized by R-23. Increases the affinity for leucine and 2-oxoisocaproate due to the absence of gamma-carboxyl group.
G40 (= G33) binding substrate
Y70 (= Y63) binding pyridoxal 5'-phosphate
N174 (= N170) binding pyridoxal 5'-phosphate; binding substrate
R245 (= R237) binding pyridoxal 5'-phosphate
R368 (= R360) binding substrate

3cbfA Crystal structure of lysn, alpha-aminoadipate aminotransferase, from thermus thermophilus hb27 (see paper)
45% identity, 99% coverage: 3:387/388 of query aligns to 6:391/392 of 3cbfA

query
sites
3cbfA

I

F

A

G

K

K

R

G

M

A

D

G

N

R

V

I

Q

Q

R

A

S

S

Y

T

I
|
I

R
|
R

E

E

I

L

L

L

K

K

V

L

T

T

A

Q

R

R

P

P

D

G

I

I

I

L

S

S

F

F

A

A

G
|
G

L

L

P

P

H

A

P

P

D

E

S

L

F

F

P

P

V

K

Q

E

G

E

V

A

A

A

E

E

A

A

A

R

V

I

L

L

A

R

E

E

S

K

G

G

S

E

E

V

A

A

L

L

Q

Q

Y

Y

S

S

T

P

T

T

E

E

G

G

Y

Y

L

A

P

P

L

L

R

R

E

A

W

F

I

V

S

A

A

-

R

-

Y

-

A

-

R

-

Q

E

G

W

I

I

E

G

V

V

S

R

P

P

D

E

E

E

I

V

L

L

I

I

T

T

G
|
G

S
|
S

Q
|
Q

Q

Q

A

A

L

L

D

D

L

L

V

V

A

G

K

K

T

V

T

F

I

L

D

D

R

E

G

G

A

S

P

P

V

V

V

L

I

L

E

E

R

A

P

P

G

S

Y
|
Y

L

M

G

G

A

A

I

I

Q

Q

C

A

F

F

S

R

F

L

Y

Q

G

G

A

P

Q

R

F

F

R

L

T

T

V

V

D

P

L

A

T

G

P

E

L

E

G

G

V

P

D

D

V

L

E

D

A

A

L

L

R

E

E

V

A

L

K

K

G

R

A

E

-

R

-

P

R

R

L

F

F

L

Y

Y

A

L

V

I

P

P

S

S

F

F

Q

Q

N
|
N

P

P

S

T

G

G

I

G

T

L

Y

T

D

P

E

L

P

P

T

A

R

R

R

K

E

R

V

L

A

L

A

Q

I

M

M

V

A

M

E

E

T

R

G

G

C

L

M

V

L

V

V

V

E

E

D
|
D

N

D

P

A

Y
|
Y

G

R

E

E

L

L

R

Y

F

F

M

-

G

G

T

E

P

A

V

R

A

L

P

P

-

S

-

L

-

F

-

E

I

L

R

A

K

R

W

E

A

A

E

G

S

Y

P

P

S

G

V

V

L

I

-

Y

L

L

G

G

S
|
S

F

F

S
|
S

K
|
K

V

V

V

L

S

S

P

P

G

G

L

L

R
|
R

I

V

G

A

W

F

A

A

C

V

A

A

P

H

A

P

E

E

L

A

M

L

R

Q

H

K

M

L

V

V

T

Q

A

A

K

K

Q

Q

A

G

S

A

D

D

L

L

H

H

T

T

P

P

M

M

F

L

T

N

Q

Q

R

M

L

L

L

V

H

H

R

E

F

L

L

L

V

K

D

E

N

G

D

-

V

F

D

S

E

E

H

R

I

L

A

E

S

R

I

V

R

R

K

R

R

V

Y

Y

G

R

A

E

Q

K

R

A

Q

Q

C

A

M

M

M

L

D

H

A

A

I

L

R

D

K

R

H

E

F

V

P

P

E

K

C

E

V

V

T

R

V

Y

T

T

E

R

P

P

E

K

G

G

M

M

F

F

L

V

W

W

C

M

G

E

L

L

P

P

E

K

G

G

V

L

T

S

S

A

E

E

H

G

L

L

F

F

H

R

K

R

A

A

I

L

E

E

R

E

K

N

V

V

A

A

F

F

V

V

P

P

G

G

C

G

P

P

F

F

Y

F

V

A

D

N

-

G

G

G

T

G

D

E

T

N

G

T

F

L

R
|
R

L

L

N

S

F

Y

S

A

N

T

A

L

S

D

Q

R

D

E

D

G

I

I

V

A

E

E

G

G

I

V

A

R

R

R

L

L

G

G

A

R

C

A

L

L

T

K

E

G

E

L

L

L

A

A

binding (2S)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]hexanedioic acid: I18 (= I15), R19 (= R16), G35 (= G32), G36 (= G33), G95 (= G97), S96 (= S98), Q97 (= Q99), Y121 (= Y123), N170 (= N170), D198 (= D198), Y201 (= Y201), S231 (= S227), S233 (= S229), K234 (= K230), R241 (= R237), R364 (= R360)

2egyA Crystal structure of lysn, alpha-aminoadipate aminotransferase (substrate free form), from thermus thermophilus hb27
45% identity, 99% coverage: 3:387/388 of query aligns to 6:391/392 of 2egyA

query
sites
2egyA

I

F

A

G

K

K

R

G

M

A

D

G

N

R

V

I

Q

Q

R

A

S

S

Y

T

I

I

R

R

E

E

I

L

L

L

K

K

V

L

T

T

A

Q

R

R

P

P

D

G

I

I

I

L

S

S

F

F

A

A

G

G

L

L

P

P

H

A

P

P

D

E

S

L

F

F

P

P

V

K

Q

E

G

E

V

A

A

A

E

E

A

A

A

R

V

I

L

L

A

R

E

E

S

K

G

G

S

E

E

V

A

A

L

L

Q

Q

Y

Y

S

S

T

P

T

T

E

E

G

G

Y

Y

L

A

P

P

L

L

R

R

E

A

W

F

I

V

S

A

A

-

R

-

Y

-

A

-

R

-

Q

E

G

W

I

I

E

G

V

V

S

R

P

P

D

E

E

E

I

V

L

L

I

I

T

T

G
|
G

S
|
S

Q
|
Q

Q

Q

A

A

L

L

D

D

L

L

V

V

A

G

K

K

T

V

T

F

I

L

D

D

R

E

G

G

A

S

P

P

V

V

V

L

I

L

E

E

R

A

P

P

G

S

Y
|
Y

L

M

G

G

A

A

I

I

Q

Q

C

A

F

F

S

R

F

L

Y

Q

G

G

A

P

Q

R

F

F

R

L

T

T

V

V

D

P

L

A

T

G

P

E

L

E

G

G

V

P

D

D

V

L

E

D

A

A

L

L

R

E

E

V

A

L

K

K

G

R

A

E

-

R

-

P

R

R

L

F

F

L

Y

Y

A

L

V

I

P

P

S

S

F

F

Q

Q

N
|
N

P

P

S

T

G

G

I

G

T

L

Y

T

D

P

E

L

P

P

T

A

R

R

R

K

E

R

V

L

A

L

A

Q

I

M

M

V

A

M

E

E

T

R

G

G

C

L

M

V

L

V

V

V

E

E

D
|
D

N

D

P
x
A

Y
|
Y

G

R

E

E

L

L

R

Y

F

F

M

-

G

G

T

E

P

A

V

R

A

L

P

P

-

S

-

L

-

F

-

E

I

L

R

A

K

R

W

E

A

A

E

G

S

Y

P

P

S

G

V

V

L

I

-

Y

L

L

G

G

S
|
S

F

F

S
|
S

K
|
K

V

V

V

L

S

S

P

P

G

G

L

L

R
|
R

I

V

G

A

W

F

A

A

C

V

A

A

P

H

A

P

E

E

L

A

M

L

R

Q

H

K

M

L

V

V

T

Q

A

A

K

K

Q

Q

A

G

S

A

D

D

L

L

H

H

T

T

P

P

M

M

F

L

T

N

Q

Q

R

M

L

L

L

V

H

H

R

E

F

L

L

L

V

K

D

E

N

G

D

-

V

F

D

S

E

E

H

R

I

L

A

E

S

R

I

V

R

R

K

R

R

V

Y

Y

G

R

A

E

Q

K

R

A

Q

Q

C

A

M

M

M

L

D

H

A

A

I

L

R

D

K

R

H

E

F

V

P

P

E

K

C

E

V

V

T

R

V

Y

T

T

E

R

P

P

E

K

G

G

M

M

F

F

L

V

W

W

C

M

G

E

L

L

P

P

E

K

G

G

V

L

T

S

S

A

E

E

H

G

L

L

F

F

H

R

K

R

A

A

I

L

E

E

R

E

K

N

V

V

A

A

F

F

V

V

P

P

G

G

C

G

P

P

F

F

Y

F

V

A

D

N

-

G

G

G

T

G

D

E

T

N

G

T

F

L

R

R

L

L

N

S

F

Y

S

A

N

T

A

L

S

D

Q

R

D

E

D

G

I

I

V

A

E

E

G

G

I

V

A

R

R

R

L

L

G

G

A

R

C

A

L

L

T

K

E

G

E

L

L

L

A

A

binding pyridoxal-5'-phosphate: G95 (= G97), S96 (= S98), Q97 (= Q99), Y121 (= Y123), N170 (= N170), D198 (= D198), A200 (≠ P200), Y201 (= Y201), S231 (= S227), S233 (= S229), K234 (= K230), R241 (= R237)

3wx9A Crystal structure of pyrococcus horikoshii kynurenine aminotransferase in complex with pmp, gla, 4ad, 2og, glu and kya
41% identity, 99% coverage: 4:386/388 of query aligns to 11:402/404 of 3wx9A

query
sites
3wx9A

A

S

K

K

R

K

M

A

D

L

N

E

V

M

Q

R

R

A

S
|
S

Y

E

I
x
V

R
|
R

E

E

I

L

L

L

K

K

V

L

T

V

A

E

R

T

P

S

D

D

I

I

S

S

F

L

A

A

G

G

G
|
G

L
|
L

P

P

H

N

P

P

D

K

S

T

F

F

P

P

V

K

Q

E

G

I

V

I

A

R

E

D

A

I

A

L

A

V

A

E

V

I

L

M

A

E

E

K

S

Y

G

A

S

D

E

K

A

A

L

L

Q

Q

Y

Y

S

G

T

T

E

K

G

G

Y

F

L

T

P

P

L

L

R

R

E

E

-

T

-

L

-

M

-

K

W

W

I

L

S

G

A

K

R

R

Y

Y

A

-

R

-

Q

-

G

G

I

I

E

S

V

Q

S

D

P

N

D

D

E

-

I

I

L

M

I

I

T

T

T

S

G
|
G

S
|
S

Q
|
Q

Q

Q

A

A

L

L

D

D

L

L

V

I

A

G

K

R

T

V

T

F

I

L

D

N

R

P

G

G

A

D

P

I

V

V

I

V

E

E

R

A

P

P

G

T

Y
|
Y

L
|
L

G

A

A

A

I

L

Q

Q

C

A

F

F

S

N

F

F

Y

Y

G

E

A

P

Q

Q

F

Y

R

I

T

Q

V

I

D

P

L

L

T

D

P

D

L

E

G

G

V

M

D

K

V

V

E

E

-

I

-

L

-

E

-

K

-

L

-

K

A

E

L

L

R

K

R

S

E

Q

A

G

K

K

G

K

A

V

R

K

L

V

F

V

Y

Y

A

T

V

V

P

P

S

T

F

F

Q

Q

N
|
N

P

P

S

A

G

G

I

V

T

T

Y

M

D

N

E

E

P

D

T

R

R

R

R

K

E

Y

V

L

A

L

A

E

I

L

M

A

A

S

E

E

T

Y

G

D

C

F

M

I

L

V

V

V

E

E

D
|
D

N
x
D

P
|
P

Y
|
Y

G
|
G

E
|
E

L

L

R

R

F

Y

M

S

G

G

T

N

P

P

V

E

A

K

P

K

I

I

R

K

K

A

W

L

-

D

A

N

E

E

S

G

P

R

S

V

V

I

L

Y

L

L

G
|
G

S
x
T

F

F

S
|
S

K
|
K

V
x
I

V

L

S

A

P

P

G

G

L

F

R
|
R

I

I

G

G

W

W

A

M

C

V

A

G

P

D

A

P

E

G

L

I

M

I

R

R

H

K

M

M

V

E

T

I

A

A

K

K

Q

Q

A

S

S

T

D

D

L

L

H

C

T

T

P

N

M

V

F

F

T

G

Q

Q

R

V

L

V

L

A

H

W

R

R

F

Y

L

V

V

D

D

G

N

G

D

Y

V

L

D

E

E

K

H

H

I

I

A

P

S

E

I

I

R

R

K

K

R

F

Y

Y

G

K

A

P

Q

R

R

R

Q

D

C

A

M

M

M

L

D

E

A

A

I

L

R

E

K

E

H

F

F

M

P

P

E

E

C

G

V

V

T

K

V

W

T

T

E

K

P

P

E

E

G

G

M

M

F

F

L

I

W

W

C

V

G

T

L

L

P

P

E

D

G

G

V

I

T

D

S

S

E

K

H

K

L

M

F

L

H

E

K

R

A

A

I

I

E

K

R

K

K

G

V

V

A

A

F

Y

V
|
V

P

P

G

G

C

E

P
x
A

F

F

Y

Y

V

A

-

H

-
x
R

D

D

G

V

T

K

D

N

T

T

G

-

F

M

R
|
R

L

L

N

N

F

F

S

T

N

Y

A

V

S

D

Q

E

D

D

D

K

I

I

V

M

E

E

G

G

I

I

A

K

R

R

L

L

G

A

A

E

C

T

L

I

T

K

E

E

L

L

binding 4-(2-aminophenyl)-2,4-dioxobutanoic acid: R23 (= R16), G40 (= G33), L41 (= L34)
binding 2-oxoglutaric acid: D213 (≠ N199), P214 (= P200), Y215 (= Y201), G216 (= G202), E217 (= E203), G241 (= G226), T242 (≠ S227), I246 (≠ V231)
binding (2E)-pent-2-enedioic acid: G40 (= G33), Y130 (= Y123), N184 (= N170), R376 (= R360)
binding glutamic acid: S20 (= S13), V22 (≠ I15), L131 (= L124), V360 (= V345), A364 (≠ P349), R369 (vs. gap)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G104 (= G97), S105 (= S98), Q106 (= Q99), Y130 (= Y123), N184 (= N170), D212 (= D198), P214 (= P200), Y215 (= Y201), T242 (≠ S227), S244 (= S229), K245 (= K230), R252 (= R237)

3av7A Crystal structure of pyrococcus horikoshii kynurenine aminotransferase in complex with pmp, kyn as substrates and kya as products
41% identity, 99% coverage: 4:386/388 of query aligns to 11:402/404 of 3av7A

query
sites
3av7A

A

S

K

K

R

K

M

A

D

L

N

E

V

M

Q

R

R

A

S
|
S

Y

E

I
x
V

R
|
R

E

E

I

L

L

L

K

K

V

L

T

V

A

E

R

T

P

S

D

D

I

I

S

S

F

L

A

A

G

G

G
|
G

L

L

P

P

H

N

P

P

D

K

S

T

F

F

P

P

V

K

Q

E

G

I

V

I

A

R

E

D

A

I

A

L

A

V

A

E

V

I

L

M

A

E

E

K

S

Y

G

A

S

D

E

K

A

A

L

L

Q

Q

Y

Y

S

G

T

T

E

K

G

G

Y

F

L

T

P

P

L

L

R

R

E

E

-

T

-

L

-

M

-

K

W

W

I

L

S

G

A

K

R

R

Y

Y

A

-

R

-

Q

-

G

G

I

I

E

S

V

Q

S

D

P

N

D

D

E

-

I

I

L

M

I

I

T

T

T

S

G
|
G

S
|
S

Q
|
Q

Q

Q

A

A

L

L

D

D

L

L

V

I

A

G

K

R

T

V

T

F

I

L

D

N

R

P

G

G

A

D

P

I

V

V

I

V

E

E

R

A

P

P

G

T

Y
|
Y

L
|
L

G
x
A

A

A

I

L

Q
|
Q

C

A

F

F

S

N

F

F

Y

Y

G

E

A

P

Q

Q

F

Y

R

I

T

Q

V

I

D

P

L

L

T

D

P

D

L

E

G

G

V

M

D

K

V

V

E

E

-

I

-

L

-

E

-

K

-

L

-

K

A

E

L

L

R

K

R

S

E

Q

A

G

K

K

G

K

A

V

R

K

L

V

F

V

Y

Y

A

T

V
|
V

P

P

S

T

F

F

Q

Q

N
|
N

P

P

S

A

G

G

I

V

T

T

Y

M

D

N

E

E

P

D

T

R

R

R

R

K

E

Y

V

L

A

L

A

E

I

L

M

A

A

S

E

E

T

Y

G

D

C

F

M

I

L

V

V

V

E

E

D
|
D

N

D

P
|
P

Y
|
Y

G

G

E

E

L

L

R

R

F

Y

M

S

G

G

T

N

P

P

V

E

A

K

P

K

I

I

R

K

K

A

W

L

-

D

A

N

E

E

S

G

P

R

S

V

V

I

L

Y

L

L

G

G

S
x
T

F

F

S
|
S

K
|
K

V

I

V

L

S

A

P

P

G

G

L

F

R
|
R

I

I

G

G

W

W

A

M

C

V

A

G

P

D

A

P

E

G

L

I

M

I

R

R

H

K

M

M

V

E

T

I

A

A

K

K

Q

Q

A

S

S

T

D

D

L

L

H

C

T

T

P

N

M

V

F

F

T

G

Q

Q

R

V

L

V

L

A

H

W

R

R

F

Y

L

V

V

D

D

G

N

G

D

Y

V

L

D

E

E

K

H

H

I

I

A

P

S

E

I

I

R

R

K

K

R

F

Y

Y

G

K

A

P

Q

R

R

R

Q

D

C

A

M

M

M

L

D

E

A

A

I

L

R

E

K

E

H

F

F

M

P

P

E

E

C

G

V

V

T

K

V

W

T

T

E

K

P

P

E

E

G

G

M

M

F

F

L

I

W

W

C

V

G

T

L

L

P

P

E

D

G

G

V

I

T

D

S

S

E

K

H

K

L

M

F

L

H

E

K

R

A

A

I

I

E

K

R

K

K

G

V

V

A

A

F

Y

V

V

P

P

G

G

C

E

P
x
A

F

F

Y

Y

V

A

-

H

-
x
R

D

D

G

V

T

K

D

N

T

T

G

-

F

M

R
|
R

L

L

N

N

F

F

S

T

N

Y

A

V

S

D

Q

E

D

D

D

K

I

I

V

M

E

E

G

G

I

I

A

K

R

R

L

L

G

A

A

E

C

T

L

I

T

K

E

E

L

L

binding 4-hydroxyquinoline-2-carboxylic acid: S20 (= S13), V22 (≠ I15), R23 (= R16), L131 (= L124), Q135 (= Q128), A364 (≠ P349), R369 (vs. gap)
binding (2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid: R23 (= R16), G40 (= G33), Y130 (= Y123), L131 (= L124), A132 (≠ G125), N184 (= N170), R376 (= R360)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G104 (= G97), S105 (= S98), Q106 (= Q99), Y130 (= Y123), V179 (= V165), N184 (= N170), D212 (= D198), P214 (= P200), Y215 (= Y201), T242 (≠ S227), S244 (= S229), K245 (= K230), R252 (= R237)

3aowC Crystal structure of pyrococcus horikoshii kynurenine aminotransferase in complex with akg
41% identity, 99% coverage: 4:386/388 of query aligns to 11:402/404 of 3aowC

query
sites
3aowC

A

S

K

K

R

K

M

A

D

L

N

E

V

M

Q

R

R

A

S

S

Y

E

I

V

R
|
R

E

E

I

L

L

L

K

K

V

L

T

V

A

E

R

T

P

S

D

D

I

I

S

S

F

L

A

A

G

G

L

L

P

P

H

N

P

P

D

K

S

T

F

F

P

P

V

K

Q

E

G

I

V

I

A

R

E

D

A

I

A

L

A

V

A

E

V

I

L

M

A

E

E

K

S

Y

G

A

S

D

E

K

A

A

L

L

Q

Q

Y
|
Y

S

G

T

T

E

K

G

G

Y

F

L

T

P

P

L

L

R

R

E

E

-

T

-

L

-

M

-

K

W

W

I

L

S

G

A

K

R

R

Y

Y

A

-

R

-

Q

-

G

G

I

I

E

S

V

Q

S

D

P

N

D

D

E

-

I

I

L

M

I

I

T

T

T

S

G
|
G

S
|
S

Q
|
Q

Q

Q

A

A

L

L

D

D

L

L

V

I

A

G

K

R

T

V

T

F

I

L

D

N

R

P

G

G

A

D

P

I

V

V

I

V

E

E

R

A

P

P

G

T

Y
|
Y

L

L

G

A

A

A

I

L

Q

Q

C

A

F

F

S

N

F

F

Y

Y

G

E

A

P

Q

Q

F

Y

R

I

T

Q

V

I

D

P

L

L

T

D

P

D

L

E

G

G

V

M

D

K

V

V

E

E

-

I

-

L

-

E

-

K

-

L

-

K

A

E

L

L

R

K

R

S

E

Q

A

G

K

K

G

K

A

V

R

K

L

V

F

V

Y

Y

A

T

V
|
V

P

P

S

T

F

F

Q

Q

N
|
N

P

P

S

A

G

G

I

V

T

T

Y

M

D

N

E

E

P

D

T

R

R

R

R

K

E

Y

V

L

A

L

A

E

I

L

M

A

A

S

E

E

T

Y

G

D

C

F

M

I

L

V

V

V

E

E

D
|
D

N

D

P
|
P

Y
|
Y

G

G

E

E

L

L

R

R

F

Y

M

S

G

G

T

N

P

P

V

E

A

K

P

K

I

I

R

K

K

A

W

L

-

D

A

N

E

E

S

G

P

R

S

V

V

I

L

Y

L

L

G

G

S
x
T

F

F

S
|
S

K
|
K

V

I

V

L

S

A

P

P

G

G

L

F

R
|
R

I

I

G

G

W

W

A

M

C

V

A

G

P

D

A

P

E

G

L

I

M

I

R

R

H

K

M

M

V

E

T

I

A

A

K

K

Q

Q

A

S

S

T

D

D

L
|
L

H

C

T

T

P

N

M

V

F

F

T

G

Q

Q

R

V

L

V

L

A

H

W

R

R

F

Y

L

V

V

D

D

G

N

G

D

Y

V

L

D

E

E

K

H

H

I

I

A

P

S

E

I

I

R

R

K

K

R

F

Y

Y

G

K

A

P

Q

R

R

R

Q

D

C

A

M

M

M

L

D

E

A

A

I

L

R

E

K

E

H

F

F

M

P

P

E

E

C

G

V

V

T

K

V

W

T

T

E

K

P

P

E

E

G

G

M

M

F

F

L

I

W

W

C

V

G

T

L

L

P

P

E

D

G

G

V

I

T

D

S

S

E

K

H

K

L

M

F

L

H

E

K

R

A

A

I

I

E

K

R

K

K

G

V

V

A

A

F

Y

V

V

P

P

G

G

C

E

P

A

F

F

Y

Y

V

A

-

H

-

R

D

D

G

V

T

K

D

N

T

T

G

-

F

M

R

R

L

L

N

N

F

F

S

T

N

Y

A

V

S

D

Q

E

D

D

D

K

I

I

V

M

E

E

G

G

I

I

A

K

R

R

L

L

G

A

A

E

C

T

L

I

T

K

E

E

L

L

binding 2-oxoglutaric acid: R23 (= R16), Y70 (= Y63), Y130 (= Y123), L275 (= L260)
binding pyridoxal-5'-phosphate: G104 (= G97), S105 (= S98), Q106 (= Q99), Y130 (= Y123), V179 (= V165), N184 (= N170), D212 (= D198), P214 (= P200), Y215 (= Y201), T242 (≠ S227), S244 (= S229), K245 (= K230), R252 (= R237)

3aovA Crystal structure of pyrococcus horikoshii kynurenine aminotransferase in complex with plp
41% identity, 99% coverage: 4:386/388 of query aligns to 11:402/404 of 3aovA

query
sites
3aovA

A

S

K

K

R

K

M

A

D

L

N

E

V

M

Q

R

R

A

S

S

Y

E

I

V

R

R

E

E

I

L

L

L

K

K

V

L

T

V

A

E

R

T

P

S

D

D

I

I

S

S

F

L

A

A

G

G

L

L

P

P

H

N

P

P

D

K

S

T

F

F

P

P

V

K

Q

E

G

I

V

I

A

R

E

D

A

I

A

L

A

V

A

E

V

I

L

M

A

E

E

K

S

Y

G

A

S

D

E

K

A

A

L

L

Q

Q

Y

Y

S

G

T

T

E

K

G

G

Y

F

L

T

P

P

L

L

R

R

E

E

-

T

-

L

-

M

-

K

W

W

I

L

S

G

A

K

R

R

Y

Y

A

-

R

-

Q

-

G

G

I

I

E

S

V

Q

S

D

P

N

D

D

E

-

I

I

L

M

I

I

T

T

T

S

G
|
G

S
|
S

Q
|
Q

Q

Q

A

A

L

L

D

D

L

L

V

I

A

G

K

R

T

V

T

F

I

L

D

N

R

P

G

G

A

D

P

I

V

V

I

V

E

E

R

A

P

P

G

T

Y
|
Y

L

L

G

A

A

A

I

L

Q

Q

C

A

F

F

S

N

F

F

Y

Y

G

E

A

P

Q

Q

F

Y

R

I

T

Q

V

I

D

P

L

L

T

D

P

D

L

E

G

G

V

M

D

K

V

V

E

E

-

I

-

L

-

E

-

K

-

L

-

K

A

E

L

L

R

K

R

S

E

Q

A

G

K

K

G

K

A

V

R

K

L

V

F

V

Y

Y

A

T

V
|
V

P

P

S

T

F

F

Q

Q

N
|
N

P

P

S

A

G

G

I

V

T

T

Y

M

D

N

E

E

P

D

T

R

R

R

R

K

E

Y

V

L

A

L

A

E

I

L

M

A

A

S

E

E

T

Y

G

D

C

F

M

I

L

V

V

V

E

E

D
|
D

N

D

P
|
P

Y
|
Y

G

G

E

E

L

L

R

R

F

Y

M

S

G

G

T

N

P

P

V

E

A

K

P

K

I

I

R

K

K

A

W

L

-

D

A

N

E

E

S

G

P

R

S

V

V

I

L

Y

L

L

G

G

S
x
T

F

F

S
|
S

K
|
K

V

I

V

L

S

A

P

P

G

G

L

F

R
|
R

I

I

G

G

W

W

A

M

C

V

A

G

P

D

A

P

E

G

L

I

M

I

R

R

H

K

M

M

V

E

T

I

A

A

K

K

Q

Q

A

S

S

T

D

D

L

L

H

C

T

T

P

N

M

V

F

F

T

G

Q

Q

R

V

L

V

L

A

H

W

R

R

F

Y

L

V

V

D

D

G

N

G

D

Y

V

L

D

E

E

K

H

H

I

I

A

P

S

E

I

I

R

R

K

K

R

F

Y

Y

G

K

A

P

Q

R

R

R

Q

D

C

A

M

M

M

L

D

E

A

A

I

L

R

E

K

E

H

F

F

M

P

P

E

E

C

G

V

V

T

K

V

W

T

T

E

K

P

P

E

E

G

G

M

M

F

F

L

I

W

W

C

V

G

T

L

L

P

P

E

D

G

G

V

I

T

D

S

S

E

K

H

K

L

M

F

L

H

E

K

R

A

A

I

I

E

K

R

K

K

G

V

V

A

A

F

Y

V

V

P

P

G

G

C

E

P

A

F

F

Y

Y

V

A

-

H

-

R

D

D

G

V

T

K

D

N

T

T

G

-

F

M

R

R

L

L

N

N

F

F

S

T

N

Y

A

V

S

D

Q

E

D

D

D

K

I

I

V

M

E

E

G

G

I

I

A

K

R

R

L

L

G

A

A

E

C

T

L

I

T

K

E

E

L

L

binding pyridoxal-5'-phosphate: G104 (= G97), S105 (= S98), Q106 (= Q99), Y130 (= Y123), V179 (= V165), N184 (= N170), D212 (= D198), P214 (= P200), Y215 (= Y201), T242 (≠ S227), S244 (= S229), K245 (= K230), R252 (= R237)

2z1yA Crystal structure of lysn, alpha-aminoadipate aminotransferase (complexed with n-(5'-phosphopyridoxyl)-l-leucine), from thermus thermophilus hb27
45% identity, 99% coverage: 3:387/388 of query aligns to 7:387/389 of 2z1yA

query
sites
2z1yA

I

F

A

G

K

K

R

G

M

A

D

G

N

R

V

I

Q

Q

R

A

S

S

Y

T

I

I

R

R

E

E

I

L

L

L

K

K

V

-

T

-

A

-

R

-

P

-

D

G

I

I

I

L

S

S

F

F

A

A

G

G

G
|
G

L

L

P

P

H

A

P

P

D

E

S

L

F

F

P

P

V

K

Q

E

G

E

V

A

A

A

E

E

A

A

A

R

V

I

L

L

A

R

E

E

S

K

G

G

S

E

E

V

A

A

L

L

Q

Q

Y

Y

S

S

T

P

T

T

E

E

G

G

Y

Y

L

A

P

P

L

L

R

R

E

A

W

F

I

V

S

A

A

-

R

-

Y

-

A

-

R

-

Q

E

G

W

I

I

E

G

V

V

S

R

P

P

D

E

E

E

I

V

L

L

I

I

T

T

G
|
G

S
|
S

Q
|
Q

Q

Q

A

A

L

L

D

D

L

L

V

V

A

G

K

K

T

V

T

F

I

L

D

D

R

E

G

G

A

S

P

P

V

V

V

L

I

L

E

E

R

A

P

P

G

S

Y
|
Y

L

M

G

G

A

A

I

I

Q

Q

C

A

F

F

S

R

F

L

Y

Q

G

G

A

P

Q

R

F

F

R

L

T

T

V

V

D

P

L

A

T

G

P

E

L

E

G

G

V

P

D

D

V

L

E

D

A

A

L

L

R

E

E

V

A

L

K

K

G

R

A

E

-

R

-

P

R

R

L

F

F

L

Y

Y

A

L

V

I

P

P

S

S

F

F

Q

Q

N
|
N

P

P

S

T

G

G

I

G

T

L

Y

T

D

P

E

L

P

P

T

A

R

R

R

K

E

R

V

L

A

L

A

Q

I

M

M

V

A

M

E

E

T

R

G

G

C

L

M

V

L

V

V

V

E

E

D
|
D

N

D

P

A

Y
|
Y

G

R

E

E

L

L

R

Y

F

F

M

-

G

G

T

E

P

A

V

R

A

L

P

P

-

S

-

L

-

F

-

E

I

L

R

A

K

R

W

E

A

A

E

G

S

Y

P

P

S

G

V

V

L

I

-

Y

L

L

G

G

S
|
S

F

F

S
|
S

K
|
K

V

V

V

L

S

S

P

P

G

G

L

L

R
|
R

I

V

G

A

W

F

A

A

C

V

A

A

P

H

A

P

E

E

L

A

M

L

R

Q

H

K

M

L

V

V

T

Q

A

A

K

K

Q

Q

A

G

S

A

D

D

L

L

H

H

T

T

P

P

M

M

F

L

T

N

Q

Q

R

M

L

L

L

V

H

H

R

E

F

L

L

L

V

K

D

E

N

G

D

-

V

F

D

S

E

E

H

R

I

L

A

E

S

R

I

V

R

R

K

R

R

V

Y

Y

G

R

A

E

Q

K

R

A

Q

Q

C

A

M

M

M

L

D

H

A

A

I

L

R

D

K

R

H

E

F

V

P

P

E

K

C

E

V

V

T

R

V

Y

T

T

E

R

P

P

E

K

G

G

M

M

F

F

L

V

W

W

C

M

G

E

L

L

P

P

E

K

G

G

V

L

T

S

S

A

E

E

H

G

L

L

F

F

H

R

K

R

A

A

I

L

E

E

R

E

K

N

V

V

A

A

F

F

V

V

P

P

G

G

C

G

P

P

F

F

Y

F

V

A

D

N

-

G

G

G

T

G

D

E

T

N

G

T

F

L

R
|
R

L

L

N

S

F

Y

S

A

N

T

A

L

S

D

Q

R

D

E

D

G

I

I

V

A

E

E

G

G

I

V

A

R

R

R

L

L

G

G

A

R

C

A

L

L

T

K

E

G

E

L

L

L

A

A

binding leucine: G32 (= G33), Y117 (= Y123), R360 (= R360)
binding pyridoxal-5'-phosphate: G91 (= G97), S92 (= S98), Q93 (= Q99), Y117 (= Y123), N166 (= N170), D194 (= D198), Y197 (= Y201), S227 (= S227), S229 (= S229), K230 (= K230), R237 (= R237)

1wstA Crystal structure of multiple substrate aminotransferase (msat) from thermococcus profundus
40% identity, 98% coverage: 10:388/388 of query aligns to 14:402/403 of 1wstA

query
sites
1wstA

V

M

Q

K

R

A

S

S

Y

E

I

V

R

R

E

E

I

L

L

L

K

K

V

L

T

V

A

E

R

T

P

S

D

D

I

V

I

I

S

S

F

L

A

A

G

G

L

L

P

P

H

A

P

P

D

E

S

T

F

F

P

P

V

V

Q

E

G

T

V

I

A

K

E

K

A

I

A

A

A

V

A

E

V

V

L

L

A

E

E

E

S

H

G

A

S

D

E

K

A

A

L

L

Q

Q

Y

Y

S

G

T

T

E

K

G

G

Y

F

L

T

P

P

L

L

R

R

-

L

-

A

-

L

-

A

E

R

W

W

I

M

S

E

A

K

R

R

Y

Y

A

-

R

-

Q

-

G

D

I

I

E

P

V

M

S

S

P

K

D

V

E

E

I

I

L

M

I

T

T

V

T

A

G
|
G

S
|
S

Q
|
Q

Q

Q

A

A

L

L

D

D

L

L

V

I

A

G

K

R

T

V

T

F

I

L

D

N

R

P

G

G

A

D

P

P

V

I

V

V

I

V

E

E

R

A

P

P

G

T

Y
|
Y

L

L

G

A

A

A

I

I

Q

Q

C

A

F

F

S

K

F

Y

Y

Y

G

D

A

P

Q

E

F

F

R

I

T

S

V

I

D

P

L

L

T

D

P

D

L

K

G

G

V

M

D

R

V

V

E

D

A

L

L

L

-

E

-

K

-

L

-

E

-

L

R

R

R

K

E

Q

A

G

K

K

G

R

A

V

R

K

L

I

F

V

Y

Y

A

T

V
|
V

P

S

S

T

F

F

Q

Q

N
|
N

P

P

S

A

G

G

I

V

T

T

Y

M

D

S

E

V

P

D

T

R

R

R

R

K

E

K

V

L

A

L

A

E

I

L

M

A

A

N

E

E

T

Y

G

D

C

F

M

L

L

I

V

V

E

E

D
|
D

N

G

P
|
P

Y
|
Y

G

S

E

E

L

L

R

R

F

Y

M

S

G

G

T

E

P

P

V

T

A

P

P

P

I

I

R

K

K

H

W

F

A

D

E

D

S

Y

P

G

S

R

V

V

L

I

-

Y

L

L

G

G

S
x
T

F

F

S
|
S

K
|
K

V

I

V

L

S

A

P

P

G

G

L

F

R
|
R

I

I

G

G

W

W

A

V

C

A

A

A

P

H

A

P

E

H

L

L

M

I

R

R

H

K

M

M

V

E

T

I

A

A

K

K

Q

Q

A

S

S

I

D

D

L

L

H

C

T

T

P

N

M

T

F

F

T

G

Q

Q

R

A

L

I

L

A

H

W

R

K

F

Y

L

V

V

E

D

N

N

G

D

Y

V

L

D

D

E

E

H

H

I

I

A

P

S

K

I

I

R

I

K

E

R

F

Y

Y

G

K

A

P

Q

R

R

R

Q

D

C

A

M

M

M

L

D

E

A

A

I

L

R

E

K

E

H

Y

F

M

P

P

E

E

C

G

V

V

T

E

V

W

T

T

E

K

P

P

E

E

G

G

M

M

F

F

L

V

W

R

C

V

G

T

L

L

P

P

E

E

G

G

V

I

T

D

S

T

E

K

H

L

L

M

F

M

H

E

K

R

A

A

I

V

E

A

R

K

K

G

V

V

A

A

F

Y

V

V

P

P

G

G

C

E

P

A

F

F

Y

F

V

V

-

H

-

R

D

D

G

K

T

K

D

N

T

T

G

-

F

M

R

R

L

L

N

N

F

F

S

T

N

Y

A

V

S

P

Q

E

D

E

D

T

I

I

V

R

E

E

G

G

I

V

A

R

R

R

L

L

G

A

A

E

C

T

L

I

T

K

E

E

L

M

A

K

R

R

binding pyridoxal-5'-phosphate: G102 (= G97), S103 (= S98), Q104 (= Q99), Y128 (= Y123), V177 (= V165), N182 (= N170), D210 (= D198), P212 (= P200), Y213 (= Y201), T240 (≠ S227), S242 (= S229), K243 (= K230), R250 (= R237)

1vp4A Crystal structure of a putative aminotransferase (tm1131) from thermotoga maritima msb8 at 1.82 a resolution
39% identity, 99% coverage: 2:384/388 of query aligns to 15:412/420 of 1vp4A

query
sites
1vp4A

Q

K

I

I

A

S

K

K

R

I

M

G

D

Q

N

N

V

M

Q

K

R

S

S

S

Y

I

I

I

R

R

E

E

I

I

L

L

K

K

V

F

T

A

A

A

R

D

P

K

D

D

I

A

I

I

S

S

F

F

A

G

G

G

L

V

P

P

H

D

P

P

D

E

S

T

F

F

P

P

V

R

Q

K

G

E

V

L

A

A

E

E

A

I

A

A

A

K

A

E

V

I

L

I

A

E

E

K

S

E

G

Y

S

H

E

Y

A

T

L

L

Q

Q

Y

Y

S

S

T

T

E

E

G

G

Y

D

L

P

P

V

L

L

R

K

E

Q

W

Q

I

I

S

L

A

K

R

L

Y

L

A

E

R

R

Q

M

-

Y

G

G

I

I

E

T

-

G

V

L

S

D

P

E

D

D

E

N

I

L

L

I

I

F

T

T

T

V

G
|
G

S
|
S

Q
|
Q

Q

Q

A

A

L

L

D

D

L

L

V

I

A

G

K

K

T

L

T

F

I

L

D

D

R

D

G

E

A

S

P

Y

V

C

V

V

I

L

E

D

R

D

P

P

G

A

Y
|
Y

L

L

G

G

A

A

I

I

Q

N

C

A

F

F

S

R

F

Q

Y

Y

G

L

A

A

Q

N

F

F

R

V

T

V

V

V

D

P

L

L

T

E

P

D

L

D

G

G

V

M

D

D

V

L

E

N

A

V

L

L

R

E

R

R

E

K

-

L

-

S

-

E

-

F

-

D

-

K

-

N

-

G

-

K

A

I

K

K

G

Q

A

V

R

K

L

F

F

I

Y

Y

A

V

V

V

P

S

S

N

F

F

Q

H

N
|
N

P

P

S

A

G

G

I

V

T

T

Y

T

D

S

E

L

P

E

T

K

R

R

R

K

E

A

V

L

A

V

A

E

I

I

M

A

A

E

E

K

T

Y

G

D

C

L

M

F

L

I

V

V

E

E

D
|
D

N

D

P
|
P

Y
|
Y

G

G

E

A

L

L

R

R

F

Y

M

E

G

G

T

E

P

T

V

V

A

D

P

P

I

I

R

F

K

K

W

I

A

G

E

-

S

G

P

P

S

E

-

R

-

V

V

V

L

L

G

N

S
x
T

F

F

S
|
S

K
|
K

V

V

V

L

S

A

P

P

G

G

L

L

R
|
R

I

I

G

G

W

M

A

V

C

A

A

G

P

S

A

K

E

E

L

F

M

I

R

R

H

K

M

I

V

V

T

Q

A

A

K

K

Q

Q

A

S

S

A

D

D

L

L

H

C

T

S

P

P

M

A

F

I

T

T

Q

H

R

R

L

L

L

A

H

A

R

R

F

Y

L

L

V

E

D

R

N

Y

D

D

V

L

D

L

E

E

H

Q

I

L

A

K

S

P

I

T

R

I

K

E

R

L

Y

Y

G

R

A

R

Q

K

R

R

Q

T

C

V

M

M

M

L

D

N

A

A

I

L

R

E

K

E

H

Y

F

F

P

S

E

D

C

I

-

P

-

G

V

V

T

K

V

W

T

V

E

K

P

S

E

E

G

G

M

L

F

F

L

I

W

W

C

L

G

T

L

L

P

P

E

E

G

G

V

F

T

D

S

T

E

W

H

E

L

M

F

F

H

E

K

Y

A

A

I

K

E

R

R

K

K

K

V

V

A

F

F

Y

V

V

P

P

G

G

C

R

P

V

F

F

Y

K

V

V

-

Y

D

D

G

E

T

P

D

S

T

P

G

S

F

M

R

R

L

L

N

S

F

F

S

C

N

L

A

P

S

P

Q

D

D

E

D

K

I

I

V

V

E

E

G

G

I

I

A

K

R

R

L

L

G

R

A

E

C

V

L

V

T

L

E

E

binding pyridoxal-5'-phosphate: G112 (= G97), S113 (= S98), Q114 (= Q99), Y138 (= Y123), N194 (= N170), D222 (= D198), P224 (= P200), Y225 (= Y201), T252 (≠ S227), S254 (= S229), K255 (= K230), R262 (= R237)

2zc0A Crystal structure of an archaeal alanine:glyoxylate aminotransferase (see paper)
32% identity, 93% coverage: 27:386/388 of query aligns to 36:405/405 of 2zc0A

query
sites
2zc0A

I

L

I

I

S

S

F

L

A

A

G

A

G

G

L

D

P

P

H

D

P

P

D

E

S

L

F

I

P

P

V

R

Q

A

G

V

V

L

A

G

E

E

A

I

A

A

A

K

A

E

V

V

L

L

A

-

E

E

S

K

G

E

S

P

E

K

A

S

L

V

Q

M

Y

Y

S

T

T

P

T

A

E

N

G

G

Y

I

L

P

P

E

L

L

R

R

E

E

W

E

I

L

S

A

A

A

R

F

Y

L

A

K

R

K

-

Y

Q

D

G

H

I

L

E

E

V

V

S

S

P

P

D

E

E

N

I

I

L

V

I

I

T

T

T

I

G
|
G

S
x
G

Q
x
T

Q

G

A

A

L

L

D

D

L

L

V

L

A

G

K

R

T

V

T

L

I

I

D

D

R

P

G

G

A

D

P

V

V

V

V

I

I

T