SitesBLAST – Find functional sites

 

SitesBLAST

Comparing 207892 FitnessBrowser__DvH:207892 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 3 hits to proteins with known functional sites (download)

5odcD Heterodisulfide reductase / [nife]-hydrogenase complex from methanothermococcus thermolithotrophicus at 2.3 a resolution (see paper)
52% identity, 26% coverage: 8:133/494 of query aligns to 3:128/138 of 5odcD

query
sites
5odcD
E
 
E
L
 
P
R
 
K
V
 
I
V
 
I
G
 
G
F
 
F
L
 
C
C
|
C
N
 
N
W
 
W
C
 
C
S
 
T
Y
 
Y
G
 
G
G
 
G
A
 
A
D
 
D
T
 
T
A
 
A
G
 
G
V
 
V
G
 
G
R
 
R
F
 
M
S
 
Q
Q
 
Y
P
 
P
T
 
P
D
 
S
L
 
I
R
 
R
I
 
I
V
 
I
R
 
R
V
 
V
P
 
M
C
|
C
S
|
S
G
 
G
R
 
R
V
 
I
D
 
E
P
 
P
L
 
S
F
 
L
I
 
I
I
 
L
K
 
K
A
 
A
L
 
F
I
 
K
S
 
E
G
 
G
A
 
A
D
 
D
G
 
G
V
 
V
L
 
F
V
 
V
S
 
G
G
 
G
C
|
C
H
 
H
P
 
L
R
 
G
D
 
D
C
|
C
H
|
H
Y
 
Y
S
 
D
H
 
S
G
 
G
N
 
N
F
 
Y
Y
 
K
A
 
W
R
 
Q
R
 
R
R
 
R
L
 
V
E
 
M
T
 
M
L
 
L
K
 
Y
S
 
E
F
 
L
L
 
L
P
 
E
A
 
E
L
 
L
G
 
G
I
 
I
D
 
E
P
 
K
E
 
E
R
 
R
F
 
L
Q
 
N
Y
 
H
T
 
E
W
 
W
V
 
I
S
 
S
A
 
A
S
 
S
E
 
E
G
 
G
Q
 
E
R
 
K
W
 
F
K
 
Q
N
 
N
V
 
T
V
 
M
S
 
K
T
 
D
F
 
F
V
 
Y
E
 
N
K
 
K
V
 
I
H
 
E
Q
 
A
L
 
L
G
 
G

7bkbF Formate dehydrogenase - heterodisulfide reductase - formylmethanofuran dehydrogenase complex from methanospirillum hungatei (hexameric, composite structure) (see paper)
50% identity, 26% coverage: 10:136/494 of query aligns to 5:131/137 of 7bkbF

query
sites
7bkbF
R
 
Q
V
 
I
V
 
L
G
 
A
F
 
I
L
 
I
C
|
C
N
 
N
W
|
W
C
 
C
S
 
S
Y
 
Y
G
 
A
G
 
G
A
 
A
D
 
D
T
 
L
A
 
A
G
 
G
V
 
G
G
 
A
R
 
R
F
 
I
S
 
Q
Q
 
Y
P
 
P
T
 
P
D
 
T
L
 
V
R
 
R
I
 
A
V
 
I
R
 
R
V
 
V
P
 
M
C
|
C
S
x
T
G
 
G
R
 
R
V
 
V
D
 
D
P
 
M
L
 
L
F
 
F
I
 
I
I
 
L
K
 
K
A
 
A
L
 
F
I
 
V
S
 
E
G
 
G
A
 
A
D
 
D
G
 
G
V
 
V
L
 
L
V
 
V
S
 
S
G
 
G
C
|
C
H
 
H
P
 
F
R
 
G
D
 
D
C
|
C
H
|
H
Y
 
Y
S
 
L
H
 
E
G
 
G
N
 
N
F
 
Y
Y
 
K
A
 
A
R
 
A
R
 
K
R
 
R
L
 
M
E
 
F
T
 
M
L
 
I
K
 
K
S
 
N
F
 
L
L
 
L
P
 
R
A
 
N
L
 
I
G
 
G
I
 
L
D
 
D
P
 
D
E
 
R
R
 
R
F
 
F
Q
 
R
Y
 
M
T
 
T
W
 
F
V
 
V
S
 
S
A
 
A
S
 
S
E
 
E
G
 
G
Q
 
A
R
 
K
W
 
W
K
 
G
N
 
M
V
 
V
V
 
M
S
 
E
T
 
D
F
 
V
V
 
T
E
 
N
K
 
T
V
 
I
H
 
K
Q
 
E
L
 
L
G
 
G
H
 
P
A
 
S
P
 
P

7bkbE Formate dehydrogenase - heterodisulfide reductase - formylmethanofuran dehydrogenase complex from methanospirillum hungatei (hexameric, composite structure) (see paper)
25% identity, 69% coverage: 148:487/494 of query aligns to 1:391/411 of 7bkbE

query
sites
7bkbE
A
 
A
A
 
A
A
 
K
G
 
G
D
 
D
A
 
M
L
 
L
R
 
Y
A
 
A
P
 
W
L
 
A
R
 
K
P
 
D
L
 
A
A
 
E
Y
 
I
P
 
Q
P
 
K
A
 
K
G
|
G
S
x
E
L
x
C
A
 
G
Q
x
G
S
 
A
L
x
V
E
x
T
R
 
A
L
 
L
R
 
-
E
 
-
R
 
-
I
 
L
R
 
K
A
 
H
A
 
A
L
 
L
P
 
E
E
 
T
-
 
K
-
 
M
L
 
V
D
 
D
C
 
A
V
 
V
I
 
V
G
 
A
W
x
I
Q
 
K
Q
 
K
G
 
G
Y
 
K
D
 
D
A
 
L
L
 
Y
H
 
D
A
 
A
T
 
V
P
 
P
L
 
T
F
 
V
M
 
I
R
 
T
K
 
N
P
 
P
E
 
E
D
 
D
V
 
I
D
 
I
K
 
Q
L
 
-
T
|
T
W
x
A
G
|
G
P
x
S
L
|
L
N
x
H
V
 
C
H
x
G
N
 
T
L
 
L
-
 
L
-
 
I
-
 
P
-
 
K
-
 
L
-
 
I
A
 
K
T
 
K
Y
 
Y
L
 
L
P
 
N
Q
 
G
F
 
A
K
 
K
N
 
D
R
 
M
K
 
K
V
 
L
G
 
A
V
 
V
V
x
T
V
 
C
K
 
K
G
|
G
C
|
C
D
 
D
S
 
A
R
 
M
S
 
A
V
 
F
I
 
Y
E
 
E
L
 
L
L
 
A
Q
 
K
E
 
R
K
 
N
L
 
Q
I
 
I
E
 
N
P
 
L
D
 
D
N
 
N
V
 
I
R
 
I
V
 
M
F
 
I
G
 
G
M
 
V
P
x
N
C
|
C
E
x
G
G
 
G
V
 
S
V
 
V
D
 
S
V
 
P
T
 
V
Q
 
T
V
 
A
Q
 
R
K
 
K
A
 
M
L
 
I
G
 
S
T
 
N
D
 
K
D
 
F
G
 
G
G
 
V
D
 
D
H
 
P
A
 
D
G
 
T
T
 
V
A
 
H
P
 
K
A
 
E
S
 
E
M
 
I
S
 
D
V
 
K
E
 
G
G
 
Q
D
 
F
V
 
I
L
 
I
T
 
E
V
 
Y
T
 
E
G
 
G
A
 
G
T
 
H
P
 
K
A
 
G
Q
 
-
L
 
I
K
 
K
L
 
I
A
 
D
D
 
E
V
 
L
V
 
E
A
 
E
E
 
E
-
 
G
-
 
Y
-
 
G
-
 
R
-
 
R
-
 
S
K
 
N
C
|
C
R
 
R
T
 
R
C
|
C
D
 
K
T
 
M
P
 
K
S
 
I
P
 
P
L
 
R
L
 
Q
G
 
A
E
 
D
V
 
I
V
 
A
E
 
A
G
|
G
-
x
N
-
x
W
-
 
G
V
 
V
A
 
I
S
 
G
T
 
D
P
 
K
A
 
A
G
 
G
A
 
K
-
 
A
-
x
T
-
 
F
-
 
L
-
 
E
-
 
I
-
 
C
-
 
S
-
 
E
-
 
K
-
 
G
-
 
A
-
 
N
-
 
L
-
 
V
-
 
N
-
 
S
-
 
A
-
 
Q
-
 
S
-
 
K
-
 
G
-
 
A
-
 
L
-
 
E
-
 
I
P
 
S
P
 
P
A
 
A
A
 
D
P
 
P
P
 
K
G
 
G
L
 
I
D
 
D
-
 
I
-
 
R
-
 
A
-
 
K
-
 
V
-
 
E
-
 
K
A
 
A
L
 
M
D
 
F
A
 
N
M
 
L
T
 
G
P
 
D
E
 
E
Q
 
W
R
 
R
R
 
H
G
 
R
F
 
D
W
 
F
R
 
E
G
 
G
-
 
M
-
 
G
-
 
K
-
 
G
-
 
K
-
 
D
-
 
R
-
 
L
-
 
K
-
 
L
-
 
M
-
 
M
-
 
S
Q
 
E
M
 
S
E
 
S
R
 
K
C
|
C
L
x
I
R
x
K
C
|
C
Y
|
Y
A
|
A
C
|
C
R
 
V
N
 
E
A
 
A
C
|
C
P
|
P
M
 
I
C
|
C
V
 
Y
C
|
C
R
 
-
D
 
-
Q
 
-
C
 
-
I
 
I
G
 
E
E
x
C
S
|
S
R
 
T
D
 
K
P
 
K
H
 
P
W
 
W
T
 
Y
T
 
I
Q
 
A
E
 
P
G
 
G
N
 
V
V
 
L
R
 
P
E
 
T
K
 
S
L
 
F
Q
 
M
F
|
F
Q
 
H
I
 
L
I
 
I
H
 
R
A
 
F
L
 
A
H
|
H
L
 
V
A
 
S
G
 
D
R
 
S
C
|
C
T
x
I
E
x
N
C
|
C
G
|
G
E
 
Q
C
|
C
Q
 
E
R
 
E
A
 
L
C
|
C
P
|
P
V
 
M
N
 
E
I
 
I
P
 
P
V
x
N
L
 
A
A
 
L
L
 
F
K
x
M
Q
 
H
W
 
S
M
 
Q
N
 
Q
R
 
V
S
 
E
V
 
I
R
 
E
D
 
K
L
 
M
F
 
F
D
 
G
Y
 
H
R
 
I
A
 
P
G
 
G
M
 
Q
D
 
D
V
 
M
E
 
-
A
 
-
V
 
T
P
 
P
P
 
P
L
 
I
L
 
H
S
 
A
F
 
F
A
 
-
V
 
V
E
 
E
E
 
E
K
 
K

Query Sequence

>207892 FitnessBrowser__DvH:207892
MPVLKGKELRVVGFLCNWCSYGGADTAGVGRFSQPTDLRIVRVPCSGRVDPLFIIKALIS
GADGVLVSGCHPRDCHYSHGNFYARRRLETLKSFLPALGIDPERFQYTWVSASEGQRWKN
VVSTFVEKVHQLGHAPHIEDAVPYLPLAAAGDALRAPLRPLAYPPAGSLAQSLERLRERI
RAALPELDCVIGWQQGYDALHATPLFMRKPEDVDKLTWGPLNVHNLATYLPQFKNRKVGV
VVKGCDSRSVIELLQEKLIEPDNVRVFGMPCEGVVDVTQVQKALGTDDGGDHAGTAPASM
SVEGDVLTVTGATPAQLKLADVVAEKCRTCDTPSPLLGEVVEGVASTPAGAPPAAPPGLD
ALDAMTPEQRRGFWRGQMERCLRCYACRNACPMCVCRDQCIGESRDPHWTTQEGNVREKL
QFQIIHALHLAGRCTECGECQRACPVNIPVLALKQWMNRSVRDLFDYRAGMDVEAVPPLL
SFAVEEKNIKEHGL

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory