Comparing 208411 MicrobesOnline__882:208411 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P05654 Aspartate carbamoyltransferase catalytic subunit; Aspartate transcarbamylase; ATCase; EC 2.1.3.2 from Bacillus subtilis (strain 168) (see paper)
40% identity, 93% coverage: 12:306/317 of query aligns to 2:285/304 of P05654
Sites not aligning to the query:
3r7lA Crystal structure of pala-bound aspartate transcarbamoylase from bacillus subtilis (see paper)
40% identity, 93% coverage: 12:306/317 of query aligns to 2:285/290 of 3r7lA
3r7fA Crystal structure of cp-bound aspartate transcarbamoylase from bacillus subtilis (see paper)
40% identity, 93% coverage: 12:306/317 of query aligns to 2:285/291 of 3r7fA
3r7dA Crystal structure of unliganded aspartate transcarbamoylase from bacillus subtilis (see paper)
40% identity, 93% coverage: 12:306/317 of query aligns to 2:285/291 of 3r7dA
4bjhB Crystal structure of the aquifex reactor complex formed by dihydroorotase (h180a, h232a) with dihydroorotate and aspartate transcarbamoylase with n-(phosphonacetyl)-l-aspartate (pala) (see paper)
37% identity, 92% coverage: 20:311/317 of query aligns to 10:291/291 of 4bjhB
3d6nB Crystal structure of aquifex dihydroorotase activated by aspartate transcarbamoylase (see paper)
37% identity, 92% coverage: 20:311/317 of query aligns to 10:291/291 of 3d6nB
6pnzA The structure of the aspartate transcarbamoylase trimer from staphylococcus aureus complexed with pala at 2.27 resolution.
38% identity, 92% coverage: 14:306/317 of query aligns to 4:288/293 of 6pnzA
5g1nE Aspartate transcarbamoylase domain of human cad bound to pala (see paper)
35% identity, 93% coverage: 12:306/317 of query aligns to 6:300/307 of 5g1nE
1ml4A The pala-liganded aspartate transcarbamoylase catalytic subunit from pyrococcus abyssi (see paper)
35% identity, 95% coverage: 9:309/317 of query aligns to 2:303/307 of 1ml4A
5g1pA Aspartate transcarbamoylase domain of human cad bound to carbamoyl phosphate (see paper)
35% identity, 93% coverage: 12:306/317 of query aligns to 3:285/292 of 5g1pA
P08955 Multifunctional protein CAD; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Mesocricetus auratus (Golden hamster) (see paper)
35% identity, 93% coverage: 12:306/317 of query aligns to 1924:2218/2225 of P08955
Sites not aligning to the query:
P27708 Multifunctional protein CAD; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Homo sapiens (Human) (see 7 papers)
35% identity, 93% coverage: 12:306/317 of query aligns to 1924:2218/2225 of P27708
Sites not aligning to the query:
8bplA Aspartate transcarbamoylase mutant (n2045c, r2238c) from chaetomium thermophilum cad-like bound to carbamoyl phosphate (see paper)
33% identity, 96% coverage: 7:311/317 of query aligns to 11:316/316 of 8bplA
P20054 Multifunctional protein pyr1-3; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Dictyostelium discoideum (Social amoeba)
30% identity, 94% coverage: 12:309/317 of query aligns to 1923:2220/2225 of P20054
Sites not aligning to the query:
P05990 Multifunctional protein r; Protein rudimentary; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Drosophila melanogaster (Fruit fly) (see 2 papers)
34% identity, 97% coverage: 12:317/317 of query aligns to 1918:2220/2224 of P05990
Sites not aligning to the query:
4eknB Structure of the catalytic chain of methanococcus jannaschii aspartate transcarbamoylase in a hexagonal crystal form (see paper)
32% identity, 93% coverage: 12:306/317 of query aligns to 2:296/304 of 4eknB
7zstB Crystal structure of truncated aspartate transcarbamoylase from plasmodium falciparum in complex with fla-01 (see paper)
27% identity, 96% coverage: 11:313/317 of query aligns to 12:326/329 of 7zstB
P49077 Aspartate carbamoyltransferase, chloroplastic; Aspartate transcarbamylase; ATCase; EC 2.1.3.2 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
34% identity, 97% coverage: 1:309/317 of query aligns to 72:386/390 of P49077
Q09794 Multifunctional protein ura1; Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase; CPSase-ATCase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
33% identity, 93% coverage: 12:306/317 of query aligns to 1937:2233/2244 of Q09794
Sites not aligning to the query:
7zidB Crystal structure of truncated aspartate transcarbamoylase from plasmodium falciparum in complex with bda-14 (see paper)
27% identity, 96% coverage: 11:313/317 of query aligns to 11:328/331 of 7zidB
>208411 MicrobesOnline__882:208411
MQNETRSLWPHKDLLDVDQLSKDELLHLLDTAAQFHEINRRPVKKVPTLKGKSVILFFAE
PSTRTKTSFDVAGKRLSADTFSLAKSGSSLQKGESLKDTALTLEAMNPDVLVIRHSSSGA
ARFLAERLACGVVNAGDGWHAHPTQALLDCYSLRQVWGDTFEGRTLCILGDIAHSRVARS
NVKLLTSLGVRVRLCAPRTLLPAGVGNWPVEVFTDLDAAVRDADAVMCLRLQLERQQAGL
LPDLREYSNRYCLTPRRLELAKPEAKVLHPGPMNRGLEIASSIADAPASLVLDQVAAGVA
TRMAILFLLATRTDGGR
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory