SitesBLAST

HLN 66:68 (≠ HIN 66:68) binding
Y138 (≠ F129) binding
GFA 199:201 (≠ GYA 190:192) binding
N203 (= N194) binding
R206 (= R197) binding
PL 236:237 (≠ PI 224:225) mutation to FW: No detectable water or glycerol permeability.

1fx8A Crystal structure of the e. Coli glycerol facilitator (glpf) with substrate glycerol (see paper)
38% identity, 96% coverage: 5:244/251 of query aligns to 1:251/254 of 1fx8A

query
sites
1fx8A

S

T

L

L

G

K

K

G

E

Q

M

C

L

I

S

A

E

E

F

F

M

L

G

G

T

T

M

G

V

L

L

L

I

I

I

F

F

F

G

G

A

V

G

G

N

C

V

V

A

A

M

A

T

L

V

K

L

V

F

A

G

G

K

A

T

S

L

F

N

G

I

Q

T

W

W

E

D

I

N

S

I

V

T

I

F
x
W

G

G

W

L

G

G

L
x
V

A

A

V

M

L

A

L

I

G

Y

I

L

M

T

A

A

G

G

L

V

P

-

S

S

G

G

A

A

H
|
H

I
x
L

N
|
N

P

P

A

A

V

V

S

T

L

I

A

A

L

L

A

W

A

L

T

F

G

A

R

C

F

F

P

D

W

K

R

R

K

K

V

V

L

I

P

P

Y

F

S

I

V

V

A

S

Q

Q

V

V

A

A

G

G

G

A

F

F

A

C

G

A

A

A

I

L

V

V

-

Y

-

G

-

L

-

Y

-

N

-

L

F

F

L

F

D

D

F

F

K

E

A

Q

K

T

W

H

L

H

G

I

V

V

D

R

P

G

Q

S

L

V

A

E

S

S

T

V

-

D

-

L

A

A

G

G

I

T

F

F

C

S

T

T

F
x
Y

P
|
P

A
x
N

I
x
P

T

H

T

I

S

N

Y

F

L

V

P

Q

G

A

F

F

I

A

D

V

Q

E

I

M

I

V

G

I

T

T

A

A

V

I

L

L

M

M

F

G

G

L

I

I

L

L

A

A

I

L

G

T

D

D

F

D

A

G

G

N

K

G

N

V

N

P

V

R

G

G

W

P

M

L

G

A

P

P

V

L

L

L

V

I

A

G

A

L

L

L

I
|
I

V

A

A

V

I

I

G

G

M

A

S

S

L

M

G
|
G

A
x
P

M

L

H

T

G
|
G

Y
x
F

A
|
A

I

M

N
|
N

P

P

A

A

R
|
R

D

D

F

F

G

G

P

P

R

K

F

V

F

F

A

A

L

W

V

L

A

A

G

G

F

W

T

G

Q

N

P

V

N

A

L

F

-

T

-

G

M

R

E

D

P

I

G

P

I

Y

V

F

L

L

V

V

P

P

I

L

V

F

G

G

P

P

I

I

I

V

G

G

G

A

P

I

L

V

G

G

A

A

F

F

I

A

Y

Y

D

R

W

K

T

L

T

I

G

G

binding glycerol: W43 (≠ F47), V47 (≠ L51), H61 (= H66), L62 (≠ I67), N63 (= N68), Y133 (≠ F129), P134 (= P130), N135 (≠ A131), P136 (≠ I132), I182 (= I178), G190 (= G186), P191 (≠ A187), G194 (= G190), G194 (= G190), F195 (≠ Y191), A196 (= A192), N198 (= N194), R201 (= R197)

Q96PS8 Aquaporin-10; AQP-10; Aquaglyceroporin-10; Small intestine aquaporin from Homo sapiens (Human) (see 2 papers)
37% identity, 94% coverage: 6:240/251 of query aligns to 20:261/301 of Q96PS8

query
sites
Q96PS8

L

L

G

A

K

R

E

Q

M

C

L

L

S

A

E
|
E

F

F

M

L

G

G

T

V

M

F

V

V

L

L

I

M

I

L

F

L

G

T

A

Q

G

G

N

A

V

V

A

A

M

Q

T

A

V

V

L

T

F

S

G

G

K

E

T

T

L

K

N

G

I

-

T

N

W

F

D

F

N

T

I

M

T

F

F

L

G

A

W

G

G

S

L

L

A

A

V

V

L

T

L

I

G

A

I

I

-

Y

M

V

A
x
G

G

G

L

N

P

V

S
|
S

G

G

A

A

H
|
H

I

L

N

N

P

P

A

A

V
x
F

S

S

L

L

A

A

L

M

A

C

A

I

T

V

G

G

R
|
R

F

L

P

P

W

W

R

V

K

K

V

L

L

P

P

I

Y

Y

S

I

V

L

A

V

Q

Q

V

L

A

L

G

S

G

A

F

F

A

C

G

A

A

S

A

G

-

A

-

T

-

Y

I

V

V

L

F

Y

L

H

D

D

F

A

K

L

A

Q

K

N

W

Y

L

T

G

G

V

G

D
x
N

P

L

Q

T

L

V

A

T

-

G

-

P

-

K

S

E

T

T

A

A

G

S

I

I

F

F

C

A

T

T

F

Y

P

P

A

A

I

P

T

Y

T

L

S

S

Y

L

L

N

P

N

G

G

F

F

I

L

D

D

Q

Q

I

V

I

L

G

G

T

T

A

G

V

M

L

L

M

I

F

V

G

G

I

L

L

L

A

A

I

I

G

L

D

D

F

R

A

R

G

N

K

K

N

G

N

V

V

P

G

A

W

G

M

L

G

E

P

P

V

V

L

V

V

V

A

G

A

M

L

L

I

I

V

L

A

A

I

L

G

G

M

L

S

S

L

M

G

G

A

A

M

N

H

C

G

G

Y

I

A

P

I

L

N

N

P

P

A

A

R

R

D

D

F

L

G

G

P

P

R

R

F

L

F

F

A

T

L

Y

V

V

A

A

G

G

F

W

T

G

Q

-

P

P

N

E

L

V

M

F

E

S

P

A

G

G

I

N

-

G

-

W

V

W

L

W

V

V

P

P

I

V

V

V

G

A

P

P

I

L

I

V

G

G

G

A

P

T

L

V

G

G

A

T

F

A

I

T

Y

Y

D

Q

E27 (= E13) mutation to Q: Abolishes permeability to glycerol.
G73 (≠ A59) mutation to A: Increased permeability to glycerol at acidic pH.; mutation to F: Abolishes permeability to glycerol.
S77 (= S63) mutation S->A,D: Nearly abolishes permeability to glycerol.
H80 (= H66) mutation to A: Abolishes permeability to glycerol.
F85 (≠ V71) mutation to A: Nearly abolishes permeability to glycerol.
R94 (= R80) mutation to A: Abolishes permeability to glycerol.
N133 (≠ D116) modified: carbohydrate, N-linked (GlcNAc...) asparagine; mutation to Q: Abolishes N-glycosylation.

6f7hD Crystal structure of human aqp10 (see paper)
38% identity, 94% coverage: 6:240/251 of query aligns to 8:249/256 of 6f7hD

query
sites
6f7hD

L

L

G

A

K

R

E

Q

M

C

L

L

S

A

E

E

F

F

M

L

G

G

T

V

M

F

V

V

L

L

I

M

I

L

F

L

G

T

A

Q

G

G

N

A

V

V

A

A

M

Q

T

A

V

V

L

T

F

S

G

G

K

E

T

T

L

K

N

G

I

N

T

F

W

F

D

T

N

M

I

F

T

L

F

A

G

G

W

-

G

S

L

L

A

A

V

V

L

T

L

I

G

A

I

I

-

Y

M

V

A

G

G

G

L

N

P

V

S

S

G

G

A

A

H
|
H

I

L

N
|
N

P

P

A

A

V

F

S

S

L

L

A

A

L

M

A

C

A

I

T

V

G

G

R

R

F

L

P

P

W

W

R

V

K

K

V

L

L

P

P

I

Y

Y

S

I

V

L

A

V

Q

Q

V

L

A

L

G

S

G

A

F

F

A

C

G

A

A

S

A

G

-

A

-

T

-

Y

I

V

V

L

F

Y

L

H

D

D

F

A

K

L

A

Q

K

N

W

Y

L

T

G

G

V

G

D

N

P

L

Q

T

L

V

A

T

-

G

-

P

-

K

S

E

T

T

A

A

G

S

I

I

F

F

C

A

T

T

F

Y

P

P

A

A

I

P

T

Y

T

L

S

S

Y

L

L

N

P

N

G

G

F

F

I

L

D

D

Q

Q

I

V

I

L

G

G

T

T

A

G

V

M

L
|
L

M

I

F

V

G

G

I
x
L

L

L

A

A

I

I

G

L

D

D

F

R

A

R

G

N

K

K

N

G

N

V

V

P

G

A

W

G

M

L

G

E

P

P

V

V

L

V

V

V

A

G

A

M

L

L

I

I

V

L

A

A

I

L

G

G

M

L

S

S

L

M

G

G

A

A

M

N

H

C

G

G

Y

I

A

P

I

L

N
|
N

P

P

A

A

R

R

D

D

F

L

G

G

P

P

R

R

F

L

F

F

A

T

L

Y

V

V

A

A

G

G

F

W

T

-

Q

G

P

P

N

E

L

V

M

F

E

S

P

A

G

G

I

N

-

G

-

W

V

W

L

W

V

V

P

P

I

V

V

V

G

A

P

P

I

L

I

V

G

G

G

A

P

T

L

V

G

G

A

T

F

A

I

T

Y

Y

D

Q

binding glycerol: H68 (= H66), N70 (= N68), L158 (= L150), L162 (≠ I154), N202 (= N194)

P37451 Propanediol uptake facilitator PduF from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
34% identity, 98% coverage: 5:250/251 of query aligns to 4:263/264 of P37451

query
sites
P37451

S

S

L

L

G

K

K

A

E

Q

M

C

L

G

S

A

E

E

F

F

M

L

G

G

T

T

M

G

V

L

L

F

I

L

I

F

F

F

G

G

A

I

G

G

N

C

V

L

A

S

M

A

T

L

V

K

L

V

F

A

G

G

K

A

T

S

L

L

N

G

I

L

T

W

W

E

D

I

N

C

I

I

T

I

F

W

G

G

W

L

G

G

L

I

A

S

V

L

L

A

L

V

G

Y

I

L

M

T

A

A

G

G

L

I

P

-

S

S

G

G

A

G

H

H

I

L

N
|
N

P
|
P

A
|
A

V

V

S

T

L

I

A

A

L

L

A

W

A

L

T

F

G

A

R

C

F

F

P

P

W

K

R

Q

K

K

V

V

L

L

P

P

Y

Y

S

I

V

I

A

A

Q

Q

V

F

A

A

G

G

G

A

F

F

A

G

G

G

A

A

A

L

I

L

-

A

-

Y

-

V

-

L

-

Y

-

S

V

L

F

F

L

T

D

E

F

F

K

E

A

T

K

A

W

H

L

H

G

M

V

V

D

R

P

G

Q

S

L

V

A

E

S

S

T

L

-

Q

-

L

A

A

G

S

I

I

F

F

C

S

T

T

F

Y

P

P

A

A

I

A

T

A

T

L

S

N

Y

V

L

W

P

Q

G

A

F

A

I

L

D

V

Q

E

I

V

G

I

T

T

A

S

V

I

L

L

M

M

F

G

G

M

I

I

L

M

A

A

I

L

G

T

D

D

F

D

A

G

G

N

K

G

N

I

N

P

V

K

G

G

W

P

M

L

G

A

P

P

V

L

L

L

V

I

A

G

A

I

L

L

I

V

V

A

A

V

I

I

G

G

M

A

S

S

L

T

G

G

A

P

M

L

H

T

G

G

Y

F

A

A

I

M

N
|
N

P
|
P

A
|
A

R

R

D

D

F

F

G

G

P

P

R

K

F

L

F

F

A

T

L

W

V

L

A

A

G

G

F

W

T

G

Q

N

P

M

N

A

L

M

-

S

-

G

M

R

E

E

P

I

G

P

I

Y

V

F

L

I

V

V

P

P

I

I

V

V

G

A

P

P

I

V

I

I

G

G

G

A

P

C

L

A

G

G

A

A

F

A

I

I

Y

Y

D

R

W

Y

T

F

T

I

G

G

A

K

-

N

-

L

-

P

V

C

N

N

K

R

A

C

Q

E

NPA 66:68 (= NPA 68:70) NPA 1
NPA 201:203 (= NPA 194:196) NPA 2

I1CR68 Aquaporin-1 from Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar) (see paper)
36% identity, 91% coverage: 8:235/251 of query aligns to 59:292/306 of I1CR68

query
sites
I1CR68

K

R

E

E

M

F

L

L

S

A

E

E

F

F

M

I

G

G

T

T

M

V

V

I

L

L

I

V

I

L

F

L

G

T

A

C

G

G

N

F

V

C

A

A

M

E

T

Q

V

T

L

L

F

H

G

I

K

E

T

E

L

-

N

S

I

K

T

S

W

W

D

L

N

T

I

S

T

S

F

F

G

G

W

S

G

G

L

L

A

S

V

V

L

L

L

I

G

G

I

I

-

C

M

V

A

S

G

G

L

H

P

V

S

S

G

G

A

A

H

H

I

L

N

N

P

P

A

A

V

V

S

T

L

I

A

A

L

F

A

C

A

I

T

F

G

S

R

G

F

F

P

P

W

I

R

R

K

K

V

V

L

P

P

S

Y

Y

S

I

V

T

A

A

Q

Q

V

L

A

L

G

G

G

A

F

F

A

A

G

G

A

A

I

L

V

L

F

Y

L

I

D

I

F

I

K

E

A

P

K

A

W

I

L

V

G

Q

V

F

D

D

P

G

Q

G

L

Q

-

R

-

Y

-

I

-

L

-

G

-

E

A

K

S

S

T

T

A

A

G

G

I

I

F

F

C

G

T

T

F

Y

P

P

A

P

I

L

T

Y

T

V

S

G

Y

I

L

G

P

S

G

A

F

I

I

A

D

S

Q

E

I

I

I

M

G

G

T

T

A

A

V

M

L

L

M

L

F

L

G

V

I

I

L

M

A

V

I

T

G

G

D

H

F

-

A

-

G

-

K

P

N

N

V

L

G

P

W

Y

M

K

G

S

P

A

-

Q

-

G

V

A

L

M

V

I

A

A

A

L

L

G

I

I

V

T

A

T

I

I

G

S

M

L

S

C

L

I

G

G

A

Y

M

T

H

S

G

G

Y

F

A

S

I

L

N

N

P

P

A

A

R

R

D

D

F

F

G

G

P

P

R

R

F

L

F

F

A

T

L

A

V

I

A

A

-

G

-

W

G

G

F

F

T

D

Q

V

P

F

N

K

L

V

M

Y

E
x
H

P

Y

G

-

I

Y

V

A

L

L

V

V

P

P

I

M

V

F

G

A

P

P

I

I

I

L

G

G

P

L

L

V

G

G

H275 (≠ E217) mutation to A: Affects pH sensing; when associated with A-85.

O14520 Aquaporin-7; AQP-7; Aquaglyceroporin-7; Aquaporin adipose; AQPap; Aquaporin-7-like from Homo sapiens (Human) (see 4 papers)
38% identity, 92% coverage: 8:239/251 of query aligns to 35:272/342 of O14520

query
sites
O14520

K

R

E

E

M

F

L

L

S

A

E

E

F

F

M

M

G

S

T

T

M

Y

V

V

L

M

I

M

I

V

F

F

G

G

A

L

G

G

N

S

V

V

A

A

M

H

T

M

V
|
V

L

L

F

N

G

K

K

K

T

Y

L

G

N

S

I

Y

T

L

W

G

D

V

N

N

I

L

T

G

F

F

G

G

W

F

G

G

L

-

A

-

V

V

L

T

L

M

G

G

I

V

-

H

M

V

A

A

G

G

L

R

P

I

S

S

G

G

A

A

H

H

I

M

N

N

P

A

A

A

V

V

S

T

L

F

A

A

L

N

A

C

A

A

T

L

G

G

R

R

F

V

P

P

W

W

R

R

K

K

V

F

L

P

P

V

Y

Y

S

V

V

L

A

G

Q

Q

V

F

A

L

G

G

G

S

F

F

A

L

G

A

A

A

I

T

V

I

F

Y

-

S

-

L

-

F

-
x
Y

-

T

-

A

-

I

L

L

D

H

F

F

K

S

A

G

K

G

W

Q

L

L

G

M

V

V

D

T

P

G

Q

P

L

V

A

A

S

-

T

T

A

A

G

G

I

I

F

F

C

A

T

T

F

Y

P

L

A

P

I

D

T
x
H

T

M

S

T

Y

L

L

W

P

R

G

G

F

F

I

L

D

N

Q

E

I

A

I

W

G

L

T

T

A

G

V

M

L

L

M

Q

F

L

G

C

I

L

L

F

A

A

I

I

G

T

D

D

F

Q

A

E

G

N

K

N

N

P

N

A

V

L

G

P

W

G

M

T

G

E

P

A

V

L

L

V

V

I

A

G

A

I

L

L

I

V

V

V

A

I

I

I

G

G

M

V

S

S

L

L

G

G

A

M

M

N

H

T

G

G

Y

Y

A

A

I

I

N

N

P

P

A

S

R

R

D

D

F

L

G

P

P

P

R

R

F

I

F

F

A

T

L

F

V

I

A

A

G

G

F

W

T

G

Q

K

P

Q

N

V

L

F

M

S

E

N

-

G

P

E

G

N

I

W

V

W

L

W

V

V

P

P

I

V

V

V

G

A

P

P

I

L

G
|
G

G

A

P

Y

L

L

G

G

A

G

F

I

I

I

Y

Y

V59 (= V32) to L: in dbSNP:rs4008659
Y135 (vs. gap) Important for permeability to glycerol; mutation to A: Strongly decreased permeability to glycerol. Mildly decreased water permeability.
H165 (≠ T133) mutation to A: Decreased permeability to glycerol. Mildly decreased water permeability.
G264 (= G231) to V: affects water and glycerol transport; dbSNP:rs62542743

Sites not aligning to the query:

1:32 mutation Missing: Decreased interaction with PLIN1.
12 R → C: in dbSNP:rs139297434

6n1gA Crystal structure of aquaglyceroporin aqp7 (see paper)
38% identity, 92% coverage: 8:239/251 of query aligns to 4:241/249 of 6n1gA

query
sites
6n1gA

K

R

E

E

M

F

L

L

S

A

E

E

F

F

M

M

G

S

T

T

M

Y

V

V

L

M

I

M

I

V

F

F

G

G

A

L

G

G

N

S

V

V

A

A

M

H

T

M

V

V

L

L

F

N

G

K

K

K

T

Y

L

G

N

S

I

Y

T

L

W

G

D

V

N

N

I

L

T

G

F

F

G

G

W

F

G

G

L

-

A

-

V

V

L

T

L

M

G

G

I

V

-

H

M

V

A

A

G

G

L

R

P

I

S

S

G

G

A

A

H

H

I

M

N

N

P

A

A

A

V

V

S

T

L

F

A

A

L

N

A

C

A

A

T
x
L

G
|
G

R
|
R

F

V

P

P

W

W

R

R

K

K

V

F

L

P

P

V

Y

Y

S

V

V

L

A

G

Q

Q

V

F

A

L

G

G

G

S

F

F

A

L

G

A

A

A

I

T

V

I

F

Y

-

S

-

L

-

F

-

Y

-

T

-

A

-

I

L

L

D

H

F

F

K

S

A

G

K

G

W

Q

L

L

G

M

V

V

D

T

P

G

Q

P

L

V

A

A

S

-

T

T

A

A

G

G

I

I

F

F

C

A

T

T

F

Y

P

L

A

P

I

D

T

H

T

M

S

T

Y

L

L

W

P

R

G

G

F

F

I

L

D

N

Q

E

I

A

I

W

G

L

T

T

A

G

V

M

L

L

M

Q

F

L

G

C

I

L

L
x
F

A

A

I

I

G

T

D

D

F

Q

A

E

G

N

K

N

N

P

N

A

V

L

G

P

W

G

M

T

G

E

P

A

V

L

L

V

V

I

A

G

A

I

L

L

I

V

V

V

A

I

I

I

G

G

M

V

S

S

L

L

G

G

A

M

M

N

H

T

G

G

Y

Y

A

A

I

I

N

N

P

P

A

S

R

R

D

D

F

L

G

P

P

P

R

R

F

I

F

F

A

T

L

F

V

I

A

A

G

G

F

W

T

G

Q

K

P

Q

N

V

L

F

M

S

E

N

-

G

P

E

G

N

I

W

V

W

L

W

V

V

P

P

I

V

V

V

G

A

P

P

I

L

G

G

G

A

P

Y

L

L

G

G

A

G

F

I

I

I

Y

Y

binding glycerol: L73 (≠ T78), G74 (= G79), R75 (= R80), F156 (≠ L155)

3c02A X-ray structure of the aquaglyceroporin from plasmodium falciparum (see paper)
33% identity, 93% coverage: 8:240/251 of query aligns to 4:232/242 of 3c02A

query
sites
3c02A

K

R

E

E

M

F

L

I

S

G

E

E

F

F

M

L

G

G

T

T

M

F

V

V

L
|
L

I

M

I

F

F

L

G

G

A

E

G

G

N

A

V

T

A

A

M

N

T
x
F

V

H

L

T

F

T

G

G

K

-

T

-

L

L

N

S

I

G

T

D

W
|
W

D

Y

N

K

I

L

T

C

F

L

G

G

W
|
W

G

G

L

L

A

A

V
|
V

L

F

G

G

I
|
I

M

L

A

V

G

S

L

A

P

K

-

L

S

S

G
|
G

A
|
A

H
|
H

I
x
L

N
|
N

P

L

A

A

V

V

S

S

L

I

A

G

L
|
L

A

S

T

I

G

N

R

K

F

F

P

D

W

L

R

K

K

K

V

I

L

P

P

V

Y

Y

S

F

V

F

A

A

Q

Q

V

L

A

L

G

G

G

A

F

F

A

V

G

G

A

T

A

S

I

T

V

V

F

Y

L

G

D

L

F

Y

K

H

A

G

K

F

W

I

L

S

G

N

V

S

D

K

-

I

P

P

Q

Q

L

F

A

A

S

W

T

E

A

T

G
x
S

I

-

F

-

C

-

T

R

F
x
N

P
|
P

A

S

I

I

T

S

T

L

S

T

Y

-

L

-

P

G

G

A

F

F

I

F

D

N

Q

E

I

L

I

I

G

L

T

T

A

G

V

I

L
|
L

M

L

F

L

G

V

I
|
I

L

L

A

V

I

V

G
x
V

D

D

-

E

-

N

F

I

A

C

G

G

K

K

N

F

N

H

V

I

G

L

W

K

M

L

G

S

P

S

V

V

L

-

V

V

A

G

A

L

L

I

I
|
I

V

L

A

C

I

I

G

G

M

I

S

T

L

F

G

G

A
x
G

M

N

H
x
T

G
|
G

Y
x
F

A
|
A

I

L

N
|
N

P

P

A

S

R
|
R

D

D

F

L

G

G

P

S

R

R

F

F

F

L

A

S

L

L

V

I

A

A

-

Y

-

G

-

K

-

D

G

T

F

F

T

T

Q

K

P

D

N

N

L

F

M

Y

E

-

P

-

G

-

I

-

V

F

L

W

V

V

P

P

I

L

V

V

G

A

P

P

I

C

I

V

G

G

G

S

P

V

L

V

G

F

A

C

F

Q

I

F

Y

Y

D

D

binding glycerol: L16 (= L20), F27 (≠ T31), W36 (= W42), W43 (= W49), V47 (= V53), I51 (= I57), G59 (= G64), A60 (= A65), H61 (= H66), H61 (= H66), L62 (≠ I67), N63 (= N68), L70 (= L75), S120 (≠ G124), N122 (≠ F129), P123 (= P130), L141 (= L150), I145 (= I154), V149 (≠ G158), I170 (= I178), G179 (≠ A187), G179 (≠ A187), T181 (≠ H189), G182 (= G190), G182 (= G190), F183 (≠ Y191), A184 (= A192), N186 (= N194), R189 (= R197)

2evuA Crystal structure of aquaporin aqpm at 2.3a resolution (see paper)
32% identity, 96% coverage: 4:243/251 of query aligns to 2:244/245 of 2evuA

query
sites
2evuA

I

V

S

S

L

L

G

T

K

K

E

R

M

C

L

I

S

A

E

E

F

F

M

I

G

G

T

T

M

F

V

I

L
|
L

I

V

I

F

F

F

G

G

A

A

G

G

N

S

V
x
A

A

A

M

V

T

T

V

L

L

M

F

I

-
x
A

-
x
S

-

G

G
|
G

K

T

T
x
S

L

P

N

N

-

P

-

F

-
x
N

-
x
I

-
x
G

-
x
I

-

G

-

L

-

G

-

L

I

G

T

D

W
|
W

D

V

N

A

I

I

T

G

F

L

G

A

W

F

G

G

L

F

A

A

V
x
I

L

A

G

S

I

I

M

Y

A

A

-

L

G

G

L

N

P

I

S

S

G
|
G

A
x
C

H
|
H

I
|
I

N
|
N

P

P

A

A

V

V

S

T

L

I

A

G

L
|
L

A

W

A

S

T

V

G

K

R

K

F

F

P

P

W

G

R

R

K

E

V

V

L

V

P

P

Y

Y

S

I

V

I

A

A

Q

Q

V

L

A

L

G

G

G

A

F

A

A

F

G

G

A

S

A

-

I

-

V

-

F

F

L

I

D

F

F

L

K

Q

A

C

K

A

W

G

L

I

G

G

V

A

D

-

P

-

Q

-

L

-

A

A

S
x
T

T

V

A

G

G
|
G

I

L

F
x
G

C
x
A

T
|
T

F
x
A

P
|
P

A
x
F

I
x
P

T

G

T

I

S

S

Y

Y

L

W

P

Q

G

A

F

M

I

L

D

A

Q

E

I

V

G

G

T

T

A

F

V

L

L
|
L

M

M

F

I

G

T

I
|
I

L

M

-

G

-

I

A
|
A

I

V

G

D

D

E

F

R

A

A

G

P

K

K

N

G

N

F

V

A

G

G

W

I

M

I

G
x
I

P

G

V

L

L

T

V

V

A

A

A

G

L

I

I

I

V

T

A

-

I

-

G

-

M

-

S

T

L

L

G

G

A

N

M

I

H

S

G
|
G

Y

S

A

S

I

L

N
|
N

P

P

A

A

R
|
R

D

T

F

F

G

G

P

P

R

Y

F

L

F

N

A

D

L

M

V

I

-

F

A

A

G

G

F

T

T

D

Q

L

P

W

N

N

L

Y

M

Y

E

S

P

-

G

-

I

-

V

-

L

-

V

I

P

Y

I

V

V

I

G

G

P

P

I

I

I

V

G

G

G

A

P

V

L

L

G

A

A

A

F

L

I

T

Y

Y

D

Q

W

Y

T

L

T

T

binding glycerol: L18 (= L20), A26 (≠ V28), A33 (vs. gap), S34 (vs. gap), G36 (= G35), S38 (≠ T37), N43 (vs. gap), I44 (vs. gap), I44 (vs. gap), G45 (vs. gap), I46 (vs. gap), W55 (= W42), I66 (≠ V53), G78 (= G64), C79 (≠ A65), H80 (= H66), I81 (= I67), N82 (= N68), L89 (= L75), T128 (≠ S121), G131 (= G124), G133 (≠ F126), A134 (≠ C127), T135 (= T128), A136 (≠ F129), P137 (= P130), F138 (≠ A131), P139 (≠ I132), L157 (= L150), I161 (= I154), A165 (= A156), I179 (≠ G170), G195 (= G190), N199 (= N194), R202 (= R197)

P08995 Nodulin-26; N-26 from Glycine max (Soybean) (Glycine hispida) (see paper)
30% identity, 93% coverage: 8:240/251 of query aligns to 38:245/271 of P08995

query
sites
P08995

K

Q

E

K

M

L

L

V

S

A

E

E

F

A

M

V

G

G

T

T

M

Y

V

F

L

L

I

I

I

F

F

A

G

G

A

C

G

A

N

S

V

L

A

V

M

V

T

N

V

E

L

N

F

Y

G

Y

K

N

T

M

L

-

N

-

I

I

T

T

W

F

D

P

N

G

I

I

T

A

F

I

G

V

W

W

G

G

L

L

A

V

V

L

-

T

L

V

L

L

G

V

I

Y

M

T

A

V

G

G

L

H

P

I

S

S

G

G

A

G

H

H

I

F

N

N

P

P

A

A

V

V

S

T

L

I

A

A

L

F

A

A

A

S

T

T

G

R

R

R

F

F

P

P

W

L

R

I

K

Q

V

V

L

P

P

A

Y

Y

S

V

V

V

A

A

Q

Q

V

L

A

L

G

G

G

S

F

I

A

L

G

A

A

S

A

G

I

T

V

L

F

R

L

L

D

L

F

F

K

-

A

-

K

-

W

-

L

M

G

G

V

N

D

H

P

D

Q

Q

L

F

A

S

S

G

T

T

A

V

G

-

I

-

F

-

C

-

T

-

F

-

P

P

A

N

I

G

T

T

T

N

S

-

Y

-

L

L

P

Q

G

A

F

F

I

V

D

F

Q

E

I

F

I

I

G

M

T

T

A

F

V

F

L

L

M

M

F

F

G

V

I

I

L

C

-

G

-

V

-

A

-

T

-

D

-

N

-

R

A

A

I

V

G

G

D

E

F

F

A

A

G

G

K

I

N

A

N

-

V

-

G

-

W

-

M

I

G

G

P

S

V

T

L

L

V

L

A

L

A

N

L

V

I

I

V

I

A

G

I

-

G

-

M

-

S

-

L

-

G

G

A

P

M

V

H

T

G

G

Y

A

A

S

I

M

N

N

P

P

A

A

R

R

D

S

F

L

G

G

P

P

R

A

F

F

F

-

A

-

L

-

V

V

A

H

G

G

F

-

T

-

Q

-

P

-

N

-

L

-

M

-

E

E

P

Y

G

E

I

G

V

I

L

W

V

I

P

Y

I

L

V

L

G

A

P

P

I

V

G

G

G

A

P

I

L

A

G

G

A

A

F

W

I

V

Y

Y

D

N

Sites not aligning to the query:

262 modified: Phosphoserine; by CPK

Q92R43 Aquaglyceroporin AqpS from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
39% identity, 43% coverage: 1:109/251 of query aligns to 1:110/233 of Q92R43

query
sites
Q92R43

M

M

K

Q

E

E

I

F

S

D

L

L

G

T

K

R

E

R

M

C

L

V

S

A

E

E

F

A

M

L

G

G

T

T

M

G

V

L

L

L

I

V

-

A

I

V

F

V

G

G

A

S

G

G

N

I

V

M

A

A

M

D

T

A

V

L

L

T

F

A

G

D

K

D

T

A

L

L

N

A

I

L

T

V

W

A

D

N

N

T

I

I

T

A

F
x
T

G

G

W

A

G

I

L

L

A

V

V

V

L

L

L

V

G

T

I

I

M

L

A

G

G

P

L

L

P

-

S

S

G

G

A

A

H

H

I

F

N

N

P

P

A

A

V

V

S

S

L

L

A

V

L

F

A

A

A

L

T

S

G

G

R

R

F

L

P

T

W

R

R

R

K

D

V

C

L

A

P

A

Y

Y

S

V

V

I

A

A

Q

Q

V

V

A

A

G

G

G

A

F

I

A

A

G

G

A

T

A

A

I

L

V

A

F

H

L

L

D

M

F

F

K

D

T49 (≠ F47) mutation T->F,W: Increases uptake of both methylarsenite and methylarsenate and exhibits higher sensitivity to methylarsenite.

Sites not aligning to the query:

177 V→I: Decreases methylarsenite transport activity and results in higher resistance to methylarsenite. Slight decrease in methylarsenate transport activity.; V→R: Increases methylarsenite transport activity, leading to lower resistance to methylarsenite. Nearly complete loss of methylarsenate transport activity.

P09011 Lens fiber major intrinsic protein; Aquaporin-0; MIP26; MP26 from Rattus norvegicus (Rat) (see 2 papers)
28% identity, 96% coverage: 1:241/251 of query aligns to 2:219/261 of P09011

query
sites
P09011

M

L

K

R

E

S

I

A

S

S

L

F

G

W

K

R

E

A

M

I

L

F

S

A

E

E

F

F

M

F

G

A

T

T

M

L

V

F

L

Y

I

V

I

F

F

F

G

G

A

L

G

G

N

S

V

S

A

L

M

R

T

W

V

A

L

-

F

-

G

P

K

G

T

P

L

L

N

H

I

V

T

L

W

Q

D

V

N

A

I

L

T

A

F

F

G

G

W

L

G

A

L

L

A

A

V

T

L

L

L

V

G

Q

I

T

M

V

A

-

G

G

L

H

P

I

S

S

G

G

A

A

H

H

I

V

N

N

P

P

A

A

V

V

S

T

L

F

A

A

L

F

A

L

A

V

T

G

G

S

R

Q

F

M

P

S

W

L

R

L

K

R

V

A

L

F

P

C

Y

Y

S

I

V

A

A

A

Q

Q

V

L

A

L

G

G

G

A

F

V

A

A

G

G

A

A

I

V

V

L

F

Y

-

S

-

V

-

T

-

P

-

A

-

V

-

R

-

G

-

N

L

L

D

A

F

L

K

N

A

T

K

L

W

H

L

A

G

G

V

V

D

S

P

V

Q

G

L

Q

A

A

S

T

T

T

A

V

G

E

I

I

F

F

C

L

T

T

F

-

P

-

A

-

I

-

T

-

S

-

Y

-

L

-

P

-

G

-

F

-

I

-

D

-

Q

-

I

-

G

-

T

-

A

-

V

-

L

L

M

Q

F

F

G

V

I

L

L

C

A

I

I

F

G

A

D

T

F

Y

A

D

G

E

K

R

N

R

N

N

V

-

G

G

W

R

M

M

G

G

P

S

V

V

L

-

V

-

A

-

A

A

L

L

I

A

V

V

A

G

I

F

G

S

M

L

S

T

L

L

G

G

A

H

M

L

H

F

G

G

Y

M

-

Y

-

T

-

G

-

A

A

G

I

M

N

N

P

P

A

A

R

R

D

S

F

F

G

A

P

P

R

A

F

I

F

-

A

-

L

L

V

T

A

R

G

N

F

F

T

S

Q

N

P

H

N

-

L

-

M

-

E

-

P

-

G

-

I

-

V

-

L

W

V

V

P

Y

I

W

V

V

G

G

P

P

I

I

G

G

P

G

L

L

G

G

A

S

F

L

I

L

Y

Y

D

D

W

F

Sites not aligning to the query:

233 modified: Phosphoserine
244 N→D: No effects.

P55088 Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4 from Mus musculus (Mouse) (see 2 papers)
28% identity, 92% coverage: 8:239/251 of query aligns to 36:252/323 of P55088

query
sites
P55088

K

K

E

A

M

V

L

S

S

A

E

E

F

F

M

L

G

A

T

T

M

L

V

I

L

F

I

V

I

L

F

L

G

G

A

V

G

G

N

S

V

-

A

-

M

-

T

T

V

I

L

N

F

W

G

G

K

G

T

S

L

E

N

N

-

P

-

L

-

P

-

V

-

D

I

M

T

V

W

L

D

I

N

S

I

L

T

C

F

F

G

G

W

L

G

S

L

I

A

A

V

T

L

M

L

V

G

Q

I

C

M

F

A

-

G

G

L

H

P

I

S

S

G

G

A

G

H

H

I

I

N

N

P

P

A

A

V

V

S

T

L

V

A

A

L

M

A

V

A

C

T

T

G

R

R

K

F

I

P
x
S

W

I

R

A

K

K

V

S

L

V

P

F

Y

Y

S

I

V

I

A

A

Q

Q

V

C

A

L

G

G

G

A

F

I

A

I

G

G

A

A

A

G

I

I

V

L

F

Y

L

L

D

V

F

-

K

-

A

-

K

-

W

-

L

-

G

-

V

T

D

P

P

P

Q

S

L

V

A

V

S

G

T

G

A

L

G

G

I

V

F

T

C

T

T

V

F

H

P

G

A

N

I

L

T

T

T

A

S

G

Y

H

L

-

P

-

G

G

F

L

I

L

D

V

Q

E

I

L

I

I

G

I

T

T

A

F

V

Q

L

L

M

V

F

F

G

T

I

I

L

F

A

A

I

S

G

C

D

D

F

S

A

K

G

R

K

T

N

D

N

V

V

T

G

G

W

-

M

-

G

-

P

-

V

-

L

-

V

-

A

-

A

S

L

I

I

A

V

L

A

A

I

I

G

G

M

F

S

S

L

V

G

A

A

I

M

G

H

H

G

L

Y

F

A

A

I

I

-

N

-

Y

-

T

-

G

-

A

-

S

-

M

N

N

P

P

A

A

R

R

D

S

F

F

G

G

P

P

R

-

F

-

A

A

L

V

V

I

A

M

G

G

F

-

T

-

Q

-

P

-

N

N

L

W

M

A

E

N

P

H

G

W

I

I

V

Y

L

W

V

V

-

G

P

P

I

I

V

M

G

G

P

A

I

V

I

L

G

A

G

G

P

A

L

L

G

Y

A

E

F

Y

I

V

Y

F

S111 (≠ P82) modified: Phosphoserine; by PKG; mutation to A: Loss of phosphorylation by PKG (in vitro). No effect on location at cell membrane.

Sites not aligning to the query:

4 natural variant: G -> R

P30301 Lens fiber major intrinsic protein; Aquaporin-0; MIP26; MP26 from Homo sapiens (Human) (see 10 papers)
28% identity, 96% coverage: 1:241/251 of query aligns to 4:221/263 of P30301

query
sites
P30301

M

L

K

R

E

S

I

A

S

S

L

F

G

W

K

R

E

A

M

I

L

F

S

A

E

E

F

F

M

F

G

A

T

T

M

L

V

F

L

Y

I

V

I

F

F

F

G

G

A

L

G

G

N

S

V

S

A

L

M
x
R

T

W

V

A

L

-

F

-

G

P

K

G

T

P

L

L

N

H

I

V

T

L

W

Q

D

V

N

A

I

M

T

A

F

F

G

G

W

L

G

A

L

L

A

A

V

T

L

L

L

V

G

Q

I

S

M

V

A

-

G

G

L

H

P

I

S

S

G

G

A

A

H

H

I

V

N

N

P

P

A

A

V

V

S

T

L

F

A

A

L

F

A

L

A

V

T

G

G

S

R

Q

F

M

P

S

W

L

R

L

K

R

V

A

L

F

P

C

Y

Y

S

M

V

A

A

A

Q

Q

V

L

A

L

G

G

G

A

F

V

A

A

G

G

A

A

I

V

V

L

F

Y

L

S

D
x
V

F

-

K

-

A

-

K

-

W

-

L

-

G

-

V

T

D

P

P

P

Q

A

L

V

A

R

S

G

T

N

A

L

G

A

I

L

F

N

C

T

T

L

F

H

P

P

A

A

I

V

T

S

T

V

S

G

Y

-

L

-

P

Q

G

A

F

T

I

T

D

V

Q
x
E

I

I

I

F

G

L

T
|
T

A

L

V

Q

L

F

M

V

F

L

G

C

I

I

L

F

A

A

I

T

G

Y

D
|
D

F

-

A

-

G

-

K

E

N

R

V

N

G

G

W

Q

M

L

G

G

P

S

V

V

L

-

V

-

A

-

A

A

L

L

I

A

V

V

A
x
G

I

F

G

S

M

L

S

A

L

L

G

G

A

H

M

L

H

F

G

G

Y

M

-
x
Y

-

Y

-

T

-

G

-

A

A

G

I

M

N

N

P

P

A

A

R

R

D

S

F

F

G

A

P

P

R

A

F

I

F

-

A

-

L

L

V

T

A

G

G

N

F

F

T

T

Q

N

P

H

N

-

L

-

M

-

E

-

P

-

G

-

I

-

V

-

L

W

V

V

P
x
Y

I
x
W

V
|
V

G
|
G

P
|
P

I
|
I

G
|
G

P
x
G

L
|
L

G
|
G

A
x
S

F
x
L

I
x
L

Y
|
Y

D
|
D

W
x
F

R33 (≠ M30) to C: in CTRCT15; reduces cell-to-cell adhesion, reduces cell-to-cell gap junction coupling, no loss of cell membrane localization, no loss of water channel activity; dbSNP:rs864309693
V107 (≠ D107) to I: in CTRCT15; likely benign variant; dbSNP:rs74641138
E134 (≠ Q143) to G: in CTRCT15; non-progressive lamellar cataract; loss of activity; dbSNP:rs121917869
T138 (= T147) to R: in CTRCT15; progressive polymorphic and lamellar cataract; loss of activity; dbSNP:rs121917867
D150 (= D159) to H: in CTRCT15; loss of plasma membrane expression; dbSNP:rs778327521
G165 (≠ A180) to D: in CTRCT15; unknown pathological significance; loss of plasma membrane expression
Y177 (vs. gap) to C: in CTRCT15; unknown pathological significance

Sites not aligning to the query:

204:263 natural variant: Missing (in CTRCT15; unknown pathological significance)
211:263 natural variant: Missing (in CTRCT15; unknown pathological significance)
235 modified: Phosphoserine
246 modified: Deamidated asparagine; by deterioration
259 modified: Deamidated asparagine; by deterioration

P06624 Lens fiber major intrinsic protein; Aquaporin-0; MIP26; MP26 from Bos taurus (Bovine) (see 4 papers)
28% identity, 96% coverage: 1:241/251 of query aligns to 4:221/263 of P06624

query
sites
P06624

M

L

K

R

E

S

I

A

S

S

L

F

G

W

K

R

E

A

M

I

L

C

S

A

E

E

F

F

M

F

G

A

T

S

M

L

V

F

L

Y

I

V

I

F

F

F

G

G

A

L

G

G

N

-

V

-

A

A

M

S

T

L

V

R

L

W

F

A

G

P

K

G

T

P

L

L

N

H

I

V

T

L

W

Q

D

V

N

A

I

L

T

A

F

F

G

G

W

L

G

A

L

L

A

A

V

T

L

L

L

V

G

Q

I

A

M

V

A

-

G

G

L

H

P

I

S

S

G

G

A

A

H

H

I

V

N

N

P

P

A

A

V

V

S

T

L

F

A

A

L

F

A

L

A

V

T

G

G

S

R

Q

F

M

P

S

W

L

R

L

K

R

V

A

L

I

P

C

Y

Y

S

M

V

V

A

A

Q

Q

V

L

A

L

G

G

G

A

F

V

A

A

G

G

A

A

I

V

V

L

F

Y

L

S

D

V

F

-

K

-

A

-

K

-

W

-

L

-

G

-

V

T

D

P

P

P

Q

A

L

V

A

R

S

G

T

N

A

L

G

A

I

L

F

N

C

T

T

L

F

H

P

P

A

G

I

V

T

S

T

V

S

G

Y

-

L

-

P

Q

G

A

F

T

I

I

D

V

Q

E

I

I

I

F

G

L

T

T

A

L

V

Q

L

F

M

V

F

L

G

C

I

I

L

F

A

A

I

T

G
x
Y

D

D

F

-

A

-

G

-

K

E

N

R

V

N

G

G

W

R

M

L

G

G

P

S

V

V

L

-

V

-

A

-

A

A

L

L

I

A

V

V

A

G

I

F

G

S

M

L

S

T

L

L

G

G

A

H

M

L

H

F

G

G

Y

M

-

Y

-

T

-

G

-

A

A

G

I

M

N

N

P

P

A

A

R

R

D

S

F

F

G

A

P

P

R

A

F

I

F

-

A

-

L

L

V

T

A

R

G

N

F

F

T

T

Q

N

P

H

N

-

L

-

M

-

E

-

P

-

G

-

I

-

V

-

L

W

V

V

P

Y

I

W

V

V

G

G

P

P

I

V

I

I

G

G

G

A

P

G

L

L

G

G

A

S

F

L

I

L

Y

Y

D

D

W

F

Y149 (≠ G158) mutation to G: Increases constitutive water permeability. Abolishes regulation by cytoplasmic calcium levels.; mutation to L: Strongly decreases water permeability. Abolishes regulation by cytoplasmic calcium levels.; mutation to S: Slightly decreases water permeability, but has a minor effect on the regulation by cytoplasmic calcium levels.

Sites not aligning to the query:

227 L→A: Strongly reduced CALM binding.
227:237 Interaction with CALM
230 V→A: Strongly reduced CALM binding.
235 modified: Phosphoserine
243 modified: Phosphoserine; by PKA
245 modified: Phosphoserine
246 Interaction with BFSP1; modified: Deamidated asparagine
250 interaction with BFSP1

P55064 Aquaporin-5; AQP-5 from Homo sapiens (Human) (see 2 papers)
31% identity, 92% coverage: 8:239/251 of query aligns to 12:221/265 of P55064

query
sites
P55064

K

K

E

A

M

V

L

F

S

A

E

E

F

F

M

L

G

A

T

T

M

L

V

I

L

F

I

V

I

F

F

F

G

G

A

L

G

G

N

-

V

-

A

-

M

-

T

S

V

A

L

L

F

K

G

W

K

P

T

S

L
x
A

N

L

I

P

T

T

W

I

D

L

N

Q

I
|
I

T

A

F

L

G

A

W

F

G

G

L

L

A

A

V

I

-

G

L

T

L

L

G

A

I

Q

M

A

A

L

G

G

L

P

P

V

S

S

G

G

A

G

H

H

I

I

N

N

P

P

A

A

V

I

S

T

L

L

A

A

L

L

A

L

A

V

T

G

G

N

R

Q

F

I

P

S

W

L

R

L

K

R

V

A

L

F

P

F

Y

Y

S

V

V

A

A

A

Q

Q

V

L

A

V

G

G

G

A

F

I

A

A

G

G

A

A

A

G

I

I

V

L

F

Y

L

-

D

-

F

-

K

-

A

-

K

-

W

-

L

-

G

G

V

V

D

A

P

P

Q

-

L

L

A

N

S

A

T

R

A

G

G

N

I

L

F

A

C

V

T

N

F

A

P

L

A
x
N

I

N

T

N

T

T

S

T

Y

Q

L

G

P

Q

G

A

F

M

I

V

D

V

Q

E

I

L

I

I

G

L

T

T

A

F

V

Q

L

L

M

A

F

L

G

C

I

I

L

F

A

A

I

S

G

T

D

D

F

S

A

R

G

R

K

T

N
x
S

N

P

V

V

G

G

W

-

M

-

G

S

P

P

V

A

L

L

V

S

A

I

A

G

L

L

I

S

V

V

A

T

I

L

G

G

M

H

S

L

L

V

G

G

-
x
I

A

Y

M

F

H

T

G

G

Y

C

A

S

I

M

N

N

P

P

A

A

R
|
R

D

S

F

F

G

G

P

P

R

-

F

-

A

A

L

V

V

V

A

M

G

N

F

R

T

F

Q

S

P

P

N

A

L

H

M

W

E

-

P

-

G

-

I

-

V

-

L

-

V

V

P

F

I

W

V

V

G

G

P

P

I

I

I

V

G

G

G

A

P

V

L

L

G

A

A

A

F

I

I

L

Y

Y

A38 (≠ L38) to E: in PPKB; retains the ability to traffic to the cell membrane; dbSNP:rs398123054
I45 (= I45) to S: in PPKB; retains the ability to traffic to the cell membrane; dbSNP:rs398123055
N123 (≠ A131) to D: in PPKB; retains the ability to traffic to the cell membrane; dbSNP:rs398123057
S156 (≠ N164) mutation to A: No effect on location at the cell membrane.; mutation to E: Increased location at the cell membrane.
I177 (vs. gap) to F: in PPKB; retains the ability to traffic to the cell membrane; dbSNP:rs398123056
R188 (= R197) to C: in PPKB; retains the ability to traffic to the cell membrane; dbSNP:rs368292687

P47863 Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4 from Rattus norvegicus (Rat) (see 4 papers)
27% identity, 93% coverage: 8:241/251 of query aligns to 36:250/323 of P47863

query
sites
P47863

K

K

E

A

M

V

L

T

S

A

E

E

F

F

M

L

G

A

T

M

M

L

V

I

L

F

I

V

I

L

F

L

G

S

A

V

G

G

N

S

V

-

A

-

M

-

T

T

V

I

L

N

F

W

G

G

K

G

T

S

L

E

N

N

-

P

-

L

-

P

-

V

-

D

I

M

T

V

W

L

D

I

N

S

I

L

T

C

F

F

G

G

W

L

G

S

L

I

A

A

V

T

L

M

L

V

G

Q

I

C

M

F

A

-

G

G

L

H

P

I

S

S

G

G

A

G

H

H

I

I

N

N

P

P

A

A

V

V

S

T

L

V

A

A

L

M

A

V

A

C

T

T

G

R

R

K

F

I

P

S

W

I

R

A

K

K

V

S

L

V

P

F

Y

Y

S

I

V

T

A

A

Q

Q

V

C

A

L

G

G

G

A

F

I

A

I

G

G

A

A

A

G

I

I

V

L

F

Y

L

L

D

V

F

-

K

-

A

-

K

-

W

-

L

-

G

-

V

T

D

P

P

P

Q

S

L

V

A

V

S

G

T

G

A

L

G

G

I

V

F

T

C

T

T

V

F

H

P

G

A

N

I

L

T

T

T

A

S

G

Y

H

L

-

P

-

G

G

F

L

I

L

D

V

Q

E

I

L

I

I

G

I

T

T

A

F

V

Q

L

L

M

V

F

F

G

T

I

I

L

F

A

A

I

S

G

C

D

D

F
x
S

A

K

G

R

K

T

N

D

N

V

V

T

G

G

W

-

M

-

G

-

P

-

V

-

L

-

V

-

A

-

A

S

L

V

I

A

V

L

A

A

I

I

G

G

M

F

S

S

L

V

G

A

A

I

M

G

H
|
H

G

L

Y

F

A

A

I

I

-

N

-

Y

-

T

-

G

-

A

-

S

-

M

N

N

P

P

A

A

R

R

D

S

F

F

G

G

P

P

R

-

F

-

A

A

L

V

V

I

A

M

G

G

F

N

T

W

Q

E

P

N

N

H

L

-

M

-

E

-

P

-