SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing 208718 MicrobesOnline__882:208718 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

4whxA X-ray crystal structure of an amino acid aminotransferase from burkholderia pseudomallei bound to the co-factor pyridoxal phosphate
55% identity, 99% coverage: 2:306/309 of query aligns to 1:305/306 of 4whxA

query
sites
4whxA

S

S

M

M

V

A

Q

D

K

R

S

D

E

G

T

K

I

I

W

W

F

M

D

D

G

G

K

K

Q

L

V

I

P

E

W

W

D

R

E

D

A

A

N

K

V

I

H

H

V

V

L

L

T

T

H

H

A

T

L

L

H

H

Y

Y

G

G

V

M

G

G

V

V

F
|
F

E

E

G

G

I

V

R

R

A

A

Y

Y

R

K

C

T

A

A

D

D

G

G

S

G

S

T

A

A

V

I

F

F

R

R

L

L

R

K

E

E

H

H

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Q

K

R

R

L

L

F

L

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N

S

S

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M

M

E

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P

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E

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A

A

A

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Q

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R

E

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L

L

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Y
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Y

I

L

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R

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P

L

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I

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G

A

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G

E

A

K

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Y

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D

G

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N

P

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Q

H

T

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I

A

I

I

A

A

V

A

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W

P

P

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W

G

G

A

A

Y

Y

L

L

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G

A

E

E

E

A

G

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L

E

A

K

K

G

G

I

I

R

R

V

V

K

K

T

T

S

S

F

F

A

T

R

R

H

H

V

V

N

N

A

V

M

S

M

M

T

V

K

R

A

A

K
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K

A

A

S

S

G

G

N

W

Y

Y

V

V

N

N

S

S

V

I

L

L

A

A

K

N

M

Q

E

E

A

A

K

T

A

A

D

D

G

G

Y

Y

D

D

E

E

A

A

L

L

M

L

L

L

D

D

V

V

S

D

G

G

F

Y

V

V

S

S

E
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E

A

G

T

S

G
|
G

E

E

N

N

I

F

F

F

M

L

V

V

R

N

N

R

G

G

V

K

I

L

K

Y

T

T

T

P

P

D

L

L

T

A

S

S

I

C

L
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L

D

D

G

G

I

I

T

T

R

R

N

D

S

T

L

V

M

I

T

T

L

L

A

A

R

K

D

E

L

A

G

G

Y

I

E

E

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V

I

E

E

Q

K

Q

R

F

I

T

T

R

R

D

D

E

E

L

V

Y

Y

V

T

A

A

D

D

E

E

A

A

F

F

C

T

G

G

T
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T

A
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A

A

A

E

E

V

V

T

T

P

P

I

I

R

R

E

E

V

L

D

D

R

N

R

R

V

T

I

I

G

G

K

G

G

G

S

A

A

R

G

G

P

P

V

I

T

T

K

E

H

K

L

L

Q

Q

Q

S

E

A

Y

F

F

F

K

D

A

V

V

V

K

N

G

G

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S

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K

Y

H

D

A

H

D

W

W

L

L

H

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R

K

active site: F37 (= F38), K160 (= K161), E194 (= E195), L217 (= L218)
binding alanine: Y97 (= Y98), K160 (= K161), G197 (= G198), T257 (= T258), A258 (= A259)

2ej0B Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase with pyridoxamine 5'-phosphate
55% identity, 97% coverage: 6:304/309 of query aligns to 3:301/305 of 2ej0B

query
sites
2ej0B

K

K

S

A

E

G

T

L

I

I

W

W

F

M

D

N

G

G

K

A

Q

F

V

V

P

P

W

Q

D

E

E

E

A

A

N

K

V

T

H

S

V

V

L

L

T

S

H

H

A

A

L

L

H

H

Y

Y

G

G

V

T

G

S

V

V

F
|
F

E

E

G
|
G

I

I

R

R

A

A

Y

Y

R

E

C

T

A

A

D

K

G

G

S

P

S

-

A

A

V

I

F

F

R

R

L

L

R

K

E

E

H

H

V

V

Q

K

R
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R

L

F

F

Y

S

N

S

S

A

A

K

K

I

V

L

L

R

R

M

M

E

E

I

I

P

P

F

F

T

A

E

P

D

E

A

E

I

L

F

E

D

E

A

A

I

I

V

K

E

E

T

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L

V

Q

R

R

R

N

N

R

G

L

Y

A

R

E

S

G

C

Y

Y

I

I

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R

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P

L

L

S

A

F

W

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M

G

G

A

A

G

K

A

A

M

L

G

G

V

V

Y

N

P

P

-

L

G

P

D

N

N

N

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P

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Q

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M

I

V

A

A

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A

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E

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W

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G

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A

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L

L

G

G

A

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E

E

A

A

L

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E

R

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K

G

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I

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K

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W

A

A

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R

H

F

H

P

V

A

N

N

A

V

M

M

M

P

T

G

K

K

A

A

K
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K

A

V

S

G

G

G

N

N

Y
|
Y

V

V

N

N

S

S

V

A

L

L

A

A

K

K

M

M

E

E

A

A

K

V

A

A

D

A

G

G

Y

A

D

D

E

E

A

A

L

L

M

L

L

L

D

D

V

E

S

E

G

G

F

Y

V

V

S

A

E
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E

A

G

T

S

G
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G

E
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E

N
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N

I

L

F

F

M

F

V

V

R

R

N

D

G

G

V

V

I

I

K

Y

T

A

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L

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E

L

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I

N

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L

D

E

G
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G

I
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I

T
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T

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R

N

D

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S

L

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M

I

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R

L

I

A

A

R

K

D

D

L

L

G

G

Y

Y

E

E

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V

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Q

E

V

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Q

R

F

A

T

T

R

R

D

D

E

Q

L

L

Y

Y

V

M

A

A

D

D

E

E

A

V

F

F

F

M

C

T

G
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G

T
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T

A

A

E

E

V

V

T

T

P

P

I

V

R

S

E

M

V

I

D

D

R

W

R

R

V

P

I

I

G

G

K

K

G

G

S

T

A

A

G

G

P

P

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V

T

A

K

L

H

R

L

L

Q

R

Q

E

E

V

Y

Y

F

L

K

E

A

A

V

V

K

T

G

G

D

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R

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S

E

Y

Y

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W

L

L

active site: F35 (= F38), G37 (= G40), K158 (= K161), E192 (= E195), L215 (= L218)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: R58 (= R62), K158 (= K161), Y163 (= Y166), E192 (= E195), G195 (= G198), E196 (= E199), N197 (= N200), L215 (= L218), G217 (= G220), I218 (= I221), T219 (= T222), G254 (= G257), T255 (= T258)

2ej3A Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase complexed with gabapentin
53% identity, 97% coverage: 6:304/309 of query aligns to 3:293/297 of 2ej3A

query
sites
2ej3A

K

K

S

A

E

G

T

L

I

I

W

W

F

M

D

N

G

G

K

A

Q

F

V

V

P

P

W

Q

D

E

E

E

A

A

N

K

V

T

H

S

V

V

L

L

T

S

H

H

A

A

L

L

H

H

Y

Y

G

G

V

T

G

S

V

V

F
|
F

E

E

G
|
G

I

I

R

R

A

A

Y

Y

R

E

C

T

A

A

D

K

G

G

S

P

S

-

A

A

V

I

F

F

R

R

L

L

R

K

E

E

H

H

V

V

Q

K

R
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R

L

F

F

Y

S

N

S

S

A

A

K

K

I

V

L

L

R

R

M

M

E

E

I

I

P

P

F

F

T

A

E

P

D

E

A

E

I

L

F

E

D

E

A

A

I

I

V

K

E

E

T

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L

V

Q

R

R

R

N

N

R

G

L

Y

A

R

E

S

G

C

Y
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Y

I

I

R
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R

P

P

L

L

S

A

F

W

V

M

G

G

A

A

G

K

A

A

M

L

G

G

V

V

Y

N

P

P

-

L

G

P

D

N

N

N

P

P

V

A

Q

E

T

V

I

M

I

V

A

A

V

A

W

W

P

E

W

W

G

-

A

-

Y

-

L

-

G

-

A

-

E

-

A

-

L

V

E

R

K

K

G

G

I

A

R

R

V

L

K

I

T

T

S

S

F

W

A

A

R
|
R

H

F

H

P

V

A

N

N

A

V

M

M

M

P

T

G

K

K

A

A

K
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K

A

V

S

G

G

G

N

N

Y
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Y

V

V

N

N

S

S

V

A

L

L

A

A

K

K

M

M

E

E

A

A

K

V

A

A

D

A

G

G

Y

A

D

D

E

E

A

A

L

L

M

L

L

L

D

D

V

E

S

E

G

G

F

Y

V

V

S

A

E
|
E

A

G

T

S

G
|
G

E
|
E

N

N

I

L

F

F

M

F

V

V

R

R

N

D

G

G

V

V

I

I

K

Y

T

A

T

L

P

E

L

H

T

S

S

V

I

N

L
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L

D

E

G
|
G

I
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I

T
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T

R

R

N

D

S

S

L

V

M

I

T

R

L

I

A

A

R

K

D

D

L

L

G

G

Y

Y

E

E

V

V

V

Q

E

V

Q

V

Q

R

F

A

T

T

R

R

D

D

E

Q

L

L

Y

Y

V

M

A

A

D

D

E

E

A

V

F

F

F

M

C

T

G
|
G

T
|
T

A
|
A

E

E

V

V

T

T

P

P

I

V

R

S

E

M

V

I

D

D

R

W

R

R

V

P

I

I

G

G

K

K

G

G

S

T

A

A

G

G

P

P

V

V

T

A

K

L

H

R

L

L

Q

R

Q

E

E

V

Y

Y

F

L

K

E

A

A

V

V

K

T

G

G

D

R

N

R

P

P

S

E

Y

Y

D

E

H

G

W

W

L

L

active site: F35 (= F38), G37 (= G40), K150 (= K161), E184 (= E195), L207 (= L218)
binding [1-(aminomethyl)cyclohexyl]acetic acid: Y94 (= Y98), R96 (= R100), Y155 (= Y166), G187 (= G198), E188 (= E199), G246 (= G257), T247 (= T258), A248 (= A259), A249 (= A260)
binding pyridoxal-5'-phosphate: R58 (= R62), R139 (= R150), K150 (= K161), Y155 (= Y166), E184 (= E195), G187 (= G198), E188 (= E199), L207 (= L218), G209 (= G220), I210 (= I221), T211 (= T222), G246 (= G257), T247 (= T258)

2eiyA Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase complexed with 4-methylvaleric acid
53% identity, 97% coverage: 6:304/309 of query aligns to 3:293/297 of 2eiyA

query
sites
2eiyA

K

K

S

A

E

G

T

L

I

I

W

W

F

M

D

N

G

G

K

A

Q

F

V

V

P

P

W

Q

D

E

E

E

A

A

N

K

V

T

H

S

V

V

L

L

T

S

H

H

A

A

L

L

H

H

Y

Y

G

G

V

T

G

S

V

V

F
|
F

E

E

G
|
G

I

I

R

R

A

A

Y

Y

R

E

C

T

A

A

D

K

G

G

S

P

S

-

A

A

V

I

F

F

R

R

L

L

R

K

E

E

H

H

V

V

Q

K

R
|
R

L

F

F

Y

S

N

S

S

A

A

K

K

I

V

L

L

R

R

M

M

E

E

I

I

P

P

F

F

T

A

E

P

D

E

A

E

I

L

F

E

D

E

A

A

I

I

V

K

E

E

T

V

L

V

Q

R

R

R

N

N

R

G

L

Y

A

R

E

S

G

C

Y
|
Y

I

I

R

R

P

P

L

L

S

A

F

W

V

M

G

G

A

A

G

K

A

A

M

L

G

G

V

V

Y

N

P

P

-

L

G

P

D

N

N

N

P

P

V

A

Q

E

T

V

I

M

I

V

A

A

V

A

W

W

P

E

W

W

G

-

A

-

Y

-

L

-

G

-

A

-

E

-

A

-

L

V

E

R

K

K

G

G

I

A

R

R

V

L

K

I

T

T

S

S

F

W

A

A

R
|
R

H

F

H

P

V

A

N

N

A

V

M

M

M

P

T

G

K

K

A

A

K
|
K

A

V

S

G

G

G

N

N

Y
|
Y

V

V

N

N

S

S

V

A

L

L

A

A

K

K

M

M

E

E

A

A

K

V

A

A

D

A

G

G

Y

A

D

D

E

E

A

A

L

L

M

L

L

L

D

D

V

E

S

E

G

G

F

Y

V

V

S

A

E
|
E

A

G

T

S

G
|
G

E
|
E

N
|
N

I

L

F

F

M

F

V

V

R

R

N

D

G

G

V

V

I

I

K

Y

T

A

T

L

P

E

L

H

T

S

S

V

I

N

L
|
L

D

E

G
|
G

I
|
I

T
|
T

R

R

N

D

S

S

L

V

M

I

T

R

L

I

A

A

R

K

D

D

L

L

G

G

Y

Y

E

E

V

V

V

Q

E

V

Q

V

Q

R

F

A

T

T

R

R

D

D

E

Q

L

L

Y

Y

V

M

A

A

D

D

E

E

A

V

F

F

F

M

C

T

G
|
G

T
|
T

A
|
A

A

A

E

E

V

V

T

T

P

P

I

V

R

S

E

M

V

I

D

D

R

W

R

R

V

P

I

I

G

G

K

K

G

G

S

T

A

A

G

G

P

P

V

V

T

A

K

L

H

R

L

L

Q

R

Q

E

E

V

Y

Y

F

L

K

E

A

A

V

V

K

T

G

G

D

R

N

R

P

P

S

E

Y

Y

D

E

H

G

W

W

L

L

active site: F35 (= F38), G37 (= G40), K150 (= K161), E184 (= E195), L207 (= L218)
binding 4-methyl valeric acid: F35 (= F38), Y94 (= Y98), Y155 (= Y166), T247 (= T258), A248 (= A259)
binding pyridoxal-5'-phosphate: R58 (= R62), R139 (= R150), K150 (= K161), Y155 (= Y166), E184 (= E195), G187 (= G198), E188 (= E199), N189 (= N200), L207 (= L218), G209 (= G220), I210 (= I221), T211 (= T222), G246 (= G257), T247 (= T258)

1wrvA Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase
53% identity, 97% coverage: 6:304/309 of query aligns to 3:293/297 of 1wrvA

query
sites
1wrvA

K

K

S

A

E

G

T

L

I

I

W

W

F

M

D

N

G

G

K

A

Q

F

V

V

P

P

W

Q

D

E

E

E

A

A

N

K

V

T

H

S

V

V

L

L

T

S

H

H

A

A

L

L

H

H

Y

Y

G

G

V

T

G

S

V

V

F
|
F

E

E

G
|
G

I

I

R

R

A

A

Y

Y

R

E

C

T

A

A

D

K

G

G

S

P

S

-

A

A

V

I

F

F

R

R

L

L

R

K

E

E

H

H

V

V

Q

K

R
|
R

L

F

F

Y

S

N

S

S

A

A

K

K

I

V

L

L

R

R

M

M

E

E

I

I

P

P

F

F

T

A

E

P

D

E

A

E

I

L

F

E

D

E

A

A

I

I

V

K

E

E

T

V

L

V

Q

R

R

R

N

N

R

G

L

Y

A

R

E

S

G

C

Y

Y

I

I

R

R

P

P

L

L

S

A

F

W

V

M

G

G

A

A

G

K

A

A

M

L

G

G

V

V

Y

N

P

P

-

L

G

P

D

N

N

N

P

P

V

A

Q

E

T

V

I

M

I

V

A

A

V

A

W

W

P

E

W

W

G

-

A

-

Y

-

L

-

G

-

A

-

E

-

A

-

L

V

E

R

K

K

G

G

I

A

R

R

V

L

K

I

T

T

S

S

F

W

A

A

R
|
R

H

F

H

P

V

A

N

N

A

V

M

M

M

P

T

G

K

K

A

A

K
|
K

A

V

S

G

G

G

N

N

Y
|
Y

V

V

N

N

S

S

V

A

L

L

A

A

K

K

M

M

E

E

A

A

K

V

A

A

D

A

G

G

Y

A

D

D

E

E

A

A

L

L

M

L

L

L

D

D

V

E

S

E

G

G

F

Y

V

V

S

A

E
|
E

A

G

T

S

G
|
G

E
|
E

N
|
N

I

L

F

F

M

F

V

V

R

R

N

D

G

G

V

V

I

I

K

Y

T

A

T

L

P

E

L

H

T

S

S

V

I

N

L
|
L

D

E

G
|
G

I
|
I

T
|
T

R

R

N

D

S

S

L

V

M

I

T

R

L

I

A

A

R

K

D

D

L

L

G

G

Y

Y

E

E

V

V

V

Q

E

V

Q

V

Q

R

F

A

T

T

R

R

D

D

E

Q

L

L

Y

Y

V

M

A

A

D

D

E

E

A

V

F

F

F

M

C

T

G
|
G

T
|
T

A

A

E

E

V

V

T

T

P

P

I

V

R

S

E

M

V

I

D

D

R

W

R

R

V

P

I

I

G

G

K

K

G

G

S

T

A

A

G

G

P

P

V

V

T

A

K

L

H

R

L

L

Q

R

Q

E

E

V

Y

Y

F

L

K

E

A

A

V

V

K

T

G

G

D

R

N

R

P

P

S

E

Y

Y

D

E

H

G

W

W

L

L

active site: F35 (= F38), G37 (= G40), K150 (= K161), E184 (= E195), L207 (= L218)
binding pyridoxal-5'-phosphate: R58 (= R62), R139 (= R150), K150 (= K161), Y155 (= Y166), E184 (= E195), G187 (= G198), E188 (= E199), N189 (= N200), L207 (= L218), G209 (= G220), I210 (= I221), T211 (= T222), G246 (= G257), T247 (= T258)

2ej2A Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase complexed with n-(5'-phosphopyridoxyl)-l-glutamate
53% identity, 97% coverage: 6:304/309 of query aligns to 3:290/294 of 2ej2A

query
sites
2ej2A

K

K

S

A

E

G

T

L

I

I

W

W

F

M

D

N

G

G

K

A

Q

F

V

V

P

P

W

Q

D

E

E

E

A

A

N

K

V

T

H

S

V

V

L

L

T

S

H

H

A

A

L

L

H

H

Y

Y

G

G

V

T

G

S

V

V

F
|
F

E

E

G
|
G

I

I

R

R

A

A

Y

Y

R

E

C

T

A

A

D

K

G

G

S

P

S

-

A

A

V

I

F

F

R

R

L

L

R

K

E

E

H

H

V

V

Q

K

R
|
R

L

F

F

Y

S

N

S

S

A

A

K

K

I

V

L

L

R

R

M

M

E

E

I

I

P

P

F

F

T

A

E

P

D

E

A

E

I

L

F

E

D

E

A

A

I

I

V

K

E

E

T

V

L

V

Q

R

R

R

N

N

R

G

L

Y

A

R

E

S

G

C

Y
|
Y

I

I

R

R

P

P

L

L

S

A

F

W

V

M

G

G

A

A

G

K

A

A

M

L

G

G

V

V

Y

N

P

P

-

L

G

P

D

N

N

N

P

P

V

A

Q

E

T

V

I

M

I

V

A

A

V

A

W

W

P

E

W

W

G

G

A

A

Y

-

L

-

G

-

A

-

E

-

A

-

L

-

E

-

K

-

G

-

I

-

R

R

V

L

K

I

T

T

S

S

F

W

A

A

R
|
R

H

F

H

P

V

A

N

N

A

V

M

M

M

P

T

G

K

K

A

A

K
|
K

A

V

S

G

G

G

N

N

Y
|
Y

V

V

N

N

S

S

V

A

L

L

A

A

K

K

M

M

E

E

A

A

K

V

A

A

D

A

G

G

Y

A

D

D

E

E

A

A

L

L

M

L

L

L

D

D

V

E

S

E

G

G

F

Y

V

V

S

A

E
|
E

A

G

T
x
S

G
|
G

E
|
E

N
|
N

I

L

F

F

M

F

V

V

R

R

N

D

G

G

V

V

I

I

K

Y

T

A

T

L

P

E

L

H

T

S

S

V

I

N

L
|
L

D

E

G
|
G

I
|
I

T
|
T

R

R

N

D

S

S

L

V

M

I

T

R

L

I

A

A

R

K

D

D

L

L

G

G

Y

Y

E

E

V

V

V

Q

E

V

Q

V

Q

R

F

A

T

T

R

R

D

D

E

Q

L

L

Y

Y

V

M

A

A

D

D

E

E

A

V

F

F

F

M

C

T

G
|
G

T
|
T

A
|
A

A

A

E

E

V

V

T

T

P

P

I

V

R

S

E

M

V

I

D

D

R

W

R

R

V

P

I

I

G

G

K

K

G

G

S

T

A

A

G

G

P

P

V

V

T

A

K

L

H

R

L

L

Q

R

Q

E

E

V

Y

Y

F

L

K

E

A

A

V

V

K

T

G

G

D

R

N

R

P

P

S

E

Y

Y

D

E

H

G

W

W

L

L

active site: F35 (= F38), G37 (= G40), K147 (= K161), E181 (= E195), L204 (= L218)
binding 4-[(1,3-dicarboxy-propylamino)-methyl]-3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridinium: G37 (= G40), R58 (= R62), Y94 (= Y98), R136 (= R150), K147 (= K161), Y152 (= Y166), E181 (= E195), S183 (≠ T197), G184 (= G198), E185 (= E199), N186 (= N200), L204 (= L218), G206 (= G220), I207 (= I221), T208 (= T222), G243 (= G257), T244 (= T258), A245 (= A259)

1iyeA Crystal structure of eschelichia coli branched-chain amino acid aminotransferase (see paper)
50% identity, 97% coverage: 6:306/309 of query aligns to 1:302/304 of 1iyeA

query
sites
1iyeA

K

K

S

A

E

D

T

Y

I

I

W

W

F

F

D

N

G

G

K

E

Q

M

V

V

P

R

W

W

D

E

E

D

A

A

N

K

V

V

H

H

V

V

L

M

T

S

H

H

A

A

L

L

H

H

Y

Y

G

G

V

T

G

S

V

V

F
|
F

E

E

G
|
G

I

I

R

R

A

C

Y

Y

R

D

C

S

A

H

D

K

G

G

S

P

S

-

A

V

V

V

F

F

R

R

L

H

R

R

E

E

H

H

V

M

Q

Q

R
|
R

L

L

F

H

S

D

S

S

A

A

K

K

I

I

L

Y

R

R

M

F

E

P

I

V

P

S

F

Q

T

S

E

I

D

D

A

E

I

L

F

M

D

E

A

A

I

C

V

R

E

D

T

V

L

I

Q

R

R

K

N

N

R

N

L

L

A

T

E

S

G

A

Y
|
Y

I

I

R
|
R

P

P

L

L

S

I

F

F

V

V

G

G

A

D

G

V

A

G

M

M

G

G

V

V

Y

N

P

P

-

P

G

A

D

G

N

Y

P

S

V

T

Q

D

T

V

I

I

A

A

V

A

W

F

P

P

W

W

G

G

A

A

Y
|
Y

L

L

G

G

A

A

E

E

A

A

L

L

E

E

K

Q

G

G

I

I

R

D

V

A

K

M

T

V

S

S

F

W

A

N

R

R

H

A

V

P

N

N

A

T

M

I

M

P

T

T

K

A

A

A

K
|
K

A
|
A

S

G

G

G

N

N

Y
|
Y

V

L

N

S

S

S

V

L

L

L

A

V

K

G

M

S

E

E

A

A

K

R

A

R

D

H

G

G

Y

Y

D

Q

E

E

A

G

L

I

M

A

L

L

D

D

V

V

S

N

G

G

F

Y

V

I

S

S

E
|
E

A

G

T
x
A

G
|
G

E
|
E

N
|
N

I

L

F

F

M

E

V

V

R

K

N

D

G

G

V

V

I

L

K

F

T

T

T

P

P

P

L

F

T

T

-

S

S

S

I

A

L
|
L

D

P

G
|
G

I
|
I

T
|
T

R

R

N

D

S

A

L

I

M

I

T

K

L

L

A

A

R

K

D

E

L

L

G

G

Y

I

E

E

V

V

V

R

E

E

Q

Q

Q

V

F

L

T

S

R

R

D

E

E

S

L

L

Y

Y

V

L

A

A

D

D

E

E

A

V

F

F

F

M

C

S

G
|
G

T
|
T

A
|
A

A

A

E

E

V

I

T

T

P

P

I

V

R

R

E

S

V

V

D

D

R

G

R

I

V

Q

I

V

G

G

K

E

G

G

S

R

A

C

G

G

P

P

V

V

T

T

K

K

H

R

L

I

Q

Q

E

A

Y

F

F

F

K

G

A

L

V

F

K

T

G

G

D

E

N

T

P

E

S

D

Y

K

D

W

H

G

W

W

L

L

H

D

R

Q

active site: F33 (= F38), G35 (= G40), K156 (= K161), A157 (= A162), E190 (= E195), L214 (= L218)
binding N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-glutamic acid: R56 (= R62), Y92 (= Y98), R94 (= R100), Y126 (= Y131), K156 (= K161), Y161 (= Y166), E190 (= E195), A192 (≠ T197), G193 (= G198), E194 (= E199), N195 (= N200), L214 (= L218), G216 (= G220), I217 (= I221), T218 (= T222), G253 (= G257), T254 (= T258), A255 (= A259)

1iydA Crystal structure of eschelichia coli branched-chain amino acid aminotransferase (see paper)
50% identity, 97% coverage: 6:306/309 of query aligns to 1:302/304 of 1iydA

query
sites
1iydA

K

K

S

A

E

D

T

Y

I

I

W

W

F

F

D

N

G

G

K

E

Q

M

V

V

P

R

W

W

D

E

E

D

A

A

N

K

V

V

H

H

V

V

L

M

T

S

H

H

A

A

L

L

H

H

Y

Y

G

G

V

T

G

S

V

V

F
|
F

E

E

G
|
G

I

I

R

R

A

C

Y

Y

R

D

C

S

A

H

D

K

G

G

S

P

S

-

A

V

V

V

F

F

R

R

L

H

R

R

E

E

H

H

V

M

Q

Q

R
|
R

L

L

F

H

S

D

S

S

A

A

K

K

I

I

L

Y

R

R

M

F

E

P

I

V

P

S

F

Q

T

S

E

I

D

D

A

E

I

L

F

M

D

E

A

A

I

C

V

R

E

D

T

V

L

I

Q

R

R

K

N

N

R

N

L

L

A

T

E

S

G

A

Y
|
Y

I

I

R
|
R

P

P

L

L

S

I

F

F

V

V

G

G

A

D

G

V

A

G

M

M

G

G

V

V

Y

N

P

P

-

P

G

A

D

G

N

Y

P

S

V

T

Q

D

T

V

I

I

A

A

V

A

W

F

P

P

W
|
W

G

G

A

A

Y
|
Y

L

L

G

G

A

A

E

E

A

A

L

L

E

E

K

Q

G

G

I

I

R

D

V

A

K

M

T

V

S

S

F

W

A

N

R

R

H

A

V

P

N

N

A

T

M

I

M

P

T

T

K

A

A

A

K
|
K

A
|
A

S

G

G

G

N

N

Y
|
Y

V

L

N

S

S

S

V

L

L

L

A

V

K

G

M

S

E

E

A

A

K

R

A

R

D

H

G

G

Y

Y

D

Q

E

E

A

G

L

I

M

A

L

L

D

D

V

V

S

N

G

G

F

Y

V

I

S

S

E
|
E

A

G

T

A

G
|
G

E
|
E

N
|
N

I

L

F

F

M

E

V

V

R

K

N

D

G

G

V

V

I

L

K

F

T

T

T

P

P

P

L

F

T

T

-

S

S

S

I

A

L
|
L

D

P

G
|
G

I
|
I

T
|
T

R

R

N

D

S

A

L

I

M

I

T

K

L

L

A

A

R

K

D

E

L

L

G

G

Y

I

E

E

V

V

V

R

E

E

Q

Q

Q

V

F

L

T

S

R

R

D

E

E

S

L

L

Y

Y

V

L

A

A

D

D

E

E

A

V

F

F

F

M

C

S

G
|
G

T
|
T

A
|
A

A

A

E

E

V

I

T

T

P

P

I

V

R

R

E

S

V

V

D

D

R

G

R

I

V

Q

I

V

G

G

K

E

G

G

S

R

A

C

G

G

P

P

V

V

T

T

K

K

H

R

L

I

Q

Q

E

A

Y

F

F

F

K

G

A

L

V

F

K

T

G

G

D

E

N

T

P

E

S

D

Y

K

D

W

H

G

W

W

L

L

H

D

R

Q

active site: F33 (= F38), G35 (= G40), K156 (= K161), A157 (= A162), E190 (= E195), L214 (= L218)
binding glutaric acid: G35 (= G40), Y92 (= Y98), R94 (= R100), W123 (= W128), Y126 (= Y131), K156 (= K161), Y161 (= Y166), T254 (= T258), A255 (= A259)
binding pyridoxal-5'-phosphate: R56 (= R62), K156 (= K161), Y161 (= Y166), E190 (= E195), G193 (= G198), E194 (= E199), N195 (= N200), L214 (= L218), G216 (= G220), I217 (= I221), T218 (= T222), G253 (= G257), T254 (= T258)

1i1mA Crystal structure of escherichia coli branched-chain amino acid aminotransferase. (see paper)
50% identity, 97% coverage: 6:306/309 of query aligns to 1:302/304 of 1i1mA

query
sites
1i1mA

K

K

S

A

E

D

T

Y

I

I

W

W

F

F

D

N

G

G

K

E

Q

M

V

V

P

R

W

W

D

E

E

D

A

A

N

K

V

V

H

H

V

V

L

M

T

S

H

H

A

A

L

L

H

H

Y

Y

G

G

V

T

G

S

V

V

F

F

E

E

G
|
G

I

I

R

R

A

C

Y

Y

R

D

C

S

A

H

D

K

G

G

S

P

S

-

A

V

V

V

F

F

R

R

L

H

R

R

E

E

H

H

V

M

Q

Q

R
|
R

L

L

F

H

S

D

S

S

A

A

K

K

I

I

L

Y

R

R

M

F

E

P

I

V

P

S

F

Q

T

S

E

I

D

D

A

E

I

L

F

M

D

E

A

A

I

C

V

R

E

D

T

V

L

I

Q

R

R

K

N

N

R

N

L

L

A

T

E

S

G

A

Y
|
Y

I

I

R

R

P

P

L

L

S

I

F

F

V

V

G

G

A

D

G

V

A

G

M

M

G

G

V

V

Y

N

P

P

-

P

G

A

D

G

N

Y

P

S

V

T

Q

D

T

V

I

I

A

A

V

A

W

F

P

P

W

W

G

G

A

A

Y

Y

L

L

G

G

A

A

E

E

A

A

L

L

E

E

K

Q

G

G

I

I

R

D

V

A

K

M

T

V

S

S

F

W

A

N

R
|
R

H

A

V

P

N

N

A

T

M

I

M

P

T

T

K

A

A

A

K
|
K

A

A

S

G

G

G

N

N

Y
|
Y

V

L

N

S

S

S

V

L

L

L

A

V

K

G

M

S

E

E

A

A

K

R

A

R

D

H

G

G

Y

Y

D

Q

E

E

A

G

L

I

M

A

L

L

D

D

V

V

S

N

G

G

F

Y

V

I

S

S

E
|
E

A

G

T

A

G
|
G

E
|
E

N
|
N

I

L

F

F

M

E

V

V

R

K

N

D

G

G

V

V

I

L

K

F

T

T

T

P

P

P

L

F

T

T

-

S

S

S

I

A

L
|
L

D

P

G
|
G

I
|
I

T
|
T

R

R

N

D

S

A

L

I

M

I

T

K

L

L

A

A

R

K

D

E

L

L

G

G

Y

I

E

E

V

V

V

R

E

E

Q

Q

Q

V

F

L

T

S

R

R

D

E

E

S

L

L

Y

Y

V

L

A

A

D

D

E

E

A

V

F

F

F

M

C

S

G
|
G

T
|
T

A
|
A

A

A

E

E

V

I

T

T

P

P

I

V

R

R

E

S

V

V

D

D

R

G

R

I

V

Q

I

V

G

G

K

E

G

G

S

R

A

C

G

G

P

P

V

V

T

T

K

K

H

R

L

I

Q

Q

E

A

Y

F

F

F

K

G

A

L

V

F

K

T

G

G

D

E

N

T

P

E

S

D

Y

K

D

W

H

G

W

W

L

L

H

D

R

Q

active site: K156 (= K161)
binding 4-methyl valeric acid: G35 (= G40), Y92 (= Y98), K156 (= K161), Y161 (= Y166), G193 (= G198), T254 (= T258), A255 (= A259)
binding pyridoxal-5'-phosphate: R56 (= R62), R145 (= R150), K156 (= K161), Y161 (= Y166), E190 (= E195), G193 (= G198), E194 (= E199), N195 (= N200), L214 (= L218), G216 (= G220), I217 (= I221), T218 (= T222), G253 (= G257), T254 (= T258)

1i1lA Crystal structure of eschelichia coli branched-chain amino acid aminotransferase. (see paper)
50% identity, 97% coverage: 6:306/309 of query aligns to 1:302/304 of 1i1lA

query
sites
1i1lA

K

K

S

A

E

D

T

Y

I

I

W

W

F

F

D

N

G

G

K

E

Q

M

V

V

P

R

W

W

D

E

E

D

A

A

N

K

V

V

H

H

V

V

L

M

T

S

H

H

A

A

L

L

H

H

Y

Y

G

G

V

T

G

S

V

V

F

F

E

E

G
|
G

I

I

R

R

A

C

Y

Y

R

D

C

S

A

H

D

K

G

G

S

P

S

-

A

V

V

V

F

F

R

R

L

H

R

R

E

E

H

H

V

M

Q

Q

R
|
R

L

L

F

H

S

D

S

S

A

A

K

K

I

I

L

Y

R

R

M

F

E

P

I

V

P

S

F

Q

T

S

E

I

D

D

A

E

I

L

F

M

D

E

A

A

I

C

V

R

E

D

T

V

L

I

Q

R

R

K

N

N

R

N

L

L

A

T

E

S

G

A

Y
|
Y

I

I

R

R

P

P

L

L

S

I

F

F

V

V

G

G

A

D

G

V

A

G

M

M

G

G

V

V

Y

N

P

P

-

P

G

A

D

G

N

Y

P

S

V

T

Q

D

T

V

I

I

A

A

V

A

W

F

P

P

W
|
W

G

G

A

A

Y
|
Y

L

L

G

G

A

A

E

E

A

A

L

L

E

E

K

Q

G

G

I

I

R

D

V

A

K

M

T

V

S

S

F

W

A

N

R

R

H

A

V

P

N

N

A

T

M

I

M

P

T

T

K

A

A

A

K
|
K

A

A

S

G

G

G

N

N

Y
|
Y

V

L

N

S

S

S

V

L

L

L

A

V

K

G

M

S

E

E

A

A

K

R

A

R

D

H

G

G

Y

Y

D

Q

E

E

A

G

L

I

M

A

L

L

D

D

V

V

S

N

G

G

F

Y

V

I

S

S

E
|
E

A

G

T

A

G
|
G

E
|
E

N
|
N

I

L

F

F

M

E

V

V

R

K

N

D

G

G

V

V

I

L

K

F

T

T

T

P

P

P

L

F

T

T

-

S

S

S

I

A

L
|
L

D

P

G
|
G

I
|
I

T
|
T

R

R

N

D

S

A

L

I

M

I

T

K

L

L

A

A

R

K

D

E

L

L

G

G

Y

I

E

E

V

V

V

R

E

E

Q

Q

Q

V

F

L

T

S

R

R

D

E

E

S

L

L

Y

Y

V

L

A

A

D

D

E

E

A

V

F

F

F

M

C

S

G
|
G

T
|
T

A
|
A

A

A

E

E

V

I

T

T

P

P

I

V

R

R

E

S

V

V

D

D

R

G

R

I

V

Q

I

V

G

G

K

E

G

G

S

R

A

C

G

G

P

P

V

V

T

T

K

K

H

R

L

I

Q

Q

E

A

Y

F

F

F

K

G

A

L

V

F

K

T

G

G

D

E

N

T

P

E

S

D

Y

K

D

W

H

G

W

W

L

L

H

D

R

Q

active site: K156 (= K161)
binding 2-methylleucine: G35 (= G40), Y92 (= Y98), W123 (= W128), Y126 (= Y131), K156 (= K161), G193 (= G198), T254 (= T258), A255 (= A259)
binding pyridoxal-5'-phosphate: R56 (= R62), K156 (= K161), Y161 (= Y166), E190 (= E195), G193 (= G198), E194 (= E199), N195 (= N200), L214 (= L218), G216 (= G220), I217 (= I221), T218 (= T222), G253 (= G257), T254 (= T258)

6thqB Crystal structure of branched-chain aminotransferase from thermophilic archaea thermoproteus uzoniensis with norvaline
45% identity, 96% coverage: 7:304/309 of query aligns to 6:297/301 of 6thqB

query
sites
6thqB

S

S

E

M

T

K

I

V

W

W

F

L

D

D

G

G

K

R

Q

L

V

V

P

D

W

E

D

E

E

E

A

A

N

K

V

V

H

T

V

V

L

L

T

S

H

P

A

S

L

L

H

N

Y
|
Y

G

G

V

F

G

G

V

V

F
|
F

E

E

G

G

I

I

R

R

A

A

Y

Y

R

W

C

N

A

G

D

E

G

-

S

N

S

L

A

Y

V

V

F

F

R

R

L

L

R

R

E

D

H

H

V

M

Q

E

R
|
R

L

L

F

L

S

R

S

S

A

A

K

K

I

I

L

I

R

G

M

L

E

D

I

V

P

P

F

Y

T

T

E

A

D

E

A

E

I

L

F

S

D

K

A

A

I

V

V

V

E

E

T

T

L

V

Q

R

R

A

N

N

R

G

L

F

A

K

E

E

G

D

-

L

Y
|
Y

I

I

R

R

P

P

L

V

S

A

F

Y

V

I

G

S

A

K

G

P

A

Q

M
x
I

G

S

V

L

Y

D

P

V

G

R

D

G

N

L

P

Q

V

A

Q

S

T

V

I

A

I

I

A

A

V

A

W

I

P

P

W

F

G

G

A

K

Y

Y

L

L

G

K

A

V

E

E

A

-

L

-

E

-

K

-

G

G

I

V

R

R

V

A

K

A

T

V

S

V

S

S

F

W

A

R

R
|
R

H

V

H

H

V

T

N

S

A

M

M

M

M

P

T

V

K

M

A

A

K
|
K

A

A

S

T

G

G

N

I

Y
|
Y

V

L

N

N

S

S

V

I

L

M

A

A

K

A

M

V

E

E

A

A

K

R

A

A

D

R

G

G

Y

Y

D

D

E

E

A

A

L

I

M

M

L

L

D

N

V

A

S

E

G

G

F

K

V

V

S

V

E
|
E

A

G

T
x
S

G
|
G

E
|
E

N
|
N

I

I

F

F

M

I

V

V

R

R

N

R

G

G

V

V

I

L

K

M

T

T

T

P

P

P

L

L

T

E

S

D

-

G

I

I

L
|
L

D

E

G
|
G

I
|
I

T
|
T

R

R

N

E

S

T

L

V

M

I

T

S

L

I

A

A

R

G

D

D

L

L

G

G

Y

I

E

P

V

L

E

E

Q

K

Q

S

F

I

T

T

R

R

D

E

E

E

L

L

Y

Y

V

A

A

A

D

D

E

E

A

A

F

F

C

V

G
|
G

T
|
T

A
|
A

A

A

E

E

V

I

T

T

P

P

I

I

R

I

E

E

V

I

D

D

R

G

R

R

V

V

I

L

G

Q

K

R

G

-

S

-

A

-

G

G

P

P

V

I

T

T

K

Q

H

K

L

I

Q

A

Q

E

E

T

Y

Y

F

R

K

R

A

I

V

V

K

L

G

G

D

K

N

E

P

E

S

K

Y

Y

D

L

H

P

W

W

L

L

active site: F37 (= F38), K156 (= K161), E190 (= E195), L214 (= L218)
binding pyridoxal-5'-phosphate: R60 (= R62), R145 (= R150), K156 (= K161), Y161 (= Y166), E190 (= E195), G193 (= G198), E194 (= E199), N195 (= N200), L214 (= L218), G216 (= G220), I217 (= I221), T218 (= T222), G253 (= G257), T254 (= T258)
binding 2-[o-phosphonopyridoxyl]-amino-pentanoic acid: Y32 (= Y33), R60 (= R62), Y97 (= Y98), I109 (≠ M110), K156 (= K161), Y161 (= Y166), E190 (= E195), S192 (≠ T197), G193 (= G198), E194 (= E199), N195 (= N200), L214 (= L218), G216 (= G220), I217 (= I221), T218 (= T222), G253 (= G257), T254 (= T258), A255 (= A259)

5mr0D Thermophilic archaeal branched-chain amino acid transaminases from geoglobus acetivorans and archaeoglobus fulgidus: biochemical and structural characterisation (see paper)
42% identity, 94% coverage: 10:301/309 of query aligns to 4:290/290 of 5mr0D

query
sites
5mr0D

I

V

W

Y

F

M

D

D

G

G

K

E

Q

F

V

V

P

P

W

E

D

N

E

E

A

A

N

K

V

V

H

S

V

I

L

F

T

D

H

H

A

G

L

F

H

L

Y

Y

G

G

V

D

G

G

V

V

F
|
F

E

E

G
|
G

I

I

R

R

A

A

Y

Y

R

-

C

-

A

-

D

-

G

-

S

N

S

G

A

R

V

V

F

F

R

R

L

L

R

K

E

E

H

H

V

I

Q

D

R
|
R

L

L

F

Y

S

D

S

S

A

A

K

K

I

A

L

I

R

D

M

L

E

E

I

I

P

P

F

I

T

T

E

K

D

E

A

E

I

F

F

M

D

E

A

I

I

I

V

L

E

E

T

T

L

L

Q

R

R

K

N

N

R

N

L

L

A

R

E

D

G

A

Y

Y

I

I

R
|
R

P

P

L

I

S

V

F

T

V

R

G

G

A

I

G

G

A

D

M

L

G
|
G

V
x
L

Y

D

P

P

-

R

-

K

G

C

D

Q

N

N

P

P

V

-

Q

S

T

I

I

I

I

V

A

I

V

T

W

K

P

P

W

W

G

G

A

K

Y

L

L

Y

G

G

A

-

E

D

A

L

L

Y

E

E

K

K

G

G

I

L

R

T

V

A

K

I

T

T

S

V

S

A

F

V

A

R

R

R

H

N

H

S

V

F

N

D

A

A

M

L

M

P

T

P

K

N

A

I

K
|
K

A

-

S

S

G

L

N

N

Y
|
Y

V

L

N

N

S

N

V

I

L

L

A

A

K

K

M

I

E

E

A

A

K

N

A

A

D

K

G

G

Y

G

D

D

E

E

A

A

L

I

M

F

L

L

D

D

V

R

S

N

G

G

F

Y

V

V

S

S

E
|
E

A

G

T

S

G
|
G

E
x
D

N
|
N

I

I

F

F

M

V

V

V

R

K

N

N

G

G

V

A

I

I

K

T

T

T

T

P

P

P

L

T

T

I

S

N

I

N

L
|
L

D

R

G
|
G

I
|
I

T
|
T

R

R

N

E

S

A

L

V

M

I

T

E

L

I

A

I

R

N

D

R

L

L

G

G

Y

I

E

P

V

F

V

K

E

E

Q

T

Q

N

F

I

T

G

R

L

D

Y

E

D

L

L

Y

Y

V

T

A

A

D

D

E

E

A

V

F

F

F

V

C

T

G
|
G

T
|
T

A

A

E

E

V

I

T

A

P

P

I

I

R

V

E

V

V

I

D

D

R

G

R

R

V

K

I

I

G

G

K

D

G

G

S

K

A

P

G

G

P

E

V

I

T

T

K

R

H

K

L

L

Q

M

Q

E

E

E

Y

F

F

S

K

K

A

L

V

T

K

E

G

S

D

E

N

G

-

V

P

P

S

I

Y

Y

D

E

active site: F32 (= F38), G34 (= G40), K150 (= K161), E183 (= E195), L206 (= L218)
binding 3-[o-phosphonopyridoxyl]--amino-benzoic acid: F32 (= F38), R51 (= R62), R89 (= R100), G100 (= G111), L101 (≠ V112), K150 (= K161), Y154 (= Y166), E183 (= E195), G186 (= G198), D187 (≠ E199), N188 (= N200), L206 (= L218), G208 (= G220), I209 (= I221), T210 (= T222), G245 (= G257), T246 (= T258)

5e25A Crystal structure of branched-chain aminotransferase from thermophilic archaea geoglobus acetivorans complexed with alpha-ketoglutarate (see paper)
41% identity, 91% coverage: 10:289/309 of query aligns to 5:278/290 of 5e25A

query
sites
5e25A

I

V

W

Y

F

M

D

N

G

G

K

E

Q

F

V

V

P

P

W

E

D

S

E

Q

A

A

N

K

V

V

H

S

V

V

L

F

T

D

H

H

A

G

L

F

H

L

Y

Y

G

G

V

D

G

G

V

V

F
|
F

E

E

G
|
G

I

I

R

R

A

A

Y

Y

R

-

C

-

A

-

D

-

G

-

S

N

S

G

A

K

V

V

F

F

R

K

L

L

R

Y

E

E

H

H

V

I

Q

D

R
|
R

L

L

F

Y

S

D

S

C

A

A

K

R

I

V

L

I

R

D

M

L

E

K

I

I

P

P

F

L

T

S

E

K

D

E

A

E

I

F

F

A

D

E

A

A

I

I

V

L

E

E

T

T

L

L

Q

R

R

R

N

N

R

N

L

L

A

R

E

D

G

A

Y
|
Y

I

I

R
|
R

P

P

L

I

S

V

F

T

V

R

G

G

A

A

G

G

A

D

M

L

G

G

V

L

Y

D

P

P

G

R

D

K

N

C

P

P

V

S

Q

P

T

N

I

V

I

I

A

I

V

I

W

T

-

K

P

P

W

W

G

G

A

K

Y

L

L

Y

G

G

A

-

E

D

A

L

L

Y

E

E

K

K

G

G

I

L

R

K

V

A

K

I

T

T

S

V

S

A

F

I

A

R

R

R

H

N

H

A

V

I

N

D

A

S

M

L

M

P

T

P

K

N

A

I

K
|
K

A

-

S

S

G

L

N

N

Y
|
Y

V

L

N

N

S

N

V

I

L

L

A

A

K

K

M

I

E

E

A

A

K

N

A

A

D

K

G

G

Y

G

D

D

E

E

A

A

L

I

M

F

L

L

D

D

V

H

S

N

G

G

F

Y

V

I

S

S

E
|
E

A

G

T

S

G
|
G

E
x
D

N
|
N

I

I

F

F

M

I

V

V

R

K

N

N

G

G

V

T

I

I

K

T

T

T

T

P

P

P

L

T

T

L

S

N

I

N

L
|
L

D

K

G
|
G

I
|
I

T
|
T

R

R

N

Q

S

V

L

V

M

I

T

E

L

L

A

I

R

N

D

E

L

L

G

E

Y

I

E

P

V

F

V

R

E

E

Q

A

Q

N

F

I

T

G

R

L

D

F

E

D

L

L

Y

Y

V

S

A

A

D

D

E

E

A

I

F

F

F

V

C

T

G
|
G

T
|
T

A
|
A

A

A

E

E

V

I

T

A

P

P

I

V

R

T

E

Y

V

I

D

D

R

G

R

R

V

T

I

V

G

G

K

N

G

G

S

K

A

P

G

G

P

K

V

V

T

T

K

K

H

M

L

L

Q

M

Q

E

E

K

Y

F

active site: F33 (= F38), G35 (= G40), K151 (= K161), E184 (= E195), L207 (= L218)
binding 2-oxoglutaric acid: F33 (= F38), G35 (= G40), Y88 (= Y98), R90 (= R100), K151 (= K161), G187 (= G198), G246 (= G257), T247 (= T258), A248 (= A259)
binding pyridoxal-5'-phosphate: R52 (= R62), K151 (= K161), Y155 (= Y166), E184 (= E195), G187 (= G198), D188 (≠ E199), N189 (= N200), L207 (= L218), G209 (= G220), I210 (= I221), T211 (= T222), G246 (= G257), T247 (= T258)

6h65C Crystal structure of the branched-chain-amino-acid aminotransferase from haliangium ochraceum
36% identity, 95% coverage: 11:304/309 of query aligns to 8:303/308 of 6h65C

query
sites
6h65C

W

W

F

M

D

N

G

G

K

Q

Q

C

V

I

P

P

W

W

D

D

E

Q

A

C

N

S

V

L

H

H

V

V

L

S

T

T

H

Q

A

A

L

A

H

F

Y

F

G

G

V

A

G

S

V

L

F
|
F

E

E

G

G

I

V

R

R

A

A

Y

Y

R

W

C

N

A

A

D

E

G

R

S

E

S

Q

A

L

-

Y

V

V

F

F

R

R

L

L

R

D

E

E

H
|
H

V

L

Q

R

R
|
R

L

L

F

E

S

Q

S

S

A

A

K

K

I

M

L

L

R

R

M

M

E

K

I

L

P

S

F

M

T

P

E

I

D

A

A

D

I

I

F

R

D

Q

A

G

I

V

V

L

E

E

T

L

L

L

Q

R

R

A

N

N

R

E

L

F

-

R

A

S

E

D

G

V

Y

H

I

L

R

Y

P

V

L

A

S

S

F

Y

V

F

G

G

A

I

G

N

-

H

-

D

A

P

M

D

G

P

V

L

Y

F

P

P

G

T

D

D

N

D

P

T

V

-

Q

-

T

-

I

-

A

-

V

-

W

-

P

-

W

-

G

G

A

V

Y

Y

L

V

G

T

A

G

E

T

A

A

L

V

E

S

K

R

-

L

-

P

-

L

-

V

-

H

-

T

G

G

I

I

R

S

V

A

K

C

T

M

S

S

F

W

A

R

R

R

H

I

H

S

V

D

N

D

A

S

M

V

M

P

T

P

K

R

A

I

K
|
K

A

I

S

G

G

A

N

N

Y
|
Y

V

Q

N

N

S

S

V

R

L

L

A

A

K

Q

M

T

E

E

A

A

K

R

A

V

D

N

G

G

Y

Y

D

H

E

T

A

S

L

V

M

L

L

L

D

N

V

S

S

R

G

G

F

K

V

V

S

S

E
|
E

A

T

T
x
P

G
|
G

E
x
A

N
x
C

I

L

F

L

M

M

V

V

R

R

N

D

G

G

V

R

I

V

K

I

T

S

T

P

P

P

L

V

T

T

S

A

-

D

I

I

L
|
L

D

E

G
x
S

I
x
V

T
|
T

R

R

N

K

S

T

L

L

M

M

T

S

L

L

A

S

R

E

-

A

D

E

L

L

G

D

Y

S

E

P

V

V

V

I

E

E

Q

R

Q

D

F

M

T

D

R

R

D

T

E

E

L

L

Y

Y

V

I

A

A

D

E

E

E

A

V

F

F

F

L

C

C