Comparing 208789 MicrobesOnline__882:208789 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 8 hits to proteins with known functional sites (download)
E9AE57 Fumarate hydratase 2; Fumarase 2; LmFH-2; EC 4.2.1.2 from Leishmania major (see paper)
37% identity, 84% coverage: 21:174/183 of query aligns to 408:563/568 of E9AE57
Sites not aligning to the query:
6uoiA Crystal structure of cytosolic fumarate hydratase from leishmania major in a complex with malonate (see paper)
37% identity, 84% coverage: 21:174/183 of query aligns to 375:530/535 of 6uoiA
Sites not aligning to the query:
6unzA Crystal structure of cytosolic fumarate hydratase from leishmania major (see paper)
37% identity, 84% coverage: 21:174/183 of query aligns to 379:534/539 of 6unzA
Sites not aligning to the query:
6msnA Crystal structure of cytosolic fumarate hydratase from leishmania major in a complex with inhibitor thiomalate (see paper)
37% identity, 84% coverage: 21:174/183 of query aligns to 372:527/532 of 6msnA
Sites not aligning to the query:
6uqnB Crystal structure of r173a variant of cytosolic fumarate hydratase from leishmania major in a complex with fumarate and s-malate (see paper)
37% identity, 84% coverage: 21:174/183 of query aligns to 372:527/532 of 6uqnB
Sites not aligning to the query:
P14407 Fumarate hydratase class I, anaerobic; D-tartrate dehydratase; Fumarase B; EC 4.2.1.2; EC 4.2.1.81 from Escherichia coli (strain K12) (see paper)
40% identity, 81% coverage: 26:174/183 of query aligns to 385:535/548 of P14407
Sites not aligning to the query:
6msoA Crystal structure of mitochondrial fumarate hydratase from leishmania major in a complex with inhibitor thiomalate (see paper)
36% identity, 81% coverage: 26:174/183 of query aligns to 387:537/540 of 6msoA
Sites not aligning to the query:
Q4QAU9 Fumarate hydratase 1, mitochondrial; Fumarase 1; LmFH-1; EC 4.2.1.2 from Leishmania major (see paper)
36% identity, 81% coverage: 26:174/183 of query aligns to 396:546/549 of Q4QAU9
Sites not aligning to the query:
>208789 MicrobesOnline__882:208789
MPVHHLTTPLTDTAVDALRSGDVILLSGTIYTARDAAHRRLCDALDRGEQPPFDLRGAVI
YYVGPSPAPPGHPIGAAGPTTSYRMDSYAPRLHALGLKATIGKGRRHATVRKALSEHTAV
YFGATGGAGALLAQRITAARVIAYDDLGPEAIRELTVQDFPLLVINDAHGGELYVTPQLP
EGD
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory