SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing 208845 DVU3319 proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

4nmaA Crystal structure of proline utilization a (puta) from geobacter sulfurreducens pca in complex with l-tetrahydro-2-furoic acid (see paper)
66% identity, 100% coverage: 1:1005/1006 of query aligns to 1:977/977 of 4nmaA

query
sites
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active site: N629 (= N657), K652 (= K680), E733 (= E761), C767 (= C795), E863 (= E891), A943 (≠ T971)
binding flavin-adenine dinucleotide: D226 (= D245), M227 (= M246), V256 (= V277), Q258 (= Q279), Y260 (= Y281), R285 (= R306), V287 (= V308), K288 (= K309), G289 (= G310), A290 (= A311), Y291 (= Y312), W292 (= W313), W309 (= W330), T310 (= T331), I311 (≠ D332), K312 (= K333), S315 (= S336), A338 (= A359), S339 (= S360), H340 (= H361), N341 (= N362), Q365 (= Q386), V366 (= V387), L367 (= L388), Y388 (= Y409), R404 (= R425), E407 (= E428), S413 (= S434), F414 (= F435)
binding tetrahydrofuran-2-carboxylic acid: K185 (= K204), D226 (= D245), A290 (= A311), L367 (= L388), Y388 (= Y409), Y400 (= Y421), R403 (= R424), R404 (= R425)

4nmfB Crystal structure of proline utilization a (puta) from geobacter sulfurreducens pca inactivated by n-propargylglycine and complexed with menadione bisulfite (see paper)
66% identity, 99% coverage: 6:1005/1006 of query aligns to 2:979/979 of 4nmfB

query
sites
4nmfB

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active site: N631 (= N657), K654 (= K680), E735 (= E761), C769 (= C795), E865 (= E891), A945 (≠ T971)
binding (2R)-2-methyl-1,4-dioxo-1,2,3,4-tetrahydronaphthalene-2-sulfonic acid: D126 (= D146), K184 (= K204), A289 (= A311), Y290 (= Y312), L366 (= L388), Y387 (= Y409), Y399 (= Y421), R402 (= R424), R403 (= R425)
binding (2S)-2-methyl-1,4-dioxo-1,2,3,4-tetrahydronaphthalene-2-sulfonic acid: K184 (= K204), A289 (= A311), Y290 (= Y312), L366 (= L388), Y399 (= Y421), R402 (= R424), R403 (= R425)
binding N-propargylglycine-modified flavin adenine dinucleotide: K184 (= K204), D225 (= D245), M226 (= M246), V255 (= V277), Q257 (= Q279), Y259 (= Y281), R284 (= R306), V286 (= V308), K287 (= K309), G288 (= G310), A289 (= A311), Y290 (= Y312), W291 (= W313), W308 (= W330), T309 (= T331), I310 (≠ D332), K311 (= K333), S314 (= S336), A337 (= A359), S338 (= S360), H339 (= H361), N340 (= N362), Q364 (= Q386), V365 (= V387), L366 (= L388), Y387 (= Y409), E406 (= E428), E411 (= E433), S412 (= S434), F413 (= F435)

4nmdA Crystal structure of proline utilization a (puta) from geobacter sulfurreducens pca reduced with dithionite (see paper)
66% identity, 100% coverage: 1:1005/1006 of query aligns to 2:979/979 of 4nmdA

query
sites
4nmdA

M

M

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active site: N631 (= N657), K654 (= K680), E735 (= E761), C769 (= C795), E865 (= E891), A945 (≠ T971)
binding dihydroflavine-adenine dinucleotide: D226 (= D245), M227 (= M246), V256 (= V277), Q258 (= Q279), Y260 (= Y281), R285 (= R306), V287 (= V308), K288 (= K309), G289 (= G310), A290 (= A311), Y291 (= Y312), W292 (= W313), W309 (= W330), T310 (= T331), I311 (≠ D332), K312 (= K333), S315 (= S336), A338 (= A359), S339 (= S360), H340 (= H361), N341 (= N362), Q365 (= Q386), V366 (= V387), L367 (= L388), Y388 (= Y409), S413 (= S434), F414 (= F435)

4nmcB Crystal structure of oxidized proline utilization a (puta) from geobacter sulfurreducens pca complexed with zwittergent 3-12 (see paper)
67% identity, 99% coverage: 6:1003/1006 of query aligns to 4:969/969 of 4nmcB

query
sites
4nmcB

L

L

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N

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P

Q

H

V

V

L

L

Y

Y

S

S

A

A

F

F

G

G

F

F

Q

Q

G

G

Q

Q

K

K

C
|
C

S

S

A

A

C

C

S

S

R

R

V

V

I

I

V

V

L

L

D

D

A

A

I

V

Y

Y

D

D

R

K

F

F

I

I

E

E

R

R

L

L

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V

K

S

A

M

A

A

S

K

S

A

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T

H

K

I

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G

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P

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S

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E

D

D

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N

N

Y

Y

M

M

G

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V

A

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D

D

A

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L

A

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G

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P

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E

H

H

R

R

I

I

A

A

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Q

E

E

E
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E

I

I

F

F

G

G

P

P

V

V

L

L

A

A

V

V

M

M

R

R

A

A

A

K

T

D

F

F

D

D

E

Q

A

A

L

I

S

E

I

W

A

A

N

N

G

S

T

T

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Q

F

F

A

A

L

L

T

T

G

G

A

G

V

I

F

F

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S

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R

S

S

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P

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H

H

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L

D

A

K

K

A

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R

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F

F

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R

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V

G

G

N

N

L

L

Y

Y

L

I

N

N

K

R

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N

S

N

T

T

G

G

A

A

L

L

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V

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F

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G

G

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M

M

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S

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G

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V

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G

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K

K

T
x
A

G

G

G

G

P

P

D

D

Y

Y

L

L

L

L

Q

H

F

F

M

M

D

D

P

P

R

R

V

V

V

V

T

T

E

E

N

N

T

T

M

M

R

R

R

R

G

G

F

F

T

A

P

P

I

I

D

E

E

E

D

D

D

D

D

D

active site: N623 (= N657), K646 (= K680), E727 (= E761), C761 (= C795), E857 (= E891), A937 (≠ T971)
binding n-dodecyl-n,n-dimethyl-3-ammonio-1-propanesulfonate: W32 (= W34), F74 (= F76)
binding flavin-adenine dinucleotide: D220 (= D245), M221 (= M246), V250 (= V277), Q252 (= Q279), Y254 (= Y281), R279 (= R306), V281 (= V308), K282 (= K309), G283 (= G310), A284 (= A311), Y285 (= Y312), W286 (= W313), W303 (= W330), T304 (= T331), I305 (≠ D332), K306 (= K333), S309 (= S336), A332 (= A359), S333 (= S360), H334 (= H361), N335 (= N362), Q359 (= Q386), V360 (= V387), L361 (= L388), Y382 (= Y409), R398 (= R425), E401 (= E428), E406 (= E433), S407 (= S434), F408 (= F435)

7na0A Structure of geobacter sulfurreducens proline utilization a (puta) variant a206w (see paper)
66% identity, 100% coverage: 1:1005/1006 of query aligns to 2:980/981 of 7na0A

query
sites
7na0A

M

M

D

L

Q

N

Q

S

H

E

L

L

D

N

G

T

K

K

V

I

V

V

E

N

R

R

G

G

K

K

E

E

F

F

F

F

R

G

S

S

I

I

S

-

G

-

E

E

A

K

P

P

S

S

I

L

F

F

N

N

K

K

G

G

W

A

W

W

T

M

G

G

K

K

V

A

M

M

D

D

W

W

A

S

M

M

Q

Q

N

N

E

E

D

Q

F

F

K

K

V

I

Q

Q

L

M

F

F

R

R

F

F

V

V

D

D

V

V

L

F

P

P

Y

S

L

L

N

T

T

T

S

S

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K

S

L

L

L

L

T

R

E

H

H

I

I

R

R

E

E

Y

Y

F

F

A

G

T

N

E

E

D

Q

A

-

D

D

I

M

P

P

P

-

V

-

L

-

K

-

W

-

G

-

A

-

G

-

K

-

A

-

G

-

I

-

G

-

G

-

A

-

L

-

T

-

A

A

K

F

L

M

M

L

G

N

M

K

T

V

I

L

R

T

S

S

N

N

I

I

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E

G

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M

M

A

A

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R

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Q

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F

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K

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A

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V

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K

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N

L

L

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K

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L

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K

D

D

G

G

F

F

T

A

F

A

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V

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D

L

V

L

L

G

G

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E

A

A

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L

S

S

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A

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A

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Y

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W

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G

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F

L

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W

W

G

G

A

H

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A

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P

K

K

V

V

N

N

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A

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K

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A

W

L

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K

K

K

V

V

V

M

A

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M

L

G

N

G

G

F

F

L

L

C

C

I

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D

M
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M

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E

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Y

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K

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V

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Y

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R

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V

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K

G
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G

A
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A

Y
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Y

W
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W

D

D

Y

Y

E

E

T

T

V

V

I

K

A

A

K

K

Q

Q

N

N

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D

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W
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W

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T

D
x
I

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K

P

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S

D

D

I

A

A

A

Y

Y

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E

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L

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N

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C

Y

H

F

F

A

A

C

C

A
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A

S
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S

H
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H

N
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N

V

I

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R

T

T

I

I

A

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A

A

V

V

M

M

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A

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A

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L

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N

N

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Y

Y

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E

F

F

Q
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Q

V
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V

L
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L

Y

Y

G

G

M

M

A

A

E

E

P

P

V

V

R

R

K

K

G

G

L

I

K

L

N

K

V

V

A

A

G

G

R

R

V

I

R

R

L

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Y
|
Y

C

A

P

P

Y

Y

G

G

E

N

L

M

I

V

P

P

G

G

M

M

A

G

Y

Y

L

L

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V

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R

R

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L

L