SitesBLAST – Find functional sites

 

SitesBLAST

Comparing 209405 MicrobesOnline__882:209405 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 3 hits to proteins with known functional sites (download)

1piiA Three-dimensional structure of the bifunctional enzyme phosphoribosylanthranilate isomerase: indoleglycerolphosphate synthase from escherichia coli refined at 2.0 angstroms resolution (see paper)
35% identity, 81% coverage: 39:268/284 of query aligns to 258:451/452 of 1piiA

query
sites
1piiA
K
 
K
V
 
V
C
|
C
G
 
G
L
 
L
T
 
T
R
 
R
Q
 
G
E
 
Q
D
 
D
A
 
A
A
 
K
S
 
A
C
 
A
A
 
Y
R
 
D
L
 
A
G
 
G
V
 
A
H
 
I
L
 
Y
G
 
G
G
 
G
F
 
L
I
 
I
F
 
F
H
 
V
A
 
A
S
 
T
S
 
S
P
 
P
R
 
R
N
 
C
V
 
V
D
 
N
P
 
V
A
 
E
C
 
Q
V
 
A
A
 
Q
D
 
E
-
 
V
M
 
M
D
 
A
T
 
A
G
 
A
R
 
P
M
 
L
L
 
Q
R
 
Y
V
 
V
G
 
G
V
 
V
F
 
F
V
 
R
R
 
N
Q
 
H
S
 
D
V
 
I
D
 
A
E
 
D
V
 
V
V
 
V
R
 
D
T
 
K
M
 
A
R
 
K
V
 
V
A
 
L
R
 
S
L
 
L
H
 
A
M
 
A
A
 
V
Q
 
Q
L
 
L
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H
G
 
G
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N
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E
D
 
E
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Q
A
 
L
F
 
Y
C
 
-
K
 
-
E
 
-
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I
A
 
D
A
 
T
L
 
L
A
 
R
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E
I
 
A
L
 
L
P
 
P
E
 
A
V
 
H
L
 
V
S
 
A
G
 
I
M
 
W
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K
P
 
A
S
 
L
S
 
S
G
 
V
G
 
G
E
 
E
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P
 
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D
 
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M
 
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A
 
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A
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R
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E
A
 
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-
T
 
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F
E
 
Q
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E
 
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-
Y
 
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V
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D
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K
F
 
Y
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L
D
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D
A
 
N
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G
T
 
Q
A
 
-
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-
G
 
G
G
 
G
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S
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G
A
 
Q
T
 
R
L
 
F
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D
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W
D
 
S
A
 
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L
 
L
E
 
N
G
 
G
M
 
Q
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S
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L
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-
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L
L
 
L
A
 
A
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G
G
|
G
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L
G
 
G
P
 
A
D
 
D
N
 
N
-
 
C
V
 
V
E
 
E
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A
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A
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R
 
T
A
 
G
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C
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A
P
 
-
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D
L
 
F
N
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A
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E
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G
 
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I
 
I
K
 
K
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D
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L
I
 
L
E
 
A
N
 
S
A
 
V
L
 
F
V
 
Q
A
 
T
L
 
L
A
 
R
A
 
A

Sites not aligning to the query:

1nsjA Crystal structure of phosphoribosyl anthranilate isomerase from thermotoga maritima (see paper)
28% identity, 79% coverage: 36:260/284 of query aligns to 2:196/205 of 1nsjA

query
sites
1nsjA
L
 
V
R
 
R
V
 
V
K
 
K
V
 
I
C
|
C
G
 
G
L
 
I
T
 
T
R
 
N
Q
 
L
E
 
E
D
 
D
A
 
A
A
 
L
S
 
F
C
 
S
A
 
V
R
 
E
L
 
S
G
 
G
V
 
A
H
 
D
L
 
A
G
 
V
G
 
G
F
 
F
I
 
V
F
 
F
H
 
Y
A
 
P
S
 
K
S
 
S
P
 
K
R
 
R
N
 
Y
V
 
I
D
 
S
P
 
P
A
 
E
C
 
D
V
 
A
A
 
R
D
 
R
M
 
I
D
 
S
T
 
V
G
 
E
R
 
L
-
 
P
-
 
P
-
 
F
M
 
V
L
 
F
R
 
R
V
 
V
G
 
G
V
 
V
F
 
F
V
 
V
R
 
N
Q
 
E
S
 
E
V
 
P
D
 
E
E
 
K
V
 
I
V
 
L
R
 
D
T
 
V
M
 
A
R
 
S
V
 
Y
A
 
V
R
 
Q
L
 
L
H
 
N
M
 
A
A
 
V
Q
 
Q
L
 
L
H
 
H
G
 
G
G
 
E
Q
 
E
D
 
P
V
 
I
A
 
E
F
 
L
C
 
C
K
 
R
E
 
K
L
 
I
V
 
A
A
 
E
A
 
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L
 
I
A
 
L
D
 
-
I
 
-
L
 
-
P
 
-
E
 
-
V
 
V
L
 
I
S
 
K
G
 
A
M
 
V
S
 
G
P
 
V
S
 
S
S
 
-
G
 
-
G
 
-
E
 
-
H
 
-
A
 
-
D
 
-
S
 
N
P
 
E
H
 
R
D
 
D
M
 
M
A
 
E
R
 
R
G
 
A
R
 
L
L
 
N
L
 
Y
R
 
R
A
 
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V
 
-
W
 
-
P
 
-
A
 
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-
H
 
-
A
 
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T
 
-
T
 
-
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-
S
 
E
F
 
F
E
 
P
H
 
I
E
 
L
L
 
L
A
x
D
T
 
T
L
 
K
A
 
T
P
 
P
Y
 
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V
 
-
G
 
-
H
 
-
F
 
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V
 
-
F
 
-
D
 
-
A
 
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G
 
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-
A
 
E
G
 
Y
G
|
G
G
 
G
H
 
S
G
 
G
A
 
K
T
 
T
L
 
F
P
 
D
W
 
W
D
 
S
-
 
L
A
 
I
L
 
L
E
 
P
G
 
Y
M
 
R
S
 
D
C
 
R
P
 
F
R
 
R
P
 
Y
W
 
L
L
 
V
L
 
L
A
 
S
G
 
G
G
 
G
L
 
L
G
 
N
P
 
P
D
 
E
N
 
N
V
 
V
E
 
R
R
 
S
A
 
A
V
 
I
R
 
D
A
 
V
C
 
V
H
 
R
P
 
P
W
 
F
G
 
A
V
 
V
D
 
D
L
x
V
N
x
S
S
|
S
G
 
G
V
 
V
E
 
E
S
 
A
A
 
F
P
 
P
G
 
G
I
 
K
K
 
K
D
 
D
M
 
H
Q
 
D
R
 
S
I
 
I
E
 
K

1lbmA Crystal structure of phosphoribosyl anthranilate isomerase (prai) in complex with reduced 1-(o-carboxyphenylamino)-1-deoxyribulose 5- phosphate (rcdrp) (see paper)
26% identity, 79% coverage: 36:260/284 of query aligns to 2:185/194 of 1lbmA

query
sites
1lbmA
L
 
V
R
 
R
V
 
V
K
 
K
V
 
I
C
|
C
G
 
G
L
 
I
T
 
T
R
 
N
Q
 
L
E
 
E
D
 
D
A
 
A
A
 
L
S
 
F
C
 
S
A
 
V
R
 
E
L
 
S
G
 
G
V
 
A
H
 
D
L
 
A
G
 
V
G
 
G
F
 
F
I
 
V
F
 
F
H
 
Y
A
 
P
S
 
K
S
|
S
P
 
K
R
|
R
N
 
Y
V
 
I
D
 
S
P
 
P
A
 
E
C
 
D
V
 
A
A
 
R
D
 
R
M
 
I
D
 
S
T
 
V
G
 
E
R
 
L
-
 
P
-
 
P
-
 
F
M
 
V
L
 
F
R
 
R
V
 
V
G
 
G
V
 
V
F
 
F
V
 
V
R
 
N
Q
 
E
S
 
E
V
 
P
D
 
E
E
 
K
V
 
I
V
 
L
R
 
D
T
 
V
M
 
A
R
 
S
V
 
Y
A
 
V
R
 
Q
L
 
L
H
 
N
M
 
A
A
 
V
Q
 
Q
L
 
L
H
|
H
G
 
G
G
 
E
Q
 
E
D
 
P
V
 
I
A
 
E
F
 
L
C
 
C
K
 
R
E
 
K
L
 
I
V
 
A
A
 
E
A
 
R
L
 
I
A
 
L
D
 
-
I
 
-
L
 
-
P
 
-
E
 
-
V
 
V
L
 
I
S
 
K
G
 
A
M
 
V
S
 
G
P
 
V
S
 
S
S
 
-
G
 
-
G
 
-
E
 
-
H
 
-
A
 
-
D
 
-
S
 
N
P
 
E
H
 
R
D
 
D
M
 
M
A
 
E
R
 
R
G
 
A
R
 
L
L
 
N
L
 
Y
R
 
R
A
 
E
V
 
-
W
 
F
P
 
P
A
 
I
R
 
L
H
 
L
A
x
D
T
 
T
T
 
-
V
 
-
S
 
-
F
 
-
E
 
-
H
 
F
E
 
D
L
 
W
A
 
S
T
 
L
L
 
I
A
 
L
P
 
P
Y
 
Y
V
 
R
G
 
D
H
 
R
F
 
F
V
 
-
F
 
-
D
 
-
A
 
-
G
 
-
T
 
-
A
 
-
G
 
-
G
 
-
G
 
-
H
 
-
G
 
-
A
 
-
T
 
-
L
 
-
P
 
-
W
 
-
D
 
-
A
 
-
L
 
-
E
 
-
G
 
-
M
 
-
S
 
-
C
 
-
P
 
-
R
 
R
P
 
Y
W
 
L
L
 
V
L
 
L
A
 
S
G
|
G
G
|
G
L
 
L
G
 
N
P
 
P
D
 
E
N
 
N
V
 
V
E
 
R
R
 
S
A
 
A
V
 
I
R
 
D
A
 
V
C
 
V
H
 
R
P
 
P
W
 
F
G
 
A
V
 
V
D
|
D
L
 
V
N
x
S
S
|
S
G
 
G
V
 
V
E
 
E
S
 
A
A
 
F
P
 
P
G
 
G
I
 
K
K
 
K
D
 
D
M
 
H
Q
 
D
R
 
S
I
 
I
E
 
K

Query Sequence

>209405 MicrobesOnline__882:209405
MASPALSPDEPDEPGVSGESGASGEPGASTSRQTRLRVKVCGLTRQEDAASCARLGVHLG
GFIFHASSPRNVDPACVADMDTGRMLRVGVFVRQSVDEVVRTMRVARLHMAQLHGGQDVA
FCKELVAALADILPEVLSGMSPSSGGEHADSPHDMARGRLLRAVWPARHATTVSFEHELA
TLAPYVGHFVFDAGTAGGGHGATLPWDALEGMSCPRPWLLAGGLGPDNVERAVRACHPWG
VDLNSGVESAPGIKDMQRIENALVALAACGDVSGPEARIGDARS

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory