Comparing 209407 MicrobesOnline__882:209407 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5ey5A Lbcats
42% identity, 98% coverage: 4:256/257 of query aligns to 2:247/261 of 5ey5A
6uapC Crystal structure of tryptophan synthase from m. Tuberculosis - open form with brd6309 bound
36% identity, 94% coverage: 3:244/257 of query aligns to 1:232/250 of 6uapC
6usaA Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and gsk1-bound form (see paper)
36% identity, 94% coverage: 3:244/257 of query aligns to 2:231/249 of 6usaA
6u6cA Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and gsk2-bound form (see paper)
36% identity, 94% coverage: 3:244/257 of query aligns to 2:231/249 of 6u6cA
6dweA Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and brd0059-bound form
36% identity, 94% coverage: 3:244/257 of query aligns to 2:231/249 of 6dweA
5tciA Crystal structure of tryptophan synthase from m. Tuberculosis - brd4592-bound form (see paper)
36% identity, 94% coverage: 3:244/257 of query aligns to 2:231/249 of 5tciA
6u6cE Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and gsk2-bound form (see paper)
36% identity, 94% coverage: 3:244/257 of query aligns to 1:229/245 of 6u6cE
Sites not aligning to the query:
8b08A Tryptophan synthase - cryo-trapping by the spitrobot crystal plunger after 30 sec (see paper)
32% identity, 79% coverage: 20:221/257 of query aligns to 19:221/269 of 8b08A
Sites not aligning to the query:
2clkA Tryptophan synthase in complex with d-glyceraldehyde 3- phosphate (g3p) (see paper)
32% identity, 79% coverage: 20:221/257 of query aligns to 18:220/267 of 2clkA
Sites not aligning to the query:
1k3uA Crystal structure of wild-type tryptophan synthase complexed with n- [1h-indol-3-yl-acetyl]aspartic acid (see paper)
32% identity, 79% coverage: 20:221/257 of query aligns to 18:220/268 of 1k3uA
Sites not aligning to the query:
1tjpA Crystal structure of wild-type tryptophan synthase complexed with 1- [(2-hydroxylphenyl)amino]3-glycerolphosphate (see paper)
32% identity, 79% coverage: 20:221/257 of query aligns to 18:220/267 of 1tjpA
Sites not aligning to the query:
3cepA Structure of a tryptophan synthase quinonoid intermediate (see paper)
32% identity, 79% coverage: 20:221/257 of query aligns to 17:219/266 of 3cepA
Sites not aligning to the query:
7jllA The internal aldimine crystal structure of salmonella typhimurium tryptophan synthase mutant beta-s377a in complex with inhibitor 2- ({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)ethyl dihydrogen phosphate (f9f) at the alpha-site, cesium ion at the metal coordination site and l-tryptophan at the enzyme beta-site
32% identity, 79% coverage: 20:221/257 of query aligns to 17:219/267 of 7jllA
Sites not aligning to the query:
6xncA Salmonella typhimurium tryptophan synthase complexed with l-tryptophan and d-glycerol-3-phosphate (see paper)
32% identity, 79% coverage: 20:221/257 of query aligns to 17:219/267 of 6xncA
Sites not aligning to the query:
1cx9A Crystal structure of the complex of bacterial tryptophan synthase with the transition state analogue inhibitor 4-(2-aminophenylthio)- butylphosphonic acid (see paper)
33% identity, 79% coverage: 20:221/257 of query aligns to 17:217/264 of 1cx9A
Sites not aligning to the query:
1cw2A Crystal structure of the complex of bacterial tryptophan synthase with the transition state analogue inhibitor 4-(2-hydroxyphenylsulfinyl)- butylphosphonic acid (see paper)
33% identity, 79% coverage: 20:221/257 of query aligns to 17:217/264 of 1cw2A
Sites not aligning to the query:
1c9dA Crystal structure of the complex of bacterial tryptophan synthase with the transition state analogue inhibitor 4-(2-hydroxy-4- fluorophenylthio)-butylphosphonic acid (see paper)
33% identity, 79% coverage: 20:221/257 of query aligns to 17:217/264 of 1c9dA
Sites not aligning to the query:
1c29A Crystal structure of the complex of bacterial tryptophan synthase with the transition state analogue inhibitor 4-(2-hydroxyphenylthio)-1- butenylphosphonic acid (see paper)
33% identity, 79% coverage: 20:221/257 of query aligns to 17:217/264 of 1c29A
Sites not aligning to the query:
2trsA Crystal structures of mutant (betak87t) tryptophan synthase alpha2 beta2 complex with ligands bound to the active sites of the alpha and beta subunits reveal ligand-induced conformational changes (see paper)
33% identity, 79% coverage: 20:221/257 of query aligns to 18:214/262 of 2trsA
Sites not aligning to the query:
1a50A Crystal structure of wild-type tryptophan synthase complexed with 5- fluoroindole propanol phosphate (see paper)
33% identity, 79% coverage: 20:221/257 of query aligns to 17:213/260 of 1a50A
Sites not aligning to the query:
>209407 MicrobesOnline__882:209407
MSASRLERRIREAQAAGRPALIPFLTAGFPTKERFWDELEALDAAGADIIEVGVPFSDPV
ADGPVVAAASQRALESGVTLRWIMDGLAARKGRLRAGLVLMGYLNPFMQYGFERFVSDAA
DAGVAGCIIPDLPLDEDADLRALLAARDMDLIALVGPNTGEGRMREYAAVASGYVYVVSV
MGTTGVRDGLPVEVADTLARARQCFSIPVALGFGISRPAQLEGLSHPPDAVIFGSALLRH
LDAGGDAASFMKAWAER
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory