SitesBLAST
Comparing 2629601819 IMG__TrieryIMS101_FD:2629601819 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
2zsjA Crystal structure of threonine synthase from aquifex aeolicus vf5
37% identity, 79% coverage: 71:415/437 of query aligns to 6:342/350 of 2zsjA
- active site: K61 (= K125), T85 (= T149), Q218 (= Q284), A222 (≠ C288), A240 (≠ S313), T317 (= T390)
- binding pyridoxal-5'-phosphate: F60 (= F124), K61 (= K125), N87 (= N151), V186 (≠ I251), G187 (≠ A252), N188 (≠ S253), A189 (≠ G254), G190 (≠ S255), N191 (≠ L256), A240 (≠ S313), T317 (= T390), G318 (= G391)
1uimA Crystal structure of threonine synthase from thermus thermophilus hb8, orthorhombic crystal form (see paper)
37% identity, 80% coverage: 68:415/437 of query aligns to 3:342/350 of 1uimA
- active site: K61 (= K125), T85 (= T149), P212 (≠ V278), G216 (= G282), Q218 (= Q284), A240 (≠ S313), T317 (= T390)
- binding pyridoxal-5'-phosphate: F60 (= F124), K61 (= K125), N87 (= N151), G187 (≠ A252), N188 (≠ S253), A189 (≠ G254), G190 (≠ S255), N191 (≠ L256), A240 (≠ S313), E287 (= E360), T317 (= T390), G318 (= G391)
3aexA Catalytic intermediate analogue of threonine synthase from thermus thermophilus hb8 (see paper)
37% identity, 80% coverage: 68:415/437 of query aligns to 3:342/351 of 3aexA
- active site: K61 (= K125), T85 (= T149), P212 (≠ V278), G216 (= G282), Q218 (= Q284), A240 (≠ S313), T317 (= T390)
- binding (3E)-4-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}-2-oxobut-3-enoic acid: K61 (= K125), S84 (= S148), T85 (= T149), N87 (= N151), T88 (≠ L152), V186 (≠ I251), G187 (≠ A252), N188 (≠ S253), A189 (≠ G254), G190 (≠ S255), N191 (≠ L256), A240 (≠ S313), I241 (= I314), E287 (= E360), T317 (= T390)
- binding phosphate ion: K61 (= K125), T88 (≠ L152), N154 (= N217), S155 (≠ N219), R160 (≠ Y224), N188 (≠ S253)
1v7cA Crystal structure of threonine synthase from thermus thermophilus hb8 in complex with a substrate analogue (see paper)
37% identity, 80% coverage: 68:415/437 of query aligns to 3:342/351 of 1v7cA
- active site: K61 (= K125), T85 (= T149), P212 (≠ V278), G216 (= G282), Q218 (= Q284), A240 (≠ S313), T317 (= T390)
- binding (2e)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-5-phosphonopent-2-enoic acid: K61 (= K125), S84 (= S148), T85 (= T149), N87 (= N151), T88 (≠ L152), F134 (≠ Y197), N154 (= N217), S155 (≠ N219), R160 (≠ Y224), V186 (≠ I251), G187 (≠ A252), N188 (≠ S253), A189 (≠ G254), G190 (≠ S255), N191 (≠ L256), A240 (≠ S313), I241 (= I314), E287 (= E360), T317 (= T390)
3aeyA Apo form of threonine synthase from thermus thermophilus hb8 (see paper)
37% identity, 80% coverage: 68:415/437 of query aligns to 2:341/350 of 3aeyA
- active site: K60 (= K125), T84 (= T149), P211 (≠ V278), G215 (= G282), Q217 (= Q284), A239 (≠ S313), T316 (= T390)
- binding sulfate ion: K60 (= K125), K60 (= K125), G85 (= G150), N86 (= N151), T87 (≠ L152), T87 (≠ L152), S154 (≠ N219), R159 (≠ Y224), N187 (≠ S253), R228 (≠ F295), V230 (≠ E297), E231 (= E298), R232 (= R299), A239 (≠ S313)
6cgqB Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala (see paper)
36% identity, 79% coverage: 71:417/437 of query aligns to 5:341/345 of 6cgqB
- active site: K58 (= K125), T82 (= T149), E214 (≠ Q284), S218 (≠ C288), A236 (≠ S313), T313 (= T390)
- binding (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-alanine: K58 (= K125), S81 (= S148), T82 (= T149), N84 (= N151), T85 (≠ L152), V183 (≠ I251), G184 (≠ A252), N185 (≠ S253), A186 (≠ G254), N188 (≠ L256), A236 (≠ S313), I237 (= I314), E283 (= E360), T313 (= T390)
- binding phosphate ion: K58 (= K125), T85 (≠ L152), N151 (= N217), S152 (≠ N219), R157 (≠ Y224), N185 (≠ S253)
6nmxA Threonine synthase from bacillus subtilis atcc 6633 with plp and appa (see paper)
35% identity, 79% coverage: 71:417/437 of query aligns to 7:343/350 of 6nmxA
- active site: K60 (= K125), T84 (= T149), E216 (≠ Q284), S220 (≠ C288), A238 (≠ S313), T315 (= T390)
- binding (2E,3Z)-2-{[(Z)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4(1H)-ylidene}methyl]imino}-5-phosphonopent-3-enoic acid: K60 (= K125), S83 (= S148), T84 (= T149), N86 (= N151), T87 (≠ L152), F133 (≠ Y197), N153 (= N217), S154 (≠ N219), R159 (≠ Y224), V185 (≠ I251), G186 (≠ A252), N187 (≠ S253), A188 (≠ G254), G189 (≠ S255), N190 (≠ L256), A238 (≠ S313), I239 (= I314), E285 (= E360), T315 (= T390)
6cgqA Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala (see paper)
35% identity, 79% coverage: 71:417/437 of query aligns to 3:333/339 of 6cgqA
- active site: K56 (= K125), T80 (= T149), E206 (≠ Q284), S210 (≠ C288), A228 (≠ S313), T305 (= T390)
- binding pyridoxal-5'-phosphate: F55 (= F124), K56 (= K125), N82 (= N151), V175 (≠ I251), G176 (≠ A252), N177 (≠ S253), A178 (≠ G254), G179 (≠ S255), N180 (≠ L256), A228 (≠ S313), E275 (= E360), T305 (= T390), G306 (= G391)
A0R220 Threonine synthase; TS; EC 4.2.3.1 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
36% identity, 75% coverage: 68:395/437 of query aligns to 13:331/360 of A0R220
- K151 (≠ S210) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
P9WG59 Threonine synthase; TS; EC 4.2.3.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
35% identity, 76% coverage: 62:395/437 of query aligns to 7:331/360 of P9WG59
- K69 (= K125) modified: N6-(pyridoxal phosphate)lysine
- N95 (= N151) binding pyridoxal 5'-phosphate
- K151 (≠ S210) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
- GNAGN 196:200 (≠ ASGSL 252:256) binding pyridoxal 5'-phosphate
- T326 (= T390) binding pyridoxal 5'-phosphate
2d1fA Structure of mycobacterium tuberculosis threonine synthase (see paper)
35% identity, 75% coverage: 68:395/437 of query aligns to 4:322/349 of 2d1fA
- active site: K60 (= K125), T84 (= T149), D209 (= D275), R213 (= R279), L215 (≠ S281), A240 (≠ S313), T317 (= T390)
- binding pyridoxal-5'-phosphate: F59 (= F124), K60 (= K125), N86 (= N151), V186 (≠ I251), G187 (≠ A252), N188 (≠ S253), A189 (≠ G254), G190 (≠ S255), N191 (≠ L256), A240 (≠ S313), T317 (= T390)
2c2bA Crystallographic structure of arabidopsis thaliana threonine synthase complexed with pyridoxal phosphate and s-adenosylmethionine (see paper)
28% identity, 82% coverage: 44:403/437 of query aligns to 34:410/444 of 2c2bA
- binding pyridoxal-5'-phosphate: F127 (= F124), K128 (= K125), D159 (≠ N151), G259 (≠ I251), G260 (≠ A252), N261 (≠ S253), L262 (vs. gap), G263 (= G254), N264 (≠ S255), A321 (≠ S313), H369 (≠ A362), T397 (= T390)
- binding s-adenosylmethionine: S64 (≠ A62), T65 (= T63), W66 (≠ I64), P67 (≠ E65), G69 (= G67), S90 (≠ D87), F92 (≠ G89), N97 (≠ P94), L98 (= L95), W100 (≠ K97), W115 (≠ Y111), W115 (≠ Y111), Q246 (= Q238), F247 (≠ L239)
Q9S7B5 Threonine synthase 1, chloroplastic; Protein METHIONINE OVER-ACCUMULATOR 2; EC 4.2.3.1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
28% identity, 82% coverage: 44:403/437 of query aligns to 109:485/526 of Q9S7B5
- N172 (≠ P94) binding S-adenosyl-L-methionine
- L173 (= L95) binding S-adenosyl-L-methionine
- K181 (≠ R103) binding in monomer B; binding in monomer A
- N187 (≠ K108) binding in monomer B
- L205 (≠ R127) mutation to R: In mto2-1; causes a strong decrease in the concentration of soluble threonine and over-accumulation of methionine.
2c2gA Crystal structure of threonine synthase from arabidopsis thaliana in complex with its cofactor pyridoxal phosphate (see paper)
28% identity, 82% coverage: 44:403/437 of query aligns to 52:412/448 of 2c2gA
5ey5B Lbcats
26% identity, 69% coverage: 93:395/437 of query aligns to 51:376/383 of 5ey5B
- binding pyridoxal-5'-phosphate: H81 (≠ S123), K82 (≠ F124), Q109 (≠ N151), S185 (≠ F215), G227 (≠ A252), G229 (= G254), S230 (= S255), N231 (≠ L256), E345 (≠ A362), S371 (≠ T390), G372 (= G391)
P20132 L-serine dehydratase/L-threonine deaminase; SDH; L-serine deaminase; L-threonine dehydratase; TDH; EC 4.3.1.17; EC 4.3.1.19 from Homo sapiens (Human) (see paper)
26% identity, 69% coverage: 93:392/437 of query aligns to 11:305/328 of P20132
- C303 (≠ T390) mutation to A: Loss of enzyme activity.
1pwhA Rat liver l-serine dehydratase- complex with pyridoxyl-(o-methyl- serine)-5-monophosphate (see paper)
26% identity, 69% coverage: 93:392/437 of query aligns to 11:305/327 of 1pwhA
- active site: K41 (= K125), A65 (≠ T149), E194 (≠ Q284), A198 (≠ C288), S200 (≠ P290), A222 (= A315), A269 (= A362), C303 (≠ T390)
- binding n-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-o-methyl-l-serine: F40 (= F124), K41 (= K125), S64 (= S148), A65 (≠ T149), N67 (= N151), A68 (≠ L152), F136 (≠ N219), G168 (≠ A252), G169 (≠ S253), G170 (= G254), G171 (≠ S255), A222 (= A315), G224 (= G317), C303 (≠ T390), G304 (= G391)
1p5jA Crystal structure analysis of human serine dehydratase (see paper)
26% identity, 69% coverage: 93:392/437 of query aligns to 8:302/319 of 1p5jA
- active site: K38 (= K125), A62 (≠ T149), E191 (≠ R279), A195 (= A283), S197 (≠ A285), A219 (= A315), C300 (≠ T390)
- binding pyridoxal-5'-phosphate: F37 (= F124), K38 (= K125), N64 (= N151), V164 (≠ I251), G165 (≠ A252), G166 (≠ S253), G167 (= G254), G168 (≠ S255), A219 (= A315), C300 (≠ T390), G301 (= G391), G302 (≠ N392)
5ygrB Crystal structure of plp bound diaminopropionate ammonia lyase from salmonella typhimurium (see paper)
25% identity, 41% coverage: 92:269/437 of query aligns to 34:232/365 of 5ygrB
Q8VBT2 L-serine dehydratase/L-threonine deaminase; SDH; L-serine deaminase; L-threonine dehydratase; TDH; EC 4.3.1.17; EC 4.3.1.19 from Mus musculus (Mouse)
25% identity, 68% coverage: 93:391/437 of query aligns to 11:304/327 of Q8VBT2
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2 modified: N-acetylalanine
Query Sequence
>2629601819 IMG__TrieryIMS101_FD:2629601819
MTHATKTHNQIETTNTAVENLRCKECGEEYPLEAKHICEDVCFGPLEVKYNYEKLSQIVS
RATIEAGPKSIWRYRHFLPVVTDNFIDVGTGMTPLVKSERLARRLGLKNLYIKNDAVNMP
TLSFKDRVVSVALSRARELGFSTVSCASTGNLANSTAAIAAKAGLECCVFIPADLEAGKV
LGTLIYNPTLMAVKGNYDQVNRLCCEVANSYGWGFVNINLRPYYSEGSKTLGFEVAEQLG
WQLPDHVVAPIASGSLYTKIYKGFQEFIKVGLVEDKAVRFSGAQAEGCSPVAQAFKEERD
FISPVKPNTIAKSIAIGNPADGVYALELARKTNGNIESVNDTEIIEGIKLLAETEGIFTE
TAGGTTIAVLKKLVEAGKIDPEETTVVYITGNGLKTQEAVQGYVGEPLTIEAKLDSFERA
WERAQTLERLDWQQVLV
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory