SitesBLAST

7bkbL Formate dehydrogenase - heterodisulfide reductase - formylmethanofuran dehydrogenase complex from methanospirillum hungatei (hexameric, composite structure) (see paper)
40% identity, 76% coverage: 7:63/75 of query aligns to 3:68/79 of 7bkbL

query
sites
7bkbL

A

A

I

V

V

H

V

V

D

N

T

M

E

E

R

R

C
|
C

K
x
T

G

G

C
|
C

N
|
N

L

N

C
|
C

V

V

A

A

C
|
C

P
|
P

L

V

D

N

V

A

I

L

A

E

L

L

N

N

K

T

E

-

V

V

N

N

-

P

-

S

-

T

-

D

-

K

-

I

-
x
Y

-

K

-

V

M

I

K

N

G

G

Y

D

N
x
A

Y

V

A

I

W

L

Q

D

V

V

K

K

E

H

D

E

T

L

C
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C

N
x
A

G
|
G

C
|
C

S
x
G

S

I

C
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C

A

V

M

D

V

A

C
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C

P

P

binding iron/sulfur cluster: C11 (= C15), T12 (≠ K16), C14 (= C18), N15 (= N19), C17 (= C21), C21 (= C25), P22 (= P26), Y40 (vs. gap), A47 (≠ N42), C57 (= C52), A58 (≠ N53), G59 (= G54), C60 (= C55), G61 (≠ S56), C63 (= C58), C67 (= C62)

Sites not aligning to the query:

binding iron/sulfur cluster: 69, 72

2c3uA Crystal structure of pyruvate-ferredoxin oxidoreductase from desulfovibrio africanus, oxygen inhibited form (see paper)
31% identity, 68% coverage: 13:63/75 of query aligns to 686:755/1231 of 2c3uA

query
sites
2c3uA

E

E

R

N

C
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C

K
x
I

G

Q

C
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C

N
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N

L

Q

C
|
C

V

A

V

F

A

V

C
|
C

P
|
P

-

H

-

S

-
x
A

-
x
I

L

L

D

P

V

V

I

L

A

A

L

K

N

E

K

E

E

E

V

L

-

V

-

G

-

A

-

P

-

A

-

N

-

F

-

T

-

A

-

L

-

E

-

A

-

K

-

G

-

K

N

E

M

L

K

K

G

G

Y

Y

N

K

Y

F

A

R

W

I

Q

Q

V

I

K

N

E

T

D

L

T

D

C
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C

N
x
M

G
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G

C
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C

S
x
G

S

N

C
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C

A

A

M

D

V

I

C
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C

P
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P

binding iron/sulfur cluster: C688 (= C15), I689 (≠ K16), C691 (= C18), N692 (= N19), C694 (= C21), C698 (= C25), P699 (= P26), A702 (vs. gap), I703 (vs. gap), C744 (= C52), M745 (≠ N53), G746 (= G54), C747 (= C55), G748 (≠ S56), C750 (= C58), C754 (= C62), P755 (= P63)

Sites not aligning to the query:

active site: 30, 63, 113, 995
binding 2-(3-{[4-(hydroxyamino)-2-methylpyrimidin-5-yl]methyl}-4-methyl-2,3-dihydro-1,3-thiazol-5-yl)ethyl trihydrogen diphosphate: 28, 29, 63, 87, 816, 837, 839, 868, 869, 961, 962, 963, 964, 992, 993, 994, 995, 996
binding calcium ion: 982, 984, 1055, 1056, 1058, 1060, 1062
binding magnesium ion: 962, 990, 992
binding pyruvic acid: 30, 113, 122, 995
binding iron/sulfur cluster: 458, 681, 683, 760, 761, 811, 814, 816, 839, 1070, 1071

2c3pA Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase from desulfovibrio africanus (see paper)
31% identity, 68% coverage: 13:63/75 of query aligns to 686:755/1231 of 2c3pA

query
sites
2c3pA

E

E

R

N

C
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C

K
x
I

G
x
Q

C
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C

N
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N

L

Q

C
|
C

V

A

V

F

A

V

C
|
C

P
|
P

-

H

-

S

-
x
A

-
x
I

L

L

D

P

V

V

I

L

A

A

L

K

N

E

K

E

E

E

V

L

-

V

-

G

-

A

-

P

-

A

-

N

-

F

-

T

-

A

-

L

-

E

-

A

-

K

-

G

-

K

N

E

M

L

K

K

G

G

Y

Y

N

K

Y

F

A

R

W

I

Q

Q

V

I

K

N

E

T

D

L

T

D

C
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C

N
x
M

G
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G

C
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C

S
x
G

S

N

C
|
C

A

A

M

D

V

I

C
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C

P
|
P

binding iron/sulfur cluster: C688 (= C15), I689 (≠ K16), Q690 (≠ G17), C691 (= C18), N692 (= N19), C694 (= C21), C698 (= C25), P699 (= P26), A702 (vs. gap), I703 (vs. gap), C744 (= C52), M745 (≠ N53), G746 (= G54), C747 (= C55), G748 (≠ S56), C750 (= C58), C754 (= C62), P755 (= P63)

Sites not aligning to the query:

active site: 30, 63, 113, 995
binding 1-(2-{(2s,4r,5r)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-[(1s)-1-carboxy-1-hydroxyethyl]-4-methyl-1,3-thiazolidin-5-yl}ethoxy)-1,1,3,3-tetrahydroxy-1lambda~5~-diphosphox-1-en-2-ium 3-oxide: 28, 29, 30, 63, 87, 113, 816, 837, 838, 839, 868, 869, 961, 962, 963, 992, 993, 994, 995, 996
binding calcium ion: 982, 983, 984, 1055, 1056, 1058, 1060, 1062
binding magnesium ion: 962, 990, 992
binding iron/sulfur cluster: 458, 681, 683, 760, 761, 810, 811, 814, 816, 839, 994, 1070, 1071

2c3oA Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase from desulfovibrio africanus (see paper)
31% identity, 68% coverage: 13:63/75 of query aligns to 686:755/1231 of 2c3oA

query
sites
2c3oA

E

E

R

N

C
|
C

K
x
I

G

Q

C
|
C

N
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N

L

Q

C
|
C

V

A

V

F

A

V

C
|
C

P
|
P

-

H

-

S

-
x
A

-
x
I

L

L

D

P

V

V

I

L

A

A

L

K

N

E

K

E

E

E

V

L

-

V

-

G

-

A

-

P

-

A

-

N

-

F

-

T

-

A

-

L

-

E

-

A

-

K

-

G

-

K

N

E

M

L

K

K

G

G

Y

Y

N

K

Y

F

A

R

W

I

Q

Q

V

I

K

N

E

T

D

L

T

D

C
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C

N

M

G
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G

C
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C

S
x
G

S
x
N

C
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C

A

A

M

D

V

I

C
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C

P

P

binding iron/sulfur cluster: C688 (= C15), I689 (≠ K16), C691 (= C18), N692 (= N19), C694 (= C21), C698 (= C25), P699 (= P26), A702 (vs. gap), I703 (vs. gap), C744 (= C52), G746 (= G54), C747 (= C55), G748 (≠ S56), N749 (≠ S57), C750 (= C58), C754 (= C62)

Sites not aligning to the query:

active site: 30, 63, 113, 995
binding calcium ion: 982, 984, 1056, 1058, 1060
binding magnesium ion: 962, 990, 992
binding pyruvic acid: 30, 113, 996
binding iron/sulfur cluster: 458, 681, 760, 761, 810, 811, 814, 816, 839, 1070, 1071
binding thiamine diphosphate: 28, 29, 63, 87, 816, 837, 838, 839, 868, 961, 962, 963, 992, 993, 994, 995, 996

1kekA Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase (see paper)
31% identity, 68% coverage: 13:63/75 of query aligns to 686:755/1231 of 1kekA

query
sites
1kekA

E

E

R

N

C
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C

K
x
I

G
x
Q

C
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C

N
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N

L

Q

C
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C

V

A

V

F

A

V

C
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C

P
|
P

-

H

-

S

-

A

-
x
I

L

L

D

P

V

V

I

L

A

A

L

K

N

E

K

E

E

E

V

L

-

V

-

G

-

A

-

P

-

A

-

N

-

F

-

T

-

A

-

L

-

E

-

A

-

K

-

G

-

K

N

E

M

L

K

K

G

G

Y

Y

N

K

Y

F

A

R

W
x
I

Q

Q

V

I

K

N

E

T

D

L

T

D

C
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C

N
x
M

G
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G

C
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C

S
x
G

S

N

C
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C

A

A

M

D

V

I

C
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C

P
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P

binding iron/sulfur cluster: C688 (= C15), I689 (≠ K16), Q690 (≠ G17), C691 (= C18), N692 (= N19), C694 (= C21), C698 (= C25), P699 (= P26), I703 (vs. gap), I737 (≠ W45), C744 (= C52), M745 (≠ N53), G746 (= G54), C747 (= C55), G748 (≠ S56), C750 (= C58), C754 (= C62), P755 (= P63)

Sites not aligning to the query:

active site: 30, 63, 113, 995
binding calcium ion: 982, 984, 1055, 1056, 1058, 1062
binding 2-acetyl-thiamine diphosphate: 29, 63, 87, 113, 816, 837, 838, 839, 868, 961, 962, 963, 992, 993, 994, 995, 996
binding magnesium ion: 962, 990, 992
binding iron/sulfur cluster: 458, 681, 683, 760, 761, 810, 811, 814, 816, 839, 1070, 1071

1b0pA Crystal structure of pyruvate-ferredoxin oxidoreductase from desulfovibrio africanus (see paper)
31% identity, 68% coverage: 13:63/75 of query aligns to 686:755/1231 of 1b0pA

query
sites
1b0pA

E

E

R

N

C
|
C

K
x
I

G
x
Q

C
|
C

N
|
N

L

Q

C
|
C

V

A

V

F

A

V

C
|
C

P
|
P

-

H

-

S

-
x
A

-
x
I

L

L

D

P

V

V

I

L

A

A

L

K

N

E

K

E

E

E

V

L

-

V

-

G

-

A

-

P

-

A

-

N

-

F

-

T

-

A

-

L

-

E

-

A

-

K

-

G

-

K

N

E

M

L

K

K

G

G

Y

Y

N

K

Y

F

A

R

W
x
I

Q

Q

V

I

K

N

E

T

D

L

T

D

C
|
C

N
x
M

G

G

C
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C

S
x
G

S

N

C
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C

A

A

M

D

V

I

C
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C

P
|
P

binding iron/sulfur cluster: C688 (= C15), I689 (≠ K16), Q690 (≠ G17), C691 (= C18), N692 (= N19), C694 (= C21), C698 (= C25), P699 (= P26), A702 (vs. gap), I703 (vs. gap), I737 (≠ W45), C744 (= C52), M745 (≠ N53), C747 (= C55), G748 (≠ S56), C750 (= C58), C754 (= C62), P755 (= P63)

Sites not aligning to the query:

active site: 30, 63, 113, 995
binding calcium ion: 982, 984, 1055, 1056, 1058, 1060
binding magnesium ion: 962, 990, 992
binding iron/sulfur cluster: 458, 681, 683, 760, 811, 814, 816, 839, 994, 1070, 1071
binding thiamine diphosphate: 28, 29, 63, 816, 837, 838, 839, 868, 961, 962, 963, 992, 993, 994, 995, 996

P94692 Pyruvate:ferredoxin oxidoreductase; PFOR; POR; Pyruvate synthase; EC 1.2.7.1 from Desulfocurvibacter africanus (Desulfovibrio africanus) (see 3 papers)
31% identity, 68% coverage: 13:63/75 of query aligns to 687:756/1232 of P94692

query
sites
P94692

E

E

R

N

C
|
C

K

I

G

Q

C
|
C

N

N

L

Q

C
|
C

V

A

V

F

A

V

C
|
C

P

P

-

H

-

S

-

A

-

I

L

L

D

P

V

V

I

L

A

A

L

K

N

E

K

E

E

E

V

L

-

V

-

G

-

A

-

P

-

A

-

N

-

F

-

T

-

A

-

L

-

E

-

A

-

K

-

G

-

K

N

E

M

L

K

K

G

G

Y

Y

N

K

Y

F

A

R

W

I

Q

Q

V

I

K

N

E

T

D

L

T

D

C
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C

N

M

G

G

C
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C

S

G

S

N

C
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C

A

A

M

D

V

I

C
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C

P

P

C689 (= C15) binding
C692 (= C18) binding
C695 (= C21) binding
C699 (= C25) binding
C745 (= C52) binding
C748 (= C55) binding
C751 (= C58) binding
C755 (= C62) binding

Sites not aligning to the query:

31 binding
64 binding
114 binding
812 binding
815 binding
817 binding
840 binding ; binding
962:965 binding
963 binding
983 binding
985 binding
991 binding
991:996 binding
993 binding
1056 binding
1059 binding
1061 binding
1063 binding
1071 binding

7bkbK Formate dehydrogenase - heterodisulfide reductase - formylmethanofuran dehydrogenase complex from methanospirillum hungatei (hexameric, composite structure) (see paper)
34% identity, 96% coverage: 1:72/75 of query aligns to 197:268/386 of 7bkbK

query
sites
7bkbK

M

I

A

G

K

K

I

V

K

E

G

G

A

E

I

V

V

I

V

W

D

D

T

E

E

A

R

Y

C
|
C

K
x
D

G

G

C
|
C

N
|
N

L

V

C
|
C

V

A

V

E

A

A

C
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C

P
|
P

L

S

D

E

V

A

I

I

A

K

L

V

N

T

K

R

E

T

-

V

V

V

N

G

M

Q

K

K

G

K

Y

L

N

G

Y

N

A
x
V

W

N

Q

I

V

I

K

D

E

E

D

D

T
x
C

C
|
C

N

T

G

-

C
|
C

S

R

S

W

C
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C

A

A

M

I

V

N

C
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C

P
|
P

D

T

G

E

C

A

I
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I

S

T

V
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V

Y

N

K

K

V

I

binding iron/sulfur cluster: C211 (= C15), D212 (≠ K16), C214 (= C18), N215 (= N19), C217 (= C21), C221 (= C25), P222 (= P26), V241 (≠ A44), C248 (≠ T51), C249 (= C52), C251 (= C55), C254 (= C58), C258 (= C62), P259 (= P63), I263 (= I67), V265 (= V69)

Sites not aligning to the query:

binding iron/sulfur cluster: 36, 37, 39, 42, 46, 47, 51, 77, 78, 79, 80, 81, 83, 87, 92, 119, 124, 125, 127, 130, 134, 139, 173, 174, 175, 176, 179, 183, 186, 273, 280, 281, 284, 286, 287, 291, 322, 323, 324, 325, 326, 328, 332, 333

2fjaB Adenosine 5'-phosphosulfate reductase in complex with substrate (see paper)
39% identity, 81% coverage: 9:69/75 of query aligns to 3:63/149 of 2fjaB

query
sites
2fjaB

V

F

V

V

D

N

T

P

E

E

R

K

C
|
C

K
x
D

G
|
G

C
|
C

-

K

-

A

-

L

-

E

-

R

N
x
T

L
x
A

C
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C

V

E

V

Y

A

I

C
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C

P

P

L

N

D

D

V
x
L

I
x
M

A

T

L

L

N

D

K

K

E

E

V

-

N

K

M

M

K

K

G

A

Y

Y

N

N

Y

R

A

-

W

-

Q

-

V

-

K

E

E

P

D

D

T

M

C
|
C

N
x
W

G
x
E

C
|
C

S
x
Y

S

S

C
|
C

A

V

M

K

V

M

C
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C

P
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P

D

Q

G

G

C

A

I
|
I

S

D

V

V

active site: W47 (≠ N53)
binding iron/sulfur cluster: C9 (= C15), D10 (≠ K16), G11 (= G17), C12 (= C18), T18 (≠ N19), A19 (≠ L20), C20 (= C21), C24 (= C25), L28 (≠ V29), M29 (≠ I30), C46 (= C52), W47 (≠ N53), E48 (≠ G54), C49 (= C55), Y50 (≠ S56), C52 (= C58), C56 (= C62), P57 (= P63), I61 (= I67)

Sites not aligning to the query:

binding iron/sulfur cluster: 2

Query Sequence

>349861 FitnessBrowser__Btheta:349861
MAKIKGAIVVDTERCKGCNLCVVACPLDVIALNKEVNMKGYNYAWQVKEDTCNGCSSCAM
VCPDGCISVYKVKVE

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory