SitesBLAST

P13009 Methionine synthase; 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12-dependent; MS; EC 2.1.1.13 from Escherichia coli (strain K12) (see 5 papers)
31% identity, 43% coverage: 339:598/602 of query aligns to 622:871/1227 of P13009

query
sites
P13009

N

N

E

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D

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E694 (≠ N427) binding
GDVHD 756:760 (≠ GDLHD 487:491) binding
D757 (= D488) mutation to E: Decreases activity by about 70%.; mutation to N: Decreases activity by about 45%.
H759 (= H490) binding axial binding residue; mutation to G: Loss of catalytic activity.
S804 (= S535) binding
T808 (= T539) binding
S810 (≠ T541) mutation to A: Decreases activity by about 40%.
A860 (= A587) binding

Sites not aligning to the query:

1 modified: Initiator methionine, Removed
247 binding
310 binding ; mutation C->A,S: Loss of zinc binding. Loss of catalytic activity.
311 binding ; mutation C->A,S: Loss of zinc binding. Loss of catalytic activity.
946 binding
1134 binding
1189:1190 binding

1bmtA How a protein binds b12: a 3.O angstrom x-ray structure of the b12- binding domains of methionine synthase (see paper)
33% identity, 34% coverage: 394:598/602 of query aligns to 11:221/246 of 1bmtA

query
sites
1bmtA

K

K

P

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L

L

Y

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N

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active site: D107 (= D488), H109 (= H490), S160 (≠ T541)
binding co-methylcobalamin: E44 (≠ N427), M48 (≠ I431), M51 (= M434), G55 (= G438), L65 (≠ V448), V68 (≠ L451), D107 (= D488), V108 (≠ L489), H109 (= H490), D110 (= D491), I111 (= I492), I115 (≠ L496), G152 (≠ C533), L153 (≠ M534), S154 (= S535), L156 (= L537), I157 (≠ L538), T158 (= T539), G183 (= G566), G184 (= G567), A185 (= A568), V207 (≠ S584), N209 (= N586), A210 (= A587)

8sseA Methionine synthase, c-terminal fragment, cobalamin and reactivation domains from thermus thermophilus hb8
36% identity, 28% coverage: 413:580/602 of query aligns to 23:185/507 of 8sseA

query
sites
8sseA

K

E

D

E

A

A

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A

A

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G

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H

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D

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N

N

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binding cobalamin: H97 (= H490), G100 (= G493), V104 (= V497), S142 (= S535), L145 (= L538), V146 (≠ T539), I169 (≠ M564), G171 (= G566), G172 (= G567), A173 (= A568)

Sites not aligning to the query:

binding cobalamin: 405, 409, 451, 452, 453, 454, 463, 485, 488, 490, 492

8g3hA Structure of cobalamin-dependent methionine synthase (meth) in a resting state (see paper)
36% identity, 30% coverage: 422:601/602 of query aligns to 656:836/841 of 8g3hA

query
sites
8g3hA

P

P

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x
A

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x
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N
x
D

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binding cobalamin: F675 (= F441), V685 (≠ L451), K693 (= K459), G720 (= G487), V722 (≠ L489), H723 (= H490), D724 (= D491), I725 (= I492), G726 (= G493), V730 (= V497), M767 (= M534), S768 (= S535), L770 (= L537), V772 (≠ T539), I795 (≠ M564), L796 (≠ I565), G797 (= G566), G798 (= G567), A799 (= A568), Y818 (= Y583), A819 (≠ S584), E820 (≠ D585), D821 (≠ N586)

Sites not aligning to the query:

binding cobalamin: 328, 330, 331

2i2xB Crystal structure of methanol:cobalamin methyltransferase complex mtabc from methanosarcina barkeri (see paper)
32% identity, 36% coverage: 384:599/602 of query aligns to 31:243/258 of 2i2xB

query
sites
2i2xB

E

E

K

L

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Y

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K

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D

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I

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H

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I

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G

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K

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T
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T

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A

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K

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L

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G

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x
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G

A
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G

P

A

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N

Q

Q

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F

A

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G

A

A

L

D

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G

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Y

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x
G

D
x
E

N
x
E

A
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A

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A

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K

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K

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G

A

active site: D134 (= D488), H136 (= H490), T187 (= T541)
binding 5-hydroxybenzimidazolylcob(iii)amide: G133 (= G487), D134 (= D488), V135 (≠ L489), H136 (= H490), D137 (= D491), I138 (= I492), G139 (= G493), V143 (= V497), T179 (≠ C533), T181 (≠ S535), L183 (= L537), M184 (≠ L538), T185 (= T539), A208 (≠ M564), G210 (= G566), G211 (= G567), G212 (≠ A568), G228 (≠ S584), E229 (≠ D585), E230 (≠ N586), A231 (= A587)

Q46EH4 Methanol--corrinoid protein; Methanol:corrinoid methyltransferase 1 subunit of 27 kDa; MT1 subunit 27 kDa from Methanosarcina barkeri (strain Fusaro / DSM 804) (see paper)
32% identity, 36% coverage: 384:599/602 of query aligns to 31:243/258 of Q46EH4

query
sites
Q46EH4

E

E

K

L

S

Y

Q

P

E

K

E

D

D

E

R

L

M

I

K

Y

P

P

L

I

Y

A

D

K

A

A

I

I

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F

A

E

G

G

K

E

L

E

E

D

P

D

A

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E

E

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T

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K

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D

A

A

A

I

I

A

E

A

A

G

G

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K

L

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P

Q

I

D

D

I

L

I

I

N

D

G

D

Y

A

M

L

I

M

T

V

A

G

M

M

G

G

E

V

V

V

G

I

Q

R

R

L

F

Y

Q

D

D

E

G

G

K

V

A

I

F

F

V

L

P

P

Q

N

L

V

L

M

M

M

A

S

G

A

R

D

A

A

M

M

K

L

G

E

A

G

L

I

E

E

L

Y

L

C

K

K

P

E

L

N

L

-

A

S

G

G

N

A

A

T

S

P

A

K

T

T

I

K

G

G

K

T

I

V

V

V

I

C

G
x
H

T

V

V

A

K

E

G

G

D

D

L

V

H
|
H

D

D

I

I

G

G

K

K

N

N

L

I

V

V

A

T

S

A

M

L

L

L

E

R

G

A

C

N

G

G

F

Y

E

N

V

V

I

V

N

D

I

L

G

G

I

R

D

D

V

V

T

P

C

A

D

E

K

E

F

V

V

L

E

A

A

A

V

V

K

Q

E

K

N

E

K

K

A

P

D

I

I

M

L

L

C

T

M

G

S

T

A

A

L

L

L

M

T

T

M

M

T

Y

Y

A

M

F

Q

K

D

E

V

V

I

N

R

D

A

M

L

L

E

L

E

E

A

N

G

G

I

I

R

K

D

-

Q

-

V

I

K

P

V

F

M

A

I

C

G

G

A

G

P

A

V

V

S

N

Q

Q

G

D

F

F

A

V

D

S

E

Q

I

F

G

A

A

L

D

G

G

V

Y

Y

S

G

D

E

N

E

A

A

N

A

T

D

A

A

V

P

A

K

V

I

A

A

K

D

V

A

L

I

M

I

G

A

H129 (≠ G483) mutation to K: Does not affect cobalamin-binding.
H136 (= H490) mutation H->G,K: Abolishes cobalamin-binding.

Sites not aligning to the query:

256:258 HKH→KKK: Does not affect cobalamin-binding.

Q99707 Methionine synthase; MS; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; Vitamin-B12 dependent methionine synthase; EC 2.1.1.13 from Homo sapiens (Human) (see 6 papers)
37% identity, 25% coverage: 422:572/602 of query aligns to 704:865/1265 of Q99707

query
sites
Q99707

P

P

Q

L

D

N

I

I

N

E

G

G

Y

P

M

L

I

M

T

N

A

G

M

M

G

K

E

I

V

V

G

G

Q

D

R

L

F

F

Q

G

D

A

G

G

K

K

A

M

F

F

V

L

P

P

Q

Q

L

V

L

I

M

K

A

S

G

A

R

R

A

V

M

M

K

K

G

K

A

A

L

V

E

G

L

H

L

L

K

I

P

P

L

F

L

M

A

E

G

K

N

E

A

R

S

E

A

E

T

T

I

R

-

V

-

L

-

N

-

G

-

T

-

V

-

E

-

D

-

P

-

Y

-

Q

G

G

K

T

I

I

V

V

I

L

G

A

T

T

V

V

K

K

G

G

D

D

L

V

H

H

D

D

I

I

G

G

K

K

N

N

L

I

V

V

A

G

S

V

M

V

L

L

E

G

G

C

C

N

G

N

F

F

E

R

V

V

I

I

N

D

I

L

G

G

I

V

D

M

V

T

T

P

C

C

D

D

K

K

F

I

V

L

E

K

A

A

V

A

K

L

E

D

N

H

K

K

A

A

D

D

I

I

L

I

C

G

M

L

S

S

A

G

L

L

L

I

T

T

T

P

T

S

M

L

T

D

Y

E

M

M

Q

I

D

F

V

V

I

A

R

K

A

E

L

M

E

E

E

R

A

L

G

A

I

I

R

R

D

-

Q

-

V

I

K

P

V

L

M

L

I

I

G

G

A

A

P

T

V

T

S

S

Q

K

Sites not aligning to the query:

61 natural variant: R -> K
255 C → Y: in dbSNP:rs1140598
382:384 binding
449 binding
470 binding
537 binding
579 binding
585 binding
591 binding
919 D → G: in dbSNP:rs1805087
963 D→E: Decreases binding to MTRR; when associated with N-1071.
1071 K→N: Decreases binding to MTRR; when associated with E-963.

E3PY95 D-ornithine 4,5-aminomutase subunit beta; D-ornithine aminomutase E component; OAM-E; EC 5.4.3.5 from Acetoanaerobium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / CCUG 9281 / NCIMB 10654 / HF) (Clostridium sticklandii) (see 2 papers)
32% identity, 20% coverage: 479:601/602 of query aligns to 604:733/740 of E3PY95

query
sites
E3PY95

K

K

I

I

V

V

I

A

G

A

T

T

V

V

K

G

G

E

D

D

L
x
E

H
|
H

D
x
S

I

V

G

G

K

L

N

R

L

E

V

V

A

I

S

D

M

I

-
x
K

-

H

-

G

L

I

E

E

G

K

C

Y

G

G

F

V

E

E

V

V

I

H

N

Y

I

L

G

G

I

T

D

S

V

V

T

P

C

V

D

E

K

K

F

L

V

V

E

D

A

A

V

A

K

I

E

E

N

L

K

K

A

A

D

D

I

A

L

I

C

L

M

A

S
|
S

A
x
T

L
x
I

T
x
S

T
x
H

T

D

M

D

T

I

Y

H

M

Y

Q

K

D

N

V

M

I

K

R

R

A

I

L

H

E

E

-

L

-

A

-

V

E

E

A

K

G

G

I

I

R

R

D

D

Q

K

V

I

K

M

V

I

M

G

I

C

G

G

A

T

P

Q

V

V

S

T

Q

P

G

E

F

V

A

A

D

V

E

K

I

Q

G

G

A

V

D

D

G

A

Y

G

S

F

D

G

N

R

A

G

N

S

T

K

A

G

V

I

A

H

V

V

A

A

K

T

V

F

L

L

M

V

G

K

K

K

R

R

EHS 614:616 (≠ LHD 489:491) binding
H615 (= H490) binding axial binding residue; mutation to G: Loss of corrinoid-binding ability.
K626 (vs. gap) modified: N6-(pyridoxal phosphate)lysine
STIISH 664:669 (≠ SALLTT 535:540) binding

Sites not aligning to the query:

81 binding
182 binding

1id8A Nmr structure of glutamate mutase (b12-binding subunit) complexed with the vitamin b12 nucleotide (see paper)
31% identity, 15% coverage: 480:570/602 of query aligns to 6:95/137 of 1id8A

query
sites
1id8A

I

I

V

V

I

L

G

G

T
x
V

V

I

K

G

G

S

D
|
D

L

C

H
|
H

D

A

I

V

G

G

K

N

N

K

L

I

V

L

A

D

S

H

M

S

L

F

E

T

G

N

C

A

G

G

F

F

E

N

V

V

I

V

N

N

I

I

G

G

I

V

D

L

V

S

T

S

C

Q

D

E

K

D

F

F

V

I

E

N

A

A

V

A

K

I

E

E

N

T

K

K

A

A

D

D

I

L

L

I

C

C

M

V

S
|
S

A

S

L
|
L

L

Y

T

G

T

Q

T

G

M

E

T

I

Y

D

M

C

Q

K

D

G

V

L

I

R

R

E

A

K

L

C

E

D

E

E

A

A

G

G

I

L

R

K

D

G

Q

-

V

I

K

K

V

L

M

F

I

V

G
|
G

G

G

A

N

P

I

V

V

active site: V10 (≠ T484), D14 (= D488), H16 (= H490)
binding phosphoric acid mono-[5-(5,6-dimethyl-benzoimidazol-1-yl)-4-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl] ester: S61 (= S535), L63 (= L537), G91 (= G566)

Sites not aligning to the query:

binding phosphoric acid mono-[5-(5,6-dimethyl-benzoimidazol-1-yl)-4-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl] ester: 117, 119, 121

3koyA Crystal structure of ornithine 4,5 aminomutase in complex with ornithine (aerobic) (see paper)
32% identity, 20% coverage: 479:601/602 of query aligns to 595:724/728 of 3koyA

query
sites
3koyA

K

K

I

I

V

V

I

A

G

A

T

T

V

V

K

G

G

E

D

D

L
x
E

H
|
H

D
x
S

I
x
V

G

G

K

L

N

R

L

E

V
|
V

A

I

S

D

M

I

-
x
K

-

H

-

G

L

I

E

E

G

K

C

Y

G

G

F

V

E

E

V

V

I

H

N

Y

I

L

G

G

I

T

D

S

V

V

T

P

C

V

D

E

K

K

F

L

V

V

E

D

A

A

V

A

K

I

E

E

N

L

K

K

A

A

D

D

I

A

L

I

C

L

M

A

S
|
S

A

T

L

I

L
x
I

T
x
S

T

H

T

D

M

D

T

I

Y

H

M

Y

Q

K

D

N

V

M

I

K

R

R

A

I

L

H

E

E

-

L

-

A

-

V

E

E

A

K

G

G

I

I

R

R

D

D

Q

K

V

I

K

M

V

I

M

G

I

C

G
|
G

A
x
T

P

Q

V

V

S

T

Q

P

G

E

F

V

A

A

D

V

E

K

I

Q

G

G

A

V

D

D

G

A

Y

G

S
x
F

D

G

N

R

A
x
G

N
x
S

T

K

A

G

V

I

A

H

V

V

A

A

K

T

V

F

L

L

M

V

G

K

K

K

R

R

active site: K617 (vs. gap)
binding cobalamin: E605 (≠ L489), H606 (= H490), S607 (≠ D491), V608 (≠ I492), V613 (= V497), S655 (= S535), I658 (≠ L538), S659 (≠ T539), G689 (= G566), G690 (= G567), T691 (≠ A568), F707 (≠ S584), G710 (≠ A587), S711 (≠ N588)

Sites not aligning to the query:

active site: 183, 218, 290
binding cobalamin: 112, 483
binding (E)-N~5~-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-ornithine: 77, 105, 109, 110, 156, 158, 178, 183, 188, 218, 219, 290, 292

3koxA Crystal structure of ornithine 4,5 aminomutase in complex with 2,4- diaminobutyrate (anaerobic) (see paper)
32% identity, 20% coverage: 479:601/602 of query aligns to 595:724/728 of 3koxA

query
sites
3koxA

K

K

I

I

V

V

I

A

G

A

T

T

V

V

K

G

G

E

D

D

L
x
E

H
|
H

D
x
S

I
x
V

G
|
G

K

L

N

R

L

E

V

V

A

I

S

D

M

I

-
x
K

-

H

-

G

L

I

E

E

G

K

C

Y

G

G

F

V

E

E

V

V

I

H

N

Y

I

L

G

G

I

T

D

S

V

V

T

P

C

V

D

E

K

K

F

L

V

V

E

D

A

A

V

A

K

I

E

E

N

L

K

K

A

A

D

D

I

A

L

I

C

L

M
x
A

S
|
S

A

T

L
x
I

L

I

T
x
S

T

H

T

D

M

D

T

I

Y

H

M

Y

Q

K

D

N

V

M

I

K

R

R

A

I

L

H

E

E

-

L

-

A

-

V

E

E

A

K

G

G

I

I

R

R

D

D

Q

K

V

I

K

M

V

I

M

G

I

C

G
|
G

A
x
T

P

Q

V

V

S

T

Q

P

G

E

F

V

A

A

D

V

E

K

I

Q

G

G

A

V

D

D

G

A

Y

G

S
x
F

D
x
G

N

R

A
x
G

N
x
S

T

K

A

G

V

I

A

H

V

V

A

A

K

T

V

F

L

L

M

V

G

K

K

K

R

R

active site: K617 (vs. gap)
binding cobalamin: E605 (≠ L489), H606 (= H490), S607 (≠ D491), V608 (≠ I492), G609 (= G493), A654 (≠ M534), S655 (= S535), I657 (≠ L537), S659 (≠ T539), G689 (= G566), G690 (= G567), T691 (≠ A568), F707 (≠ S584), G708 (≠ D585), G710 (≠ A587), S711 (≠ N588)

Sites not aligning to the query:

active site: 183, 218, 290
binding cobalamin: 112, 483
binding (2S)-2-amino-4-{[(1Z)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}butanoic acid: 77, 105, 108, 110, 156, 158, 183, 188, 218, 219, 290

3kowB Crystal structure of ornithine 4,5 aminomutase backsoaked complex (see paper)
32% identity, 20% coverage: 479:601/602 of query aligns to 595:724/728 of 3kowB

query
sites
3kowB

K

K

I

I

V

V

I

A

G

A

T

T

V

V

K

G

G

E

D

D

L
x
E

H
|
H

D
x
S

I
x
V

G
|
G

K
x
L

N

R

L

E

V

V

A

I

S

D

M

I

-
x
K

-

H

-

G

L

I

E

E

G

K

C

Y

G

G

F

V

E

E

V

V

I

H

N

Y

I

L

G

G

I

T

D

S

V

V

T

P

C

V

D

E

K

K

F

L

V

V

E

D

A

A

V

A

K

I

E

E

N

L

K

K

A

A

D

D

I

A

L

I

C

L

M

A

S

S

A

T

L
x
I

L

I

T

S

T

H

T

D

M

D

T

I

Y

H

M

Y

Q

K

D

N

V

M

I

K

R

R

A

I

L

H

E

E

-

L

-

A

-

V

E

E

A

K

G

G

I

I

R

R

D

D

Q

K

V

I

K

M

V

I

M

G

I

C

G
|
G

A
x
T

P

Q

V

V

S

T

Q

P

G

E

F

V

A

A

D

V

E

K

I

Q

G

G

A

V

D

D

G

A

Y

G

S
x
F

D

G

N

R

A

G

N
x
S

T

K

A

G

V

I

A

H

V

V

A

A

K

T

V

F

L

L

M

V

G

K

K

K

R

R

active site: K617 (vs. gap)
binding cobalamin: E605 (≠ L489), H606 (= H490), S607 (≠ D491), V608 (≠ I492), G609 (= G493), L610 (≠ K494), I657 (≠ L537), G689 (= G566), G690 (= G567), T691 (≠ A568), F707 (≠ S584), S711 (≠ N588)

Sites not aligning to the query:

active site: 183, 218, 290
binding pyridoxal-5'-phosphate: 105, 110, 156, 158, 178, 183, 188, 218, 219

E3PRJ4 Lysine 5,6-aminomutase beta subunit; 5,6-LAM; D-lysine 5,6-aminomutase beta subunit; L-beta-lysine 5,6-aminomutase beta subunit; EC 5.4.3.3 from Acetoanaerobium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / CCUG 9281 / NCIMB 10654 / HF) (Clostridium sticklandii) (see paper)
29% identity, 18% coverage: 476:582/602 of query aligns to 116:237/262 of E3PRJ4

query
sites
E3PRJ4

T

N

I

I

G

G

K

R

-

K

-

I

I

V

V

V

I

V

G

G

T

A

V

S

K

T

G

G

-
x
T

D
|
D

L
x
A

H
|
H

D
x
T

I
x
V

G
|
G

K

I

N

D

L

A

V

I

A

M

S

N

M

M

L
x
K

E

G

G

Y

C

A

G

G

-

H

-

Y

-

G

-

L

-

E

-

R

F

Y

E

E

V

M

I

I

-

D

-

A

-

Y

N

N

I

L

G

G

I

S

D

Q

V

V

T

A

C

N

D

E

K

D

F

F

V

I

E

K

A

K

V

A

K

V

E

E

N

L

K

E

A

A

D

D

I

V

L

L

C
x
L

M
x
V

S
|
S

A
x
Q

L
x
T

L
x
V

T
|
T

T
x
Q

T

K

M

N

T

V

Y

H

M

I

Q

Q

D

N

-

M

-

T

-

H

V

L

I

I

R

E

A

L

L

L

E

E

E

A

A

E

G

G

I

L

R

R

D

D

Q

R

V

F

K

V

V

L

M
x
L

I
x
C

G
|
G

A
x
P

P

R

V

I

S

N

Q

N

G

E

F

I

A

A

D

K

E

E

I

L

G

G

A

Y

D

D

G

A

130:136 (vs. 488:493, 43% identical) binding
K144 (≠ L501) modified: N6-(pyridoxal phosphate)lysine
185:192 (vs. 533:540, 25% identical) binding
LCGGP 219:223 (≠ MIGGA 564:568) binding

Sites not aligning to the query:

239:244 binding

1xrsB Crystal structure of lysine 5,6-aminomutase in complex with plp, cobalamin, and 5'-deoxyadenosine (see paper)
29% identity, 18% coverage: 476:581/602 of query aligns to 67:187/212 of 1xrsB

query
sites
1xrsB

T

N

I

I

G

G

K

R

-

K

-

I

I

V

V

V

I

V

G

G

T

A

V

S

K

T

G

G

-

T

D
|
D

L
x
A

H
|
H

D
x
T

I
x
V

G

G

K

I

N

D

L

A

V
x
I

A

M

S

N

M

M

L
x
K

E

G

G
x
Y

C

A

G

G

-

H

-

Y

-

G

-

L

-

E

-

R

F

Y

E

E

V

M

I

I

-

D

-

A

-

Y

N

N

I

L

G

G

I

S

D

Q

V

V

T

A

C

N

D

E

K

D

F

F

V

I

E

K

A

K

V

A

K

V

E

E

N

L

K

E

A

A

D

D

I

V

L

L

C
x
L

M
x
V

S
|
S

A

Q

L

T

L

V

T
|
T

T

Q

T

K

M

N

T

V

Y

H

M

I

Q

Q

D

N

-

M

-

T

-

H

V

L

I

I

R

E

A

L

L

L

E

E

E

A

A

E

G

G

I

L

R

R

D

D

Q

R

V

F

K

V

V

L

M
x
L

I
x
C

G
|
G

A
x
P

P

R

V

I

S

N

Q

N

G

E

F

I

A

A

D

K

E

E

I

L

G

G

A

Y

D

D

active site: K95 (≠ L501)
binding cobalamin: D82 (= D488), A83 (≠ L489), H84 (= H490), T85 (≠ D491), V86 (≠ I492), I91 (≠ V497), Y97 (≠ G503), L136 (≠ C533), V137 (≠ M534), S138 (= S535), T142 (= T539), L170 (≠ M564), C171 (≠ I565), G172 (= G566), G173 (= G567), P174 (≠ A568)

Sites not aligning to the query:

binding cobalamin: 190, 191, 192, 194

Query Sequence

>349868 FitnessBrowser__Btheta:349868
MKTWKTNLEETKQRYINWWNHKGIILSMWEHFQEGVKPHADIAPPAPARDLSQKWFDPQW
RAEYLDWYVAHSSLMADMLPVANTQLGPGSLAAILGGVFEGGEDTIWIHPDPNFNDEIVF
NPEHPNWLLHKELLKACKAKANGNYFVGMPDLMEGLDVLAALKGTDMVLLDTVMQSEVLE
QQMQQINDIYFKVFDELYDIIREGDEMAFCYFSSWAPGKMSKLQSDISTMISQDDYRRFV
QPFIREQCQKIDYTLYHLDGVGAMHHLPALLEIEELNAIQWTPGVGEPQGGSPKWYDLYK
KILAGGKSVMACWVTLEELKPLLDHIGADGVHLEMDFHNEREVEQAMRIIEEYTGSSSSV
SADVHTNQPVGEQDNAQESIRIREEKSQEEDRMKPLYDAIVAGKLEPAVEVTKDAIAAGV
LPQDIINGYMITAMGEVGQRFQDGKAFVPQLLMAGRAMKGALELLKPLLAGNASATIGKI
VIGTVKGDLHDIGKNLVASMLEGCGFEVINIGIDVTCDKFVEAVKENKADILCMSALLTT
TMTYMQDVIRALEEAGIRDQVKVMIGGAPVSQGFADEIGADGYSDNANTAVAVAKVLMGK
RD

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory