SitesBLAST

3nz2J Crystal structure of hexapeptide-repeat containing-acetyltransferase vca0836 complexed with acetyl co enzyme a from vibrio cholerae o1 biovar eltor
34% identity, 48% coverage: 114:233/252 of query aligns to 57:181/185 of 3nz2J

query
sites
3nz2J

L

L

Y

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Y

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-

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G

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N

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x
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binding acetyl coenzyme *a: G104 (≠ A156), Y110 (≠ W162), H114 (= H166), W138 (= W190), G140 (= G192), A158 (= A210), A159 (= A211), N164 (≠ T216), G174 (= G226), T176 (≠ I228), P177 (= P229)

Sites not aligning to the query:

binding acetyl coenzyme *a: 182

P07464 Galactoside O-acetyltransferase; GAT; Acetyl-CoA:galactoside 6-O-acetyltransferase; Thiogalactoside acetyltransferase; Thiogalactoside transacetylase; EC 2.3.1.18 from Escherichia coli (strain K12) (see 3 papers)
44% identity, 35% coverage: 147:235/252 of query aligns to 96:184/203 of P07464

query
sites
P07464

I

V

Y

T

I

I

G

G

E

D

N

N

V

V

N

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A

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N

N

V

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T

L

L

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S

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G

H
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H

D

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N

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L

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M

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N

N

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W

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x
S

N

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L

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A

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K

D

D

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R

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E

H115 (= H166) mutation to A: Results in an 1800-fold decrease in catalytic activity.
S142 (≠ P193) binding in other chain
A160 (= A211) binding in other chain
TK 165:166 (= TK 216:217) binding
R180 (≠ K231) binding
R183 (≠ A234) binding in other chain

Sites not aligning to the query:

1 modified: Initiator methionine, Removed; Partial
17 binding
71 binding
85 binding in other chain; binding in other chain
93 binding

1krrA Galactoside acetyltransferase in complex with acetyl-coenzyme a (see paper)
44% identity, 35% coverage: 147:235/252 of query aligns to 95:183/200 of 1krrA

query
sites
1krrA

I

V

Y

T

I

I

G

G

E

D

N

N

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V

N

L

I
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I

A
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A

S
x
P

N

N

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L

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binding acetyl coenzyme *a: I103 (= I155), A104 (= A156), P105 (≠ S157), T112 (≠ G164), H114 (= H166), G140 (= G192), S141 (≠ P193), N146 (≠ L198), G158 (≠ A210), A159 (= A211), A174 (≠ G226), P177 (= P229), R182 (≠ A234)

Sites not aligning to the query:

binding acetyl coenzyme *a: 84

3nz2C Crystal structure of hexapeptide-repeat containing-acetyltransferase vca0836 complexed with acetyl co enzyme a from vibrio cholerae o1 biovar eltor
34% identity, 48% coverage: 114:233/252 of query aligns to 54:178/183 of 3nz2C

query
sites
3nz2C

L

L

Y

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Y

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K

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C

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M

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A

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N

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L

binding acetyl coenzyme *a: Y107 (≠ W162), H111 (= H166), G137 (= G192), A155 (= A210), A156 (= A211), N161 (≠ T216), G171 (= G226), T173 (≠ I228), P174 (= P229), L178 (= L233)
binding magnesium ion: N157 (≠ G212), T173 (≠ I228)

Sites not aligning to the query:

binding acetyl coenzyme *a: 179

1krvA Galactoside acetyltransferase in complex with coa and pnp-beta-gal (see paper)
44% identity, 35% coverage: 147:235/252 of query aligns to 95:183/201 of 1krvA

query
sites
1krvA

I

V

Y

T

I

I

G

G

E

D

N

N

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A
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A

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P

N

N

V

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L

L

W
x
S

T

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G
x
T

G

G

H

H

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Y

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N

H

D

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M

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N

N

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W

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S

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A

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binding 4-nitrophenyl beta-D-galactopyranoside: M126 (≠ T178)
binding coenzyme a: A104 (= A156), S110 (≠ W162), T112 (≠ G164), W138 (= W190), G140 (= G192), S141 (≠ P193), N146 (≠ L198), A159 (= A211), P177 (= P229), R179 (≠ K231), R182 (≠ A234)

Sites not aligning to the query:

binding 4-nitrophenyl beta-D-galactopyranoside: 16, 25, 70, 82, 84, 90, 92

1kruA Galactoside acetyltransferase in complex with iptg and coenzyme a (see paper)
44% identity, 35% coverage: 147:235/252 of query aligns to 95:183/201 of 1kruA

query
sites
1kruA

I

V

Y

T

I

I

G

G

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D

N

N

V

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N
x
L

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I

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A

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N

N

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L

L

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H
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H

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N

H

D

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M

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A

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binding coenzyme a: H114 (= H166), W138 (= W190), G140 (= G192), S141 (≠ P193), G158 (≠ A210), A159 (= A211), P177 (= P229), R182 (≠ A234)
binding 1-methylethyl 1-thio-beta-D-galactopyranoside: L102 (≠ N154), H114 (= H166), M126 (≠ T178)

Sites not aligning to the query:

binding 1-methylethyl 1-thio-beta-D-galactopyranoside: 16, 22, 25, 62, 70, 82, 82, 84, 90, 92

3ectA Crystal structure of the hexapeptide-repeat containing- acetyltransferase vca0836 from vibrio cholerae
34% identity, 48% coverage: 114:233/252 of query aligns to 47:171/176 of 3ectA

query
sites
3ectA

L

L

Y

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D

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M

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W

I

I

G

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G

N

N

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x
G

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I

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A

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L

binding calcium ion: G138 (≠ S200), D156 (= D218)

4isxA The crystal structure of maltose o-acetyltransferase from clostridium difficile 630 in complex with acetyl-coa
44% identity, 35% coverage: 147:235/252 of query aligns to 95:183/186 of 4isxA

query
sites
4isxA

I

I

Y

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I

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G

G

E

D

N

N

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A
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A

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N

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L

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G

A

G

Y

H

H

D

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N

-

D

D

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S

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W

I

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G

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x
G

N

G

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G

N

A

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A
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A

G

G

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K

D

D

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K

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K

binding acetyl coenzyme *a: A104 (= A156), W138 (= W190), G140 (= G192), G141 (≠ P193), A159 (= A211), V174 (≠ G226), K182 (≠ A234)

Sites not aligning to the query:

binding acetyl coenzyme *a: 84

4husA Crystal structure of streptogramin group a antibiotic acetyltransferase vata from staphylococcus aureus in complex with virginiamycin m1 (see paper)
53% identity, 24% coverage: 180:239/252 of query aligns to 110:169/212 of 4husA

query
sites
4husA

R

K

G

G

P

D

I

I

Y

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I

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K

G

N

N

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D

V

V

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W

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A

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K

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D

Sites not aligning to the query:

binding virginiamycin m1: 17, 36, 38

4hurA Crystal structure of streptogramin group a antibiotic acetyltransferase vata from staphylococcus aureus in complex with acetyl coenzyme a (see paper)
53% identity, 24% coverage: 180:239/252 of query aligns to 110:169/211 of 4hurA

query
sites
4hurA

R
x
K

G

G

P

D

I

I

Y

E

I

I

K

G

N

N

R

D

V

V

W
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W

I
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I

G
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G

P
x
R

N

D

V

V

T

T

I

I

L
x
M

H

P

S

G

V

V

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K

I

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G

G

A

A

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I

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A
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A

G

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A

A

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T

K

K

D

N

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A

P

P

F

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G

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P

A

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K

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K

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D

binding acetyl coenzyme *a: K110 (≠ R180), W120 (= W190), I121 (= I191), G122 (= G192), R123 (≠ P193), M128 (≠ L198), A140 (= A210), A141 (= A211), T146 (= T216), G156 (= G226), P159 (= P229), I163 (≠ L233), R164 (≠ A234)

Sites not aligning to the query:

binding acetyl coenzyme *a: 51, 67, 68, 69, 79, 80

6x3jA Crystal structure of streptogramin a acetyltransferase vata from staphylococcus aureus in complex with streptogramin analog f0224 (46) (see paper)
53% identity, 24% coverage: 180:239/252 of query aligns to 110:169/206 of 6x3jA

query
sites
6x3jA

R

K

G

G

P

D

I

I

Y

E

I

I

K

G

N

N

R

D

V

V

W
|
W

I

I

G
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G

P

R

N

D

V

V

T

T

I

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G

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K

I

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G

G

A

A

V

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I

I

A

A

G

E

A

A

V

V

T

T

K

K

D

N

I

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A

P

P

F

Y

T

S

I

I

C

V

G

G

I

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P

P

A

L

K

K

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F

L

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A

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Q

K

R

R

S

F

I

S

D

D

binding thioacetic acid s-{2-[3-(2-hydroxy-3,3-dimethyl-4-phosphonooxy-butyrylamino)-propionylamino]-ethyl} ester: W120 (= W190), G122 (= G192)

Sites not aligning to the query:

6x3cA Crystal structure of streptogramin a acetyltransferase vata from staphylococcus aureus in complex with streptogramin analog f1037 (47) (see paper)
53% identity, 24% coverage: 180:239/252 of query aligns to 110:169/207 of 6x3cA

query
sites
6x3cA

R

K

G

G

P

D

I

I

Y

E

I

I

K

G

N

N

R

D

V

V

W
|
W

I

I

G
|
G

P
x
R

N

D

V

V

T

T

I

I

L
x
M

H

P

S

G

V

V

T

K

I

I

G

G

E

D

G

G

A

A

V

I

I

I

A
|
A

G

E

A

A

V

V

T

T

K

K

D

N

I

V

P

A

P

P

F

Y

T

S

I

I

C

V

G

G

I

N

P

P

A

L

K

K

V

F

L

I

A

R

Q

K

R

R

S

F

I

S

D

D

binding thioacetic acid s-{2-[3-(2-hydroxy-3,3-dimethyl-4-phosphonooxy-butyrylamino)-propionylamino]-ethyl} ester: W120 (= W190), G122 (= G192), R123 (≠ P193), M128 (≠ L198), A140 (= A210), A141 (= A211)

Sites not aligning to the query:

6x3cE Crystal structure of streptogramin a acetyltransferase vata from staphylococcus aureus in complex with streptogramin analog f1037 (47) (see paper)
53% identity, 24% coverage: 180:239/252 of query aligns to 110:169/203 of 6x3cE

query
sites
6x3cE

R

K

G

G

P

D

I

I

Y

E

I

I

K

G

N

N

R

D

V

V

W
|
W

I

I

G
|
G

P

R

N

D

V

V

T

T

I

I

L

M

H

P

S

G

V

V

T

K

I

I

G

G

E

D

G

G

A

A

V

I

I

I

A
|
A

G

E

A

A

V

V

T

T

K

K

D

N

I

V

P

A

P

P

F

Y

T

S

I

I

C

V

G

G

I
x
N

P
|
P

A

L

K

K

V

F

L

I

A

R

Q

K

R

R

S

F

I

S

D

D

binding magnesium ion: N158 (≠ I228), P159 (= P229)
binding thioacetic acid s-{2-[3-(2-hydroxy-3,3-dimethyl-4-phosphonooxy-butyrylamino)-propionylamino]-ethyl} ester: W120 (= W190), G122 (= G192), A140 (= A210), A141 (= A211)

Sites not aligning to the query:

3igjC Crystal structure of maltose o-acetyltransferase complexed with acetyl coenzyme a from bacillus anthracis
41% identity, 35% coverage: 147:233/252 of query aligns to 97:183/188 of 3igjC

query
sites
3igjC

I

V

Y

R

I

I

G

G

E

D

N

H

V

C

N

M

I

F

A
|
A

S

P

N

G

V

V

S

H

L

I

W
x
Y

T

T

G
x
A

G

T

H
|
H

D

P

Y

L

N

H

D

P

P

V

Y

E

F

R

R

N

S

S

M

G

K

K

T

E

N

Y

R

G

G

K

P

P

I

V

Y

K

I

I

K

G

N

N

R

N

V

V

W

W

I

V

G
|
G

P

G

N

G

V

A

T

I

I

I

L
x
N

H

P

S

G

V

V

T

S

I

I

G

G

E

D

G

N

A

A

V

V

I

I

A
|
A

A
x
S

G

G

A

A

V

V

T
|
T

K

K

D

D

I

V

P

P

P

N

F

N

T

V

I

V

C

V

G

G

I
x
N

P

P

A

A

K

K

V

V

L

I

binding acetyl coenzyme *a: A106 (= A156), Y112 (≠ W162), A114 (≠ G164), H116 (= H166), G142 (= G192), N148 (≠ L198), A160 (= A210), S161 (≠ A211), T166 (= T216), N178 (≠ I228)

Sites not aligning to the query:

binding acetyl coenzyme *a: 84

4mzuF Crystal structure of fdtd, a bifunctional ketoisomerase/n- acetyltransferase from shewanella denitrificans (see paper)
34% identity, 46% coverage: 117:232/252 of query aligns to 14:140/294 of 4mzuF

query
sites
4mzuF

G

G

S

D

E

N

I

T

R

K

A

V

P
x
W

W
x
Q

M

F

L

C

M

V

I

I

G

L

K

A

G

G

S

A

V

V

V

I

G

G

D

R

N

N

S

C

I

N

L

I

D
x
C

A

A

R

N

-

S

-

L

-

I

R

E

G

N

G

D

I

V

Y

V

I

I

G

G

E

D

N

N

V

V

N

T

I

I

A

K

S

S

N

G

V

V

S

Q

L

I

W

W

T

D

G

G

G

I

H

H

D

I

Y

Q

N

D

D

D

P

V

Y

F

-

I

-

G

-

P

-

N

-

V

-

T

F

F

R

T

S
x
N

M
x
D

K
|
K

T

Q

N

P

R

R

G

S

P

K

I

I

Y

K

-

T

-

I

I

V

K

K

N

K

R

G

V

A

W

S

I

I

G
|
G

P
x
A

N

N

V

S

T

T

I

I

L
|
L

H

P

S

G

V

I

T

L

I

I

G

G

E

E

G

N

A

A

V

M

I

V

A
x
G

A
|
A

G

G

A

A

V

V

V

I

T
|
T

K
|
K

D

N

I

V

P

P

P

D

F

N

T

A

I

I

C

V

G
x
I

G

G

I
x
N

P

P

A

G

K
x
R

V

I

binding coenzyme a: N81 (≠ S175), D82 (≠ M176), K83 (= K177), G100 (= G192), A101 (≠ P193), L106 (= L198), G118 (≠ A210), A119 (= A211), T124 (= T216), K125 (= K217), I134 (≠ G226), N136 (≠ I228), R139 (≠ K231)
binding thymine: W20 (≠ P123), Q21 (≠ W124), C38 (≠ D141)

Sites not aligning to the query:

binding thymidine-5'-diphosphate: 189, 203, 205, 270

3dhoA Structure of streptogramin acetyltransferase in complex with an inhibitor
49% identity, 23% coverage: 180:236/252 of query aligns to 111:167/203 of 3dhoA

query
sites
3dhoA

R

K

G

G

P

D

I

T

Y

I

I

I

K

G

N

N

R

D

V

V

W

W

I

I

G

G

P

K

N

D

V

V

T

V

I

I

L

M

H

P

S

G

V

V

T

K

I

I

G

G

E

D

G

G

A

A

V
x
I

I

V

A
|
A

A

A

G

N

A

S

V

V

T
x
V

K

K

D

D

I

I

P

A

P

P

F

Y

T

M

I
x
L

C

A

G
|
G

G

G

I

N

P
|
P

A

A

K

N

V

E

L
x
I

A

K

Q

Q

R

R

binding 6-bromo-N'-[(1Z)-(3,5-dichloro-2-hydroxyphenyl)methylidene]-2-methylquinoline-4-carbohydrazide: I139 (≠ V208), A141 (= A210), V147 (≠ T216), L155 (≠ I224), G157 (= G226), P160 (= P229), I164 (≠ L233)

Sites not aligning to the query:

binding 6-bromo-N'-[(1Z)-(3,5-dichloro-2-hydroxyphenyl)methylidene]-2-methylquinoline-4-carbohydrazide: 84

1mrlA Crystal structure of streptogramin a acetyltransferase with dalfopristin (see paper)
49% identity, 23% coverage: 180:236/252 of query aligns to 111:167/204 of 1mrlA

query
sites
1mrlA

R

K

G

G

P

D

I

T

Y

I

I

I

K

G

N

N

R

D

V

V

W

W

I

I

G

G

P

K

N

D

V

V

T

V

I

I

L

M

H

P

S

G

V

V

T

K

I

I

G

G

E

D

G

G

A

A

V

I

I

V

A

A

G

N

A

S

V

V

T

V

K

K

D

D

I

I

P

A

P

P

F

Y

T

M

I

L

C

A

G

G

I

N

P

P

A

A

K

N

V

E

L

I

A

K

Q

Q

R

R

Sites not aligning to the query:

binding 5-(2-diethylamino-ethanesulfonyl)-21-hydroxy-10-isopropyl-11,19-dimethyl-9,26-dioxa-3,15,28-triaza-tricyclo[23.2.1.00,255]octacosa-1(27),12,17,19,25(28)-pentaene-2,8,14,23-tetraone: 37, 39, 54, 56, 81, 82, 93, 102, 108

1khrA Crystal structure of vat(d) in complex with virginiamycin and coenzyme a (see paper)
49% identity, 23% coverage: 180:236/252 of query aligns to 111:167/206 of 1khrA

query
sites
1khrA

R

K

G

G

P

D

I

T

Y

I

I

I

K

G

N

N

R

D

V

V

W
|
W

I

I

G

G

P

K

N

D

V

V

T

V

I

I

L

M

H

P

S

G

V

V

T

K

I

I

G

G

E

D

G

G

A

A

V

I

I

V

A
|
A

G

N

A

S

V

V

T
x
V

K

K

D

D

I

I

P

A

P

P

F

Y

T

M

I
x
L

C

A

G
|
G

G

G

I

N

P
|
P

A

A

K

N

V

E

L
x
I

A

K

Q

Q

R

R

binding coenzyme a: W121 (= W190), A141 (= A210), A142 (= A211), V147 (≠ T216), L155 (≠ I224), G157 (= G226), P160 (= P229), I164 (≠ L233)

Sites not aligning to the query:

binding coenzyme a: 82, 84
binding virginiamycin m1: 37, 39, 54, 80, 81, 82, 93

1kk4A Crystal structure of vat(d) in complex with acetyl-coa (see paper)
49% identity, 23% coverage: 180:236/252 of query aligns to 111:167/205 of 1kk4A

query
sites
1kk4A

R
x
K

G

G

P

D

I

T

Y

I

I

I

K

G

N

N

R

D

V

V

W
|
W

I

I

G
|
G

P
x
K

N

D

V

V

T

V

I

I

L

M

H

P

S

G

V

V

T

K

I

I

G

G

E

D

G

G

A

A

V

I

I

V

A
|
A

G

N

A

S

V

V

T
x
V

K
|
K

D

D

I

I

P

A

P

P

F

Y

T

M

I
x
L

C

A

G
|
G

I

N

P
|
P

A

A

K

N

V

E

L
x
I

A

K

Q

Q

R

R

binding acetyl coenzyme *a: K111 (≠ R180), W121 (= W190), G123 (= G192), K124 (≠ P193), A141 (= A210), A142 (= A211), V147 (≠ T216), K148 (= K217), L155 (≠ I224), G157 (= G226), G158 (= G227), P160 (= P229), I164 (≠ L233)

Sites not aligning to the query:

binding acetyl coenzyme *a: 69, 70

Query Sequence

>350000 FitnessBrowser__Btheta:350000
MNLSVVLFILIVVFIKYWLLLFTSPLLMAYCWLHRRKNMANPEGEVSEIRDSGITSSSCS
KKLFKRIDKRGLINIVDGYFRWMIKIISDIPSHHIRDFFYKYIFLVKMEKNSVLYYGSEI
RAPWMLMIGKGSVVGDNSILDARRGGIYIGENVNIASNVSLWTGGHDYNDPYFRSMKTNR
GPIYIKNRVWIGPNVTILHSVTIGEGAVIAAGAVVTKDIPPFTICGGIPAKVLAQRSIDL
RYTLGGTYLHFL

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory