SitesBLAST
Comparing 350321 FitnessBrowser__Btheta:350321 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4xkmA Crystal structure of xylose isomerase from an human intestinal tract microbe bacteroides thetaiotaomicron
100% identity, 99% coverage: 4:438/438 of query aligns to 1:435/435 of 4xkmA
- active site: F23 (= F26), E29 (= E32), H100 (= H103), D103 (= D106), W138 (= W141), E231 (= E234), K233 (= K236), E267 (= E270), H270 (= H273), D295 (= D298), D306 (= D309), D308 (= D311), D338 (= D341)
- binding manganese (ii) ion: E231 (= E234), E267 (= E270), E267 (= E270), H270 (= H273), D295 (= D298), D306 (= D309), D308 (= D311), D338 (= D341)
5yn3A Crystal structure of xylose isomerase from piromyces sp. E2 (see paper)
84% identity, 99% coverage: 4:437/438 of query aligns to 1:434/435 of 5yn3A
- active site: H100 (= H103), D103 (= D106), W138 (= W141), E231 (= E234), K233 (= K236), E267 (= E270), H270 (= H273), D295 (= D298), D306 (= D309), D308 (= D311), D338 (= D341)
- binding glycerol: H100 (= H103), W187 (= W190), E231 (= E234), D295 (= D298)
- binding manganese (ii) ion: E231 (= E234), E267 (= E270), E267 (= E270), H270 (= H273), D295 (= D298), D306 (= D309), D308 (= D311), D338 (= D341)
5nhcA Crystal structure of xylose isomerase from piromyces e2 in complex with two co2+ ions and xylulose (see paper)
84% identity, 99% coverage: 4:437/438 of query aligns to 2:435/436 of 5nhcA
- active site: H101 (= H103), D104 (= D106), W139 (= W141), E232 (= E234), K234 (= K236), E268 (= E270), H271 (= H273), D296 (= D298), D307 (= D309), D309 (= D311), D339 (= D341)
- binding cobalt (ii) ion: E232 (= E234), E268 (= E270), E268 (= E270), H271 (= H273), D296 (= D298), D307 (= D309), D309 (= D311), D339 (= D341)
- binding 4-hydroxyproline: G290 (= G292), L292 (= L294), G328 (≠ N330), G330 (= G332), V332 (≠ G334)
- binding d-xylulose: W49 (= W51), H101 (= H103), W188 (= W190), E232 (= E234), E268 (= E270), H271 (= H273), D339 (= D341)
5nhaA Crystal structure of xylose isomerase from piromyces sp. E2 in complex with two mn2+ ions and sorbitol (see paper)
84% identity, 99% coverage: 4:437/438 of query aligns to 2:435/436 of 5nhaA
- active site: H101 (= H103), D104 (= D106), W139 (= W141), E232 (= E234), K234 (= K236), E268 (= E270), H271 (= H273), D296 (= D298), D307 (= D309), D309 (= D311), D339 (= D341)
- binding manganese (ii) ion: E232 (= E234), E268 (= E270), E268 (= E270), H271 (= H273), D296 (= D298), D307 (= D309), D309 (= D311), D339 (= D341)
- binding sorbitol: W49 (= W51), H101 (= H103), W188 (= W190), E232 (= E234), D339 (= D341)
5nh9A Crystal structure of xylose isomerase from piromyces e2 in complex with two mn2+ ions and xylose (see paper)
84% identity, 99% coverage: 4:437/438 of query aligns to 2:435/436 of 5nh9A
- active site: H101 (= H103), D104 (= D106), W139 (= W141), E232 (= E234), K234 (= K236), E268 (= E270), H271 (= H273), D296 (= D298), D307 (= D309), D309 (= D311), D339 (= D341)
- binding manganese (ii) ion: E232 (= E234), E268 (= E270), E268 (= E270), H271 (= H273), D296 (= D298), D307 (= D309), D309 (= D311), D339 (= D341)
- binding D-xylose: W49 (= W51), H101 (= H103), W188 (= W190), E232 (= E234), E268 (= E270), H271 (= H273), D339 (= D341)
- binding beta-D-xylopyranose: G63 (= G65), K65 (= K67), S66 (≠ Q68), K203 (= K205), K206 (= K208), H257 (= H259), D288 (= D290), A289 (≠ N291)
5nh7A Crystal structure of xylose isomerase from piromyces e2 in complex with two mg2+ ions and xylose (see paper)
84% identity, 99% coverage: 4:437/438 of query aligns to 2:435/436 of 5nh7A
- active site: H101 (= H103), D104 (= D106), W139 (= W141), E232 (= E234), K234 (= K236), E268 (= E270), H271 (= H273), D296 (= D298), D307 (= D309), D309 (= D311), D339 (= D341)
- binding magnesium ion: E232 (= E234), E268 (= E270), E268 (= E270), H271 (= H273), D296 (= D298), D307 (= D309), D309 (= D311), D339 (= D341)
- binding D-xylose: W49 (= W51), H101 (= H103), W188 (= W190), E232 (= E234), E268 (= E270), H271 (= H273), D339 (= D341)
- binding beta-D-xylopyranose: G63 (= G65), K65 (= K67), S66 (≠ Q68)
- binding alpha-D-xylopyranose: P21 (= P23), D40 (= D42), Y97 (= Y99), K136 (= K138), E350 (= E352)
5nh6A Crystal structure of xylose isomerase from piromyces e2 complexed with one mg2+ ion and xylitol (see paper)
84% identity, 99% coverage: 4:437/438 of query aligns to 2:435/436 of 5nh6A
- active site: H101 (= H103), D104 (= D106), W139 (= W141), E232 (= E234), K234 (= K236), E268 (= E270), H271 (= H273), D296 (= D298), D307 (= D309), D309 (= D311), D339 (= D341)
- binding magnesium ion: E232 (= E234), E268 (= E270), D296 (= D298), D339 (= D341)
- binding Xylitol: W49 (= W51), H101 (= H103), W188 (= W190), E232 (= E234), E268 (= E270), H271 (= H273), D339 (= D341)
5nh5A Crystal structure of native xylose isomerase from piromyces e2 (see paper)
84% identity, 99% coverage: 4:437/438 of query aligns to 2:435/436 of 5nh5A
- active site: H101 (= H103), D104 (= D106), W139 (= W141), E232 (= E234), K234 (= K236), E268 (= E270), H271 (= H273), D296 (= D298), D307 (= D309), D309 (= D311), D339 (= D341)
- binding calcium ion: E232 (= E234), E268 (= E270), D296 (= D298), D339 (= D341)
- binding fe (ii) ion: E232 (= E234), E268 (= E270), D296 (= D298), D339 (= D341)
- binding magnesium ion: E232 (= E234), E268 (= E270), D296 (= D298), D339 (= D341)
5nh4A Crystal structure of xylose isomerase from piromyces e2 in complex with one mg2+ ions and glycerol (see paper)
84% identity, 99% coverage: 4:437/438 of query aligns to 2:435/436 of 5nh4A
- active site: H101 (= H103), D104 (= D106), W139 (= W141), E232 (= E234), K234 (= K236), E268 (= E270), H271 (= H273), D296 (= D298), D307 (= D309), D309 (= D311), D339 (= D341)
- binding magnesium ion: E232 (= E234), E268 (= E270), D296 (= D298), D339 (= D341)
1a0eA Xylose isomerase from thermotoga neapolitana
53% identity, 99% coverage: 5:438/438 of query aligns to 2:435/443 of 1a0eA
- active site: H100 (= H103), D103 (= D106), W138 (= W141), E231 (= E234), K233 (= K236), E267 (= E270), H270 (= H273), D295 (= D298), D306 (= D309), D308 (= D311), D338 (= D341)
- binding cobalt (ii) ion: E231 (= E234), E267 (= E270), E267 (= E270), H270 (= H273), D295 (= D298), D308 (= D311), D338 (= D341)
P00944 Xylose isomerase; D-xylulose keto-isomerase; EC 5.3.1.5 from Escherichia coli (strain K12) (see paper)
49% identity, 99% coverage: 6:437/438 of query aligns to 4:436/440 of P00944
- H101 (= H103) active site
1a0cA Xylose isomerase from thermoanaerobacterium thermosulfurigenes
50% identity, 99% coverage: 5:438/438 of query aligns to 2:435/437 of 1a0cA
- active site: H100 (= H103), D103 (= D106), W138 (= W141), E231 (= E234), K233 (= K236), E267 (= E270), H270 (= H273), D295 (= D298), D306 (= D309), D308 (= D311), D338 (= D341)
- binding cobalt (ii) ion: E231 (= E234), E267 (= E270), E267 (= E270), H270 (= H273), D295 (= D298), D306 (= D309), D308 (= D311), D338 (= D341)
1a0dA Xylose isomerase from bacillus stearothermophilus
49% identity, 99% coverage: 6:438/438 of query aligns to 2:433/437 of 1a0dA
- active site: H98 (= H103), D101 (= D106), W136 (= W141), E229 (= E234), K231 (= K236), E265 (= E270), H268 (= H273), D293 (= D298), D304 (= D309), D306 (= D311), D336 (= D341)
- binding manganese (ii) ion: E229 (= E234), E265 (= E270), E265 (= E270), H268 (= H273), D293 (= D298), D304 (= D309), D306 (= D311), D336 (= D341)
6intA Xylose isomerase from paenibacillus sp. R4 (see paper)
48% identity, 99% coverage: 6:438/438 of query aligns to 1:410/413 of 6intA
- active site: H74 (= H103), D77 (= D106), W112 (= W141), E205 (= E234), K207 (= K236), E241 (= E270), H244 (= H273), D269 (= D298), D280 (= D309), D282 (= D311), D313 (= D341)
- binding calcium ion: G166 (= G195), E178 (= E207), E205 (= E234), E241 (= E270), E241 (= E270), H244 (= H273), D269 (= D298), D280 (= D309), D282 (= D311), D313 (= D341)
4j4kA Crystal structure of glucose isomerase
30% identity, 69% coverage: 45:347/438 of query aligns to 8:291/385 of 4j4kA
- active site: H52 (= H103), D55 (= D106), M86 (≠ W141), E179 (= E234), K181 (= K236), E215 (= E270), H218 (= H273), D243 (= D298), D253 (= D311), D255 (vs. gap), D285 (= D341)
- binding zinc ion: E179 (= E234), E215 (= E270), E215 (= E270), H218 (= H273), D243 (= D298), D253 (= D311), D255 (vs. gap), D285 (= D341)
1oadA Glucose isomerase from streptomyces rubiginosus in p21212 crystal form (see paper)
30% identity, 69% coverage: 45:347/438 of query aligns to 9:292/387 of 1oadA
- active site: H53 (= H103), D56 (= D106), M87 (≠ W141), E180 (= E234), K182 (= K236), E216 (= E270), H219 (= H273), D244 (= D298), D254 (= D311), D256 (vs. gap), D286 (= D341)
- binding magnesium ion: E180 (= E234), E216 (= E270), D244 (= D298), D286 (= D341)
- binding manganese (ii) ion: E216 (= E270), H219 (= H273), D254 (= D311), D256 (vs. gap)
- binding 2-methylpentane-1,2,4-triol: W15 (= W51), H53 (= H103), F93 (= F147), W136 (= W190), E180 (= E234), D286 (= D341)
1xiiA Modes of binding substrates and their analogues to the enzyme d-xylose isomerase (see paper)
31% identity, 69% coverage: 45:347/438 of query aligns to 8:291/385 of 1xiiA
- active site: H52 (= H103), D55 (= D106), M86 (≠ W141), E179 (= E234), K181 (= K236), E215 (= E270), H218 (= H273), D243 (= D298), D253 (= D311), D255 (vs. gap), D285 (= D341)
- binding manganese (ii) ion: E179 (= E234), E215 (= E270), E215 (= E270), H218 (= H273), D243 (= D298), D253 (= D311), D255 (vs. gap), D285 (= D341)
- binding d-xylulose: W14 (= W51), H52 (= H103), W135 (= W190), E179 (= E234), H218 (= H273), D285 (= D341)
1xihA Modes of binding substrates and their analogues to the enzyme d-xylose isomerase (see paper)
31% identity, 69% coverage: 45:347/438 of query aligns to 8:291/385 of 1xihA
- active site: H52 (= H103), D55 (= D106), M86 (≠ W141), E179 (= E234), K181 (= K236), E215 (= E270), H218 (= H273), D243 (= D298), D253 (= D311), D255 (vs. gap), D285 (= D341)
- binding manganese (ii) ion: E179 (= E234), E215 (= E270), D243 (= D298), D285 (= D341)
- binding sorbitol: H52 (= H103), T88 (= T143), V133 (= V188), W135 (= W190), E179 (= E234), K181 (= K236), E215 (= E270), H218 (= H273), D285 (= D341)
1xicA Modes of binding substrates and their analogues to the enzyme d-xylose isomerase (see paper)
31% identity, 69% coverage: 45:347/438 of query aligns to 8:291/385 of 1xicA
- active site: H52 (= H103), D55 (= D106), M86 (≠ W141), E179 (= E234), K181 (= K236), E215 (= E270), H218 (= H273), D243 (= D298), D253 (= D311), D255 (vs. gap), D285 (= D341)
- binding manganese (ii) ion: E179 (= E234), E215 (= E270), E215 (= E270), H218 (= H273), D243 (= D298), D253 (= D311), D255 (vs. gap), D285 (= D341)
- binding D-xylose: W14 (= W51), H52 (= H103), W135 (= W190), E179 (= E234), H218 (= H273), D285 (= D341)
1gw9A Tri-iodide derivative of xylose isomerase from streptomyces rubiginosus (see paper)
31% identity, 69% coverage: 45:347/438 of query aligns to 8:291/384 of 1gw9A
- active site: H52 (= H103), D55 (= D106), M86 (≠ W141), E179 (= E234), K181 (= K236), E215 (= E270), H218 (= H273), D243 (= D298), D253 (= D311), D255 (vs. gap), D285 (= D341)
- binding calcium ion: E179 (= E234), E215 (= E270), E215 (= E270), H218 (= H273), D243 (= D298), D253 (= D311), D255 (vs. gap), D285 (= D341)
- binding beta-L-xylopyranose: H52 (= H103), F92 (= F147), W135 (= W190), E179 (= E234), D285 (= D341)
Query Sequence
>350321 FitnessBrowser__Btheta:350321
MATKEFFPGIEKIKFEGKDSKNPMAFRYYDAEKVINGKKMKDWLRFAMAWWHTLCAEGGD
QFGGGTKQFPWNGNADAIQAAKDKMDAGFEFMQKMGIEYYCFHDVDLVSEGASVEEYEAN
LKEIVAYAKQKQAETGIKLLWGTANVFGHARYMNGAATNPDFDVVARAAVQIKNAIDATI
ELGGENYVFWGGREGYMSLLNTDQKREKEHLAQMLTIARDYARARGFKGTFLIEPKPMEP
TKHQYDVDTETVIGFLKAHGLDKDFKVNIEVNHATLAGHTFEHELAVAVDNGMLGSIDAN
RGDYQNGWDTDQFPIDNYELTQAMMQIIRNGGLGTGGTNFDAKTRRNSTDLEDIFIAHIA
GMDAMARALESAAALLDESPYKKMLADRYASFDGGKGKEFEDGKLTLEDVVAYAKTKGEP
KQTSGKQELYEAILNMYC
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory