Comparing 350403 FitnessBrowser__Btheta:350403 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5h8iC Crystal structure of medicago truncatula n-carbamoylputrescine amidohydrolase (mtcpa) in complex with n-(dihydroxymethyl)putrescine (see paper)
39% identity, 98% coverage: 2:288/294 of query aligns to 7:291/301 of 5h8iC
5h8jB Crystal structure of medicago truncatula n-carbamoylputrescine amidohydrolase (mtcpa) in complex with cadaverine (see paper)
39% identity, 98% coverage: 2:288/294 of query aligns to 3:287/297 of 5h8jB
5h8lB Crystal structure of medicago truncatula n-carbamoylputrescine amidohydrolase (mtcpa) c158s mutant in complex with putrescine (see paper)
39% identity, 98% coverage: 2:288/294 of query aligns to 4:288/298 of 5h8lB
6ypaB The c146a variant of an amidase from pyrococcus horikoshii with bound glutaramide
34% identity, 96% coverage: 4:285/294 of query aligns to 9:267/269 of 6ypaB
7ovgA The c146a variant of an amidase from pyrococcus horikoshii with bound acetamide (see paper)
34% identity, 96% coverage: 4:285/294 of query aligns to 3:261/263 of 7ovgA
3klcB Crystal structure of hyperthermophilic nitrilase (see paper)
34% identity, 90% coverage: 20:285/294 of query aligns to 18:259/261 of 3klcB
Sites not aligning to the query:
3klcA Crystal structure of hyperthermophilic nitrilase (see paper)
34% identity, 90% coverage: 20:285/294 of query aligns to 18:259/261 of 3klcA
Sites not aligning to the query:
Q9UYV8 Nitrilase; PaNit; EC 3.5.5.1 from Pyrococcus abyssi (strain GE5 / Orsay) (see paper)
34% identity, 90% coverage: 20:285/294 of query aligns to 19:260/262 of Q9UYV8
Q9NQR4 Omega-amidase NIT2; Nitrilase homolog 2; EC 3.5.1.3 from Homo sapiens (Human) (see 2 papers)
29% identity, 97% coverage: 1:285/294 of query aligns to 1:269/276 of Q9NQR4
Q9UBR1 Beta-ureidopropionase; BUP-1; Beta-alanine synthase; N-carbamoyl-beta-alanine amidohydrolase; EC 3.5.1.6 from Homo sapiens (Human) (see 4 papers)
28% identity, 88% coverage: 28:285/294 of query aligns to 104:365/384 of Q9UBR1
Sites not aligning to the query:
Q964D8 Beta-ureidopropionase; Beta-alanine synthase; N-carbamoyl-beta-alanine amidohydrolase; EC 3.5.1.6 from Dictyostelium discoideum (Social amoeba)
27% identity, 99% coverage: 4:294/294 of query aligns to 75:377/391 of Q964D8
Sites not aligning to the query:
Q44185 N-carbamoyl-D-amino acid hydrolase; D-N-alpha-carbamilase; EC 3.5.1.77 from Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium radiobacter) (see paper)
28% identity, 89% coverage: 32:292/294 of query aligns to 36:304/304 of Q44185
8hpcC Crystal structure of c171a mutant of n-carbamyl-d-amino acid amidohydrolase complexed with n-carbamyl-d-hydroxyphenylglycine
27% identity, 91% coverage: 21:288/294 of query aligns to 24:299/303 of 8hpcC
1uf8A Crystal structure of c171a/v236a mutant of n-carbamyl-d-amino acid amidohydrolase complexed with n-carbamyl-d-phenylalanine
27% identity, 91% coverage: 21:288/294 of query aligns to 24:299/303 of 1uf8A
1uf7A Crystal structure of c171a/v236a mutant of n-carbamyl-d-amino acid amidohydrolase complexed with n-carbamyl-d-valine
27% identity, 91% coverage: 21:288/294 of query aligns to 24:299/303 of 1uf7A
1uf5A Crystal structure of c171a/v236a mutant of n-carbamyl-d-amino acid amidohydrolase complexed with n-carbamyl-d-methionine
27% identity, 91% coverage: 21:288/294 of query aligns to 24:299/303 of 1uf5A
Q94JV5 Deaminated glutathione amidase, chloroplastic/cytosolic; dGSH amidase; Nitrilase-like protein 2; Protein nitrilase 1 homolog; AtNit1; Protein Nit1 homolog; EC 3.5.1.128 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
24% identity, 95% coverage: 2:280/294 of query aligns to 35:302/307 of Q94JV5
Sites not aligning to the query:
O25836 Formamidase; Formamide amidohydrolase; EC 3.5.1.49 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see paper)
29% identity, 88% coverage: 16:274/294 of query aligns to 31:270/334 of O25836
P47016 Deaminated glutathione amidase; dGSH amidase; Nitrilase homolog 1; EC 3.5.1.128 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
27% identity, 64% coverage: 99:285/294 of query aligns to 110:306/307 of P47016
4hg5A Structural insights into yeast nit2: wild-type yeast nit2 in complex with oxaloacetate (see paper)
27% identity, 64% coverage: 99:285/294 of query aligns to 107:303/304 of 4hg5A
>350403 FitnessBrowser__Btheta:350403
MKKIKVGLIQQSNTADIRVNLMNLAKSIEACAAHGAQLIVLQELHNSLYFCQTENTNLFD
LAEPIPGPSTGFYSELAAANKVVLVASLFEKRAPGLYHNTAVVFDRDGSIAGKYRKMHIP
DDPAYYEKFYFTPGDIGFEPIQTSLGKLGVLVCWDQWYPEAARLMALKGAELLIYPTAIG
WESSDTDDEKARQLNAWIISQRAHAVANGLPVISVNRVGHEPDPSGQTNGIQFWGNSFVA
GPQGEFLAQASNDHPENMVVEIDMERSENVRRWWPFLRDRRIDEYDGLTKRFLD
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory