Comparing 350906 FitnessBrowser__Btheta:350906 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q9X0C6 Imidazole glycerol phosphate synthase subunit HisF; IGP synthase cyclase subunit; IGP synthase subunit HisF; ImGP synthase subunit HisF; IGPS subunit HisF; EC 4.3.2.10 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
56% identity, 100% coverage: 1:250/251 of query aligns to 1:249/253 of Q9X0C6
7ac8A Molecular basis for the unique allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex. (see paper)
56% identity, 100% coverage: 1:250/251 of query aligns to 1:249/252 of 7ac8A
1gpwC Structural evidence for ammonia tunneling across the (beta/alpha)8 barrel of the imidazole glycerol phosphate synthase bienzyme complex. (see paper)
55% identity, 100% coverage: 1:250/251 of query aligns to 1:249/253 of 1gpwC
7qc8A Imidazole glycerol phosphate synthase subunit HisF (see paper)
53% identity, 99% coverage: 2:250/251 of query aligns to 2:249/250 of 7qc8A
5d2tA Directed evolutionary changes in kemp eliminase ke07 - crystal 3 wild type
50% identity, 99% coverage: 3:250/251 of query aligns to 1:247/251 of 5d2tA
6dnjA Directed evolutionary changes in kemp eliminase ke07 - crystal 28 round 5 (see paper)
50% identity, 99% coverage: 2:250/251 of query aligns to 1:248/250 of 6dnjA
3zr4E Structural evidence for ammonia tunneling across the (beta-alpha)8 barrel of the imidazole glycerol phosphate synthase bienzyme complex (see paper)
53% identity, 100% coverage: 1:250/251 of query aligns to 1:240/244 of 3zr4E
4ewnD Structure of hisf-d130v+d176v with bound rcdrp (see paper)
53% identity, 99% coverage: 2:250/251 of query aligns to 1:242/243 of 4ewnD
1h5yB Hisf protein from pyrobaculum aerophilum (see paper)
51% identity, 99% coverage: 2:250/251 of query aligns to 3:252/253 of 1h5yB
P60664 Imidazole glycerol phosphate synthase subunit HisF; IGP synthase cyclase subunit; IGP synthase subunit HisF; ImGP synthase subunit HisF; IGPS subunit HisF; EC 4.3.2.10 from Escherichia coli (strain K12) (see paper)
50% identity, 100% coverage: 1:250/251 of query aligns to 1:256/258 of P60664
2wjzE Crystal structure of (hish) k181a y138a mutant of imidazoleglycerolphosphate synthase (hish hisf) which displays constitutive glutaminase activity (see paper)
52% identity, 100% coverage: 1:250/251 of query aligns to 1:235/237 of 2wjzE
3iivB Evolutionary optimization of computationally designed enzymes: kemp eliminases of the ke07 series (see paper)
49% identity, 99% coverage: 2:250/251 of query aligns to 2:248/262 of 3iivB
1ox4B Towards understanding the mechanism of the complex cyclization reaction catalyzed by imidazole glycerophosphate synthase (see paper)
34% identity, 99% coverage: 2:250/251 of query aligns to 239:536/538 of 1ox4B
P33734 Imidazole glycerol phosphate synthase hisHF; IGP synthase; IGPS; ImGP synthase; EC 4.3.2.10; EC 3.5.1.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
34% identity, 99% coverage: 2:250/251 of query aligns to 236:548/552 of P33734
1ox5A Towards understanding the mechanism of the complex cyclization reaction catalyzed by imidazole glycerophosphate synthase (see paper)
35% identity, 99% coverage: 2:250/251 of query aligns to 239:530/532 of 1ox5A
5abtA S.Enterica hisa mutant d7n, g102a, v106m, d176a
35% identity, 53% coverage: 6:139/251 of query aligns to 2:138/246 of 5abtA
Sites not aligning to the query:
5ab3A S.Enterica hisa mutant d7n, d10g, dup13-15, q24l, g102a (see paper)
34% identity, 53% coverage: 6:139/251 of query aligns to 2:141/241 of 5ab3A
Sites not aligning to the query:
3tdmA Computationally designed tim-barrel protein, halfflr (see paper)
43% identity, 38% coverage: 123:217/251 of query aligns to 1:95/120 of 3tdmA
Sites not aligning to the query:
2y85A Crystal structure of mycobacterium tuberculosis phosphoribosyl isomerase with bound rcdrp (see paper)
25% identity, 82% coverage: 6:211/251 of query aligns to 5:200/234 of 2y85A
Sites not aligning to the query:
3zs4A Crystal structure of mycobacterium tuberculosis phosphoribosyl isomerase with bound prfar
25% identity, 82% coverage: 6:211/251 of query aligns to 5:209/244 of 3zs4A
Sites not aligning to the query:
>350906 FitnessBrowser__Btheta:350906
MLAKRIIPCLDIKDGQTVKGTNFVNLRQAGDPVELGRAYSEQGADELVFLDITASHEGRK
TFTELVKRIAANINIPFTVGGGINELSDVDRLLNAGADKISINSSAIRNPQLIDDIAKNF
GSQVCVLAVDAKQTENGWKCYLNGGRIETDKELLAWTKEAQERGAGEILFTSMNHDGVKT
GYANEALASLADQLSIPVIASGGAGLKEHFRDAFLVGKADAALAASVFHFGEIKIPELKS
YLCGEGITIRG
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Lawrence Berkeley National Laboratory