SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing 352022 FitnessBrowser__Btheta:352022 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

5xu1B Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
55% identity, 91% coverage: 1:217/238 of query aligns to 3:220/226 of 5xu1B

query
sites
5xu1B

M

L

I

I

K

S

L

L

T

K

D

N

I

I

N

F

K

R

T

S

Y

Y

N

R

N

N

G

G

-

D

A

Q

P

E

L

L

H

Q

V

V

L

L

K

K

G

N

I

I

N

N

L

L

D

E

I

V

Q

N

R

E

G

G

E

E

F

F

V

V

S

A

I

I

M

M

G

G

A

P

S

S

G

G

S

S

G
|
G

K
|
K

S
|
S

T

T

L

L

L

M

N

N

I

T

L

I

G

G

I

M

L

L

D

D

N

T

Y

P

D

T

T

S

G

G

D

E

Y

Y

Y

Y

L

L

N

E

N

G

V

Q

L

E

I

V

K

A

D

G

L

L

S

G

E

E

T

K

K

Q

A

L

A

A

E

K

Y

V

R

R

N

N

R

Q

M

Q

I

I

G

G

F

F

I

V

F

F

Q

Q

S

Q

F

F

N

F

L

L

I

L

S

S

F

K

K

L

D

N

A

A

V

L

E

Q

N

N

V

V

A

E

L

L

P

P

L

L

F

I

Y

Y

Q

A

G

G

V

V

S

S

R

S

K

S

K

K

R

R

N

R

A

K

L

L

A

A

L

E

E

E

Y

Y

L

L

D

D

R

K

L

V

G

E

L

L

K

T

E

E

W

R

A

S

H

H

H

H

M

L

P

P

N

S

E

E

M

L

S

S

G

G

G

G

Q

Q

K

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

V

T

N

Q

N

P

P

Q

S

I

I

I

I

L

L

A

A

D

D

E

E

P

P

T

T

G

G

A

A

L

L

D

D

S

T

K

K

T

T

S

G

V

N

E

Q

V

I

M

M

Q

Q

I

L

L

L

K

V

D

D

L

L

H

N

R

K

M

E

G

G

M

K

T

T

I

I

V

I

V

M

V

V

T

T

H

H

E

E

S

P

G

E

V

I

A

A

N

A

Q

Y

T

A

D

K

K

R

I

Q

I

I

H

V

I

I

K

R

D

D

G

G

I

V

I

I

binding magnesium ion: G45 (= G42), K46 (= K43), S47 (= S44)

1f3oA Crystal structure of mj0796 atp-binding cassette (see paper)
52% identity, 93% coverage: 1:222/238 of query aligns to 1:228/232 of 1f3oA

query
sites
1f3oA

M

M

I

I

K

K

L

L

T

K

D

N

I

V

N

T

K

K

T

T

Y
|
Y

N

K

N

M

G

G

A

E

P

E

L

I

-

I

H

Y

V

A

L

L

K

K

G

N

I

V

N

N

L

L

D

N

I

I

Q

K

R

E

G

G

E

E

F

F

V

V

S

S

I

I

M

M

G

G

A

P

S

S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

M

L

L

N

N

I

I

L

I

G

G

I

C

L

L

D

D

N

K

Y

P

D

T

T

E

G

G

D

E

Y

V

Y

Y

L

I

N

D

N

N

V

I

L

K

I

T

K

N

D

D

L

L

S

D

E

D

T

D

K

E

A

L

A

T

E

K

Y

I

R

R

N

R

R

D

M

K

I

I

G

G

F

F

I

V

F

F

Q

Q

S

Q

F

F

N

N

L

L

I

I

S

P

F

L

K

L

D

T

A

A

V

L

E

E

N

N

V

V

A

E

L

L

P

P

L

L

F

I

Y

F

Q

K

-

Y

-

R

-

G

G

A

V

M

S

S

R

G

K

E

K

E

R

R

N

R

A

K

L

R

A

A

L

L

E

E

Y

C

L

L

D

K

R

M

L

A

G

E

L

L

K

E

E

E

-

R

W

F

A

A

H

N

H

H

M

K

P

P

N

N

E

Q

M

L

S

S

G

G

G

G

Q

Q

K

Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

A

T

N

Q

N

P

P

Q

P

I

I

I

I

L

L

A

A

D

D

E

E

P

P

T

T

G

G

A

A

L

L

D

D

S

S

K

K

T

T

S

G

V

E

E

K

V

I

M

M

Q

Q

I

L

L

L

K

K

D

K

L

L

H

N

R

E

M

E

-

D

G

G

M

K

T

T

I

V

V

V

V

V

V

V

T

T

H

H

E

D

S

I

G

N

V

V

A

A

N

R

Q

F

T

G

D

E

K

R

I

I

I

I

H

Y

I

L

K

K

D

D

G

G

I

E

I

V

E

E

R

R

I

E

E

E

E

K

binding adenosine-5'-diphosphate: Y11 (= Y11), G41 (= G40), G43 (= G42), K44 (= K43), S45 (= S44), T46 (= T45)

1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette (see paper)
52% identity, 93% coverage: 1:222/238 of query aligns to 1:228/230 of 1l2tA

query
sites
1l2tA

M

M

I

I

K

K

L

L

T

K

D

N

I

V

N

T

K

K

T

T

Y
|
Y

N

K

N

M

G

G

A

E

P

E

L

I

-

I

H

Y

V

A

L

L

K

K

G

N

I

V

N

N

L

L

D

N

I

I

Q

K

R

E

G

G

E

E

F

F

V

V

S

S

I

I

M

M

G

G

A

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

L

M

L

L

N

N

I

I

L

I

G

G

I

C

L

L

D

D

N

K

Y

P

D

T

T

E

G

G

D

E

Y

V

Y

Y

L

I

N

D

N

N

V

I

L

K

I

T

K

N

D

D

L

L

S

D

E

D

T

D

K

E

A

L

A

T

E

K

Y

I

R

R

N

R

R

D

M

K

I

I

G

G

F

F

I

V

F

F

Q

Q

S

Q

F

F

N

N

L

L

I

I

S

P

F

L

K

L

D

T

A

A

V

L

E

E

N

N

V

V

A

E

L

L

P

P

L

L

F

I

Y

F

Q

K

-

Y

-

R

-

G

G

A

V

M

S

S

R

G

K

E

K

E

R

R

N

R

A

K

L

R

A

A

L

L

E

E

Y

C

L

L

D

K

R

M

L

A

G

E

L

L

K

E

E

E

-

R

W
x
F

A

A

H

N

H

H

M

K

P

P

N

N

E
x
Q

M

L

S
|
S

G

G

G
|
G

Q
|
Q

K

Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

A

T

N

Q

N

P

P

Q

P

I

I

I

I

L

L

A

A

D

D

E

Q

P

P

T

T

G

G

A

A

L

L

D

D

S

S

K

K

T

T

S

G

V

E

E

K

V

I

M

M

Q

Q

I

L

L

L

K

K

D

K

L

L

H

N

R

E

M

E

-

D

G

G

M

K

T

T

I

V

V

V

V

V

V

V

T

T

H
|
H

E

D

S

I

G

N

V

V

A

A

N

R

Q

F

T

G

D

E

K

R

I

I

I

I

H

Y

I

L

K

K

D

D

G

G

I

E

I

V

E

E

R

R

I

E

E

E

E

K

binding adenosine-5'-triphosphate: Y11 (= Y11), S40 (= S39), G41 (= G40), S42 (= S41), G43 (= G42), K44 (= K43), S45 (= S44), T46 (= T45), F138 (≠ W133), Q145 (≠ E140), S147 (= S142), G149 (= G144), Q150 (= Q145), H204 (= H198)

P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
49% identity, 92% coverage: 1:219/238 of query aligns to 4:223/648 of P75831

query
sites
P75831

M

L

I

L

K

E

L

L

T

K

D

D

I

I

N

R

K

R

T

S

Y

Y

N

P

N

A

G

G

-

D

A

E

P

Q

L

V

H

E

V

V

L

L

K

K

G

G

I

I

N

S

L

L

D

D

I

I

Q

Y

R

A

G

G

E

E

F

M

V

V

S

A

I

I

M

V

G

G

A

A

S

S

G

G

S

S

G

G

K
|
K

S

S

T

T

L

L

L

M

N

N

I

I

L

L

G

G

I

C

L

L

D

D

N

K

Y

A

D

T

T

S

G

G

D

T

Y

Y

Y

R

L

V

N

A

N

G

V

Q

L

D

I

V

K

A

D

T

L

L

S

D

E

A

T

D

K

A

A

L

A

A

E

Q

Y

L

R

R

N

R

R

E

M

H

I

F

G

G

F

F

I

I

F

F

Q

Q

S

R

F

Y

N

H

L

L

I

L

S

S

F

H

K

L

D

T

A

A

V

E

E

Q

N

N

V

V

A

E

L

V

P

P

L

A

F

V

Y

Y

Q

A

G

G

V

L

S

E

R

R

K

K

K

Q

R

R

N

L

A

L

L

R

A

A

L

Q

E

E

Y

L

L

L

D

Q

R

R

L

L

G

G

L

L

K

E

E

D

W

R

A

T

H

E

H

Y

M

Y

P

P

N

A

E

Q

M

L

S

S

G

G

G

G

Q

Q

K

Q

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

L

L

I

M

T

N

Q

G

P

G

Q

Q

I

V

I

I

L

L

A

A

D
|
D

E

E

P

P

T

T

G

G

A

A

L

L

D

D

S

S

K

H

T

S

S

G

V

E

E

E

V

V

M

M

Q

A

I

I

L

L

K

H

D

Q

L

L

H

R

R

D

M

R

G

G

M

H

T

T

I

V

V

I

V

I

V

V

T

T

H

H

E

D

S

P

G

Q

V

V

A

A

N

A

Q

Q

T

A

D

E

K

R

I

V

I

I

H

E

I

I

K

R

D

D

G

G

I

E

I

I

E

V

R

R

K47 (= K43) mutation to L: Lack of activity.
D169 (= D165) mutation to N: Lack of activity.

5lilA Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
47% identity, 90% coverage: 1:215/238 of query aligns to 3:218/615 of 5lilA

query
sites
5lilA

M

I

I

I

K

E

L

I

T

K

D

Q

I

L

N

N

K

R

T

Y

Y
x
F

N

G

N

E

G

G

A

E

-

N

P

R

L

V

H

H

V
|
V

L

L

K

K

G

D

I

I

N

S

L

L

D

S

I

I

Q

E

R

R

G

G

E

D

F

F

V

V

S

A

I

I

M

M

G

G

A

Q

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

M

N

N

I

I

L

I

G

G

I

C

L

L

D

D

N

T

Y

A

D

T

T

G

G

G

D

S

Y

S

Y

K

L

I

N

D

N

G

V

K

L

E

I

T

K

I

D

E

L

L

S

T

E

N

T

D

K

Q

A

L

A

S

E

D

Y

L

R

R

N

S

R

Q

M

K

I

F

G

G

F

F

I

I

F

F

Q
|
Q

S

R

F

Y

N

N

L

L

I

L

S

S

F

S

K

L

D

T

A

A

V

A

E

E

N

N

V

V

A

A

L

L

P

P

L

A

F

I

Y

Y

Q

A

G

G

V

M

S

P

R

Q

K

S

K

Q

R

R

N

L

A

E

L

R

A

A

L

K

E

Q

Y

L

L

L

D

E

R

K

L

L

G

G

L

L

K

G

E

D

W
x
K

A

W

H

Q

H

N

M

K

P

P

N

N

E
x
Q

M

L

S
|
S

G

G

G
|
G

Q
|
Q

K

Q

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

L

L

I

M

T

N

Q

G

P

G

Q

E

I

I

I

I

L

L

A

A

D

D

E

Q

P

P

T

T

G

G

A

A

L

L

D

D

S

S

K

H

T

S

S

G

V

E

E

N

V

V

M

M

Q

E

I

I

L

L

K

R

D

Q

L

L

H

H

R

E

M

E

G

G

M

H

T

T

I

I

V

I

V

M

V

V

T

T

H

H

E

D

S

K

G

H

V

I

A

A

N

A

Q

S

T

A

D

N

K

R

I

I

I

I

H

E

I

I

K

K

D

D

G

G

binding adenosine-5'-triphosphate: F13 (≠ Y11), V22 (= V19), S42 (= S39), G43 (= G40), G45 (= G42), K46 (= K43), S47 (= S44), T48 (= T45), Q92 (= Q89), K136 (≠ W133), Q143 (≠ E140), S145 (= S142), G147 (= G144), Q148 (= Q145)
binding magnesium ion: S47 (= S44), Q92 (= Q89)

5lj7A Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
47% identity, 90% coverage: 1:215/238 of query aligns to 3:218/592 of 5lj7A

query
sites
5lj7A

M

I

I

I

K

E

L

I

T

K

D

Q

I

L

N

N

K

R

T

Y

Y

F

N

G

N

E

G

G

A

E

-

N

P

R

L

V

H

H

V
|
V

L

L

K

K

G

D

I

I

N

S

L

L

D

S

I

I

Q

E

R

R

G

G

E

D

F

F

V

V

S

A

I

I

M

M

G

G

A

Q

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

M

N

N

I

I

L

I

G

G

I

C

L

L

D

D

N

T

Y

A

D

T

T

G

G

G

D

S

Y

S

Y

K

L

I

N

D

N

G

V

K

L

E

I

T

K

I

D

E

L

L

S

T

E

N

T

D

K

Q

A

L

A

S

E

D

Y

L

R

R

N

S

R

Q

M

K

I

F

G

G

F

F

I

I

F

F

Q
|
Q

S

R

F

Y

N

N

L

L

I

L

S

S

F

S

K

L

D

T

A

A

V

A

E

E

N

N

V

V

A

A

L

L

P

P

L

A

F

I

Y

Y

Q

A

G

G

V

M

S

P

R

Q

K

S

K

Q

R

R

N

L

A

E

L

R

A

A

L

K

E

Q

Y

L

L

L

D

E

R

K

L

L

G

G

L

L

K

G

E

D

W
x
K

A

W

H

Q

H

N

M

K

P

P

N

N

E
x
Q

M

L

S
|
S

G

G

G
|
G

Q
|
Q

K

Q

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

L

L

I

M

T

N

Q

G

P

G

Q

E

I

I

I

I

L

L

A

A

D

D

E

Q

P

P

T

T

G

G

A

A

L

L

D

D

S

S

K

H

T

S

S

G

V

E

E

N

V

V

M

M

Q

E

I

I

L

L

K

R

D

Q

L

L

H

H

R

E

M

E

G

G

M

H

T

T

I

I

V

I

V

M

V

V

T

T

H

H

E

D

S

K

G

H

V

I

A

A

N

A

Q

S

T

A

D

N

K

R

I

I

I

I

H

E

I

I

K

K

D

D

G

G

binding adenosine-5'-triphosphate: V22 (= V19), S42 (= S39), G43 (= G40), G45 (= G42), K46 (= K43), S47 (= S44), T48 (= T45), Q92 (= Q89), K136 (≠ W133), Q143 (≠ E140), S145 (= S142), G147 (= G144), Q148 (= Q145)
binding magnesium ion: S47 (= S44), Q92 (= Q89)

5ws4A Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
43% identity, 97% coverage: 1:230/238 of query aligns to 4:244/650 of 5ws4A

query
sites
5ws4A

M

L

I

L

K

E

L

V

T

S

D

N

I

L

N

V

K

R

T

E

Y

F

N

P

N

A

G

G

-

E

A

S

P

T

L

I

H

Q

V

I

L

L

K

K

G

G

I

I

N

D

L

L

D

T

I

I

Q

Y

R

E

G

G

E

E

F

L

V

V

S

A

I

I

M

V

G

G

A

Q

S
|
S

G
|
G

S

S

G

G

K

K

S
|
S

T

T

L

L

L

M

N

N

I

I

L

L

G

G

I

C

L

L

D

D

N

R

Y

P

D

T

T

S

G

G

D

S

Y

Y

Y

K

L

V

N

N

N

G

V

Q

L

E

I

T

K

G

D

K

L

L

S

E

E

P

T

D

K

Q

A

L

A

A

E

Q

Y

L

R

R

N

R

R

E

M

Y

I

F

G

G

F

F

I

I

F

F

Q

Q

S

R

F

Y

N

H

L

L

I

L

S

G

F

D

K

L

D

S

A

A

V

E

E

G

N

N

V

V

A

E

L

V

P

P

L

A

F

V

Y

Y

Q

A

G

G

V

V

S

T

R

P

K

A

K

D

R

R

N

K

A

Q

L

R

A

A

L

T

E

A

Y

L

L

L

D

T

R

E

L

L

G

G

L

L

K

G

E

T

W

K

A

T

H

Q

H

N

M

R

P

P

N

S

E

Q

M

L

S

S

G

G

G

G

Q

Q

K

Q

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

L

L

I

M

T

N

Q

G

P

G

Q

D

I

V

I

I

L

L

A

A

D

D

E

E

P

P

T

T

G

G

A

A

L

L

D

D

S

S

K

H

T

S

S

G

V

V

E

E

V

V

M

M

Q

R

I

I

L

L

K

R

D

E

L

L

H

N

R

A

M

A

G

G

M

H

T

T

I

I

V

I

V

L

V

V

T

T

H

H

E

D

S

M

G

Q

V

V

A

A

N

K

Q

N

T

A

D

T

K

R

I

I

I

I

H

E

I

I

K

S

D

D

G

G

I

E

I

I

-

I

-

S

-

D

-

R

-

P

-

N

-

V

-

P

-

D

E

Q

R

S

I

L

E

E

E

E

-

V

N

K

L

S

D

D

H

P

D

D

A

A

S

A

P

P

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: S43 (= S39), G44 (= G40), S48 (= S44)

8g4cB Bceabs atpgs high res tm (see paper)
44% identity, 90% coverage: 1:215/238 of query aligns to 3:219/248 of 8g4cB

query
sites
8g4cB

M

I

I

L

K

E

L

A

T

N

D

K

I

I

N

R

K

K

T

S

Y
|
Y

N

G

N

N

G

K

A

L

-

N

P

K

L

Q

H

E

V

V

L

L

K

K

G

G

I

I

N

D

L

I

D

H

I

I

Q

E

R

K

G

G

E

E

F

F

V

V

S

S

I

I

M

M

G

G

A

A

S
|
S

G

G

S
|
S

G

G

K

K

S
x
T

T

T

L

L

L

L

N

N

I

V

L

L

G

S

I

S

L

I

D

D

N

Q

Y

V

D

S

T

H

G

G

D

T

Y

I

Y

H

L

I

N

N

N

G

V

N

L

D

I

M

K

T

D

A

L

M

S

K

E

E

T

K

K

Q

A

L

A

A

E

E

Y

F

R

R

N

K

R

Q

M

H

I

L

G

G

F

F

I

I

F

F

Q

Q

S

D

F

Y

N

N

L

L

I

L

S

D

F

T

K

L

D

T

A

V

V

K

E

E

N

N

V

I

A

L

L

L

P

P

L

L

F

S

Y

I

Q

T

G

K

V

L

S

S

R

K

K

K

K

E

R

A

N

N

A

R

L

K

A

F

L

E

E

E

Y

V

L

A

D

K

R

E

L

L

G

G

L

I

K

Y

E

E

W

L

A

R

H

D

H

K

M

Y

P

P

N

N

E

E

M

I

S

S

G

G

G

G

Q

Q

K

K

Q

Q

R

R

V

T

A

S

I

A

A

G

R

R

A

A

L

F

I

I

T

H

Q

D

P

P

Q

S

I

I

I

I

L

F

A

A

D
|
D

E

E

P

P

T

T

G

G

A

A

L

L

D

D

S

S

K

K

T

S

S

A

V

S

E

D

V

L

M

L

Q

N

I

K

L

L

K

S

D

Q

L

L

-

N

H

Q

R

K

M

R

G

N

M

A

T

T

I

I

V

I

V

M

V

V

T

T

H

H

E

D

S

P

G

V

V

A

A

A

N

S

Q

Y

T

C

D

G

K

R

I

V

I

I

H

F

I

I

K

K

D

D

G

G

binding phosphothiophosphoric acid-adenylate ester: Y13 (= Y11), S42 (= S39), S44 (= S41), T47 (≠ S44), D168 (= D165)

7tchB Bceab e169q variant atp-bound conformation (see paper)
43% identity, 90% coverage: 1:215/238 of query aligns to 2:218/245 of 7tchB

query
sites
7tchB

M

I

I

L

K

E

L

A

T

N

D

K

I

I

N

R

K

K

T

S

Y
|
Y

N

G

N

N

G

K

A

L

-

N

P

K

L
x
Q

H

E

V
|
V

L

L

K

K

G

G

I

I

N

D

L

I

D

H

I

I

Q

E

R

K

G

G

E

E

F

F

V

V

S

S

I

I

M

M

G

G

A

A

S
|
S

G
|
G

S
|
S

G

G

K
|
K

S
x
T

T

T

L

L

L

L

N

N

I

V

L

L

G

S

I

S

L

I

D

D

N

Q

Y

V

D

S

T

H

G

G

D

T

Y

I

Y

H

L

I

N

N

N

G

V

N

L

D

I

M

K

T

D

A

L

M

S

K

E

E

T

K

K

Q

A

L

A

A

E

E

Y

F

R

R

N

K

R

Q

M

H

I

L

G

G

F

F

I

I

F

F

Q

Q

S

D

F

Y

N

N

L

L

I

L

S

D

F

T

K

L

D

T

A

V

V

K

E

E

N

N

V

I

A

L

L

L

P

P

L

L

F

S

Y

I

Q

T

G

K

V

L

S

S

R

K

K

K

K

E

R

A

N

N

A

R

L

K

A

F

L

E

E

E

Y

V

L

A

D

K

R

E

L

L

G

G

L

I

K

Y

E

E

W

L

A

R

H

D

H

K

M

Y

P

P

N

N

E
|
E

M

I

S

S

G
|
G

G
|
G

Q

Q

K

K

Q

Q

R

R

V

T

A

S

I

A

A

G

R

R

A

A

L

F

I

I

T

H

Q

D

P

P

Q

S

I

I

I

I

L

F

A

A

D

D

E

Q

P

P

T

T

G

G

A

A

L

L

D

D

S

S

K

K

T

S

S

A

V

S

E

D

V

L

M

L

Q

N

I

K

L

L

K

S

D

Q

L

L

-

N

H

Q

R

K

M

R

G

N

M

A

T

T

I

I

V

I

V

M

V

V

T

T

H

H

E

D

S

P

G

V

V

A

A

A

N

S

Q

Y

T

C

D

G

K

R

I

V

I

I

H

F

I

I

K

K

D

D

G

G

binding adenosine-5'-triphosphate: Y12 (= Y11), Q19 (≠ L17), V21 (= V19), S41 (= S39), G42 (= G40), S43 (= S41), K45 (= K43), T46 (≠ S44), E142 (= E140), G145 (= G143), G146 (= G144)

3c4jA Abc protein artp in complex with atp-gamma-s
42% identity, 95% coverage: 2:227/238 of query aligns to 1:224/242 of 3c4jA

query
sites
3c4jA

I

L

K

Q

L

M

T

I

D

D

I

V

N

H

K

Q

T

L

Y

K

N

K

N

S

G
x
F

A

G

P

S

L

L

H

E

V
|
V

L

L

K

K

G

G

I

I

N

N

L

V

D

H

I

I

Q

R

R

E

G

G

E

E

F

V

V

V

S

V

I

V

M

I

G

G

A

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

L

L

N

R

I

C

L

L

G

N

I

L

L

L

D

E

N

D

Y

F

D

D

T

E

G

G

D

E

Y

I

Y

I

L

I

N

D

-

G

-

I

N

N

V

L

L

K

I

A

K

K

D

D

L

T

S

N

E

L

T

N

K

K

A

V

A

R

E

E

Y

E

R

-

N

-

R

-

M

-

I

V

G

G

F

M

I

V

F

F

Q

Q

S

R

F

F

N

N

L

L

I

F

S

P

F

H

K

M

D

T

A

V

V

L

E

N

N

N

V

I

A

T

L

L

-

A

P

P

L

M

F

K

Y

V

Q

R

G

K

V

W

S

P

R

R

K

E

K

K

R

A

N

E

A

A

L

K

A

A

L

M

E

E

Y

L

L

L

D

D

R

K

L

V

G

G

L

L

K

K

E

D

W

K

A

A

H

H

H

A

M

Y

P

P

N

D

E

S

M

L

S

S

G

G

G

G

Q

Q

K

A

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

A

T

M

Q

E

P

P

Q

K

I

I

I

M

L

L

A

F

D

D

E

E

P

P

T

T

G

S

A

A

L

L

D

D

S

P

K

E

T

M

S

V

V

G

E

E

V

V

M

L

Q

S

I

V

L

M

K

K

D

Q

L

L

H

A

R

N

M

E

G

G

M

M

T

T

I

M

V

V

V

V

V

V

T

T

H

H

E

E

S

M

G

G

V

F

A

A

N

R

Q

E

T

V

-

G

D

D

K

R

I

V

I

L

H

F

I

M

K

D

D

G

G

G

I

Y

I

I

E

-

R

-

I

I

E

E

E

E

N

G

L

K

D

P

H

E

D

D

binding phosphothiophosphoric acid-adenylate ester: F13 (≠ G14), V18 (= V19), S38 (= S39), G39 (= G40), S40 (= S41), G41 (= G42), K42 (= K43), S43 (= S44), T44 (= T45)

3c41J Abc protein artp in complex with amp-pnp/mg2+
42% identity, 95% coverage: 2:227/238 of query aligns to 1:224/242 of 3c41J

query
sites
3c41J

I

L

K

Q

L

M

T

I

D

D

I

V

N

H

K

Q

T

L

Y

K

N

K

N

S

G
x
F

A

G

P

S

L

L

H

E

V
|
V

L

L

K

K

G

G

I

I

N

N

L

V

D

H

I

I

Q

R

R

E

G

G

E

E

F

V

V

V

S

V

I

V

M

I

G

G

A

P

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

L

L

N

R

I

C

L

L

G

N

I

L

L

L

D

E

N

D

Y

F

D

D

T

E

G

G

D

E

Y

I

Y

I

L

I

N

D

-

G

-

I

N

N

V

L

L

K

I

A

K

K

D

D

L

T

S

N

E

L

T

N

K

K

A

V

A

R

E

E

Y

E

R

-

N

-

R

-

M

-

I

V

G

G

F

M

I

V

F

F

Q

Q

S

R

F

F

N

N

L

L

I

F

S

P

F

H

K

M

D

T

A

V

V

L

E

N

N

N

V

I

A

T

L

L

-

A

P

P

L

M

F

K

Y

V

Q

R

G

K

V

W

S

P

R

R

K

E

K

K

R

A

N

E

A

A

L

K

A

A

L

M

E

E

Y

L

L

L

D

D

R

K

L

V

G

G

L

L

K

K

E

D

W

K

A

A

H

H

H

A

M

Y

P

P

N

D

E

S

M

L

S

S

G

G

G

G

Q

Q

K

A

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

A

T

M

Q

E

P

P

Q

K

I

I

I

M

L

L

A

F

D
|
D

E

E

P

P

T

T

G

S

A

A

L

L

D

D

S

P

K

E

T

M

S

V

V

G

E

E

V

V

M

L

Q

S

I

V

L

M

K

K

D

Q

L

L

H

A

R

N

M

E

G

G

M

M

T

T

I

M

V

V

V

V

V

V

T

T

H

H

E

E

S

M

G

G

V

F

A

A

N

R

Q

E

T

V

-

G

D

D

K

R

I

V

I

L

H

F

I

M

K

D

D

G

G

G

I

Y

I

I

E

-

R

-

I

I

E

E

E

E

N

G

L

K

D

P

H

E

D

D

binding phosphoaminophosphonic acid-adenylate ester: F13 (≠ G14), V18 (= V19), S38 (= S39), G39 (= G40), G41 (= G42), K42 (= K43), S43 (= S44), T44 (= T45)
binding magnesium ion: S43 (= S44), D163 (= D165)

2olkA Abc protein artp in complex with adp-beta-s
42% identity, 95% coverage: 2:227/238 of query aligns to 1:224/242 of 2olkA

query
sites
2olkA

I

L

K

Q

L

M

T

I

D

D

I

V

N

H

K

Q

T

L

Y

K

N

K

N

S

G
x
F

A

G

P

S

L

L

H

E

V
|
V

L

L

K

K

G

G

I

I

N

N

L

V

D

H

I

I

Q

R

R

E

G

G

E

E

F

V

V

V

S

V

I

V

M

I

G

G

A

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

L

L

N

R

I

C

L

L

G

N

I

L

L

L

D

E

N

D

Y

F

D

D

T

E

G

G

D

E

Y

I

Y

I

L

I

N

D

-

G

-

I

N

N

V

L

L

K

I

A

K

K

D

D

L

T

S

N

E

L

T

N

K

K

A

V

A

R

E

E

Y

E

R

-

N

-

R

-

M

-

I

V

G

G

F

M

I

V

F

F

Q

Q

S

R

F

F

N

N

L

L

I

F

S

P

F

H

K

M

D

T

A

V

V

L

E

N

N

N

V

I

A

T

L

L

-

A

P

P

L

M

F

K

Y

V

Q

R

G

K

V

W

S

P

R

R

K

E

K

K

R

A

N

E

A

A

L

K

A

A

L

M

E

E

Y

L

L

L

D

D

R

K

L

V

G

G

L

L

K

K

E

D

W

K

A

A

H

H

H

A

M

Y

P

P

N

D

E

S

M

L

S

S

G

G

G

G

Q

Q

K

A

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

A

T

M

Q

E

P

P

Q

K

I

I

I

M

L

L

A

F

D

D

E

E

P

P

T

T

G

S

A

A

L

L

D

D

S

P

K

E

T

M

S

V

V

G

E

E

V

V

M

L

Q

S

I

V

L

M

K

K

D

Q

L

L

H

A

R

N

M

E

G

G

M

M

T

T

I

M

V

V

V

V

V

V

T

T

H

H

E

E

S

M

G

G

V

F

A

A

N

R

Q

E

T

V

-

G

D

D

K

R

I

V

I

L

H

F

I

M

K

D

D

G

G

G

I

Y

I

I

E

-

R

-

I

I

E

E

E

E

N

G

L

K

D

P

H

E

D

D

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (≠ G14), V18 (= V19), S38 (= S39), G39 (= G40), S40 (= S41), G41 (= G42), K42 (= K43), S43 (= S44), T44 (= T45)

2oljA Abc protein artp in complex with adp/mg2+
42% identity, 95% coverage: 2:227/238 of query aligns to 1:224/242 of 2oljA

query
sites
2oljA

I

L

K

Q

L

M

T

I

D

D

I

V

N

H

K

Q

T

L

Y

K

N

K

N

S

G
x
F

A

G

P

S

L

L

H

E

V
|
V

L

L

K

K

G

G

I

I

N

N

L

V

D

H

I

I

Q

R

R

E

G

G

E

E

F

V

V

V

S

V

I

V

M

I

G

G

A

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

L

L

N

R

I

C

L

L

G

N

I

L

L

L

D

E

N

D

Y

F

D

D

T

E

G

G

D

E

Y

I

Y

I

L

I

N

D

-

G

-

I

N

N

V

L

L

K

I

A

K

K

D

D

L

T

S

N

E

L

T

N

K

K

A

V

A

R

E

E

Y

E

R

-

N

-

R

-

M

-

I

V

G

G

F

M

I

V

F

F

Q

Q

S

R

F

F

N

N

L

L

I

F

S

P

F

H

K

M

D

T

A

V

V

L

E

N

N

N

V

I

A

T

L

L

-

A

P

P

L

M

F

K

Y

V

Q

R

G

K

V

W

S

P

R

R

K

E

K

K

R

A

N

E

A

A

L

K

A

A

L

M

E

E

Y

L

L

L

D

D

R

K

L

V

G

G

L

L

K

K

E

D

W

K

A

A

H

H

H

A

M

Y

P

P

N

D

E

S

M

L

S

S

G

G

G

G

Q

Q

K

A

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

A

T

M

Q

E

P

P

Q

K

I

I

I

M

L

L

A

F

D

D

E

E

P

P

T

T

G

S

A

A

L

L

D

D

S

P

K

E

T

M

S

V

V

G

E

E

V

V

M

L

Q

S

I

V

L

M

K

K

D

Q

L

L

H

A

R

N

M

E

G

G

M

M

T

T

I

M

V

V

V

V

V

V

T

T

H

H

E

E

S

M

G

G

V

F

A

A

N

R

Q

E

T

V

-

G

D

D

K

R

I

V

I

L

H

F

I

M

K

D

D

G

G

G

I

Y

I

I

E

-

R

-

I

I

E

E

E

E

N

G

L

K

D

P

H

E

D

D

binding adenosine-5'-diphosphate: F13 (≠ G14), V18 (= V19), S38 (= S39), G39 (= G40), S40 (= S41), G41 (= G42), K42 (= K43), S43 (= S44), T44 (= T45)

P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
41% identity, 90% coverage: 1:215/238 of query aligns to 5:221/233 of P75957

query
sites
P75957

M

L

I

L

K

Q

L

C

T

D

D

N

I

L

N

C

K

K

T

R

Y

Y

N

Q

N

E

G

G

A

S

-

V

P

Q

L

T

H

D

V

V

L

L

K

H

G

N

I

V

N

S

L

F

D

S

I

V

Q

G

R

E

G

G

E

E

F

M

V

M

S

A

I

I

M

V

G
|
G

A

S

S

S

G

G

S

S

G

G

K

K

S

S

T

T

L

L

L

L

N

H

I

L

L

L

G

G

I

G

L

L

D

D

N

T

Y

P

D

T

T

S

G

G

D

D

Y

V

Y

I

L

F

N

N

N

G

V

Q

L

P

I

M

K

S

D

K

L

L

S

S

E

S

T

A

K

A

A

K

A

A

E

E

Y

L

R

R

N

N

R

Q

M

K

I

L

G

G

F

F

I

I

F

Y

Q

Q

S

F

F

H

N

H

L

L

I

L

S

P

F

D

K

F

D

T

A

A

V

L

E

E

N

N

V

V

A

A

L

M

P

P

L

L

F

L

Y

I

Q

G

G

K

V

K

S

K

R

P

K

A

K

E

R

I

N

N

A

S

L

R

A

A

L

L

E

E

Y

M

L

L

D

K

R

A

L

V

G

G

L

L

K

D

E

H

W

R

A

A

H

N

H

H

M

R

P

P

N

S

E

E

M

L

S

S

G

G

G

G

Q

E

K

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

V

T

N

Q

N

P

P

Q

R

I

L

I

V

L

L

A

A

D

D

E

E

P

P

T

T

G

G

A

N

L

L

D

D

S

A

K

R

T

N

S

A

V

D

E

S

V

I

M

F

Q

Q

I

L

L

L

K

G

D

E

L

L

H

N

R

R

M

L

-

Q

G

G

M

T

T

A

I

F

V

L

V

V

V

V

T

T

H

H

E

D

S

L

G

Q

V

L

A

A

N

K

Q

R

T

M

D

S

K

R

I

Q

I

L

H

E

I

M

K

R

D

D

G

G

G42 (= G37) mutation to D: Loss of lipoprotein release when overexpressed.

7arlD Lolcde in complex with lipoprotein and adp (see paper)
41% identity, 90% coverage: 1:215/238 of query aligns to 2:218/222 of 7arlD

query
sites
7arlD

M

L

I

L

K

Q

L

C

T

D

D

N

I

L

N

C

K

K

T

R

Y

Y

N

Q

N

E

G

G

A

S

-

V

P

Q

L

T

H

D

V

V

L

L

K

H

G

N

I

V

N

S

L

F

D

S

I

V

Q

G

R

E

G

G

E

E

F

M

V

M

S

A

I

I

M

V

G

G

A

S

S

S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T

T

L

L

L

L

N

H

I

L

L

L

G

G

I

G

L

L

D

D

N

T

Y

P

D

T

T

S

G

G

D

D

Y

V

Y

I

L

F

N

N

N

G

V

Q

L

P

I

M

K

S

D

K

L

L

S

S

E

S

T

A

K

A

A

K

A

A

E

E

Y

L

R

R

N

N

R

Q

M

K

I

L

G

G

F

F

I

I

F

Y

Q

Q

S

F

F

H

N

H

L

L

I

L

S

P

F

D

K

F

D

T

A

A

V

L

E

E

N

N

V

V

A

A

L

M

P

P

L

L

F

L

Y

I

Q

G

G

K

V

K

S

K

R

P

K

A

K

E

R

I

N

N

A

S

L

R

A

A

L

L

E

E

Y

M

L

L

D

K

R

A

L

V

G

G

L

L

K

D

E

H

W

R

A

A

H

N

H

H

M

R

P

P

N

S

E

E

M

L

S

S

G

G

G

G

Q

E

K

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

V

T

N

Q

N

P

P

Q

R

I

L

I

V

L

L

A

A

D

D

E

E

P

P

T

T

G

G

A

N

L

L

D

D

S

A

K

R

T

N

S

A

V

D

E

S

V

I

M

F

Q

Q

I

L

L

L

K

G

D

E

L

L

H

N

R

R

M

L

-

Q

G

G

M

T

T

A

I

F

V

L

V

V

V

V

T

T

H

H

E

D

S

L

G

Q

V

L

A

A

N

K

Q

R

T

M

D

S

K

R

I

Q

I

L

H

E

I

M

K

R

D

D

G

G

binding adenosine-5'-diphosphate: G42 (= G40), G44 (= G42), K45 (= K43), S46 (= S44)

7mdyC Lolcde nucleotide-bound
41% identity, 90% coverage: 1:215/238 of query aligns to 2:218/226 of 7mdyC

query
sites
7mdyC

M

L

I

L

K

Q

L

C

T

D

D

N

I

L

N

C

K

K

T

R

Y
|
Y

N

Q

N

E

G

G

A

S

-

V

P

Q

L

T

H

D

V

V

L

L

K

H

G

N

I

V

N

S

L

F

D

S

I

V

Q

G

R

E

G

G

E

E

F

M

V

M

S

A

I

I

M

V

G

G

A

S

S

S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

L

N

H

I

L

L

L

G

G

I

G

L

L

D

D

N

T

Y

P

D

T

T

S

G

G

D

D

Y

V

Y

I

L

F

N

N

N

G

V

Q

L

P

I

M

K

S

D

K

L

L

S

S

E

S

T

A

K

A

A

K

A

A

E

E

Y

L

R

R

N

N

R

Q

M

K

I

L

G

G

F

F

I

I

F

Y

Q
|
Q

S

F

F

H

N

H

L

L

I

L

S

P

F

D

K

F

D

T

A

A

V

L

E

E

N

N

V

V

A

A

L

M

P

P

L

L

F

L

Y

I

Q

G

G

K

V

K

S

K

R

P

K

A

K

E

R

I

N

N

A

S

L

R

A

A

L

L

E

E

Y

M

L

L

D

K

R

A

L

V

G

G

L

L

K

D

E

H

W

R

A

A

H

N

H
|
H

M

R

P

P

N

S

E
|
E

M

L

S
|
S

G
|
G

G
|
G

Q

E

K

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

V

T

N

Q

N

P

P

Q

R

I

L

I

V

L

L

A

A

D

D

E
|
E

P

P

T

T

G

G

A
x
N

L

L

D

D

S

A

K

R

T

N

S

A

V

D

E

S

V

I

M

F

Q

Q

I

L

L

L

K

G

D

E

L

L

H

N

R

R

M

L

-

Q

G

G

M

T

T

A

I

F

V

L

V

V

V

V

T

T

H
|
H

E

D

S

L

G

Q

V

L

A

A

N

K

Q

R

T

M

D

S

K

R

I

Q

I

L

H

E

I

M

K

R

D

D

G

G

binding adp orthovanadate: Y12 (= Y11), G42 (= G40), S43 (= S41), G44 (= G42), K45 (= K43), S46 (= S44), T47 (= T45), Q91 (= Q89), H138 (= H136), E142 (= E140), S144 (= S142), G145 (= G143), G146 (= G144), E168 (= E166), N172 (≠ A170), H201 (= H198)
binding magnesium ion: S46 (= S44), Q91 (= Q89)

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
42% identity, 91% coverage: 1:217/238 of query aligns to 2:214/241 of 4u00A

query
sites
4u00A

M

I

I

I

K

R

L

I

T

R

D

N

I

L

N

H

K

K

T

W

Y
x
F

N

-

N

-

G

-

A

G

P

P

L

L

H

H

V
|
V

L

L

K

K

G

G

I

I

N

H

L

L

D

E

I

V

Q

A

R

P

G

G

E

E

F

K

V

L

S

V

I

I

M

I

G

G

A

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

I

N

R

I

T

L

I

G

N

I

R

L

L

D

E

N

D

Y

F

D

Q

T

E

G

G

D

E

Y

V

Y

V

L

V

N

D

N

G

V

L

L

S

I

V

K

K

D

D

L

-

S

-

E

-

T

D

K

R

A

A

A

L

E

R

Y

E

R

I

N

R

R

R

M

E

I

V

G

G

F

M

I

V

F

F

Q

Q

S

Q

F

F

N

N

L

L

I

F

S

P

F

H

K

M

D

T

A

V

V

L

E

E

N

N

V

V

A

T

L

L

-

A

P

P

L

M

F

R

Y

V

Q

R

G

R

V

W

S

P

R

R

K

E

K

K

R

A

N

E

A

K

L

K

A

A

L

L

E

E

Y

L

L

L

D

E

R

R

L

V

G

G

L

I

K

L

E

D

W

Q

A

A

H

R

H

K

M

Y

P

P

N

A

E

Q

M

L

S

S

G

G

G

G

Q

Q

K

Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

A

T

M

Q

E

P

P

Q

K

I

I

I

M

L

L

A

F

D

D

E

E

P

P

T

T

G

S

A

A

L

L

D

D

S

P

K

E

T

M

S

V

V

G

E

E

V

V

M

L

Q

D

I

V

L

M

K

R

D

D

L

L

H

A

R

Q

M

G

G

G

M

M

T

T

I

M

V

V

V

V

V

V

T

T

H

H

E

E

S

M

G

G

V

F

A

A

N

R

Q

E

-

V

T

A

D

D

K

R

I

V

I

V

H

F

I

M

K

D

D

G

G

G

I

Q

I

I

binding adenosine-5'-diphosphate: F12 (≠ Y11), V17 (= V19), S37 (= S39), G38 (= G40), S39 (= S41), G40 (= G42), K41 (= K43), S42 (= S44), T43 (= T45)

7v8iD Lolcd(e171q)e with bound amppnp in nanodiscs (see paper)
40% identity, 90% coverage: 1:215/238 of query aligns to 4:220/229 of 7v8iD

query
sites
7v8iD

M

L

I

L

K

Q

L

C

T

D

D

N

I

L

N

C

K

K

T

R

Y

Y

N

Q

N

E

G

G

A

S

-

V

P

Q

L

T

H

D

V
|
V

L

L

K

H

G

N

I

V

N

S

L

F

D

S

I

V

Q

G

R

E

G

G

E

E

F

M

V

M

S

A

I

I

M

V

G

G

A

S

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

L

N

H

I

L

L

L

G

G

I

G

L

L

D

D

N

T

Y

P

D

T

T

S

G

G

D

D

Y

V

Y

I

L

F

N

N

N

G

V

Q

L

P

I

M

K

S

D

K

L

L

S

S

E

S

T

A

K

A

A

K

A

A

E

E

Y

L

R

R

N

N

R

Q

M

K

I

L

G

G

F

F

I

I

F

Y

Q
|
Q

S

F

F

H

N

H

L

L

I

L

S

P

F

D

K

F

D

T

A

A

V

L

E

E

N

N

V

V

A

A

L

M

P

P

L

L

F

L

Y

I

Q

G

G

K

V

K

S

K

R

P

K

A

K

E

R

I

N

N

A

S

L

R

A

A

L

L

E

E

Y

M

L

L

D

K

R

A

L

V

G

G

L

L

K

D

E

H

W
x
R

A

A

H

N

H
|
H

M

R

P

P

N

S

E
|
E

M

L

S
|
S

G

G

G
|
G

Q
x
E

K

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

V

T

N

Q

N

P

P

Q

R

I

L

I

V

L

L

A

A

D

D

E

Q

P

P

T

T

G

G

A

N

L

L

D

D

S

A

K

R

T

N

S

A

V

D

E

S

V

I

M

F

Q

Q

I

L

L

L

K

G

D

E

L

L

H

N

R

R

M

L

-

Q

G

G

M

T

T

A

I

F

V

L

V

V

V

V

T

T

H
|
H

E

D

S

L

G

Q

V

L

A

A

N

K

Q

R

T

M

D

S

K

R

I

Q

I

L

H

E

I

M

K

R

D

D

G

G

binding phosphoaminophosphonic acid-adenylate ester: V23 (= V19), S43 (= S39), G44 (= G40), G46 (= G42), K47 (= K43), S48 (= S44), T49 (= T45), Q93 (= Q89), R137 (≠ W133), H140 (= H136), E144 (= E140), S146 (= S142), G148 (= G144), E149 (≠ Q145), H203 (= H198)
binding magnesium ion: S48 (= S44), Q93 (= Q89)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
42% identity, 89% coverage: 7:217/238 of query aligns to 4:214/240 of 4ymuJ

query
sites
4ymuJ

I

V

N

N

K

D

T

V

Y

Y

N

K

N

N

G
x
F

A

G

P

S

L

L

H

E

V
|
V

L

L

K

K

G

G

I

V

N

T

L

L

D

K

I

V

Q

N

R

K

G

G

E

E

F

V

V

V

S

V

I

I

M

I

G

G

A

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

L

N

R

I

C

L

I

G

N

I

L

L

L

D

E

N

E

Y

P

D

T

T

K

G

G

D

E

Y

V

Y

F

L

I

N

D

N

G

V

V

L

K

I

I

K

N

D

N

L

-

S

G

E

K

T

V

K

N

A

I

A

N

E

K

Y

V

R

R

N

Q

R

K

M

-

I

V

G

G

F

M

I

V

F

F

Q

Q

S

H

F

F

N

N

L

L

I

F

S

P

F

H

K

L

D

T

A

A

V

I

E

E

N

N

V

I

A

T

L

L

-

A

P

P

L

V

F

K

Y

V

Q

K

G

K

V

M

S

N

R

K

K

K

K

E

R

A

N

E

A

E

L

L

A

A

L

V

E

D

Y

L

L

L

D

A

R

K

L

V

G

G

L

L

K

L

E

D

W

K

A

K

H

D

H

Q

M

Y

P

P

N

I

E

K

M

L

S

S

G

G

G

G

Q

Q

K

K

Q

Q

R

R

V

L

A

A

I

I

A

A

R

R

A

A

L

L

I

A

T

M

Q

Q

P

P

Q

E

I

V

I

M

L

L

A

F

D

D

E
|
E

P

P

T

T

G

S

A

A

L

L

D

D

S

P

K

E

T

M

S

V

V

K

E

E

V

V

M

L

Q

N

I

V

L

M

K

K

D

Q

L

L

H

A

R

N

M

E

G

G

M

M

T

T

I

M

V

V

V

V

V

V

T

T

H
|
H

E

E

S

M

G

G

V

F

A

A

N

R

Q

E

T

V

-

G

D

D

K

R

I

V

I

I

H

F

I

M

K

D

D

D

G

G

I

V

I

I

binding adenosine-5'-triphosphate: F11 (≠ G14), V16 (= V19), S36 (= S39), G37 (= G40), S38 (= S41), G39 (= G42), K40 (= K43), S41 (= S44), T42 (= T45), E162 (= E166), H194 (= H198)
binding magnesium ion: S41 (= S44), E162 (= E166)

2pclA Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
45% identity, 83% coverage: 18:215/238 of query aligns to 17:214/223 of 2pclA

query
sites
2pclA

H

E

V

I

L

L

K

K

G

G

I

I

N

S

L

L

D

S

I

V

Q

K

R

K

G

G

E

E

F

F

V

V

S

S

I

I

M

I

G

G

A

A

S

S

G

G

S

S

G

G

K

K

S

S

T

T

L

L

L

L

N

Y

I

I

L

L

G

G

I

L

L

L

D

D

N

A

Y

P

D

T

T

E

G

G

D

K

Y

V

Y

F

L

L

N

E

N

G

V

K

L

E

I

V

K

D

D

Y

L

T

S

N

E

E

T

K

K

E

A

L

A

S

E

L

Y

L

R

R

N

N

R

R

M

K

I

L

G

G

F

F

I

V

F

F

Q

Q

S

F

F

H

N

Y

L

L

I

I

S

P

F

E

K

L

D

T

A

A

V

L

E

E

N

N

V

V

A

I

L

V

P

P

L

M

F

L

Y

K

Q

M

G

G

V

K

S

P

R

K

K

K

K

E

R

A

N

K

A

E

L

R

A

G

L

E

E

Y

Y

L

L

L

D

S

R

E

L

L

G

G

L

L

K

G

E

D

W

K

A

L

H

S

H

R

M

K

P

P

N

Y

E

E

M

L

S

S

G

G

G

G

Q

E

K

Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

A

T

N

Q

E

P

P

Q

I

I

L

I

L

L

F

A

A

D

D

E
|
E

P
|
P

T
|
T

G

G

A

N

L

L

D

D

S

S

K

A

T

N

S

T

V

K

E

R

V

V

M

M

Q

D

I

I

L

F

K

L

D

K

L

I

H

N

R

E

M

G

G

G

M

T

T

S

I

I

V

V

V

M

V

V

T
|
T

H

H

E

E

S

R

G

E

V

L

A

A

N

E

Q

L

T

T

D

H

K

R

I

T

I

L

H

E

I

M

K

K

D

D

G

G

binding magnesium ion: E165 (= E166), P166 (= P167), T167 (= T168), T196 (= T197)

Query Sequence

>352022 FitnessBrowser__Btheta:352022
MIKLTDINKTYNNGAPLHVLKGINLDIQRGEFVSIMGASGSGKSTLLNILGILDNYDTGD
YYLNNVLIKDLSETKAAEYRNRMIGFIFQSFNLISFKDAVENVALPLFYQGVSRKKRNAL
ALEYLDRLGLKEWAHHMPNEMSGGQKQRVAIARALITQPQIILADEPTGALDSKTSVEVM
QILKDLHRMGMTIVVVTHESGVANQTDKIIHIKDGIIERIEENLDHDASPFGQNGIMK

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory