Comparing 354110 FitnessBrowser__Btheta:354110 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1worA Crystal structure of t-protein of the glycine cleavage system (see paper)
45% identity, 100% coverage: 1:361/361 of query aligns to 1:357/362 of 1worA
1wopA Crystal structure of t-protein of the glycine cleavage system (see paper)
45% identity, 100% coverage: 1:361/361 of query aligns to 1:357/362 of 1wopA
Sites not aligning to the query:
1wooA Crystal structure of t-protein of the glycine cleavage system (see paper)
45% identity, 100% coverage: 1:361/361 of query aligns to 1:357/362 of 1wooA
Sites not aligning to the query:
3a8iA Crystal structure of et-ehred-5-ch3-thf complex (see paper)
37% identity, 99% coverage: 2:359/361 of query aligns to 2:355/363 of 3a8iA
P48728 Aminomethyltransferase, mitochondrial; Glycine cleavage system T protein; GCVT; EC 2.1.2.10 from Homo sapiens (Human) (see 4 papers)
34% identity, 99% coverage: 1:359/361 of query aligns to 33:394/403 of P48728
Sites not aligning to the query:
1wsvA Crystal structure of human t-protein of glycine cleavage system (see paper)
34% identity, 99% coverage: 1:359/361 of query aligns to 2:363/371 of 1wsvA
Sites not aligning to the query:
Q9UI17 Dimethylglycine dehydrogenase, mitochondrial; ME2GLYDH; EC 1.5.8.4 from Homo sapiens (Human) (see 4 papers)
28% identity, 90% coverage: 34:359/361 of query aligns to 520:847/866 of Q9UI17
Sites not aligning to the query:
4pabB Crystal structure of the precursor form of rat dmgdh complexed with tetrahydrofolate (see paper)
29% identity, 90% coverage: 35:359/361 of query aligns to 477:803/824 of 4pabB
Sites not aligning to the query:
Q63342 Dimethylglycine dehydrogenase, mitochondrial; ME2GLYDH; EC 1.5.8.4 from Rattus norvegicus (Rat) (see 2 papers)
29% identity, 90% coverage: 35:359/361 of query aligns to 514:840/857 of Q63342
Sites not aligning to the query:
1pj7A Structure of dimethylglycine oxidase of arthrobacter globiformis in complex with folinic acid (see paper)
26% identity, 99% coverage: 1:359/361 of query aligns to 427:817/827 of 1pj7A
Sites not aligning to the query:
1pj6A Crystal structure of dimethylglycine oxidase of arthrobacter globiformis in complex with folic acid (see paper)
26% identity, 99% coverage: 1:359/361 of query aligns to 428:818/828 of 1pj6A
Sites not aligning to the query:
Q9AGP8 Dimethylglycine oxidase; DMGO; EC 1.5.3.10 from Arthrobacter globiformis (see 2 papers)
26% identity, 99% coverage: 1:359/361 of query aligns to 430:820/830 of Q9AGP8
Sites not aligning to the query:
3gsiA Crystal structure of d552a dimethylglycine oxidase mutant of arthrobacter globiformis in complex with tetrahydrofolate (see paper)
26% identity, 99% coverage: 1:359/361 of query aligns to 427:817/827 of 3gsiA
Sites not aligning to the query:
Q46337 Sarcosine oxidase subunit alpha; Sarcosine oxidase subunit A; Sarcosine oxidase (5,10-methylenetetrahydrofolate-forming) subunit alpha; Tetrameric sarcosine oxidase subunit alpha; TSOX subunit alpha; EC 1.5.3.24 from Corynebacterium sp. (strain P-1) (see 2 papers)
24% identity, 98% coverage: 2:354/361 of query aligns to 577:952/967 of Q46337
Sites not aligning to the query:
2gagA Heteroteterameric sarcosine: structure of a diflavin metaloenzyme at 1.85 a resolution (see paper)
26% identity, 98% coverage: 2:356/361 of query aligns to 575:951/965 of 2gagA
Sites not aligning to the query:
Q50LF0 Sarcosine oxidase subunit alpha; Sarcosine oxidase subunit A; Sarcosine oxidase (5,10-methylenetetrahydrofolate-forming) subunit alpha; Tetrameric sarcosine oxidase subunit alpha; TSOX subunit alpha; EC 1.5.3.24 from Corynebacterium sp. (strain U-96) (see 2 papers)
26% identity, 79% coverage: 10:294/361 of query aligns to 583:882/965 of Q50LF0
Sites not aligning to the query:
3ad7A Heterotetrameric sarcosine oxidase from corynebacterium sp. U-96 in complex with methylthio acetate (see paper)
26% identity, 79% coverage: 10:294/361 of query aligns to 582:881/963 of 3ad7A
Sites not aligning to the query:
1vrqA Crystal structure of heterotetrameric sarcosine oxidase from corynebacterium sp. U-96 in complex with folinic acid (see paper)
26% identity, 79% coverage: 10:294/361 of query aligns to 582:881/963 of 1vrqA
Sites not aligning to the query:
Q8GAI3 4-methylaminobutanoate oxidase (formaldehyde-forming); MABO; Demethylating gamma-N-methylaminobutyrate oxidase; Gamma-N-methylaminobutyrate oxidase 1; EC 1.5.3.19 from Paenarthrobacter nicotinovorans (Arthrobacter nicotinovorans) (see paper)
26% identity, 93% coverage: 23:359/361 of query aligns to 478:814/824 of Q8GAI3
Sites not aligning to the query:
3tfjA Dmsp-dependent demethylase from p. Ubique - with cofactor thf (see paper)
22% identity, 99% coverage: 1:359/361 of query aligns to 12:368/369 of 3tfjA
>354110 FitnessBrowser__Btheta:354110
MKTTPFTEKHIALGAKMHEFAGYNMPIEYSGIIDEHLTVCNAVGVFDVSHMGEFWVKGPQ
ALAFLQKVTSNNVAALVPGKIQYTCFPNEEGGIVDDLLVYCYEPEKYLLVVNAANIEKDW
NWCVSHNTEGAELENSSDNMAQLAVQGPKAILALQKLTDIDLSAIPYYTFTVGRFAGKEN
VIISNTGYTGAGGFELYFYPDAAEAIWKAVFEAGEEFGIKPVGLGARDTLRLEMGFCLYG
NDLDDKTSPIEAGLGWITKFVEGKEFINRPMLEKQKSEGTTRKLVGFEMIDRGIPRHGYE
LVNEEGEGIGVVTSGTMSPTRKIGIGMGYVKPEYAKVGTEICIDMRGRKLKAIVVKPPFR
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory