SitesBLAST
Comparing 3606907 FitnessBrowser__Dino:3606907 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P16171 Mercuric reductase; Hg(II) reductase; EC 1.16.1.1 from Bacillus cereus (see paper)
35% identity, 92% coverage: 8:440/470 of query aligns to 171:610/631 of P16171
- Y264 (≠ S100) mutation to F: 30-fold decrease in activity. 300-fold decrease in activity; when associated with F-605.
- Y605 (= Y435) mutation to F: 10-fold decrease in activity. 300-fold decrease in activity; when associated with F-264.; mutation to H: 2-fold decrease in activity.
D9J041 Mercuric reductase; Hg(II) reductase; EC 1.16.1.1 from Lysinibacillus sphaericus (Bacillus sphaericus) (see paper)
33% identity, 96% coverage: 1:449/470 of query aligns to 79:534/546 of D9J041
- C122 (= C44) modified: Disulfide link with 127, Redox-active
- C127 (= C49) modified: Disulfide link with 122, Redox-active
5x1yB Structure of mercuric reductase from lysinibacillus sphaericus (see paper)
33% identity, 94% coverage: 8:449/470 of query aligns to 5:453/454 of 5x1yB
- active site: A13 (≠ S16), V37 (≠ M40), C41 (= C44), C46 (= C49), S49 (= S52), A74 (≠ E76), G75 (≠ P77), Y178 (≠ P180), E182 (= E184), A318 (≠ G315), A437 (= A433), Y439 (= Y435), E444 (= E440)
- binding flavin-adenine dinucleotide: I9 (= I12), G12 (= G15), I32 (= I35), E33 (= E36), R34 (≠ G37), G39 (= G42), T40 (≠ D43), C41 (= C44), G45 (= G48), C46 (= C49), K50 (= K53), A114 (= A116), T138 (= T140), G139 (= G141), Y178 (≠ P180), R266 (= R264), G305 (= G302), D306 (= D303), F313 (= F310), V314 (≠ T311), A317 (= A314)
4k8dA Crystal structure of the c558(464)a/c559(465)a double mutant of tn501 mera in complex with NADPH and hg2+
35% identity, 94% coverage: 9:449/470 of query aligns to 6:454/466 of 4k8dA
- active site: G13 (≠ S16), I37 (≠ M40), C41 (= C44), C46 (= C49), S49 (= S52), V75 (≠ E76), P76 (= P77), V185 (≠ P180), E189 (= E184), A320 (≠ G315), F438 (≠ A433), Y440 (= Y435), E445 (= E440)
- binding flavin-adenine dinucleotide: I9 (= I12), G10 (= G13), G12 (= G15), A14 (≠ G17), E33 (= E36), R34 (≠ G37), G39 (= G42), T40 (≠ D43), C41 (= C44), G45 (= G48), C46 (= C49), K50 (= K53), E115 (≠ Y115), A116 (= A116), T145 (= T140), G146 (= G141), R268 (= R264), G307 (= G302), D308 (= D303), F315 (= F310), V316 (≠ T311), Y317 (≠ H312)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: S183 (≠ G178), S184 (≠ G179), V185 (≠ P180), V186 (≠ I181), E189 (= E184), R206 (≠ G201), N207 (≠ A202), R212 (≠ K207), T266 (≠ V262), G267 (= G263), Q314 (= Q309), F315 (= F310), V345 (≠ A341)
Sites not aligning to the query:
P00392 Mercuric reductase; Hg(II) reductase; EC 1.16.1.1 from Pseudomonas aeruginosa (see 2 papers)
35% identity, 95% coverage: 3:449/470 of query aligns to 95:549/561 of P00392
- A110 (≠ G18) binding
- G130 (≠ H38) binding
- T135 (≠ D43) binding
- C136 (= C44) modified: Disulfide link with 141, Redox-active
- C141 (= C49) modified: Disulfide link with 136, Redox-active
- K145 (= K53) binding
- A211 (= A116) binding
- D403 (= D303) binding
- V411 (≠ T311) binding
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 558 binding
- 559 binding
4k7zA Crystal structure of the c136(42)a/c141(47)a double mutant of tn501 mera in complex with NADP and hg2+
35% identity, 94% coverage: 9:449/470 of query aligns to 7:455/467 of 4k7zA
- active site: G14 (≠ S16), I38 (≠ M40), A42 (≠ C44), A47 (≠ C49), S50 (= S52), V76 (≠ E76), P77 (= P77), V186 (≠ P180), E190 (= E184), A321 (≠ G315), F439 (≠ A433), Y441 (= Y435), E446 (= E440)
- binding flavin-adenine dinucleotide: I10 (= I12), G11 (= G13), G13 (= G15), A15 (≠ G17), E34 (= E36), R35 (≠ G37), G40 (= G42), T41 (≠ D43), A42 (≠ C44), G46 (= G48), A47 (≠ C49), K51 (= K53), E116 (≠ Y115), A117 (= A116), T146 (= T140), G147 (= G141), R269 (= R264), G308 (= G302), D309 (= D303), Q315 (= Q309), F316 (= F310), V317 (≠ T311), Y318 (≠ H312)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: S184 (≠ G178), S185 (≠ G179), V186 (≠ P180), V187 (≠ I181), E190 (= E184), R207 (≠ G201), N208 (≠ A202), R213 (≠ K207), T267 (≠ V262), G268 (= G263), R269 (= R264), Q315 (= Q309), F316 (= F310), V346 (≠ A341)
Sites not aligning to the query:
P11959 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; EC 1.8.1.4 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see paper)
34% identity, 94% coverage: 5:446/470 of query aligns to 8:457/470 of P11959
- 39:47 (vs. 36:44, 44% identical) binding
- K56 (= K53) binding
- D314 (= D303) binding
- A322 (≠ T311) binding
1ebdA Dihydrolipoamide dehydrogenase complexed with the binding domain of the dihydrolipoamide acetylase (see paper)
34% identity, 94% coverage: 5:446/470 of query aligns to 2:451/455 of 1ebdA
- active site: P13 (≠ S16), L37 (≠ M40), C41 (= C44), C46 (= C49), S49 (= S52), N74 (≠ E76), V75 (≠ P77), Y180 (≠ P180), E184 (= E184), S320 (≠ G315), H438 (≠ A433), H440 (≠ Y435), E445 (= E440)
- binding flavin-adenine dinucleotide: G10 (= G13), G12 (= G15), P13 (≠ S16), V32 (≠ I35), E33 (= E36), K34 (≠ G37), G39 (= G42), V40 (≠ D43), C41 (= C44), G45 (= G48), C46 (= C49), K50 (= K53), E112 (≠ Y115), A113 (= A116), T141 (= T140), G142 (= G141), Y180 (≠ P180), I181 (= I181), R268 (= R264), D308 (= D303), A314 (≠ Q309), L315 (≠ F310), A316 (≠ T311)
4ywoA Mercuric reductase from metallosphaera sedula (see paper)
31% identity, 94% coverage: 9:451/470 of query aligns to 8:443/444 of 4ywoA
- active site: A15 (≠ S16), I39 (≠ M40), C43 (= C44), C48 (= C49), S51 (= S52), A174 (≠ P180), E178 (= E184), G308 (= G315), H425 (≠ A433), F427 (≠ Y435), E432 (= E440)
- binding flavin-adenine dinucleotide: G12 (= G13), G14 (= G15), K36 (≠ G37), G41 (= G42), T42 (≠ D43), C43 (= C44), G47 (= G48), C48 (= C49), K52 (= K53), A110 (= A116), A133 (= A139), T134 (= T140), G135 (= G141), N154 (= N160), L175 (≠ I181), L263 (= L271), G295 (= G302), D296 (= D303), M302 (≠ Q309), L303 (≠ F310), E304 (≠ T311), A307 (= A314)
P0A9P0 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes; Glycine cleavage system L protein; EC 1.8.1.4 from Escherichia coli (strain K12) (see 2 papers)
32% identity, 94% coverage: 1:440/470 of query aligns to 1:450/474 of P0A9P0
- M1 (= M1) modified: Initiator methionine, Removed
- K220 (≠ A214) modified: N6-acetyllysine
3urhB Crystal structure of a dihydrolipoamide dehydrogenase from sinorhizobium meliloti 1021
33% identity, 95% coverage: 8:452/470 of query aligns to 2:463/465 of 3urhB
- active site: Y35 (≠ M40), C39 (= C44), C44 (= C49), S47 (= S52), V183 (≠ P180), E187 (= E184), H443 (≠ A433), H445 (≠ Y435), E450 (= E440)
- binding flavin-adenine dinucleotide: I6 (= I12), G7 (= G13), G9 (= G15), P10 (≠ S16), G11 (= G17), E30 (= E36), K31 (≠ G37), G37 (= G42), T38 (≠ D43), C39 (= C44), G43 (= G48), C44 (= C49), K48 (= K53), T111 (= T110), G112 (≠ V111), A140 (= A139), T141 (= T140), G142 (= G141), I184 (= I181), R273 (= R264), G312 (= G302), D313 (= D303), M319 (≠ L308), L320 (≠ F310), A321 (≠ T311), H322 (= H312)
4jdrA Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase from escherichia coli (see paper)
32% identity, 93% coverage: 2:440/470 of query aligns to 1:449/471 of 4jdrA
- active site: P15 (≠ S16), L40 (≠ M40), C44 (= C44), C49 (= C49), S52 (= S52), E77 (= E76), P78 (= P77), I184 (≠ P180), E188 (= E184), V324 (≠ Y316), H442 (≠ A433), H444 (≠ Y435), E449 (= E440)
- binding flavin-adenine dinucleotide: G12 (= G13), G14 (= G15), P15 (≠ S16), A16 (≠ G17), E35 (= E36), R36 (≠ G37), Y37 (≠ H38), V43 (≠ D43), C44 (= C44), G48 (= G48), C49 (= C49), K53 (= K53), L115 (≠ Y115), G116 (≠ A116), A144 (≠ T140), G145 (= G141), I185 (= I181), G311 (= G302), D312 (= D303), M318 (≠ Q309), L319 (≠ F310), A320 (≠ T311), H321 (= H312)
Sites not aligning to the query:
2eq7A Crystal structure of lipoamide dehydrogenase from thermus thermophilus hb8 with psbdo
33% identity, 94% coverage: 8:451/470 of query aligns to 3:450/452 of 2eq7A
- active site: P11 (≠ S16), L36 (≠ M40), C40 (= C44), C45 (= C49), S48 (= S52), G72 (≠ E76), V73 (≠ P77), V177 (≠ P180), E181 (= E184), S314 (≠ G315), H432 (≠ A433), H434 (≠ Y435), E439 (= E440)
- binding flavin-adenine dinucleotide: G10 (= G15), P11 (≠ S16), G12 (= G17), E31 (= E36), K32 (≠ G37), G38 (= G42), T39 (≠ D43), C40 (= C44), R42 (≠ N46), G44 (= G48), C45 (= C49), K49 (= K53), T110 (≠ Y115), A111 (= A116), T137 (= T140), G138 (= G141), S157 (≠ N160), I178 (= I181), R262 (= R264), Y265 (≠ N267), D302 (= D303), M308 (≠ L308), L309 (≠ F310), A310 (≠ T311), H311 (= H312), Y341 (= Y343)
- binding nicotinamide-adenine-dinucleotide: W146 (≠ I149), G174 (= G177), G176 (= G179), V177 (≠ P180), I178 (= I181), E197 (= E200), Y198 (≠ G201), V231 (≠ A233), V260 (= V262), G261 (= G263), R262 (= R264), M308 (≠ L308), L309 (≠ F310), V339 (≠ A341)
2eq6A Crystal structure of lipoamide dehydrogenase from thermus thermophilus hb8
33% identity, 94% coverage: 8:449/470 of query aligns to 5:451/460 of 2eq6A
- active site: V37 (≠ M40), C41 (= C44), C46 (= C49), T49 (≠ S52), A176 (≠ P180), E180 (= E184), H435 (≠ A433), H437 (≠ Y435), E442 (= E440)
- binding flavin-adenine dinucleotide: I9 (= I12), G10 (= G13), G12 (= G15), P13 (≠ S16), G14 (= G17), E33 (= E36), A34 (≠ G37), G39 (= G42), V40 (≠ D43), C41 (= C44), G45 (= G48), C46 (= C49), K50 (= K53), F111 (≠ Y115), A112 (= A116), A135 (= A139), T136 (= T140), G137 (= G141), S155 (≠ N160), R269 (≠ N267), D306 (= D303), L312 (≠ Q309), L313 (≠ F310), A314 (≠ T311), H315 (= H312), Y344 (= Y343)
Sites not aligning to the query:
2yquB Crystal structures and evolutionary relationship of two different lipoamide dehydrogenase(e3s) from thermus thermophilus
33% identity, 94% coverage: 8:451/470 of query aligns to 3:450/455 of 2yquB
- active site: P11 (≠ S16), L36 (≠ M40), C40 (= C44), C45 (= C49), S48 (= S52), G72 (≠ E76), V73 (≠ P77), V177 (≠ P180), E181 (= E184), S314 (≠ G315), H432 (≠ A433), H434 (≠ Y435), E439 (= E440)
- binding carbonate ion: A310 (≠ T311), S314 (≠ G315), S423 (≠ K424), D426 (≠ A427)
- binding flavin-adenine dinucleotide: G8 (= G13), G10 (= G15), P11 (≠ S16), G12 (= G17), E31 (= E36), K32 (≠ G37), G38 (= G42), T39 (≠ D43), C40 (= C44), R42 (≠ N46), G44 (= G48), C45 (= C49), K49 (= K53), T110 (≠ Y115), A111 (= A116), T137 (= T140), G138 (= G141), I178 (= I181), Y265 (≠ N267), G301 (= G302), D302 (= D303), M308 (≠ L308), L309 (≠ F310), A310 (≠ T311), H311 (= H312)
2yquA Crystal structures and evolutionary relationship of two different lipoamide dehydrogenase(e3s) from thermus thermophilus
33% identity, 94% coverage: 8:451/470 of query aligns to 3:450/455 of 2yquA
- active site: P11 (≠ S16), L36 (≠ M40), C40 (= C44), C45 (= C49), S48 (= S52), G72 (≠ E76), V73 (≠ P77), V177 (≠ P180), E181 (= E184), S314 (≠ G315), H432 (≠ A433), H434 (≠ Y435), E439 (= E440)
- binding flavin-adenine dinucleotide: G8 (= G13), G10 (= G15), P11 (≠ S16), G12 (= G17), E31 (= E36), K32 (≠ G37), G38 (= G42), T39 (≠ D43), C40 (= C44), R42 (≠ N46), G44 (= G48), C45 (= C49), K49 (= K53), T110 (≠ Y115), A111 (= A116), T137 (= T140), G138 (= G141), S157 (≠ N160), I178 (= I181), Y265 (≠ N267), G301 (= G302), D302 (= D303), M308 (≠ L308), L309 (≠ F310), A310 (≠ T311)
6uziC Crystal structure of dihydrolipoyl dehydrogenase from elizabethkingia anophelis nuhp1
31% identity, 93% coverage: 8:446/470 of query aligns to 8:459/470 of 6uziC
- active site: C45 (= C44), C50 (= C49), S53 (= S52), V187 (≠ P180), E191 (= E184), H448 (≠ Y435), E453 (= E440)
- binding flavin-adenine dinucleotide: I12 (= I12), G13 (= G13), G15 (= G15), P16 (≠ S16), G17 (= G17), E36 (= E36), K37 (≠ G37), G43 (= G42), T44 (≠ D43), C45 (= C44), G49 (= G48), C50 (= C49), S53 (= S52), K54 (= K53), V117 (≠ Y115), G118 (≠ A116), T147 (= T140), G148 (= G141), I188 (= I181), R276 (= R264), D316 (= D303), M322 (≠ Q309), L323 (≠ F310), A324 (≠ T311)
- binding zinc ion: H448 (≠ Y435), E453 (= E440)
3o0hB Crystal structure of glutathione reductase from bartonella henselae
32% identity, 93% coverage: 5:440/470 of query aligns to 2:440/459 of 3o0hB
- active site: S13 (= S16), I37 (≠ M40), C41 (= C44), C46 (= C49), K49 (≠ S52), D74 (≠ E76), P75 (= P77), Y177 (≠ P180), E181 (= E184), I314 (≠ G315), A433 (= A433), H435 (≠ Y435), E440 (= E440)
- binding flavin-adenine dinucleotide: I9 (= I12), G10 (= G13), G12 (= G15), S13 (= S16), G14 (= G17), A32 (≠ I35), E33 (= E36), E34 (≠ G37), T40 (≠ D43), C41 (= C44), G45 (= G48), C46 (= C49), K49 (≠ S52), R112 (vs. gap), A113 (vs. gap), T139 (= T140), G140 (= G141), Y177 (≠ P180), R262 (= R264), N265 (= N267), G301 (= G302), D302 (= D303), Q308 (= Q309), L309 (≠ F310), T310 (= T311)
Sites not aligning to the query:
D0VWY5 Glutathione amide reductase; GAR; EC 1.8.1.16 from Marichromatium gracile (Chromatium gracile) (see 2 papers)
32% identity, 91% coverage: 8:436/470 of query aligns to 6:438/463 of D0VWY5
- SG 14:15 (= SG 16:17) binding
- E34 (= E36) binding
- T41 (≠ D43) binding
- C42 (= C44) modified: Disulfide link with 47, Redox-active
- C47 (= C49) modified: Disulfide link with 42, Redox-active
- K50 (≠ S52) binding ; binding
- HA 113:114 (≠ YA 115:116) binding
- 174:180 (vs. 178:184, 57% identical) binding
- LE 197:198 (= LE 199:200) binding
- V230 (≠ A233) binding
- G261 (= G263) binding
- D302 (= D303) binding
- Q308 (= Q309) binding
- QLT 308:310 (≠ QFT 309:311) binding
- V341 (≠ A341) binding
- H437 (≠ Y435) active site, Proton acceptor; binding
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2 binding
- 2:463 modified: mature protein, Glutathione amide reductase
- 3 binding
- 4 binding
5u8vA Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa bound to NAD+ (see paper)
32% identity, 93% coverage: 8:446/470 of query aligns to 4:460/472 of 5u8vA
- active site: P12 (≠ S16), L43 (≠ M40), C47 (= C44), C52 (= C49), S55 (= S52), G81 (= G69), V82 (≠ F70), V189 (≠ P180), E193 (= E184), S329 (≠ G315), F447 (≠ A433), H449 (≠ Y435), E454 (= E440)
- binding flavin-adenine dinucleotide: I8 (= I12), G11 (= G15), P12 (≠ S16), G13 (= G17), E32 (= E36), G45 (= G42), T46 (≠ D43), C47 (= C44), G51 (= G48), C52 (= C49), K56 (= K53), H119 (≠ L107), G120 (= G108), A148 (= A139), S149 (≠ T140), G150 (= G141), S169 (≠ N160), I190 (= I181), R277 (= R264), G316 (= G302), D317 (= D303), M323 (≠ Q309), L324 (≠ F310), A325 (≠ T311), H326 (= H312), H449 (≠ Y435), P450 (= P436)
- binding nicotinamide-adenine-dinucleotide: I185 (= I176), G186 (= G177), G188 (= G179), V189 (≠ P180), I190 (= I181), L208 (= L199), E209 (= E200), A210 (≠ G201), V243 (vs. gap), V275 (= V262), G276 (= G263)
Sites not aligning to the query:
Query Sequence
>3606907 FitnessBrowser__Dino:3606907
MTNRIETDICVIGAGSGGLSVAAGAVQMGARVVLIEGHLMGGDCLNFGCVPSKALIAAGK
QAHIVRAGGFGVAPAEPVIDYAAAKDHVRRVIDTIAPVDSQERFEGLGCTVIREYASFIS
ETELQAGDTVITARRFVIATGSRPFVPPIPGVEDVPYYTNETIFDLREKPEHLIIIGGGP
IGMEMAQAHVRLGCKVTVLEGAQALGKDDPELAAIALERLRGEGIEIIEGAQASNISGKG
GAITVETANGQSVTGTHLLMAVGRTPNLDKLNLEAAGVDYDRRGLKVDASLRTTNKRIYG
AGDVAGPLQFTHVAGYHAGILIRQLVLGLPAKTRDDHVPWATYTDPEIAQVGLTEAQARE
KYGAALEVARFEYDENDRAIASGKTTGLIKVMVVKGRPIGASIVGAEAGELIGLWAYAIA
NKHKMSAVANMIAPYPTLGEINKRAAGAYFSPRLFESALVKRIVRIVQKF
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory