SitesBLAST

O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 35 papers)
30% identity, 85% coverage: 13:235/261 of query aligns to 902:1112/2261 of O95477

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O95477

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D917 (= D26) to Y: in a colorectal cancer sample; somatic mutation
T929 (≠ L38) to I: in TGD; moderately decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; loss protein subcellular localization to the plasma membrane
N935 (= N44) to S: in TGD; moderately decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; dbSNP:rs28937313
K939 (= K48) mutation to M: Inhibits ATPase activity; when associated with M-1952. Decreases translocase activity; when associated with M-1952. Does not affect protein subcellular localization in plasma membrane and endosome; when associated with M-1952.
S1042 (≠ A164) modified: Phosphoserine; by PKA
P1065 (≠ V187) natural variant: P -> S
M1091 (= M214) to T: in FHA1; loss of localization to plasma membrane; decreased cholesterol efflux; decreased phospholipid efflux
C1110 (≠ L233) modified: S-palmitoyl cysteine; mutation to S: Decreased palmitoylation; when associated with S-3, S-23 and S-1111.
C1111 (= C234) modified: S-palmitoyl cysteine; mutation to S: Decreased palmitoylation; when associated with S-3, S-23 and S-1110.

Sites not aligning to the query:

3 modified: S-palmitoyl cysteine; C→S: Mild decrease of palmitoylation. Loss of localization to plasma membrane. Decreased cholesterol efflux. Decreased phospholipid efflux. Decreased palmitoylation; when associated with S-23, S-1110 and S-1111.
23 modified: S-palmitoyl cysteine; C→S: Mild decrease of palmitoylation. Loss of localization to plasma membrane. Decreased palmitoylation; when associated with S-3, S-1110 and S-1111.
74 I→C: 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with C-371.; I→K: 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with E-371.
75 modified: Disulfide link with 309
85 P → L: in FHA1; Alabama; dbSNP:rs145183203
98 modified: carbohydrate, N-linked (GlcNAc...) asparagine
100 S→C: Highly decreased protein abundance. Highly decreased ATPase activity. Highly decreased phospholipid translocase activity.
210 E → D: in a colorectal cancer sample; somatic mutation
219 R → K: in dbSNP:rs2230806
230 R → C: in dbSNP:rs9282541
244 modified: carbohydrate, N-linked (GlcNAc...) asparagine
248 P → A: in dbSNP:rs142625938
255 A → T: in TGD; deficient cellular cholesterol efflux; dbSNP:rs758100110
304 V→C: No effect on phospholipid and cholesterol efflux or localization to cell membrane; when associated with C-308.
308 V→C: No effect on phospholipid and cholesterol efflux or localization to cell membrane; when associated with C-304.
309 modified: Disulfide link with 75
364 S → C: in dbSNP:rs775035559
371 I→C: No effect on phospholipid and cholesterol efflux or localization to cell membrane. 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with C-74 or C-375.; I→E: 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-74.
375 L→C: 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with C-371.
399 V → A: in dbSNP:rs9282543
401 K → Q: in dbSNP:rs138487227
496 R → W: in dbSNP:rs147675550
568 K→A: 60-65% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane.
573 Y→F: No effect on phospholipid and cholesterol efflux and on localization to cell membrane.
581 D→K: 80-85% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-584 and K-585.
583 F→K: 90-95% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with E-590.
584 E→K: 80-85% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-581 and K-585.
585 D→K: 80-85% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-581 and K-584.
590 W → S: in TGD; moderately decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; dbSNP:rs137854496; W→E: 90-95% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-583.
593 F→L: Moderately decreased protein abundance. Highly decreased ATPase activity. Highly decreased phospholipid translocase activity.
638 R → Q: in dbSNP:rs374190304
771 V → M: in dbSNP:rs2066718
774 T → P: in dbSNP:rs35819696; natural variant: T -> S
776 K → N: in dbSNP:rs138880920
815 E → G: in dbSNP:rs145582736
825 V → I: in dbSNP:rs2066715
883 I → M: in dbSNP:rs2066714
1172 E → D: in dbSNP:rs33918808
1181 S → F: in dbSNP:rs76881554
1216 G → V: in dbSNP:rs562403512
1341 R → T: in dbSNP:rs147743782
1376 S → G: in dbSNP:rs145689805
1379 L → F: in TGD; the mutant protein is retained in the endoplasmic reticulum while the wild-type protein is located at the plasma membrane
1407 A → T: in a colorectal cancer sample; somatic mutation; dbSNP:rs189206655
1463 modified: Disulfide link with 1477
1477 modified: Disulfide link with 1463; C → R: in TGD; loss of interaction with APOE; unable to generate APOE-containing high density lipoproteins; moderately decreased protein abundance; moderately decreased ATPase activity; moderately decreased phospholipid translocase activity; dbSNP:rs137854494
1512 T→M: Moderately decreased protein abundance. Does not affect ATPase activity. Moderately decreased phospholipid translocase activity.
1555 I → T: in dbSNP:rs1997618
1587 K → R: in dbSNP:rs2230808
1611 N → D: in FHA1; deficient cellular cholesterol efflux
1615 R → Q: in dbSNP:rs1251839800
1648 L → P: in dbSNP:rs1883024
1670 A → T: in dbSNP:rs1203589782
1680 R → Q: in dbSNP:rs150125857
1704 V → D: in TGD; the mutant protein is retained in the endoplasmic reticulum while the wild-type protein is located at the plasma membrane
1731 S → C: in dbSNP:rs760507032
1897 R → W: in FHA1; uncertain significance; dbSNP:rs760768125
1925 R → Q: in Scott syndrome; shows impaired trafficking of the mutant protein to the plasma membrane; dbSNP:rs142688906
1952 K→M: Inhibits ATPase activity; when associated with M-939. Decreases translocase activity; when associated with M-939. Does not affect protein subcellular localization in plasma membrane and endosome; when associated with M-939.
2054 modified: Phosphoserine; by PKA
2081 R → W: in TGD; highly decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; loss protein subcellular localization to the plasma membrane; dbSNP:rs137854501
2109 A → T: in a colorectal cancer sample; somatic mutation
2150 P → L: in FHA1; moderately decreased protein abundance; does not affect ATPase activity; moderately decreased phospholipid translocase activity; dbSNP:rs369098049
2163 natural variant: F -> S
2168 L → P: in dbSNP:rs2853577
2243 D → E: in dbSNP:rs34879708
2244 V → I: in dbSNP:rs144588452

7tbwA The structure of atp-bound abca1 (see paper)
30% identity, 85% coverage: 13:235/261 of query aligns to 757:967/1928 of 7tbwA

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binding adenosine-5'-triphosphate: Y763 (= Y19), D765 (vs. gap), K768 (≠ V22), N790 (= N44), G791 (= G45), G793 (= G47), K794 (= K48), T795 (≠ S49), Q835 (≠ A98), Q887 (≠ T154), S889 (= S156), H944 (= H212)
binding magnesium ion: Q835 (≠ A98), D912 (= D179), Q913 (≠ E180)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 1630, 1633, 1657, 1658, 1660, 1661, 1662, 1663, 1702, 1753, 1755, 1756, 1757, 1779, 1783, 1811
binding cholesterol: 218, 219, 360, 367
binding magnesium ion: 1662, 1702

P41233 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; EC 7.6.2.1 from Mus musculus (Mouse) (see paper)
30% identity, 85% coverage: 13:235/261 of query aligns to 902:1112/2261 of P41233

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P41233

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Sites not aligning to the query:

489 modified: carbohydrate, N-linked (GlcNAc...) asparagine

1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
28% identity, 86% coverage: 16:240/261 of query aligns to 12:227/353 of 1oxvD

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K

R

L

L

V

C

Q

V

V

I

G

D

K

P

P

K

E

D

D

binding phosphoaminophosphonic acid-adenylate ester: F13 (≠ K17), S40 (≠ N44), G41 (= G45), G43 (= G47), K44 (= K48), T45 (≠ S49), T46 (≠ S50), Q89 (= Q91), E166 (= E180)
binding magnesium ion: T45 (≠ S49), Q89 (= Q91)

1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
28% identity, 86% coverage: 16:240/261 of query aligns to 12:227/353 of 1oxvA

query
sites
1oxvA

V

V

K
x
F

R

K

Y

K

G

G

R

K

V

V

T

V

A

A

L

L

D

D

H

N

C

V

D

N

F

I

E

N

L

I

Y

E

P

N

G

G

E

E

I

R

L

F

A

G

V

I

I

L

G

G

D

P

N
x
S

G
|
G

A

A

G
|
G

K
|
K

S
x
T

L

F

I

M

K

R

A

I

V

I

S

A

G

G

A

L

V

D

I

V

P

P

D

S

E

T

G

G

E

E

V

L

F

Y

L

F

E

D

G

D

K

R

R

L

V

V

-

A

-

S

-

N

-

G

R

K

F

L

Q

I

S

V

P

P

L

P

D

E

A

D

R

R

A

K

A

I

G

G

I

M

E

-

T

-

V

V

Y

F

Q

Q

Q

T

L

W

A

A

M

L

S

Y

P

P

A

N

L

L

S

T

I

A

A

F

D

E

N

N

M

I

F

A

M

F

G

-

R

-

E

-

L

-

R

-

K

-

P

P

G

L

W

T

R

N

G

M

K

K

W

M

L

S

R

K

Q

E

L

E

D

I

R

R

A

K

A

R

M

V

E

E

K

E

F

V

A

A

R

K

D

-

K

-

L

-

S

-

E

-

L

-

G

-

L

I

M

L

T

D

I

I

Q

H

N

H

I

V

-

L

N

N

Q

H

A

F

V

P

E

R

T

E

L

L

S

S

G

G

Q

Q

R

Q

Q

Q

G

R

V

V

A

A

V

L

A

A

R

R

A

A

A

L

A

V

F

K

G

D

S

P

K

S

V

L

I

L

L

L

D

D

E
|
E

P

P

T

F

A

S

A

N

L

L

G

D

V

A

K

R

E

M

S

R

R

D

R

S

V

A

L

R

E

A

L

L

I

V

L

K

D

E

V

V

R

Q

A

S

R

R

-

L

G

G

I

V

P

T

I

L

V

L

L

V

I

V

S

S

H

H

N

D

M

P

P

A

H

D

V

I

F

F

E

A

V

I

A

A

D

D

R

R

I

V

H

G

I

V

H

L

R

V

L

K

G

G

K

K

R

L

L

V

C

Q

V

V

I

G

D

K

P

P

K

E

D

D

binding phosphoaminophosphonic acid-adenylate ester: F13 (≠ K17), S40 (≠ N44), G41 (= G45), G43 (= G47), K44 (= K48), T45 (≠ S49), T46 (≠ S50), E166 (= E180)

1oxuA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
28% identity, 86% coverage: 16:240/261 of query aligns to 12:227/353 of 1oxuA

query
sites
1oxuA

V

V

K
x
F

R

K

Y

K

G

G

R

K

V

V

T

V

A
|
A

L

L

D

D

H

N

C

V

D

N

F

I

E

N

L

I

Y

E

P

N

G

G

E

E

I

R

L

F

A

G

V

I

I

L

G

G

D

P

N

S

G
|
G

A

A

G
|
G

K
|
K

S
x
T

L

F

I

M

K

R

A

I

V

I

S

A

G

G

A

L

V

D

I

V

P

P

D

S

E

T

G

G

E

E

V

L

F

Y

L

F

E

D

G

D

K

R

R

L

V

V

-

A

-

S

-

N

-

G

R

K

F

L

Q

I

S

V

P

P

L

P

D

E

A

D

R

R

A

K

A

I

G

G

I

M

E

-

T

-

V

V

Y

F

Q

Q

Q

T

L

W

A

A

M

L

S

Y

P

P

A

N

L

L

S

T

I

A

A

F

D

E

N

N

M

I

F

A

M

F

G

-

R

-

E

-

L

-

R

-

K

-

P

P

G

L

W

T

R

N

G

M

K

K

W

M

L

S

R

K

Q

E

L

E

D

I

R

R

A

K

A

R

M

V

E

E

K

E

F

V

A

A

R

K

D

-

K

-

L

-

S

-

E

-

L

-

G

-

L

I

M

L

T

D

I

I

Q

H

N

H

I

V

-

L

N

N

Q

H

A

F

V

P

E

R

T

E

L

L

S

S

G

G

Q

Q

R

Q

Q

Q

G

R

V

V

A

A

V

L

A

A

R

R

A

A

A

L

A

V

F

K

G

D

S

P

K

S

V

L

I

L

L

L

D

D

E

E

P

P

T

F

A

S

A

N

L

L

G

D

V

A

K

R

E

M

S

R

R

D

R

S

V

A

L

R

E

A

L

L

I

V

L

K

D

E

V

V

R

Q

A

S

R

R

-

L

G

G

I

V

P

T

I

L

V

L

L

V

I

V

S

S

H

H

N

D

M

P

P

A

H

D

V

I

F

F

E

A

V

I

A

A

D

D

R

R

I

V

H

G

I

V

H

L

R

V

L

K

G

G

K

K

R

L

L

V

C

Q

V

V

I

G

D

K

P

P

K

E

D

D

binding adenosine-5'-diphosphate: F13 (≠ K17), A20 (= A24), G41 (= G45), G43 (= G47), K44 (= K48), T45 (≠ S49), T46 (≠ S50)

Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
28% identity, 86% coverage: 16:240/261 of query aligns to 12:227/353 of Q97UY8

query
sites
Q97UY8

V

V

K

F

R

K

Y

K

G

G

R

K

V

V

T

V

A

A

L

L

D

D

H

N

C

V

D

N

F

I

E

N

L

I

Y

E

P

N

G

G

E

E

I

R

L

F

A

G

V

I

I

L

G

G

D

P

N

S

G

G

A

A

G

G

K

K

S

T

L

F

I

M

K

R

A

I

V

I

S

A

G

G

A

L

V

D

I

V

P

P

D

S

E

T

G

G

E

E

V

L

F

Y

L

F

E

D

G

D

K

R

R

L

V

V

-

A

-

S

-

N

-

G

R

K

F

L

Q

I

S

V

P

P

L

P

D

E

A

D

R

R

A

K

A

I

G

G

I

M

E

-

T

-

V

V

Y

F

Q

Q

Q

T

L

W

A

A

M

L

S

Y

P

P

A

N

L

L

S

T

I

A

A

F

D

E

N

N

M

I

F

A

M

F

G

-

R

-

E

-

L

-

R

-

K

-

P

P

G

L

W

T

R

N

G

M

K

K

W

M

L

S

R

K

Q

E

L

E

D

I

R

R

A

K

A

R

M

V

E

E

K

E

F

V

A

A

R

K

D

-

K

-

L

-

S

-

E

-

L

-

G

-

L

I

M

L

T

D

I

I

Q

H

N

H

I

V

-

L

N

N

Q

H

A

F

V

P

E

R

T

E

L

L

S
|
S

G

G

G
|
G

Q

Q

R

Q

Q

Q

G

R

V

V

A

A

V

L

A

A

R

R

A

A

A

L

A

V

F

K

G

D

S

P

K

S

V

L

I

L

L

L

D

D

E
|
E

P

P

T

F

A

S

A

N

L

L

G

D

V

A

K

R

E

M

S

R

R

D

R

S

V

A

L

R

E

A

L

L

I

V

L

K

D

E

V

V

R

Q

A

S

R

R

-

L

G

G

I

V

P

T

I

L

V

L

L

V

I

V

S

S

H

H

N

D

M

P

P

A

H

D

V

I

F

F

E

A

V

I

A

A

D

D

R

R

I

V

H

G

I

V

H

L

R

V

L

K

G

G

K

K

R

L

L

V

C

Q

V

V

I

G

D

K

P

P

K

E

D

D

S142 (= S156) mutation to A: Decrease in ATPase activity. Can form dimers.
G144 (= G158) mutation to A: Loss of ATPase activity. Cannot form dimers. Forms an active heterodimer; when associated with A-166.
E166 (= E180) mutation to A: Loss of ATPase activity. Can form dimers in the presence of ATP-Mg(2+). Forms an active heterodimer; when associated with A-144.; mutation to Q: Strong decrease in ATPase activity. Can form dimers in the presence of ATP alone, without Mg(2+).

2d62A Crystal structure of multiple sugar binding transport atp- binding protein
28% identity, 92% coverage: 14:252/261 of query aligns to 11:241/375 of 2d62A

query
sites
2d62A

N

N

L

I

V

W

K

K

R

R

Y

F

G

G

R

D

V

V

T

T

A

A

L

V

D

K

H

D

C

L

D

S

F

L

E

E

L

I

Y

K

P

D

G

G

E

E

I

F

L

L

A

V

V

L

I

L

G

G

D

P

N

S

G
|
G

A
x
C

G
|
G

K
|
K

S
x
T

L

T

I

L

K

R

A

M

V

I

S

A

G

G

A

L

V

E

I

E

P

P

D

T

E

R

G

G

E

Q

V

I

F

Y

L

I

E

E

G

D

K

N

R

L

V

V

R

A

-

D

-

P

-

E

-

K

-

G

-

V

F

F

Q

V

S

P

P

P

L

-

D

-

A

-

R

K

A

E

A

R

G

D

I

V

E

A

T

M

V

V

Y

F

Q

Q

Q

S

L

Y

A

A

M

L

S

Y

P

P

A

H

L

M

S

T

I

V

A

Y

D

D

N

N

M

I

F

A

M

F

G

P

R

L

E

K

L

L

R

R

K

K

P

-

G

-

W

-

R

-

G

-

K

-

W

-

L

-

R

-

Q

-

L

V

D

P

R

K

A

Q

A

E

M

I

E

D

K

K

F

R

A

V

R

R

D

E

K

V

L

A

S

E

E

M

L

L

G

G

L

L

M

T

T

E

I

L

Q

-

N

-

I

L

N

N

Q

R

A

K

V

P

E

R

T

E

L

L

S

S

G

G

Q

Q

R

R

Q

Q

G

R

V

V

A

A

V

L

A

G

R

R

A

A

A

I

F

R

G

R

S

P

K

K

V

V

I

F

I

L

L

M

D

D

E

E

P

P

T

L

A

S

A

N

L

L

G

D

V

A

K

K

E

L

S

R

R

V

R

K

V

M

-

R

L

A

E

E

L

L

I

K

L

K

D

L

V

Q

R

R

A

Q

R

L

G

G

I

V

P

T

I

T

V

I

L

Y

I

V

S

T

H

H

N

D

M

Q

P

V

H

E

V

A

F

M

E

T

V

M

A

G

D

D

R

R

I

I

H

A

I

V

H

M

R

N

L

K

G

G

K

E

R

L

L

Q

C

Q

V

V

I

G

D

T

P

P

K

D

D

E

H

V

D

Y

M

Y

S

K

D

P

A

V

V

N

A

T

F

F

M

V

T

A

G

G

binding pyrophosphate 2-: G42 (= G45), C43 (≠ A46), G44 (= G47), K45 (= K48), T46 (≠ S49), T47 (≠ S50)

3c4jA Abc protein artp in complex with atp-gamma-s
28% identity, 89% coverage: 15:246/261 of query aligns to 9:236/242 of 3c4jA

query
sites
3c4jA

L

L

V

K

K

K

R

S

Y
x
F

G

G

R

S

V

L

T

E

A
x
V

L

L

D

K

H

G

C

I

D

N

F

V

E

H

L

I

Y

R

P

E

G

G

E

E

I

V

L

V

A

V

V

V

I

I

G

G

D

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

S
x
T

L

F

I

L

K

R

A

C

V

L

S

N

G

L

A

L

V

E

I

D

P

F

D

D

E

E

G

G

E

E

V

I

F

I

L

I

E

D

G

G

K

I

R

N

V

L

R

K

F

A

Q

K

-

D

S

T

P

N

L

L

D

N

A

K

R

V

A

R

A

E

G

E

I

V

E

G

T

M

V

V

Y

F

Q

Q

Q

R

L

F

A

N

M

L

S

F

P

P

A

H

L

M

S

T

I

V

A

L

D

N

N

N

M

I

F

T

M

L

G

A

R

-

E

-

L

-

R

-

K

-

P

P

G

M

W

K

R

V

G

R

K

K

W

W

L

P

R

R

Q

E

L

K

D

A

R

E

A

A

A

K

M

-

E

-

K

-

F

-

A

A

R

M

D

E

K

L

L

L

S

D

E

K

L

V

G

G

L

L

M

K

T

-

I

-

Q

D

N

K

I

A

N

H

Q

A

A

Y

V

P

E

D

T

S

L

L

S

S

G

G

Q

Q

R

A

Q

Q

G

R

V

V

A

A

V

I

A

A

R

R

A

A

A

L

A

A

F

M

G

E

S

P

K

K

V

I

I

M

I

L

L

F

D

D

E

E

P

P

T

T

A

S

A

A

L

L

G

D

V

P

K

E

E

M

S

V

R

G

R

E

V

V

L

L

E

S

L

V

I

M

L

K

D

Q

V

L

R

A

A

N

R

E

G

G

I

M

P

T

I

M

V

V

L

V

I

V

S

T

H

H

N

E

M

M

P

G

H

F

V

A

F

R

E

E

V

V

A

G

D

D

R

R

I

V

-

L

-

F

-

M

-

D

-

G

H

Y

I

I

H

I

R

E

L

E

G

G

K

K

R

P

L

E

C

D

V

L

I

F

D

D

P

R

K

P

D

Q

H

H

D

E

M

R

S

T

D

K

A

A

binding phosphothiophosphoric acid-adenylate ester: F13 (≠ Y19), V18 (≠ A24), S38 (≠ N44), G39 (= G45), S40 (≠ A46), G41 (= G47), K42 (= K48), S43 (= S49), T44 (≠ S50)

3c41J Abc protein artp in complex with amp-pnp/mg2+
28% identity, 89% coverage: 15:246/261 of query aligns to 9:236/242 of 3c41J

query
sites
3c41J

L

L

V

K

K

K

R

S

Y
x
F

G

G

R

S

V

L

T

E

A
x
V

L

L

D

K

H

G

C

I

D

N

F

V

E

H

L

I

Y

R

P

E

G

G

E

E

I

V

L

V

A

V

V

V

I

I

G

G

D

P

N
x
S

G
|
G

A

S

G
|
G

K
|
K

S
|
S

S
x
T

L

F

I

L

K

R

A

C

V

L

S

N

G

L

A

L

V

E

I

D

P

F

D

D

E

E

G

G

E

E

V

I

F

I

L

I

E

D

G

G

K

I

R

N

V

L

R

K

F

A

Q

K

-

D

S

T

P

N

L

L

D

N

A

K

R

V

A

R

A

E

G

E

I

V

E

G

T

M

V

V

Y

F

Q

Q

Q

R

L

F

A

N

M

L

S

F

P

P

A

H

L

M

S

T

I

V

A

L

D

N

N

N

M

I

F

T

M

L

G

A

R

-

E

-

L

-

R

-

K

-

P

P

G

M

W

K

R

V

G

R

K

K

W

W

L

P

R

R

Q

E

L

K

D

A

R

E

A

A

A

K

M

-

E

-

K

-

F

-

A

A

R

M

D

E

K

L

L

L

S

D

E

K

L

V

G

G

L

L

M

K

T

-

I

-

Q

D

N

K

I

A

N

H

Q

A

A

Y

V

P

E

D

T

S

L

L

S

S

G

G

Q

Q

R

A

Q

Q

G

R

V

V

A

A

V

I

A

A

R

R

A

A

A

L

A

A

F

M

G

E

S

P

K

K

V

I

I

M

I

L

L

F

D
|
D

E

E

P

P

T

T

A

S

A

A

L

L

G

D

V

P

K

E

E

M

S

V

R

G

R

E

V

V

L

L

E

S

L

V

I

M

L

K

D

Q

V

L

R

A

A

N

R

E

G

G

I

M

P

T

I

M

V

V

L

V

I

V

S

T

H

H

N

E

M

M

P

G

H

F

V

A

F

R

E

E

V

V

A

G

D

D

R

R

I

V

-

L

-

F

-

M

-

D

-

G

H

Y

I

I

H

I

R

E

L

E

G

G

K

K

R

P

L

E

C

D

V

L

I

F

D

D

P

R

K

P

D

Q

H

H

D

E

M

R

S

T

D

K

A

A

binding phosphoaminophosphonic acid-adenylate ester: F13 (≠ Y19), V18 (≠ A24), S38 (≠ N44), G39 (= G45), G41 (= G47), K42 (= K48), S43 (= S49), T44 (≠ S50)
binding magnesium ion: S43 (= S49), D163 (= D179)

2olkA Abc protein artp in complex with adp-beta-s
28% identity, 89% coverage: 15:246/261 of query aligns to 9:236/242 of 2olkA

query
sites
2olkA

L

L

V

K

K

K

R

S

Y
x
F

G

G

R

S

V

L

T

E

A
x
V

L

L

D

K

H

G

C

I

D

N

F

V

E

H

L

I

Y

R

P

E

G

G

E

E

I

V

L

V

A

V

V

V

I

I

G

G

D

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

S
x
T

L

F

I

L

K

R

A

C

V

L

S

N

G

L

A

L

V

E

I

D

P

F

D

D

E

E

G

G

E

E

V

I

F

I

L

I

E

D

G

G

K

I

R

N

V

L

R

K

F

A

Q

K

-

D

S

T

P

N

L

L

D

N

A

K

R

V

A

R

A

E

G

E

I

V

E

G

T

M

V

V

Y

F

Q

Q

Q

R

L

F

A

N

M

L

S

F

P

P

A

H

L

M

S

T

I

V

A

L

D

N

N

N

M

I

F

T

M

L

G

A

R

-

E

-

L

-

R

-

K

-

P

P

G

M

W

K

R

V

G

R

K

K

W

W

L

P

R

R

Q

E

L

K

D

A

R

E

A

A

A

K

M

-

E

-

K

-

F

-

A

A

R

M

D

E

K

L

L

L

S

D

E

K

L

V

G

G

L

L

M

K

T

-

I

-

Q

D

N

K

I

A

N

H

Q

A

A

Y

V

P

E

D

T

S

L

L

S

S

G

G

Q

Q

R

A

Q

Q

G

R

V

V

A

A

V

I

A

A

R

R

A

A

A

L

A

A

F

M

G

E

S

P

K

K

V

I

I

M

I

L

L

F

D

D

E

E

P

P

T

T

A

S

A

A

L

L

G

D

V

P

K

E

E

M

S

V

R

G

R

E

V

V

L

L

E

S

L

V

I

M

L

K

D

Q

V

L

R

A

A

N

R

E

G

G

I

M

P

T

I

M

V

V

L

V

I

V

S

T

H

H

N

E

M

M

P

G

H

F

V

A

F

R

E

E

V

V

A

G

D

D

R

R

I

V

-

L

-

F

-

M

-

D

-

G

H

Y

I

I

H

I

R

E

L

E

G

G

K

K

R

P

L

E

C

D

V

L

I

F

D

D

P

R

K

P

D

Q

H

H

D

E

M

R

S

T

D

K

A

A

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (≠ Y19), V18 (≠ A24), S38 (≠ N44), G39 (= G45), S40 (≠ A46), G41 (= G47), K42 (= K48), S43 (= S49), T44 (≠ S50)

2oljA Abc protein artp in complex with adp/mg2+
28% identity, 89% coverage: 15:246/261 of query aligns to 9:236/242 of 2oljA

query
sites
2oljA

L

L

V

K

K

K

R

S

Y
x
F

G

G

R

S

V

L

T

E

A
x
V

L

L

D

K

H

G

C

I

D

N

F

V

E

H

L

I

Y

R

P

E

G

G

E

E

I

V

L

V

A

V

V

V

I

I

G

G

D

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

S
x
T

L

F

I

L

K

R

A

C

V

L

S

N

G

L

A

L

V

E

I

D

P

F

D

D

E

E

G

G

E

E

V

I

F

I

L

I

E

D

G

G

K

I

R

N

V

L

R

K

F

A

Q

K

-

D

S

T

P

N

L

L

D

N

A

K

R

V

A

R

A

E

G

E

I

V

E

G

T

M

V

V

Y

F

Q

Q

Q

R

L

F

A

N

M

L

S

F

P

P

A

H

L

M

S

T

I

V

A

L

D

N

N

N

M

I

F

T

M

L

G

A

R

-

E

-

L

-

R

-

K

-

P

P

G

M

W

K

R

V

G

R

K

K

W

W

L

P

R

R

Q

E

L

K

D

A

R

E

A

A

A

K

M

-

E

-

K

-

F

-

A

A

R

M

D

E

K

L

L

L

S

D

E

K

L

V

G

G

L

L

M

K

T

-

I

-

Q

D

N

K

I

A

N

H

Q

A

A

Y

V

P

E

D

T

S

L

L

S

S

G

G

Q

Q

R

A

Q

Q

G

R

V

V

A

A

V

I

A

A

R

R

A

A

A

L

A

A

F

M

G

E

S

P

K

K

V

I

I

M

I

L

L

F

D

D

E

E

P

P

T

T

A

S

A

A

L

L

G

D

V

P

K

E

E

M

S

V

R

G

R

E

V

V

L

L

E

S

L

V

I

M

L

K

D

Q

V

L

R

A

A

N

R

E

G

G

I

M

P

T

I

M

V

V

L

V

I

V

S

T

H

H

N

E

M

M

P

G

H

F

V

A

F

R

E

E

V

V

A

G

D

D

R

R

I

V

-

L

-

F

-

M

-

D

-

G

H

Y

I

I

H

I

R

E

L

E

G

G

K

K

R

P

L

E

C

D

V

L

I

F

D

D

P

R

K

P

D

Q

H

H

D

E

M

R

S

T

D

K

A

A

binding adenosine-5'-diphosphate: F13 (≠ Y19), V18 (≠ A24), S38 (≠ N44), G39 (= G45), S40 (≠ A46), G41 (= G47), K42 (= K48), S43 (= S49), T44 (≠ S50)

P0AAH0 Phosphate import ATP-binding protein PstB; ABC phosphate transporter; Phosphate-transporting ATPase; EC 7.3.2.1 from Escherichia coli (strain K12) (see paper)
30% identity, 84% coverage: 13:231/261 of query aligns to 14:229/257 of P0AAH0

query
sites
P0AAH0

R

R

N

N

L

L

V

N

K

F

R

Y

Y

Y

G

G

R

K

V

F

T

H

A

A

L

L

D

K

H

N

C

I

D

N

F

L

E

D

L

I

Y

A

P

K

G

N

E

Q

I

V

L

T

A

A

V

F

I

I

G

G

D

P

N

S

G

G

A

C

G
|
G

K
|
K

S

S

S

T

L

L

I

L

K

R

A

T

V

F

S

N

G

K

-

M

-

F

A

E

V

L

I

Y

P

P

D

E

-

Q

-

R

-

A

E

E

G

G

E

E

V

I

F

L

L

L

E

D

G

G

K

D

R

N

V

I

R

L

F

T

Q

N

S

S

P

Q

-

D

L

I

D

A

A

L

R

L

A

R

A

A

G

K

I

V

E

G

T

M

V

V

Y

F

Q

Q

Q

K

L

P

A

T

M

P

S

F

P

P

A

-

L

M

S

S

I

I

A

Y

D

D

N

N

M

I

F

A

M

F

G

G

R

V

E

R

L

L

R

-

K

-

P

-

G

-

W

-

R

-

G

-

K

-

W

-

L

F

R

E

Q

K

L

L

D

S

R

R

A

A

A

D

M

M

E

D

K

E

F

R

A

V

R

Q

D

W

K

A

L

L

S

T

E

K

L

A

G

A

L

L

M

W

-

N

-

E

T

T

I

K

Q

D

N

K

I

L

N

H

Q

Q

A

S

V

G

E

Y

T

S

L

L

S

S

G

G

Q

Q

R

Q

Q

Q

G

R

V

L

A

C

V

I

A

A

R

R

A

G

A

I

A

A

F

I

G

R

S

P

K

E

V

V

I

L

L

L

D

D

E

E

P

P

T

C

A

S

A

A

L

L

G

D

V

P

K

I

E

S

S

T

R

G

R

R

V

I

L

E

E

E

L

L

I

I

L

T

D

E

V

L

R

K

A

-

R

Q

G

D

I

Y

P

T

I

V

V

V

L

I

I

V

S

T

H

H

N

N

M

M

P

Q

H

Q

V

A

F

A

E

R

V

C

A

S

D

D

R

H

I

T

H

A

I

F

H

M

R

Y

L

L

G

G

K

E

G48 (= G47) mutation to I: Loss of phosphate transport.
K49 (= K48) mutation to Q: Loss of phosphate transport.

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

7tbyA The structure of human abca1 in nanodisc (see paper)
30% identity, 85% coverage: 13:235/261 of query aligns to 694:894/1788 of 7tbyA

query
sites
7tbyA

R

Q

N

N

L

L

V

V

K

K

R

V

Y

Y

G

-

R

-

V

-

T

L

A

A

L

L

D

N

H

-

C

-

D

-

F

-

E

-

L

F

Y

Y

P

E

G

G

E

Q

I

I

L

T

A

S

V

F

I

L

G

G

D

H

N

N

G

G

A

A

G

G

K

K

S

T

L

T

I

M

K

S

A

I

V

L

S

T

G

G

A

L

V

F

I

P

P

P

D

T

E

S

G

G

E

T

V

A

F

Y

L

I

E

L

G

G

K

K

R

D

V

I

R

R

F

-

Q

-

S

-

P

-

L

-

D

-

A

-

R

-

A

-

A

S

G

E

I

M

E

S

T

T

V

I

Y

R

Q

Q

Q

N

L

L

A

G

M

V

S

C

P

P

A

Q

L

H

S

N

I

V

A

L

D

F

N

D

M

M

F

L

M

T

G

V

R

E

E

E

L

-

R

-

K

-

P

-

G

-

W

-

R

-

G

H

K

I

W

W

L

F

R

Y

Q

A

L

R

D

L

R

K

A

G

A

L

M

S

E

E

K

K

F

H

A

V

R

K

D

A

K

E

L

M

S

E

E

Q

L

M

G

A

L

L

-

D

-

V

-

G

M

L

T

P

I

S

Q

S

N

K

I

L

N

K

Q

S

A

K

V

T

E

S

T

Q

L

L

S

S

G

G

Q

M

R

Q

Q

R

G

K

V

L

A

S

V

V

A

A

R

L

A

A

A

F

A

V

F

G

G

G

S

S

K

K

V

V

I

V

I

I

L

L

D

D

E

E

P

P

T

T

A

A

A

G

L

V

G

D

V

P

K

Y

E

S

S

R

R

R

R

G

V

I

L

W

E

E

L

L

I

L

L

L

D

K

V

Y

R

R

A

-

R

Q

G

G

I

R

P

T

I

I

V

I

L

L

I

S

S

T

H

H

N

H

M

M

P

D

H

E

V

A

F

D

E

V

V

L

A

G

D

D

R

R

I

I

H

A

I

I

H

I

R

S

L

H

G

G

K

K

R

L

L

C

C

C

V

V

Sites not aligning to the query:

binding cholesterol: 161, 162

F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 2 papers)
30% identity, 89% coverage: 8:238/261 of query aligns to 927:1144/2281 of F1MWM0

query
sites
F1MWM0

P

P

I

G

L

V

A

C

G

V

R

K

N

N

L

L

V

V

K

K

-

I

-

F

-

E

R

P

Y

Y

G

G

R

R

V

-

T

P

A

A

L

V

D

D

H

R

C

L

D

N

F

I

E

T

L

F

Y

Y

P

E

G

S

E

Q

I

I

L

T

A

A

V

F

I

L

G

G

D

H

N

N

G

G

A

A

G

G

K

K

S

T

L

T

I

L

K

S

A

I

V

M

S

T

G

G

A

L

V

L

I

P

P

P

D

T

E

S

G

G

E

T

V

V

F

L

L

V

E

G

G

G

K

K

R

D

V

I

R

-

F

-

Q

E

S

T

P

N

L

L

D

D

A

A

R

I

A

R

A

Q

G

S

I

L

E

G

T

M

V

C

Y

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N

A

I

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-

G

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-

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N

N

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A

S

V

V

A

A

R

I

A

A

A

F

A

V

F

G

G

D

S

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K

K

V

V

I

V

L

L

D

D

E

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P

T

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A

S

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V

G

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R

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S

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W

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D

L

L

I

L

L

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-

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G

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T

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I

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S

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Sites not aligning to the query:

415 modified: carbohydrate, N-linked (Hex...) asparagine
504 modified: carbohydrate, N-linked (Hex...) asparagine
901 modified: Phosphothreonine; T→A: Decreases expression level. Affects subcellular location.
1185 modified: Phosphoserine; S→A: Does not affect subcellular location. Does not affect expression level. Does not affect ATPase activity. Reduces the stimulating effect of all-trans-retinal on ATP hydrolysis.
1309 Cleavage; by trypsin
1313 modified: Phosphothreonine; T→A: Does not affect subcellular location. Does not affect expression level. Does not affect ATPase activity. Reduces the stimulating effect of all-trans-retinal on ATP hydrolysis.
1317 modified: Phosphoserine; S→A: Does not affect subcellular location. Does not affect expression level. Affects both the basal and stimulated ATPase activity.
1319 modified: Phosphoserine
1455 modified: carbohydrate, N-linked (Hex...) asparagine
1527 modified: carbohydrate, N-linked (Hex...) asparagine
1660 modified: carbohydrate, N-linked (Hex...) asparagine

Query Sequence

>3606961 Dshi_0388 ABC transporter related (RefSeq)
MTDTSQQPILAGRNLVKRYGRVTALDHCDFELYPGEILAVIGDNGAGKSSLIKAVSGAVI
PDEGEVFLEGKRVRFQSPLDARAAGIETVYQQLAMSPALSIADNMFMGRELRKPGWRGKW
LRQLDRAAMEKFARDKLSELGLMTIQNINQAVETLSGGQRQGVAVARAAAFGSKVIILDE
PTAALGVKESRRVLELILDVRARGIPIVLISHNMPHVFEVADRIHIHRLGKRLCVIDPKD
HDMSDAVAFMTGAKEPESAAA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory