SitesBLAST

G11 (= G307) to D: in cyt-12-12/cyc-1-1; characterized by slow growth and a deficiency of spectrophotometrically-detectable cytochromes aa3 and c
K77 (≠ D373) modified: N6,N6,N6-trimethyllysine

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

P00025 Cytochrome c from Katsuwonus pelamis (Skipjack tuna) (Bonito) (see 2 papers)
38% identity, 24% coverage: 306:403/404 of query aligns to 6:103/104 of P00025

query
sites
P00025

R

K

G

G

A

K

E

K

V

T

F

F

-

V

R

Q

A

K

C
|
C

A

A

V

Q

C
|
C

H
|
H

T

T

L

V

T

E

P

N

D

G

G

K

A

H

R

K

A

V

G

G

P

P

T

N

L

L

H

W

G

G

I

L

F

F

G

G

R

R

R

K

I

T

A

G

T

Q

A

A

E

E

G

G

Y

Y

Q

S

Y

Y

S

T

E

D

A

A

L

N

K

K

D

S

L

K

D

G

I

I

V

V

W

W

T

N

A

E

Q

N

T

T

I

L

S

M

E

E

L

Y

F

L

E

E

Y

-

G

N

P

P

D

K

A

K

Y

Y

T

I

P

P

G

G

S

T

R

K

M
|
M

P

I

E

F

Q

A

R

G

V

I

P

K

S

K

A

K

A

G

D

E

R

R

Q

Q

A

D

L

L

V

V

E

A

F

Y

L

L

E

K

M

S

V

A

T

T

C15 (= C314) binding covalent
C18 (= C317) binding covalent
H19 (= H318) binding axial binding residue
M81 (= M381) binding axial binding residue

Sites not aligning to the query:

1 modified: Initiator methionine, Removed
2 modified: N-acetylglycine

P00012 Cytochrome c from Mirounga leonina (Southern elephant seal) (Phoca leonina) (see paper)
34% identity, 25% coverage: 306:404/404 of query aligns to 6:104/105 of P00012

query
sites
P00012

R

K

G

G

A

K

E

K

V

I

F

F

-

V

R

Q

A

K

C
|
C

A

A

V

Q

C
|
C

H

H

T

T

L

V

T

E

P

K

D

G

G

K

A

H

R

K

A

T

G

G

P

P

T

N

L

L

H

H

G

G

I

L

F

F

G

G

R

R

R

K

I

T

A

G

T

Q

A

A

E

P

G

G

Y

F

Q

S

Y

Y

S

T

E

D

A

A

L

N

K

K

D

N

L

K

D

G

I

I

V

T

W

W

T

G

A

E

Q

E

T

T

I

L

S

M

E

E

L

Y

F

L

E

E

Y

-

G

N

P

P

D

K

A

K

Y

Y

T

I

P

P

G

G

S

T

R

K

M

M

P

I

E

F

Q

A

R

G

V

I

P

K

S

K

A

T

A

G

D

E

R

R

Q

A

A

D

L

L

V

I

E

A

F

Y

L

L

E

K

M

I

V

A

T

T

R

K

C15 (= C314) binding covalent
C18 (= C317) binding covalent

Sites not aligning to the query:

1 modified: Initiator methionine, Removed
2 modified: N-acetylglycine

1cycA The crystal structure of bonito (katsuo) ferrocytochromE C at 2.3 angstroms resolution. Ii. Structure and function (see paper)
38% identity, 24% coverage: 306:403/404 of query aligns to 5:102/103 of 1cycA

query
sites
1cycA

R

K

G

G

A

K

E

K

V

T

F

F

-

V

R

Q

A
x
K

C
|
C

A

A

V

Q

C
|
C

H
|
H

T

T

L

V

T

E

P

N

D

G

G

K

A

H

R

K

A

V

G

G

P

P

T

N

L
|
L

H

W

G

G

I

L

F

F

G

G

R
|
R

R

K

I

T

A

G

T

Q

A

A

E

E

G

G

Y
|
Y

Q

S

Y
|
Y

S

T

E

D

A

A

L
x
N

K

K

D

S

L

K

D

G

I

I

V

V

W

W

T

N

A

E

Q

N

T

T

I

L

S

M

E

E

L

Y

F

L

E

E

Y

-

G

N

P

P

D

K

A

K

Y

Y

T

I

P

P

G

G

S
x
T

R
x
K

M
|
M

P

I

E
x
F

Q

A

R

G

V

I

P

K

S

K

A

K

A

G

D

E

R

R

Q

Q

A

D

L

L

V

V

E

A

F

Y

L

L

E

K

M

S

V

A

T

T

binding heme c: K13 (≠ A313), C14 (= C314), C17 (= C317), H18 (= H318), L32 (= L332), R38 (= R338), Y46 (= Y346), Y48 (= Y348), N52 (≠ L352), T78 (≠ S379), K79 (≠ R380), M80 (= M381), F82 (≠ E383)

P00042 Cytochrome c from Wickerhamomyces anomalus (Yeast) (Hansenula anomala) (see paper)
37% identity, 25% coverage: 303:404/404 of query aligns to 8:109/109 of P00042

query
sites
P00042

T

S

N

E

P

K

R

K

G

G

A

A

E

T

V

L

F

F

R

K

A

T

-

R

C
|
C

A

L

V

Q

C
|
C

H

H

T

T

L

V

T

E

P

K

D

G

G

P

A

H

R

K

A

V

G

G

P

P

T

N

L

L

H

H

G

G

I

I

F

F

G

G

R

R

R

Q

I

S

A

G

T

K

A

A

E

E

G

G

Y

Y

Q

S

Y

Y

S

T

E

D

A

A

L

N

K

I

D

K

L
x
K

D

A

I

V

V

E

W

W

T

S

A

E

Q

Q

T

T

I

M

S

S

E

D

L

Y

F

L

E

E

Y

-

G

N

P

P

D
x
K

A
x
K

Y

Y

T

I

P

P

G

G

S

T

R

K

M

M

P

A

E

F

Q

G

R

G

V

L

P

K

S

K

A

E

A

K

D

D

R

R

Q

N

A

D

L

L

V

V

E

T

F

Y

L

L

E

A

M

N

V

A

T

T

R

K

C20 (= C314) binding covalent
C23 (= C317) binding covalent
K61 (≠ L355) modified: N6,N6-dimethyllysine; alternate; modified: N6-methyllysine; alternate
K78 (≠ D373) modified: N6,N6,N6-trimethyllysine
K79 (≠ A374) modified: N6,N6,N6-trimethyllysine

6suvAaA Cytochrome c
34% identity, 24% coverage: 306:403/404 of query aligns to 5:102/104 of 6suvAaA

query
sites
6suvAaA

R

K

G

G

A
x
K

E
x
K

V

I

F

F

-
x
V

R

Q

A

K

C
|
C

A

A

V

Q

C
|
C

H
|
H

T

T

L

V

T

E

P

K

D

G

G

K

A

H

R

K

A
x
T

G
|
G

P
|
P

T

N

L

L

H

H

G

G

I
x
L

F

F

G

G

R

R

R

K

I
x
T

A
x
G

T

Q

A

A

E

P

G

G

Y

F

Q

T

Y
|
Y

S
x
T

E

D

A

A

L
x
N

K

K

D

N

L

K

D

G

I

I

V

T

W
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W

T

K

A

E

Q

E

T

T

I

L

S

M

E

E

L
x
Y

F
x
L

E

E

Y

-

G

N

P

P

D
x
K

A
x
K

Y

Y

T

I

P
|
P

G

G

S
x
T

R
x
K

M
|
M

P

I

E
x
F

Q

A

R

G

V

I

P
x
K

S
x
K

A
x
K

A
x
T

D
x
E

R

R

Q

E

A

D

L

L

V

I

E

A

F

Y

L

L

E

K

M

K

V

A

T

T

binding heme c: C14 (= C314), C17 (= C317), H18 (= H318), T28 (≠ A328), G29 (= G329), P30 (= P330), L35 (≠ I335), T40 (≠ I340), G41 (≠ A341), Y48 (= Y348), T49 (≠ S349), N52 (≠ L352), W59 (= W359), Y67 (≠ L367), L68 (≠ F368), T78 (≠ S379), K79 (≠ R380), M80 (= M381), F82 (≠ E383)
binding octa-anionic calixarene: K7 (≠ A308), K8 (≠ E309), V11 (vs. gap), K72 (≠ D373), K73 (≠ A374), P76 (= P377), K86 (≠ P387), K87 (≠ S388), K88 (≠ A389), T89 (≠ A390), E90 (≠ D391)

Sites not aligning to the query:

binding octa-anionic calixarene: 4

4rszA The x-ray structure of the primary adduct formed in the reaction between cisplatin and cytochromE C (see paper)
34% identity, 24% coverage: 306:403/404 of query aligns to 5:102/104 of 4rszA

query
sites
4rszA

R

K

G

G

A

K

E

K

V

I

F

F

-

V

R

Q

A
x
K

C
|
C

A

A

V

Q

C
|
C

H
|
H

T

T

L

V

T

E

P

K

D

G

G

K

A

H

R

K

A

T

G
|
G

P
|
P

T

N

L

L

H

H

G

G

I

L

F

F

G

G

R

R

R

K

I

T

A

G

T

Q

A

A

E

P

G

G

Y

F

Q

T

Y
|
Y

S
x
T

E

D

A

A

L
x
N

K

K

D

N

L

K

D

G

I

I

V

T

W
|
W

T

K

A
x
E

Q

E

T

T

I

L

S
x
M

E

E

L
x
Y

F

L

E

E

Y

-

G

N

P

P

D

K

A

K

Y

Y

T

I

P

P

G

G

S
x
T

R
x
K

M
|
M

P
x
I

E

F

Q

A

R

G

V

I

P

K

S

K

A

K

A

T

D

E

R

R

Q
x
E

A

D

L

L

V

I

E

A

F

Y

L

L

E

K

M

K

V

A

T

T

binding Cisplatin: E61 (≠ A361), M65 (≠ S365), E92 (≠ Q393)
binding heme c: K13 (≠ A313), C14 (= C314), C17 (= C317), H18 (= H318), G29 (= G329), P30 (= P330), Y48 (= Y348), T49 (≠ S349), N52 (≠ L352), W59 (= W359), Y67 (≠ L367), T78 (≠ S379), K79 (≠ R380), M80 (= M381), I81 (≠ P382)

1wejF Igg1 fab fragment (of e8 antibody) complexed with horse cytochromE C at 1.8 a resolution (see paper)
34% identity, 24% coverage: 306:403/404 of query aligns to 5:102/104 of 1wejF

query
sites
1wejF

R

K

G

G

A

K

E

K

V

I

F

F

-

V

R

Q

A
x
K

C
|
C

A

A

V

Q

C
|
C

H
|
H

T

T

L

V

T

E

P

K

D

G

G

K

A

H

R

K

A

T

G
|
G

P
|
P

T

N

L

L

H

H

G

G

I

L

F

F

G

G

R

R

R

K

I

T

A
x
G

T

Q

A

A

E

P

G

G

Y

F

Q

T

Y
|
Y

S
x
T

E

D

A

A

L
x
N

K

K

D

N

L

K

D

G

I

I

V

T

W
|
W

T

K

A

E

Q

E

T

T

I

L

S

M

E

E

L
x
Y

F
x
L

E

E

Y

-

G

N

P

P

D

K

A

K

Y

Y

T

I

P

P

G

G

S
x
T

R
x
K

M
|
M

P

I

E
x
F

Q

A

R

G

V

I

P

K

S

K

A

K

A

T

D

E

R

R

Q

E

A

D

L

L

V

I

E

A

F

Y

L

L

E

K

M

K

V

A

T

T

binding protoporphyrin ix containing fe: K13 (≠ A313), C14 (= C314), C17 (= C317), H18 (= H318), G29 (= G329), P30 (= P330), G41 (≠ A341), Y48 (= Y348), T49 (≠ S349), N52 (≠ L352), W59 (= W359), Y67 (≠ L367), L68 (≠ F368), T78 (≠ S379), K79 (≠ R380), M80 (= M381), F82 (≠ E383)

1m60A Solution structure of zinc-substituted cytochromE C (see paper)
34% identity, 24% coverage: 306:403/404 of query aligns to 5:102/104 of 1m60A

query
sites
1m60A

R

K

G

G

A

K

E

K

V

I

F

F

-

V

R

Q

A
x
K

C
|
C

A

A

V

Q

C
|
C

H
|
H

T

T

L

V

T

E

P

K

D

G

G

K

A

H

R

K

A
x
T

G

G

P

P

T

N

L
|
L

H

H

G

G

I

L

F

F

G

G

R

R

R

K

I
x
T

A
x
G

T

Q

A

A

E

P

G

G

Y

F

Q

T

Y
|
Y

S
x
T

E

D

A

A

L
x
N

K

K

D

N

L

K

D

G

I

I

V

T

W
|
W

T

K

A

E

Q

E

T

T

I

L

S

M

E

E

L
x
Y

F
x
L

E

E

Y

-

G

N

P

P

D

K

A

K

Y

Y

T

I

P

P

G

G

S

T

R
x
K

M
|
M

P

I

E
x
F

Q

A

R

G

V

I

P

K

S

K

A

K

A

T

D

E

R

R

Q

E

A

D

L
|
L

V

I

E

A

F

Y

L

L

E

K

M

K

V

A

T

T

binding zinc substituted heme c: K13 (≠ A313), C14 (= C314), C17 (= C317), H18 (= H318), T28 (≠ A328), L32 (= L332), T40 (≠ I340), G41 (≠ A341), Y48 (= Y348), T49 (≠ S349), N52 (≠ L352), W59 (= W359), Y67 (≠ L367), L68 (≠ F368), K79 (≠ R380), M80 (= M381), F82 (≠ E383), L94 (= L395)

1fi7A Solution structure of the imidazole complex of cytochromE C (see paper)
34% identity, 24% coverage: 306:403/404 of query aligns to 5:102/104 of 1fi7A

query
sites
1fi7A

R

K

G

G

A

K

E

K

V

I

F

F

-

V

R

Q

A

K

C
|
C

A

A

V

Q

C
|
C

H
|
H

T

T

L

V

T

E

P

K

D

G

G

K

A

H

R

K

A
x
T

G
|
G

P
|
P

T

N

L
|
L

H

H

G

G

I

L

F

F

G

G

R

R

R

K

I

T

A

G

T

Q

A

A

E

P

G

G

Y

F

Q

T

Y

Y

S

T

E

D

A

A

L
x
N

K

K

D

N

L

K

D

G

I

I

V

T

W
|
W

T

K

A

E

Q

E

T

T

I
x
L

S

M

E

E

L
x
Y

F
x
L

E

E

Y

-

G

N

P

P

D

K

A

K

Y

Y

T

I

P

P

G

G

S

T

R
x
K

M

M

P

I

E

F

Q

A

R

G

V

I

P

K

S

K

A

K

A

T

D

E

R

R

Q

E

A

D

L

L

V

I

E

A

F

Y

L

L

E

K

M

K

V

A

T

T

binding heme c: C14 (= C314), C17 (= C317), H18 (= H318), T28 (≠ A328), G29 (= G329), P30 (= P330), L32 (= L332), N52 (≠ L352), W59 (= W359), L64 (≠ I364), L68 (≠ F368), K79 (≠ R380)
binding imidazole: Y67 (≠ L367), K79 (≠ R380)

1akkA Solution structure of oxidized horse heart cytochromE C, nmr, minimized average structure (see paper)
34% identity, 24% coverage: 306:403/404 of query aligns to 5:102/104 of 1akkA

query
sites
1akkA

R

K

G

G

A

K

E

K

V

I

F

F

-

V

R

Q

A

K

C
|
C

A

A

V

Q

C
|
C

H
|
H

T

T

L

V

T

E

P

K

D

G

G

K

A

H

R

K

A
x
T

G

G

P

P

T

N

L

L

H

H

G

G

I

L

F

F

G

G

R

R

R

K

I
x
T

A

G

T

Q

A

A

E

P

G

G

Y

F

Q

T

Y
|
Y

S
x
T

E

D

A

A

L
x
N

K

K

D

N

L

K

D

G

I

I

V

T

W
|
W

T

K

A

E

Q

E

T

T

I

L

S

M

E

E

L
x
Y

F

L

E

E

Y

-

G

N

P

P

D

K

A

K

Y

Y

T

I

P

P

G

G

S
x
T

R
x
K

M
|
M

P

I

E
x
F

Q

A

R

G

V

I

P

K

S

K

A

K

A

T

D

E

R

R

Q

E

A

D

L
|
L

V

I

E

A

F

Y

L

L

E

K

M

K

V

A

T

T

binding heme c: C14 (= C314), C17 (= C317), H18 (= H318), T28 (≠ A328), T40 (≠ I340), Y48 (= Y348), T49 (≠ S349), N52 (≠ L352), W59 (= W359), Y67 (≠ L367), T78 (≠ S379), K79 (≠ R380), M80 (= M381), F82 (≠ E383), L94 (= L395)

P00004 Cytochrome c from Equus caballus (Horse) (see 2 papers)
34% identity, 24% coverage: 306:403/404 of query aligns to 6:103/105 of P00004

query
sites
P00004

R

K

G

G

A

K

E

K

V

I

F

F

-

V

R

Q

A

K

C

C

A

A

V

Q

C

C

H
|
H

T

T

L

V

T

E

P

K

D

G

G

K

A

H

R

K

A

T

G

G

P

P

T

N

L

L

H

H

G

G

I

L

F

F

G

G

R

R

R

K

I

T

A

G

T

Q

A

A

E

P

G

G

Y

F

Q

T

Y

Y

S

T

E

D

A

A

L

N

K

K

D

N

L

K

D

G

I

I

V

T

W

W

T

K

A

E

Q

E

T

T

I

L

S

M

E

E

L

Y

F

L

E

E

Y

-

G

N

P

P

D

K

A

K

Y

Y

T

I

P

P

G

G

S

T

R

K

M

M

P

I

E

F

Q

A

R

G

V

I

P

K

S

K

A

K

A

T

D

E

R

R

Q

E

A

D

L

L

V

I

E

A

F

Y

L

L

E

K

M

K

V

A

T

T

H19 (= H318) binding axial binding residue

Sites not aligning to the query:

1 modified: Initiator methionine, Removed
2 modified: N-acetylglycine

P00017 Cytochrome c from Aptenodytes patagonicus (King penguin)
35% identity, 24% coverage: 306:403/404 of query aligns to 6:103/105 of P00017

query
sites
P00017

R

K

G

G

A

K

E

K

V

I

F

F

-

V

R

Q

A

K

C

C

A

S

V

Q

C

C

H

H

T

T

L

V

T

E

P

K

D

G

G

K

A

H

R

K

A

T

G

G

P

P

T

N

L

L

H

H

G

G

I

I

F

F

G

G

R

R

R

K

I

T

A

G

T

Q

A

A

E

E

G

G

Y

F

Q

S

Y

Y

S

T

E

D

A

A

L

N

K

K

D

N

L

K

D

G

I

I

V

T

W

W

T

G

A

E

Q

D

T

T

I

L

S

M

E

E

L

Y

F

L

E

E

Y

-

G

N

P

P

D

K

A

K

Y

Y

T

I

P

P

G

G

S

T

R

K

M

M

P

I

E

F

Q

A

R

G

V

I

P

K

S

K

A

K

A

S

D

E

R

R

Q

A

A

D

L

L

V

I

E

A

F

Y

L

L

E

K

M

D

V

A

T

T

Sites not aligning to the query:

1 modified: Initiator methionine, Removed
2 modified: N-acetylglycine

6ff5A X-ray structure of bovine heart cytochromE C at high ionic strength (see paper)
34% identity, 24% coverage: 306:403/404 of query aligns to 5:102/104 of 6ff5A

query
sites
6ff5A

R

K

G

G

A
x
K

E

K

V

I

F

F

-

V

R

Q

A
x
K

C
|
C

A

A

V

Q

C
|
C

H
|
H

T

T

L

V

T

E

P

K

D

G

G

K

A

H

R

K

A

T

G
|
G

P
|
P

T

N

L

L

H

H

G

G

I

L

F

F

G

G

R

R

R

K

I

T

A
x
G

T

Q

A

A

E

P

G

G

Y

F

Q

S

Y
|
Y

S
x
T

E

D

A

A

L
x
N

K

K

D

N

L

K

D

G

I

I

V

T

W
|
W

T

G

A

E

Q

E

T

T

I

L

S

M

E

E

L
x
Y

F

L

E
|
E

Y

-

G

N

P

P

D

K

A

K

Y

Y

T

I

P

P

G

G

S
x
T

R
x
K

M
|
M

P
x
I

E
x
F

Q

A

R

G

V

I

P
x
K

S
x
K

A

K

A

G

D
x
E

R

R

Q

E

A

D

L

L

V

I

E

A

F

Y

L

L

E

K

M
x
K

V

A

T

T

binding heme c: K13 (≠ A313), C14 (= C314), C17 (= C317), H18 (= H318), G29 (= G329), P30 (= P330), G41 (≠ A341), Y48 (= Y348), T49 (≠ S349), N52 (≠ L352), W59 (= W359), Y67 (≠ L367), T78 (≠ S379), K79 (≠ R380), M80 (= M381), I81 (≠ P382), F82 (≠ E383)
binding nitrate ion: E69 (= E369), K86 (≠ P387), K87 (≠ S388), E90 (≠ D391)
binding sulfate ion: K7 (≠ A308), K100 (≠ M401)

Sites not aligning to the query:

binding sulfate ion: 104

P62894 Cytochrome c from Bos taurus (Bovine) (see 3 papers)
34% identity, 24% coverage: 306:403/404 of query aligns to 6:103/105 of P62894

query
sites
P62894

R

K

G

G

A

K

E

K

V

I

F

F

-

V

R

Q

A

K

C

C

A

A

V

Q

C

C

H

H

T

T

L

V

T

E

P

K

D

G

G

K

A

H

R

K

A

T

G

G

P

P

T

N

L

L

H

H

G

G

I

L

F

F

G

G

R

R

R

K

I

T

A

G

T

Q

A

A

E

P

G

G

Y

F

Q

S

Y
|
Y

S

T

E

D

A

A

L

N

K

K

D

N

L

K

D

G

I

I

V

T

W

W

T

G

A

E

Q

E

T

T

I

L

S

M

E

E

L

Y

F

L

E

E

Y

-

G

N

P

P

D

K

A

K

Y

Y

T

I

P

P

G

G

S

T

R

K

M

M

P

I

E

F

Q

A

R

G

V

I

P

K

S

K

A

K

A

G

D

E

R

R

Q

E

A

D

L

L

V

I

E

A

F
x
Y

L

L

E

K

M

K

V

A

T

T

Y49 (= Y348) modified: Phosphotyrosine
Y98 (≠ F398) modified: Phosphotyrosine

Sites not aligning to the query:

1 modified: Initiator methionine, Removed
2 modified: N-acetylglycine

1lfmA Crystal structure of cobalt(iii)-substituted cytochromE C (tuna) (see paper)
38% identity, 24% coverage: 306:403/404 of query aligns to 5:102/103 of 1lfmA

query
sites
1lfmA

R

K

G

G

A

K

E

K

V

T

F

F

-

V

R

Q

A

K

C
|
C

A

A

V

Q

C
|
C

H
|
H

T

T

L

V

T

E

P

N

D

G

G

K

A

H

R

K

A
x
V

G
|
G

P
|
P

T

N

L

L

H

W

G

G

I

L

F

F

G

G

R

R

R

K

I

T

A
x
G

T

Q

A

A

E

E

G

G

Y

Y

Q

S

Y
|
Y

S
x
T

E

D

A

A

L
x
N

K

K

D

S

L

K

D

G

I

I

V

V

W
|
W

T

N

A

N

Q

D

T

T

I

L

S

M

E

E

L
x
Y

F

L

E

E

Y

-

G

N

P

P

D

K

A

K

Y

Y

T

I

P

P

G

G

S
x
T

R
x
K

M
|
M

P

I

E
x
F

Q

A

R

G

V

I

P

K

S

K

A

K

A

G

D

E

R

R

Q

Q

A

D

L

L

V

V

E

A

F

Y

L

L

E

K

M

S

V

A

T

T

binding protoporphyrin ix containing co: C14 (= C314), C17 (= C317), H18 (= H318), V28 (≠ A328), G29 (= G329), P30 (= P330), G41 (≠ A341), Y48 (= Y348), T49 (≠ S349), N52 (≠ L352), W59 (= W359), Y67 (≠ L367), T78 (≠ S379), K79 (≠ R380), M80 (= M381), F82 (≠ E383)

1i54A CytochromE C (tuna) 2fe:1zn mixed-metal porphyrins (see paper)
38% identity, 24% coverage: 306:403/404 of query aligns to 5:102/103 of 1i54A

query
sites
1i54A

R

K

G

G

A

K

E

K

V

T

F

F

-

V

R

Q

A

K

C
|
C

A

A

V

Q

C
|
C

H
|
H

T

T

L

V

T

E

P

N

D

G

G

K

A

H

R

K

A
x
V

G
|
G

P
|
P

T

N

L

L

H

W

G

G

I

L

F

F

G

G

R

R

R

K

I

T

A
x
G

T

Q

A

A

E

E

G

G

Y
|
Y

Q

S

Y
|
Y

S
x
T

E

D

A

A

L
x
N

K

K

D

S

L

K

D

G

I

I

V

V

W
|
W

T

N

A

N

Q

D

T

T

I

L

S

M

E

E

L
x
Y

F
x
L

E

E

Y

-

G

N

P

P

D

K

A

K

Y

Y

T

I

P

P

G

G

S
x
T

R
x
K

M
|
M

P

I

E
x
F

Q

A

R

G

V

I

P

K

S

K

A

K

A

G

D

E

R

R

Q

Q

A

D

L

L

V

V

E

A

F

Y

L

L

E

K

M

S

V

A

T

T

binding heme c: C14 (= C314), C17 (= C317), H18 (= H318), V28 (≠ A328), G29 (= G329), P30 (= P330), G41 (≠ A341), Y46 (= Y346), Y48 (= Y348), T49 (≠ S349), N52 (≠ L352), W59 (= W359), Y67 (≠ L367), L68 (≠ F368), T78 (≠ S379), K79 (≠ R380), M80 (= M381), F82 (≠ E383)
binding protoporphyrin ix containing zn: C14 (= C314), C17 (= C317), H18 (= H318), G29 (= G329), P30 (= P330), G41 (≠ A341), Y46 (= Y346), Y48 (= Y348), T49 (≠ S349), N52 (≠ L352), W59 (= W359), Y67 (≠ L367), L68 (≠ F368), T78 (≠ S379), K79 (≠ R380), M80 (= M381), F82 (≠ E383)

1criA The role of a conserved internal water molecule and its associated hydrogen bond network in cytochromE C (see paper)
36% identity, 24% coverage: 306:403/404 of query aligns to 10:107/108 of 1criA

query
sites
1criA

R

K

G

G

A

A

E

T

V

L

F

F

R

K

A

T

-
x
R

C
|
C

A

L

V

Q

C
|
C

H
|
H

T

T

L

V

T

E

P

K

D

G

G

P

A

H

R

K

A

V

G

G

P

P

T

N

L

L

H

H

G

G

I
|
I

F

F

G

G

R

R

R

H

I
x
S

A

G

T

Q

A

A

E

E

G

G

Y
|
Y

Q

S

Y
|
Y

S
x
T

E

D

A

A

L
x
I

K

I

D

K

L

K

D

N

I

V

V

L

W
|
W

T

D

A

E

Q

N

T

N

I
x
M

S

S

E

E

L

-

F

F

E

L

Y

T

G

N

P

P

D

K

A

K

Y

Y

T

I

P

P

G

G

S
x
T

R
x
K

M
|
M

P

A

E
x
F

Q

G

R

G

V

L

P

K

S

K

A

E

A

K

D

D

R

R

Q

N

A

D

L

L

V

I

E

T

F

Y

L

L

E

K

M

K

V

A

T

T

binding protoporphyrin ix containing fe: R18 (vs. gap), C19 (= C314), C22 (= C317), H23 (= H318), I40 (= I335), S45 (≠ I340), Y51 (= Y346), Y53 (= Y348), T54 (≠ S349), I57 (≠ L352), W64 (= W359), M69 (≠ I364), T83 (≠ S379), K84 (≠ R380), M85 (= M381), F87 (≠ E383)

Query Sequence

>3607087 FitnessBrowser__Dino:3607087
MRVASTLCAVALASAPVLAQDLRGHGGPVRALATDEAGRIYSGSFDTRAIVWDGFTAMQI
TRHHEGAVTAVVPLEGGRFASGGQDGRVVIWGDSPEPLQSEIWHPLPVGAMVALGDGLAS
AGWDGRIALWSGTGSPSYIEAHEGQITGLIGYRGGLASVGADLRLRLWNPDGTDAGQISL
PAAASALATDGAALFVASPDGILRKVTAITELDEATISSRGLLSVAASEGLVAVGAMTGD
VWLVDPDTLDVQVAIETGQGPIWALAISDGVLLTGGNDGLIRRWSLDGIALGEGSGPPDP
TLTNPRGAEVFRACAVCHTLTPDDGARAGPTLHGIFGRRIATAEGYQYSEALKDLDIVWT
AQTISELFEYGPDAYTPGSRMPEQRVPSAADRQALVEFLEMVTR

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory