SitesBLAST
Comparing 3607421 Dshi_0835 3-hydroxyacyl-CoA dehydrogenase NAD-binding (RefSeq) to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
4b3iA Crystal structure of mycobacterium tuberculosis fatty acid beta-oxidation complex with coenzymea bound at the hydratase active sites (see paper)
42% identity, 97% coverage: 4:715/737 of query aligns to 12:729/731 of 4b3iA
- active site: G79 (≠ M68), E100 (≠ M93), R104 (≠ G97), G127 (≠ I129), E130 (= E132), P151 (= P153), E152 (= E154), G160 (= G162), S452 (= S446), H473 (= H467), E485 (= E479), S523 (≠ N517)
- binding adenosine-5'-diphosphate: Q640 (= Q632), P641 (= P633), P642 (≠ E634), L643 (= L635), Q644 (≠ T636)
- binding coenzyme a: S37 (= S27), T38 (≠ M28), V40 (= V30), A77 (≠ G66), G79 (≠ M68), D80 (= D69), V81 (≠ L70), K82 (≠ N71), L125 (= L127), P151 (= P153), E152 (= E154), R186 (≠ L187), F315 (= F310), Q319 (≠ E314)
7o4uA Structure of the alpha subunit of mycobacterium tuberculosis beta- oxidation trifunctional enzyme in complex with oxidized nicotinamide adenine dinucleotide (see paper)
42% identity, 96% coverage: 12:715/737 of query aligns to 9:709/711 of 7o4uA
- binding nicotinamide-adenine-dinucleotide: G323 (= G337), A324 (= A338), G325 (= G339), M326 (= M340), M327 (= M341), K345 (≠ I359), D346 (= D360), V347 (≠ A361), A402 (= A416), V403 (= V417), F404 (= F418), E405 (= E419), N430 (= N444), S432 (= S446), H453 (= H467), S456 (= S470)
6yswA E. Coli anaerobic trifunctional enzyme subunit-alpha in complex with coenzyme a
36% identity, 98% coverage: 7:726/737 of query aligns to 4:703/707 of 6yswA
- active site: A66 (≠ M68), I71 (= I73), A84 (= A85), Q88 (≠ F89), G112 (≠ I129), E115 (= E132), P136 (= P153), E137 (= E154), G145 (= G162), D264 (≠ K287), S422 (= S446), H443 (= H467), E455 (= E479), N493 (= N517)
- binding coenzyme a: E23 (≠ K26), M25 (= M28), T27 (≠ V30), A64 (≠ G66), A66 (≠ M68), D67 (= D69), I68 (≠ L70), N69 (= N71), P136 (= P153), E137 (= E154), L140 (≠ V157), F286 (= F310), F287 (≠ I311), T290 (≠ E314), K293 (≠ E317)
P40939 Trifunctional enzyme subunit alpha, mitochondrial; 78 kDa gastrin-binding protein; Monolysocardiolipin acyltransferase; TP-alpha; EC 2.3.1.-; EC 4.2.1.17; EC 1.1.1.211 from Homo sapiens (Human) (see 5 papers)
33% identity, 96% coverage: 16:726/737 of query aligns to 49:762/763 of P40939
- V282 (≠ T248) to D: in MTPD; mild phenotype with slowly progressive myopathy and sensorimotor polyneuropathy; dbSNP:rs137852773
- I305 (≠ L271) to N: in MTPD; mild phenotype with slowly progressive myopathy and sensorimotor polyneuropathy; dbSNP:rs137852774
- L342 (= L309) to P: in LCHAD deficiency; dbSNP:rs137852772
- E510 (= E479) active site, For hydroxyacyl-coenzyme A dehydrogenase activity; to Q: in AFLP and LCHAD deficiency; loss of long-chain-3-hydroxyacyl-CoA dehydrogenase activity; dbSNP:rs137852769
1wdlA Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form ii (native4) (see paper)
35% identity, 97% coverage: 15:727/737 of query aligns to 16:715/715 of 1wdlA
- active site: A69 (≠ M68), N89 (≠ V92), N93 (≠ H96), G117 (≠ I129), E120 (= E132), P139 (= P153), E140 (= E154), P147 (= P161), G148 (= G162), S430 (= S446), H451 (= H467), E463 (= E479), N501 (= N517)
- binding nicotinamide-adenine-dinucleotide: G321 (= G337), A322 (= A338), I324 (≠ M340), M325 (= M341), D344 (= D360), I345 (≠ A361), A400 (= A416), V401 (= V417), V402 (≠ F418), E403 (= E419), K408 (= K424), V411 (= V427), N428 (= N444), T429 (= T445), S430 (= S446)
P28793 Fatty acid oxidation complex subunit alpha; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Pseudomonas fragi (see paper)
35% identity, 97% coverage: 15:727/737 of query aligns to 16:715/715 of P28793
1wdmA Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form i (native3) (see paper)
35% identity, 97% coverage: 15:727/737 of query aligns to 16:707/707 of 1wdmA