SitesBLAST
Comparing 3607424 FitnessBrowser__Dino:3607424 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
2pg0A Crystal structure of acyl-coa dehydrogenase from geobacillus kaustophilus
49% identity, 99% coverage: 3:382/382 of query aligns to 1:378/380 of 2pg0A
- active site: M124 (= M128), T125 (= T129), E243 (= E247), A364 (≠ G368), R376 (= R380)
- binding flavin-adenine dinucleotide: I122 (≠ L126), M124 (= M128), T125 (= T129), G130 (= G134), S131 (= S135), F155 (= F159), I156 (= I160), T157 (= T161), R269 (= R273), F272 (= F276), F279 (= F283), Q337 (= Q341), L338 (= L342), G340 (= G344), G341 (= G345), V359 (= V363), I362 (= I366), Y363 (= Y367), T366 (= T370), E368 (= E372), M369 (≠ I373)
P28330 Long-chain specific acyl-CoA dehydrogenase, mitochondrial; LCAD; EC 1.3.8.8 from Homo sapiens (Human) (see 2 papers)
49% identity, 98% coverage: 7:382/382 of query aligns to 53:426/430 of P28330
- E291 (= E247) active site, Proton acceptor; mutation to Q: Loss of long-chain-acyl-CoA dehydrogenase activity. No effect on protein abundance. No effect on solubility. No effect on substrate binding.
- S303 (≠ M259) to T: in dbSNP:rs1801204
- K333 (= K289) to Q: in dbSNP:rs2286963
P51174 Long-chain specific acyl-CoA dehydrogenase, mitochondrial; LCAD; EC 1.3.8.8 from Mus musculus (Mouse) (see paper)
49% identity, 98% coverage: 7:382/382 of query aligns to 53:426/430 of P51174
- K318 (≠ Q274) modified: N6-acetyllysine; mutation to R: Reduces activity by 37%; reduces activity by 80% when associated with R-322.
- K322 (≠ G278) modified: N6-acetyllysine; alternate; mutation to R: Reduces activity by 23%; reduces activity by 80% when associated with R-318.
Sites not aligning to the query:
- 42 modified: N6-acetyllysine; K→R: Reduces activity by 90% when associated with R-318 and R-322.
5lnxD Crystal structure of mmgc, an acyl-coa dehydrogenase from bacillus subtilis.
40% identity, 98% coverage: 10:382/382 of query aligns to 5:372/374 of 5lnxD
- active site: L122 (≠ M128), T123 (= T129), G239 (≠ E247), E358 (≠ G368), K370 (≠ R380)
- binding flavin-adenine dinucleotide: L122 (≠ M128), T123 (= T129), G128 (= G134), S129 (= S135), F153 (= F159), T155 (= T161), R265 (= R273), Q267 (≠ A275), F268 (= F276), I272 (= I280), N275 (≠ F283), I278 (≠ T286), Q331 (= Q341), I332 (≠ L342), G335 (= G345), Y357 (= Y367), T360 (= T370), E362 (= E372)
5ol2F The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
40% identity, 98% coverage: 8:382/382 of query aligns to 5:376/378 of 5ol2F
- active site: L124 (≠ M128), T125 (= T129), G241 (≠ E247), G374 (≠ R380)
- binding calcium ion: E29 (≠ R32), E33 (≠ Q36), R35 (≠ E38)
- binding coenzyme a persulfide: L238 (= L244), R242 (= R248), E362 (≠ G368), G363 (= G369)
- binding flavin-adenine dinucleotide: F122 (≠ L126), L124 (≠ M128), T125 (= T129), P127 (= P131), T131 (≠ S135), F155 (= F159), I156 (= I160), T157 (= T161), E198 (≠ L203), R267 (= R273), F270 (= F276), L274 (≠ I280), F277 (= F283), Q335 (= Q341), L336 (= L342), G338 (= G344), G339 (= G345), Y361 (= Y367), T364 (= T370), E366 (= E372)
8sgrA Isovaleryl-CoA dehydrogenase, mitochondrial (see paper)
36% identity, 98% coverage: 7:382/382 of query aligns to 12:388/393 of 8sgrA
- binding flavin-adenine dinucleotide: S135 (≠ T129), G140 (= G134), S141 (= S135), W165 (≠ F159), T167 (= T161), R279 (= R273), F282 (= F276), I286 (= I280), F289 (= F283), Q347 (= Q341), C348 (≠ L342), G351 (= G345), L369 (≠ V363), G375 (= G369), T376 (= T370), L382 (≠ E376)
1ivhA Structure of human isovaleryl-coa dehydrogenase at 2.6 angstroms resolution: structural basis for substrate specificity (see paper)
36% identity, 98% coverage: 7:382/382 of query aligns to 8:384/387 of 1ivhA
- active site: M130 (= M128), S131 (≠ T129), E249 (= E247), A370 (≠ G368), R382 (= R380)
- binding coenzyme a persulfide: S137 (= S135), S185 (≠ A181), R186 (≠ K182), V239 (≠ F237), Y240 (= Y238), M243 (= M241), E249 (= E247), R250 (= R248), G369 (≠ Y367), A370 (≠ G368), G371 (= G369), V375 (≠ I373)
- binding flavin-adenine dinucleotide: L128 (= L126), M130 (= M128), S131 (≠ T129), G136 (= G134), S137 (= S135), W161 (≠ F159), T163 (= T161), R275 (= R273), F278 (= F276), F285 (= F283), M288 (≠ T286), Q343 (= Q341), C344 (≠ L342), G347 (= G345), T372 (= T370), E374 (= E372)
4l1fA Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
40% identity, 98% coverage: 7:382/382 of query aligns to 5:377/380 of 4l1fA
- active site: L125 (≠ M128), T126 (= T129), G242 (≠ E247), E363 (≠ G368), R375 (= R380)
- binding coenzyme a persulfide: T132 (≠ S135), H179 (≠ K182), F232 (= F237), M236 (= M241), E237 (≠ T242), L239 (= L244), D240 (≠ P245), R243 (= R248), Y362 (= Y367), E363 (≠ G368), G364 (= G369), R375 (= R380)
- binding flavin-adenine dinucleotide: F123 (≠ L126), L125 (≠ M128), T126 (= T129), G131 (= G134), T132 (≠ S135), F156 (= F159), I157 (= I160), T158 (= T161), R268 (= R273), Q270 (≠ A275), F271 (= F276), I275 (= I280), F278 (= F283), L281 (≠ T286), Q336 (= Q341), I337 (≠ L342), G340 (= G345), I358 (≠ V363), Y362 (= Y367), T365 (= T370), Q367 (≠ E372)
- binding 1,3-propandiol: L5 (≠ M7), Q10 (≠ R12)
P26440 Isovaleryl-CoA dehydrogenase, mitochondrial; IVD; Butyryl-CoA dehydrogenase; EC 1.3.8.4; EC 1.3.8.1 from Homo sapiens (Human) (see 5 papers)
36% identity, 98% coverage: 7:382/382 of query aligns to 45:421/426 of P26440
- 165:174 (vs. 126:135, 80% identical) binding
- S174 (= S135) binding
- WIT 198:200 (≠ FIT 159:161) binding
- SR 222:223 (≠ AK 181:182) binding
- G250 (≠ A210) to A: in IVA; uncertain significance
- Y277 (= Y238) binding
- DLER 284:287 (≠ PQER 245:248) binding
- E286 (= E247) active site, Proton acceptor; mutation to D: Residual isovaleryl-CoA dehydrogenase activity.; mutation to G: Loss of isovaleryl-CoA dehydrogenase activity. Does not affect isovaleryl-CoA dehydrogenase activity; when associated with 407-E.; mutation to Q: Loss of isovaleryl-CoA dehydrogenase activity.
- A291 (= A252) to V: in IVA; uncertain significance; dbSNP:rs886042098
- R312 (= R273) binding
- Q323 (= Q284) binding
- I379 (≠ V340) to T: in IVA; uncertain significance
- QCFGG 380:384 (≠ QLHGG 341:345) binding
- R398 (≠ S359) to Q: in IVA; uncertain significance; dbSNP:rs1477527791
- Y403 (≠ Q364) to N: in IVA; uncertain significance
- A407 (≠ G368) mutation to E: Does not affect isovaleryl-CoA dehydrogenase activity; when associated with 286-D.
- AG 407:408 (≠ GG 368:369) binding
- TSE 409:411 (≠ TNE 370:372) binding
Sites not aligning to the query:
- 1:32 modified: transit peptide, Mitochondrion
3r7kA Crystal structure of a probable acyl coa dehydrogenase from mycobacterium abscessus atcc 19977 / dsm 44196 (see paper)
38% identity, 99% coverage: 6:382/382 of query aligns to 4:377/378 of 3r7kA
- active site: V126 (≠ M128), T127 (= T129), E242 (= E247), G363 (= G368), K375 (≠ R380)
- binding dihydroflavine-adenine dinucleotide: V126 (≠ M128), T127 (= T129), G132 (= G134), S133 (= S135), F157 (= F159), I158 (= I160), T159 (= T161), R268 (= R273), T270 (≠ A275), F271 (= F276), L275 (≠ I280), R278 (≠ F283), I281 (≠ T286), Q336 (= Q341), I337 (≠ L342), G340 (= G345), I358 (≠ V363), T365 (= T370), E367 (= E372)
4n5fA Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
36% identity, 98% coverage: 8:382/382 of query aligns to 7:378/378 of 4n5fA
- active site: L126 (≠ M128), T127 (= T129), G243 (≠ E247), E364 (≠ G368), R376 (= R380)
- binding dihydroflavine-adenine dinucleotide: L126 (≠ M128), T127 (= T129), G132 (= G134), S133 (= S135), F157 (= F159), T159 (= T161), T210 (= T213), Y363 (= Y367), T366 (= T370), E368 (= E372), M372 (≠ E376)
4iv6B X-ray crystal structure of an isovaleryl-coa dehydrogenase from mycobacterium smegmatis (see paper)
35% identity, 98% coverage: 7:382/382 of query aligns to 2:375/383 of 4iv6B
- active site: L121 (≠ M128), T122 (= T129), G240 (≠ E247), E361 (≠ G368), K373 (≠ R380)
- binding dihydroflavine-adenine dinucleotide: L121 (≠ M128), T122 (= T129), G126 (≠ A133), G127 (= G134), S128 (= S135), W152 (≠ F159), I153 (= I160), S154 (≠ T161), R266 (= R273), S268 (≠ A275), F269 (= F276), I273 (= I280), H276 (≠ F283), V279 (≠ T286), R334 (≠ Q341), V335 (≠ L342), G338 (= G345), L356 (≠ V363), G360 (≠ Y367), T363 (= T370), E365 (= E372), I366 (= I373)
7p9xA Structure of cyclohex-1-ene-1-carboxyl-coa dehydrogenase complexed with cyclohex-1-ene-1-carboxyl-coa (see paper)
39% identity, 98% coverage: 7:382/382 of query aligns to 2:375/378 of 7p9xA
- binding 1-monoenoyl-CoA: L82 (≠ G87), D89 (≠ S94), S129 (= S135), L131 (= L137), K176 (= K182), F229 (= F237), M233 (= M241), L236 (= L244), R240 (= R248), Y360 (= Y367), T361 (≠ G368), G362 (= G369), R373 (= R380)
- binding flavin-adenine dinucleotide: A122 (≠ M128), T123 (= T129), G128 (= G134), S129 (= S135), F153 (= F159), I154 (= I160), T155 (= T161), N206 (≠ T213), L356 (≠ V363), Y360 (= Y367), T363 (= T370), Q365 (≠ E372), I366 (= I373)
7p9aA Structure of cyclohex-1-ene-1-carboxyl-coa dehydrogenase complexed with cyclohex-1,5-diene-1-carboxyl-coa (see paper)
39% identity, 98% coverage: 7:382/382 of query aligns to 4:377/380 of 7p9aA
- binding 1,5 Dienoyl-CoA: S131 (= S135), L133 (= L137), K178 (= K182), F231 (= F237), M235 (= M241), L238 (= L244), N241 (≠ E247), R242 (= R248), Y362 (= Y367), T363 (≠ G368), G364 (= G369), R375 (= R380)
- binding flavin-adenine dinucleotide: L122 (= L126), A124 (≠ M128), T125 (= T129), G130 (= G134), S131 (= S135), F155 (= F159), I156 (= I160), T157 (= T161), K200 (= K205), N208 (≠ T213), L358 (≠ V363), T365 (= T370), Q367 (≠ E372), I368 (= I373)
6fahD Molecular basis of the flavin-based electron-bifurcating caffeyl-coa reductase reaction (see paper)
34% identity, 98% coverage: 6:378/382 of query aligns to 2:372/379 of 6fahD
- active site: L124 (≠ M128), T125 (= T129), G241 (≠ E247)
- binding flavin-adenine dinucleotide: F122 (≠ L126), L124 (≠ M128), T125 (= T129), R152 (≠ S156), F155 (= F159), T157 (= T161), E198 (≠ L203), R267 (= R273), Q269 (≠ A275), F270 (= F276), I274 (= I280), F277 (= F283), Q335 (= Q341), I336 (≠ L342), G339 (= G345), Y361 (= Y367), T364 (= T370), Q366 (≠ E372)
Sites not aligning to the query:
3owaC Crystal structure of acyl-coa dehydrogenase complexed with fad from bacillus anthracis
38% identity, 97% coverage: 7:378/382 of query aligns to 23:408/587 of 3owaC
- active site: L143 (≠ M128), T144 (= T129), G258 (≠ E247), E398 (≠ G368)
- binding flavin-adenine dinucleotide: Y141 (≠ L126), L143 (≠ M128), T144 (= T129), G149 (= G134), S150 (= S135), W176 (≠ F159), I177 (= I160), T178 (= T161), R284 (= R273), F287 (= F276), I291 (= I280), F294 (= F283), Q371 (= Q341), I372 (≠ L342), G375 (= G345), I393 (≠ V363), F397 (≠ Y367), T400 (= T370), E402 (= E372), I403 (= I373), L406 (≠ E376)
Sites not aligning to the query:
4m9aB Crystal structure of acyl-coa dehydrogenase from burkholderia thailandensis e264
37% identity, 98% coverage: 8:382/382 of query aligns to 5:376/376 of 4m9aB
- active site: L124 (≠ M128), T125 (= T129), G241 (≠ E247), E362 (≠ G368), R374 (= R380)
- binding dihydroflavine-adenine dinucleotide: F122 (≠ L126), T125 (= T129), G130 (= G134), S131 (= S135), F155 (= F159), T157 (= T161), T208 (= T213), Y361 (= Y367), T364 (= T370), E366 (= E372), M370 (≠ E376)
1bucA Three-dimensional structure of butyryl-coa dehydrogenase from megasphaera elsdenii (see paper)
38% identity, 98% coverage: 7:382/382 of query aligns to 5:381/383 of 1bucA
- active site: L128 (≠ M128), T129 (= T129), G246 (≠ E247), E367 (≠ G368), G379 (≠ R380)
- binding acetoacetyl-coenzyme a: L96 (≠ I96), F126 (≠ L126), G134 (= G134), T135 (≠ S135), T162 (= T161), N182 (≠ A181), H183 (≠ K182), F236 (= F237), M240 (= M241), M241 (≠ T242), L243 (= L244), D244 (≠ P245), T317 (≠ V318), Y366 (= Y367), E367 (≠ G368), G368 (= G369)
- binding flavin-adenine dinucleotide: F126 (≠ L126), L128 (≠ M128), T129 (= T129), G134 (= G134), T135 (≠ S135), F160 (= F159), T162 (= T161), Y366 (= Y367), T369 (= T370), E371 (= E372), M375 (≠ E376)
Q06319 Acyl-CoA dehydrogenase, short-chain specific; Butyryl-CoA dehydrogenase; BCAD; SCAD; EC 1.3.8.1 from Megasphaera elsdenii (see paper)
38% identity, 98% coverage: 7:382/382 of query aligns to 5:381/383 of Q06319
- E367 (≠ G368) active site, Proton acceptor; mutation to Q: Loss of activity.
1ukwB Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
35% identity, 98% coverage: 7:380/382 of query aligns to 5:374/379 of 1ukwB
- active site: L124 (≠ M128), S125 (≠ T129), T241 (≠ E247), E362 (≠ G368), R374 (= R380)
- binding cobalt (ii) ion: D145 (≠ N149), H146 (≠ G150)
- binding flavin-adenine dinucleotide: F122 (≠ L126), L124 (≠ M128), S125 (≠ T129), G130 (= G134), S131 (= S135), W155 (≠ F159), S157 (≠ T161), K200 (= K205), L357 (≠ V363), Y361 (= Y367), E362 (≠ G368), T364 (= T370), E366 (= E372), L370 (≠ E376)
Query Sequence
>3607424 FitnessBrowser__Dino:3607424
MSSTTWMTDEHRMLAEMTRNFITTEWAPHFERWRDQGEMDREIWQQAGELGLLCPSVPEA
YGGPGGDFGHEAAILIEIARANLSAWGAGHGIHSGIVAHYILAYGSEEQKQKWLPKMVSG
EMVGALAMTEPGAGSDLQGIKTRAVKDGNGYRLSGSKIFITNGQHANLIVVAAKTDPSAG
AKGVSLVVLETEGAEGFSRGRNLHKVGMHASDTSELFFDNVAIPPENLLGGEVGKGFYQM
MTQLPQERLIIAAGAVGAMEGAVERTVAYAKERQAFGGPILQFQNTRFKLAECQTKTTVA
RAFLNECMAEHLEGKLSVEKAAMAKYWITDTQGEVIDECVQLHGGYGYMAEYDIAQMWSD
ARVQRIYGGTNEIMKELIGRAL
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory