Comparing 3607557 FitnessBrowser__Dino:3607557 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 6 hits to proteins with known functional sites (download)
7rk5B Mannitol-2-dehydrogenase bound to nadh from aspergillus fumigatus
38% identity, 98% coverage: 5:491/499 of query aligns to 3:501/501 of 7rk5B
1m2wA Pseudomonas fluorescens mannitol 2-dehydrogenase ternary complex with NAD and d-mannitol (see paper)
43% identity, 85% coverage: 5:429/499 of query aligns to 1:429/492 of 1m2wA
1lj8A Crystal structure of mannitol dehydrogenase in complex with NAD (see paper)
43% identity, 85% coverage: 5:429/499 of query aligns to 1:429/492 of 1lj8A
4im7A Crystal structure of fructuronate reductase (ydfi) from e. Coli cft073 (efi target efi-506389) complexed with nadh and d-mannonate
41% identity, 82% coverage: 20:430/499 of query aligns to 10:419/483 of 4im7A
P09424 Mannitol-1-phosphate 5-dehydrogenase; EC 1.1.1.17 from Escherichia coli (strain K12) (see paper)
26% identity, 45% coverage: 152:374/499 of query aligns to 72:293/382 of P09424
Q4X1A4 Mannitol-1-phosphate 5-dehydrogenase; M1PDH; MPD; MPDH; EC 1.1.1.17 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see paper)
27% identity, 45% coverage: 152:374/499 of query aligns to 86:294/388 of Q4X1A4
>3607557 FitnessBrowser__Dino:3607557
MDQLISLSNATLGQLAIERPRYDRSRLTPGIVHIGVGNFHRAHQAWYLHRLMQAGQALDW
AIIGAGVRPYDAAMRDKLLAQDCLTTLIELAPDNVSAEVVGSMIDYLPIVDGNGPLIAQM
ADPAIRIVAMTVTESGYYIDPVTKGFDASHPDLVHDAAQPDRPRTAFGAIVAALRARRAA
GHGPFTCLSCDNLQGNGDILRQTVVSLARLTDPALADWIDTHASFPNSMVDCIAPATGPK
ELALAAQFGIRDVAVVTHEAFRQWVIEDEFCAGRPNWDAVGATFSDDVHAYETMKIRILN
AGHQVLANAGENLGIETISGCMAHPGIAAFFGKVQREEIAPTVAPVPGKTPASYVNLIET
RFANPRIVDTTRRVAFDGSARHPGFVLPIVRDQLAAGRSVEGLALVEALWARMCAGVRED
GTEIAPNDPLWDRLAPVARAARTDPALWLGQTGLYGDLKQSEPFADAFCAWLVLIWDKGC
EAALRRYITGTERHTATAS
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory