SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing 3607785 FitnessBrowser__Dino:3607785 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 1 hits to proteins with known functional sites (download)

8b01B Cryo-em structure of the tripartite atp-independent periplasmic (trap) transporter siaqm from photobacterium profundum in a nanodisc (see paper)
24% identity, 24% coverage: 299:480/743 of query aligns to 60:259/427 of 8b01B

query
sites
8b01B

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binding sodium ion: S103 (≠ G342), S106 (≠ N345), G107 (= G346), G145 (= G384), V148 (≠ M387), P149 (= P388), P150 (= P389)

Sites not aligning to the query:

binding sodium ion: 325, 326, 366, 367, 369, 372, 373

Query Sequence

>3607785 FitnessBrowser__Dino:3607785
MTDQTKTADDHLIAEGVDEEPTESNRRLFEGRNFILISTFAALYAAFHMAALNGLSISEW
TGIEVPFLPTFPMETWNFRIVHIAGALALGFLLFAARTDFPGPGKETPLLGYVAYGLMVP
ALFSLGMAASFSMEIASGVMWNGIDEGIKFNETWLFGLPLIVATAGGIVLSWFHKRARSG
FSAPDLVLAICGVAVATYLITIYGTLMRNSTGTPFAPIGISIAAVAGTALIMELTRRVAG
MALIVIAGIFLAYVFVGQYLPGFLNAPAVTWQRFFSQVYTDAGILGPTTAVSSTYIILFI
IFAAFLQASKVGDYFVNFAFAAAGQSRGGPAKVAIFASGLMGMINGTSAGNVVATGSLTI
PLMKKVGYHKKTAGAVEAAASTGGQIMPPIMGAGAFIMAEITGIPYTEIALAAIIPAILY
FVSVYFMVDLEAAKLGMRGMSRDELPKFNKMVRQVYLFLPIIILIYALFMGYSVIRAGTL
ATVAAAVVSWFTPFRMGPRSIAKAFEIAGTMSVQIIAVCACAGIIVGVISLTGVGARFSA
VLLGIADTSQLLALFFAMCIAILLGMGMPTTAAYAVAASVVAPGLVQLGIPLLTAHFFVF
YFAVLSAITPPVALASYAAAGISGANPMETSVTSFKIGIAAFIVPFMFFYNSAILMDGTW
FEVLRAGATAVVGVFFLSSGVQGWFMGGRAAWFLRVGLVFAALMLIEGGIMSDLIGVGTA
VAIFLIQKLAAPKGGAIPVRGAD

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory