Comparing 3608019 FitnessBrowser__Dino:3608019 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 8 hits to proteins with known functional sites (download)
6msnA Crystal structure of cytosolic fumarate hydratase from leishmania major in a complex with inhibitor thiomalate (see paper)
31% identity, 86% coverage: 54:488/504 of query aligns to 91:527/532 of 6msnA
6unzA Crystal structure of cytosolic fumarate hydratase from leishmania major (see paper)
31% identity, 86% coverage: 54:488/504 of query aligns to 98:534/539 of 6unzA
6uqnB Crystal structure of r173a variant of cytosolic fumarate hydratase from leishmania major in a complex with fumarate and s-malate (see paper)
31% identity, 86% coverage: 54:488/504 of query aligns to 91:527/532 of 6uqnB
6uoiA Crystal structure of cytosolic fumarate hydratase from leishmania major in a complex with malonate (see paper)
31% identity, 86% coverage: 54:488/504 of query aligns to 93:530/535 of 6uoiA
6msoA Crystal structure of mitochondrial fumarate hydratase from leishmania major in a complex with inhibitor thiomalate (see paper)
30% identity, 89% coverage: 42:489/504 of query aligns to 78:538/540 of 6msoA
E9AE57 Fumarate hydratase 2; Fumarase 2; LmFH-2; EC 4.2.1.2 from Leishmania major (see paper)
32% identity, 86% coverage: 54:488/504 of query aligns to 118:563/568 of E9AE57
Q4QAU9 Fumarate hydratase 1, mitochondrial; Fumarase 1; LmFH-1; EC 4.2.1.2 from Leishmania major (see paper)
30% identity, 89% coverage: 42:489/504 of query aligns to 87:547/549 of Q4QAU9
P14407 Fumarate hydratase class I, anaerobic; D-tartrate dehydratase; Fumarase B; EC 4.2.1.2; EC 4.2.1.81 from Escherichia coli (strain K12) (see paper)
30% identity, 89% coverage: 42:489/504 of query aligns to 78:536/548 of P14407
>3608019 FitnessBrowser__Dino:3608019
MTQATVLKPDDIVETVRAALQYIAVYHAPDYLAHLASAYAREQSPAAKAAMGQILESSRL
AALGRRPICQDTGMVTVFARLGQSAMIAGDRTLYELVNEGVRLAYLDAGNPLRASMVADP
LLERRNTGDNTPAVTHVELTRGNKLELLIAAKGGGSENKARYTMLNPAASVEDWVVSTIE
GLGAGWCPPGLVGVGVGGSAEQAMLIAKRAVMEEIDMSDLLARGASTPLEEMRVRLYHRI
NALGIGAQGLGGLTTVVDVKLATAPTHAASKPVALVPQCAANRHAKVVMDGSGPAYLDAP
DLAAWPRIEGSEMAGLRRVNVDRLTREEMAGWAPGETLLLSGRILTGRDAAHKRMADMLA
RGEELPVSLRGRVIYYVGPVDPVDGEAVGPAGPTTATRMDPFTSDMLGQGLFAMIGKAER
GAETVRDIARHKAAYLIAVGGAAVLVAKAIRSSKVLAFEDLGMEAIREFTVEDMPVMVAV
TTQGAAIHQTGPAAWRGAQQSAPA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory