SitesBLAST
Comparing 3608378 FitnessBrowser__Dino:3608378 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
44% identity, 96% coverage: 5:567/585 of query aligns to 8:574/596 of 1t9dA
- active site: Y29 (= Y26), G31 (= G28), G32 (= G29), A33 (= A30), I34 (≠ V31), E55 (= E52), T78 (= T75), F117 (= F114), Q118 (= Q115), E119 (= E116), K167 (= K164), R227 (≠ Q225), M263 (= M261), V290 (≠ I288), V406 (= V398), L431 (= L423), G432 (= G424), M434 (= M426), D459 (≠ E451), N486 (= N478), E488 (≠ R480), Q489 (≠ L481), M491 (= M483), V492 (= V484), W495 (= W487), L517 (= L510), G522 (= G515), L523 (≠ A516), K556 (= K549)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G29), A33 (= A30), V107 (= V104), P108 (= P105), F117 (= F114), K167 (= K164), M263 (= M261), D288 (= D286), R289 (= R287), W495 (= W487)
- binding flavin-adenine dinucleotide: R157 (= R154), G216 (= G213), A217 (≠ G214), G218 (= G215), N221 (= N218), T243 (= T241), L244 (= L242), Q245 (≠ M243), M260 (= M258), L261 (= L259), H264 (= H262), G283 (= G281), A284 (= A282), R285 (= R283), D287 (= D285), R289 (= R287), V290 (≠ I288), E316 (≠ D305), V317 (≠ I306), N321 (≠ S310), G334 (= G323), D335 (= D324), A336 (≠ I325), Q410 (= Q402), M411 (= M403), G429 (= G421), G430 (= G422)
- binding magnesium ion: D459 (≠ E451), N486 (= N478), E488 (≠ R480)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E52), P81 (= P78), Q118 (= Q115), G432 (= G424), M434 (= M426), M464 (= M456)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
44% identity, 96% coverage: 5:567/585 of query aligns to 8:574/596 of 1t9cA
- active site: Y29 (= Y26), G31 (= G28), G32 (= G29), A33 (= A30), I34 (≠ V31), E55 (= E52), T78 (= T75), F117 (= F114), Q118 (= Q115), E119 (= E116), K167 (= K164), R227 (≠ Q225), M263 (= M261), V290 (≠ I288), V406 (= V398), L431 (= L423), G432 (= G424), M434 (= M426), D459 (≠ E451), N486 (= N478), E488 (≠ R480), Q489 (≠ L481), M491 (= M483), V492 (= V484), W495 (= W487), L517 (= L510), G522 (= G515), L523 (≠ A516), K556 (= K549)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G29), V107 (= V104), P108 (= P105), F117 (= F114), K167 (= K164), D288 (= D286), R289 (= R287), W495 (= W487)
- binding flavin-adenine dinucleotide: R157 (= R154), G216 (= G213), A217 (≠ G214), G218 (= G215), N221 (= N218), T243 (= T241), L244 (= L242), Q245 (≠ M243), L261 (= L259), M263 (= M261), H264 (= H262), G283 (= G281), A284 (= A282), R285 (= R283), D287 (= D285), R289 (= R287), V290 (≠ I288), E316 (≠ D305), V317 (≠ I306), N321 (≠ S310), G334 (= G323), D335 (= D324), A336 (≠ I325), M411 (= M403), G429 (= G421), G430 (= G422)
- binding magnesium ion: D459 (≠ E451), N486 (= N478), E488 (≠ R480)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
44% identity, 96% coverage: 5:567/585 of query aligns to 9:575/597 of 1t9aA
- active site: Y30 (= Y26), G32 (= G28), G33 (= G29), A34 (= A30), I35 (≠ V31), E56 (= E52), T79 (= T75), F118 (= F114), Q119 (= Q115), E120 (= E116), K168 (= K164), R228 (≠ Q225), M264 (= M261), V291 (≠ I288), V407 (= V398), L432 (= L423), G433 (= G424), M435 (= M426), D460 (≠ E451), N487 (= N478), E489 (≠ R480), Q490 (≠ L481), M492 (= M483), V493 (= V484), W496 (= W487), L518 (= L510), G523 (= G515), L524 (≠ A516), K557 (= K549)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (= G29), V108 (= V104), P109 (= P105), F118 (= F114), K168 (= K164), M264 (= M261), D289 (= D286), R290 (= R287), M492 (= M483), V493 (= V484), W496 (= W487)
- binding flavin-adenine dinucleotide: R158 (= R154), G217 (= G213), A218 (≠ G214), G219 (= G215), N222 (= N218), T244 (= T241), L245 (= L242), Q246 (≠ M243), L262 (= L259), M264 (= M261), H265 (= H262), G284 (= G281), A285 (= A282), R286 (= R283), D288 (= D285), R290 (= R287), V291 (≠ I288), E317 (≠ D305), V318 (≠ I306), N322 (≠ S310), G335 (= G323), D336 (= D324), A337 (≠ I325), Q411 (= Q402), M412 (= M403), G430 (= G421), G431 (= G422)
- binding magnesium ion: D460 (≠ E451), N487 (= N478), E489 (≠ R480)
- binding propyl trihydrogen diphosphate: V407 (= V398), G408 (= G399), Q409 (= Q400), H410 (= H401), M435 (= M426), G459 (= G450), D460 (≠ E451), A461 (= A452), S462 (= S453), N487 (= N478), E489 (≠ R480), Q490 (≠ L481), G491 (= G482), M492 (= M483)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G424), M435 (= M426), M465 (= M456)
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
44% identity, 96% coverage: 5:567/585 of query aligns to 12:585/607 of 6u9dB
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), I38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), M274 (= M261), V301 (≠ I288), V417 (= V398), G443 (= G424), M445 (= M426), D470 (≠ E451), N497 (= N478), E499 (≠ R480), Q500 (≠ L481), M502 (= M483), V503 (= V484), W506 (= W487)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (= G29), V111 (= V104), P112 (= P105), F121 (= F114), K171 (= K164), D299 (= D286), R300 (= R287), M502 (= M483), W506 (= W487)
- binding flavin-adenine dinucleotide: R161 (= R154), A228 (≠ G214), G229 (= G215), N232 (= N218), T254 (= T241), L255 (= L242), Q256 (≠ M243), L272 (= L259), M274 (= M261), G294 (= G281), R296 (= R283), D298 (= D285), R300 (= R287), V301 (≠ I288), E327 (≠ D305), V328 (≠ I306), N332 (≠ S310), D346 (= D324), A347 (≠ I325), M422 (= M403), G440 (= G421), G441 (= G422)
- binding magnesium ion: D470 (≠ E451), N497 (= N478)
- binding thiamine diphosphate: E59 (= E52), P85 (= P78), V417 (= V398), G418 (= G399), Q419 (= Q400), H420 (= H401), G443 (= G424), M445 (= M426), A471 (= A452), S472 (= S453), N497 (= N478), E499 (≠ R480), Q500 (≠ L481), G501 (= G482), M502 (= M483), V503 (= V484)
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
45% identity, 96% coverage: 5:567/585 of query aligns to 10:577/599 of 1n0hA
- active site: Y31 (= Y26), G33 (= G28), G34 (= G29), A35 (= A30), I36 (≠ V31), E57 (= E52), T80 (= T75), F119 (= F114), Q120 (= Q115), E121 (= E116), K169 (= K164), R230 (≠ Q225), M266 (= M261), V293 (≠ I288), V409 (= V398), L434 (= L423), G435 (= G424), M437 (= M426), D462 (≠ E451), N489 (= N478), E491 (≠ R480), Q492 (≠ L481), M494 (= M483), V495 (= V484), W498 (= W487), L520 (= L510), G525 (= G515), L526 (≠ A516), K559 (= K549)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (= V398), G410 (= G399), Q411 (= Q400), H412 (= H401), G435 (= G424), M437 (= M426), G461 (= G450), D462 (≠ E451), A463 (= A452), S464 (= S453), M467 (= M456), N489 (= N478), E491 (≠ R480), Q492 (≠ L481), G493 (= G482), V495 (= V484)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (= G29), A35 (= A30), V109 (= V104), P110 (= P105), F119 (= F114), K169 (= K164), M266 (= M261), D291 (= D286), R292 (= R287), V495 (= V484), W498 (= W487)
- binding flavin-adenine dinucleotide: R159 (= R154), G219 (= G213), A220 (≠ G214), G221 (= G215), N224 (= N218), T246 (= T241), L247 (= L242), Q248 (≠ M243), L264 (= L259), G265 (= G260), M266 (= M261), H267 (= H262), G286 (= G281), A287 (= A282), R288 (= R283), D290 (= D285), R292 (= R287), V293 (≠ I288), E319 (≠ D305), V320 (≠ I306), N324 (≠ S310), G337 (= G323), D338 (= D324), A339 (≠ I325), M414 (= M403), G432 (= G421), G433 (= G422)
- binding magnesium ion: D462 (≠ E451), N489 (= N478), E491 (≠ R480)
- binding thiamine diphosphate: Y31 (= Y26), E57 (= E52), P83 (= P78)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
45% identity, 96% coverage: 5:567/585 of query aligns to 8:573/595 of 1t9bB
- active site: Y29 (= Y26), G31 (= G28), G32 (= G29), A33 (= A30), I34 (≠ V31), E55 (= E52), T78 (= T75), F117 (= F114), Q118 (= Q115), E119 (= E116), K167 (= K164), R226 (≠ Q225), M262 (= M261), V289 (≠ I288), V405 (= V398), L430 (= L423), G431 (= G424), M433 (= M426), D458 (≠ E451), N485 (= N478), E487 (≠ R480), Q488 (≠ L481), M490 (= M483), V491 (= V484), W494 (= W487), L516 (= L510), G521 (= G515), L522 (≠ A516), K555 (= K549)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V104), P108 (= P105), D287 (= D286), R288 (= R287), M490 (= M483), W494 (= W487)
- binding flavin-adenine dinucleotide: R157 (= R154), G215 (= G213), A216 (≠ G214), G217 (= G215), N220 (= N218), T242 (= T241), L243 (= L242), Q244 (≠ M243), M259 (= M258), L260 (= L259), M262 (= M261), H263 (= H262), G282 (= G281), A283 (= A282), R284 (= R283), D286 (= D285), R288 (= R287), V289 (≠ I288), E315 (≠ D305), V316 (≠ I306), N320 (≠ S310), G333 (= G323), D334 (= D324), A335 (≠ I325), Q409 (= Q402), M410 (= M403), G428 (= G421), G429 (= G422)
- binding magnesium ion: D458 (≠ E451), N485 (= N478), E487 (≠ R480)
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
44% identity, 96% coverage: 5:567/585 of query aligns to 92:665/687 of P07342
- R241 (= R154) binding
- 355:376 (vs. 262:283, 50% identical) binding
- 407:426 (vs. 305:324, 40% identical) binding
6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone (see paper)
43% identity, 97% coverage: 5:574/585 of query aligns to 12:583/598 of 6desA
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), I38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), K229 (≠ Q225), M265 (= M261), V292 (≠ I288), V408 (= V398), L433 (= L423), G434 (= G424), M436 (= M426), D461 (≠ E451), N488 (= N478), E490 (≠ R480), Q491 (≠ L481), M493 (= M483), V494 (= V484), W497 (= W487), L519 (= L510), N524 (≠ G515), V525 (≠ A516)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: M265 (= M261), D290 (= D286), R291 (= R287), W497 (= W487)
- binding flavin-adenine dinucleotide: R161 (= R154), G218 (= G213), A219 (≠ G214), G220 (= G215), N223 (= N218), T245 (= T241), L246 (= L242), Q247 (≠ M243), L263 (= L259), G285 (= G281), A286 (= A282), R287 (= R283), D289 (= D285), R291 (= R287), V292 (≠ I288), E318 (≠ D305), I319 (= I306), N323 (≠ S310), D337 (= D324), V338 (≠ I325), Q412 (= Q402), M413 (= M403), G431 (= G421)
- binding magnesium ion: D461 (≠ E451), N488 (= N478), E490 (≠ R480)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V398), G409 (= G399), Q410 (= Q400), H411 (= H401), G434 (= G424), M436 (= M426), G460 (= G450), D461 (≠ E451), A462 (= A452), S463 (= S453), N488 (= N478), E490 (≠ R480), Q491 (≠ L481), G492 (= G482), M493 (= M483), V494 (= V484)
6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl (see paper)
43% identity, 97% coverage: 5:574/585 of query aligns to 12:583/598 of 6depA
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), I38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), K229 (≠ Q225), M265 (= M261), V292 (≠ I288), V408 (= V398), L433 (= L423), G434 (= G424), M436 (= M426), D461 (≠ E451), N488 (= N478), E490 (≠ R480), Q491 (≠ L481), M493 (= M483), V494 (= V484), W497 (= W487), L519 (= L510), N524 (≠ G515), V525 (≠ A516)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D290 (= D286), R291 (= R287), M493 (= M483), W497 (= W487)
- binding flavin-adenine dinucleotide: R161 (= R154), G218 (= G213), A219 (≠ G214), G220 (= G215), N223 (= N218), T245 (= T241), L246 (= L242), Q247 (≠ M243), L263 (= L259), G264 (= G260), G285 (= G281), A286 (= A282), R287 (= R283), D289 (= D285), R291 (= R287), V292 (≠ I288), E318 (≠ D305), I319 (= I306), N323 (≠ S310), D337 (= D324), V338 (≠ I325), M413 (= M403), G431 (= G421)
- binding magnesium ion: D461 (≠ E451), N488 (= N478), E490 (≠ R480)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V408 (= V398), G409 (= G399), Q410 (= Q400), H411 (= H401), G434 (= G424), M436 (= M426), G460 (= G450), D461 (≠ E451), A462 (= A452), S463 (= S453), M466 (= M456), N488 (= N478), E490 (≠ R480), Q491 (≠ L481), G492 (= G482), M493 (= M483), V494 (= V484)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V398), G409 (= G399), Q410 (= Q400), H411 (= H401), G434 (= G424), M436 (= M426), G460 (= G450), D461 (≠ E451), A462 (= A452), S463 (= S453), M466 (= M456), N488 (= N478), E490 (≠ R480), Q491 (≠ L481), G492 (= G482), M493 (= M483), V494 (= V484)
6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam (see paper)
43% identity, 97% coverage: 5:574/585 of query aligns to 14:585/600 of 6derA
- active site: Y35 (= Y26), G37 (= G28), G38 (= G29), A39 (= A30), I40 (≠ V31), E61 (= E52), T84 (= T75), F123 (= F114), Q124 (= Q115), E125 (= E116), K173 (= K164), K231 (≠ Q225), M267 (= M261), V294 (≠ I288), V410 (= V398), L435 (= L423), G436 (= G424), M438 (= M426), D463 (≠ E451), N490 (= N478), E492 (≠ R480), Q493 (≠ L481), M495 (= M483), V496 (= V484), W499 (= W487), L521 (= L510), N526 (≠ G515), V527 (≠ A516)
- binding flavin-adenine dinucleotide: R163 (= R154), G220 (= G213), A221 (≠ G214), G222 (= G215), N225 (= N218), T247 (= T241), L248 (= L242), Q249 (≠ M243), L265 (= L259), H268 (= H262), G287 (= G281), A288 (= A282), R289 (= R283), D291 (= D285), R293 (= R287), V294 (≠ I288), E320 (≠ D305), I321 (= I306), N325 (≠ S310), G338 (= G323), D339 (= D324), V340 (≠ I325), Q414 (= Q402), M415 (= M403), G433 (= G421)
- binding Metosulam: R293 (= R287), M495 (= M483), W499 (= W487), A570 (≠ S559)
- binding magnesium ion: D463 (≠ E451), N490 (= N478), E492 (≠ R480)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V410 (= V398), G411 (= G399), Q412 (= Q400), H413 (= H401), G436 (= G424), M438 (= M426), G462 (= G450), D463 (≠ E451), A464 (= A452), S465 (= S453), N490 (= N478), E492 (≠ R480), Q493 (≠ L481), G494 (= G482), M495 (= M483), V496 (= V484)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V410 (= V398), G411 (= G399), Q412 (= Q400), H413 (= H401), G436 (= G424), M438 (= M426), G462 (= G450), D463 (≠ E451), A464 (= A452), S465 (= S453), M468 (= M456), N490 (= N478), E492 (≠ R480), Q493 (≠ L481), G494 (= G482), V496 (= V484)
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
44% identity, 96% coverage: 5:567/585 of query aligns to 8:569/591 of 5wkcA
- active site: Y29 (= Y26), G31 (= G28), G32 (= G29), A33 (= A30), I34 (≠ V31), E55 (= E52), T78 (= T75), F117 (= F114), Q118 (= Q115), E119 (= E116), K167 (= K164), R222 (≠ Q225), M258 (= M261), V285 (≠ I288), V401 (= V398), L426 (= L423), G427 (= G424), M429 (= M426), D454 (≠ E451), N481 (= N478), E483 (≠ R480), Q484 (≠ L481), M486 (= M483), V487 (= V484), W490 (= W487), L512 (= L510), G517 (= G515), L518 (≠ A516), K551 (= K549)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (= V398), G402 (= G399), Q403 (= Q400), H404 (= H401), G427 (= G424), M429 (= M426), G453 (= G450), D454 (≠ E451), A455 (= A452), S456 (= S453), M459 (= M456), N481 (= N478), E483 (≠ R480), Q484 (≠ L481), G485 (= G482), M486 (= M483), V487 (= V484)
- binding ethaneperoxoic acid: G32 (= G29), Q118 (= Q115)
- binding flavin-adenine dinucleotide: R157 (= R154), G211 (= G213), A212 (≠ G214), G213 (= G215), N216 (= N218), T238 (= T241), L239 (= L242), Q240 (≠ M243), L256 (= L259), M258 (= M261), G278 (= G281), A279 (= A282), R280 (= R283), R284 (= R287), V285 (≠ I288), E311 (≠ D305), V312 (≠ I306), N316 (≠ S310), D330 (= D324), A331 (≠ I325), M406 (= M403), G424 (= G421)
- binding magnesium ion: D454 (≠ E451), N481 (= N478), E483 (≠ R480)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (= G29), A33 (= A30), V107 (= V104), F117 (= F114), K167 (= K164), M258 (= M261), R284 (= R287), M486 (= M483), W490 (= W487)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (= P27), E55 (= E52)
6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
43% identity, 97% coverage: 5:574/585 of query aligns to 12:582/597 of 6demA
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), I38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), K228 (≠ Q225), M264 (= M261), V291 (≠ I288), V407 (= V398), L432 (= L423), G433 (= G424), M435 (= M426), D460 (≠ E451), N487 (= N478), E489 (≠ R480), Q490 (≠ L481), M492 (= M483), V493 (= V484), W496 (= W487), L518 (= L510), N523 (≠ G515), V524 (≠ A516)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (= M261), D289 (= D286), R290 (= R287), M492 (= M483), W496 (= W487), A567 (≠ S559)
- binding flavin-adenine dinucleotide: R161 (= R154), G217 (= G213), A218 (≠ G214), G219 (= G215), N222 (= N218), T244 (= T241), L245 (= L242), Q246 (≠ M243), L262 (= L259), G284 (= G281), A285 (= A282), R286 (= R283), D288 (= D285), R290 (= R287), V291 (≠ I288), E317 (≠ D305), I318 (= I306), N322 (≠ S310), D336 (= D324), V337 (≠ I325), M412 (= M403), G430 (= G421)
- binding magnesium ion: D460 (≠ E451), N487 (= N478), E489 (≠ R480)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V398), G408 (= G399), Q409 (= Q400), H410 (= H401), M435 (= M426), G459 (= G450), D460 (≠ E451), A461 (= A452), S462 (= S453), M465 (= M456), N487 (= N478), E489 (≠ R480), Q490 (≠ L481), G491 (= G482), M492 (= M483), V493 (= V484)
6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
43% identity, 97% coverage: 5:574/585 of query aligns to 12:582/597 of 6delA
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), I38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), K228 (≠ Q225), M264 (= M261), V291 (≠ I288), V407 (= V398), L432 (= L423), G433 (= G424), M435 (= M426), D460 (≠ E451), N487 (= N478), E489 (≠ R480), Q490 (≠ L481), M492 (= M483), V493 (= V484), W496 (= W487), L518 (= L510), N523 (≠ G515), V524 (≠ A516)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (= D286), R290 (= R287), W496 (= W487)
- binding flavin-adenine dinucleotide: R161 (= R154), G217 (= G213), A218 (≠ G214), G219 (= G215), N222 (= N218), T244 (= T241), L245 (= L242), Q246 (≠ M243), L262 (= L259), G284 (= G281), A285 (= A282), R286 (= R283), D288 (= D285), R290 (= R287), V291 (≠ I288), E317 (≠ D305), I318 (= I306), N322 (≠ S310), D336 (= D324), V337 (≠ I325), M412 (= M403), G430 (= G421)
- binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (= V398), G408 (= G399), Q409 (= Q400), H410 (= H401), G433 (= G424), M435 (= M426), G459 (= G450), D460 (≠ E451), A461 (= A452), S462 (= S453), M465 (= M456), N487 (= N478), E489 (≠ R480), Q490 (≠ L481), G491 (= G482), M492 (= M483), V493 (= V484)
- binding magnesium ion: D460 (≠ E451), N487 (= N478), E489 (≠ R480)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V398), G408 (= G399), Q409 (= Q400), H410 (= H401), G433 (= G424), M435 (= M426), G459 (= G450), D460 (≠ E451), A461 (= A452), S462 (= S453), M465 (= M456), N487 (= N478), E489 (≠ R480), Q490 (≠ L481), G491 (= G482), M492 (= M483), V493 (= V484)
6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl (see paper)
43% identity, 97% coverage: 5:574/585 of query aligns to 14:584/599 of 6denA
- active site: Y35 (= Y26), G37 (= G28), G38 (= G29), A39 (= A30), I40 (≠ V31), E61 (= E52), T84 (= T75), F123 (= F114), Q124 (= Q115), E125 (= E116), K173 (= K164), K230 (≠ Q225), M266 (= M261), V293 (≠ I288), V409 (= V398), L434 (= L423), G435 (= G424), M437 (= M426), D462 (≠ E451), N489 (= N478), E491 (≠ R480), Q492 (≠ L481), M494 (= M483), V495 (= V484), W498 (= W487), L520 (= L510), N525 (≠ G515), V526 (≠ A516)
- binding flavin-adenine dinucleotide: R163 (= R154), G219 (= G213), A220 (≠ G214), G221 (= G215), N224 (= N218), T246 (= T241), L247 (= L242), Q248 (≠ M243), L264 (= L259), G286 (= G281), A287 (= A282), R288 (= R283), D290 (= D285), R292 (= R287), V293 (≠ I288), E319 (≠ D305), I320 (= I306), N324 (≠ S310), D338 (= D324), V339 (≠ I325), M414 (= M403), G432 (= G421)
- binding ethyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M266 (= M261), D291 (= D286), R292 (= R287), W498 (= W487)
- binding magnesium ion: D462 (≠ E451), N489 (= N478), E491 (≠ R480)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V409 (= V398), G410 (= G399), Q411 (= Q400), H412 (= H401), G435 (= G424), M437 (= M426), G461 (= G450), D462 (≠ E451), A463 (= A452), S464 (= S453), N489 (= N478), E491 (≠ R480), Q492 (≠ L481), G493 (= G482), M494 (= M483), V495 (= V484)
1t9bA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
45% identity, 96% coverage: 5:567/585 of query aligns to 8:561/583 of 1t9bA
- active site: Y29 (= Y26), G31 (= G28), G32 (= G29), A33 (= A30), I34 (≠ V31), E55 (= E52), T78 (= T75), F117 (= F114), Q118 (= Q115), E119 (= E116), K167 (= K164), R214 (≠ Q225), M250 (= M261), V277 (≠ I288), V393 (= V398), L418 (= L423), G419 (= G424), M421 (= M426), D446 (≠ E451), N473 (= N478), E475 (≠ R480), Q476 (≠ L481), M478 (= M483), V479 (= V484), W482 (= W487), L504 (= L510), G509 (= G515), L510 (≠ A516), K543 (= K549)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V104), P108 (= P105), F117 (= F114), D275 (= D286), R276 (= R287), M478 (= M483), W482 (= W487)
- binding flavin-adenine dinucleotide: R157 (= R154), G203 (= G213), A204 (≠ G214), G205 (= G215), N208 (= N218), T230 (= T241), L231 (= L242), Q232 (≠ M243), M247 (= M258), L248 (= L259), M250 (= M261), H251 (= H262), G270 (= G281), A271 (= A282), R272 (= R283), D274 (= D285), R276 (= R287), V277 (≠ I288), E303 (≠ D305), V304 (≠ I306), N308 (≠ S310), D322 (= D324), A323 (≠ I325), Q397 (= Q402), M398 (= M403), G416 (= G421), G417 (= G422)
- binding magnesium ion: D446 (≠ E451), N473 (= N478), E475 (≠ R480)
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
45% identity, 96% coverage: 5:567/585 of query aligns to 7:560/582 of 1t9dB
- active site: Y28 (= Y26), G30 (= G28), G31 (= G29), A32 (= A30), I33 (≠ V31), E54 (= E52), T77 (= T75), F116 (= F114), Q117 (= Q115), E118 (= E116), K166 (= K164), R213 (≠ Q225), M249 (= M261), V276 (≠ I288), V392 (= V398), L417 (= L423), G418 (= G424), M420 (= M426), D445 (≠ E451), N472 (= N478), E474 (≠ R480), Q475 (≠ L481), M477 (= M483), V478 (= V484), W481 (= W487), L503 (= L510), G508 (= G515), L509 (≠ A516), K542 (= K549)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G31 (= G29), A32 (= A30), V106 (= V104), P107 (= P105), F116 (= F114), K166 (= K164), M249 (= M261), D274 (= D286), R275 (= R287), W481 (= W487)
- binding flavin-adenine dinucleotide: R156 (= R154), G202 (= G213), A203 (≠ G214), G204 (= G215), N207 (= N218), T229 (= T241), L230 (= L242), Q231 (≠ M243), L247 (= L259), M249 (= M261), H250 (= H262), G269 (= G281), A270 (= A282), R271 (= R283), D273 (= D285), R275 (= R287), V276 (≠ I288), E302 (≠ D305), V303 (≠ I306), N307 (≠ S310), G320 (= G323), D321 (= D324), A322 (≠ I325), Q396 (= Q402), M397 (= M403), G415 (= G421), G416 (= G422)
- binding magnesium ion: D445 (≠ E451), N472 (= N478), E474 (≠ R480)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E54 (= E52), P80 (= P78), G418 (= G424), M420 (= M426), M450 (= M456)
6deqA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
43% identity, 97% coverage: 5:574/585 of query aligns to 14:586/601 of 6deqA
- active site: Y35 (= Y26), G37 (= G28), G38 (= G29), A39 (= A30), I40 (≠ V31), E61 (= E52), T84 (= T75), F123 (= F114), Q124 (= Q115), E125 (= E116), K173 (= K164), K232 (≠ Q225), M268 (= M261), V295 (≠ I288), V411 (= V398), L436 (= L423), G437 (= G424), M439 (= M426), D464 (≠ E451), N491 (= N478), E493 (≠ R480), Q494 (≠ L481), M496 (= M483), V497 (= V484), W500 (= W487), L522 (= L510), N527 (≠ G515), V528 (≠ A516)
- binding flavin-adenine dinucleotide: R163 (= R154), G221 (= G213), A222 (≠ G214), G223 (= G215), N226 (= N218), T248 (= T241), L249 (= L242), Q250 (≠ M243), L266 (= L259), G288 (= G281), A289 (= A282), R290 (= R283), D292 (= D285), R294 (= R287), V295 (≠ I288), E321 (≠ D305), I322 (= I306), D340 (= D324), V341 (≠ I325), M416 (= M403), G434 (= G421)
- binding magnesium ion: D464 (≠ E451), N491 (= N478), E493 (≠ R480)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M268 (= M261), R294 (= R287), M496 (= M483), V497 (= V484), W500 (= W487), A571 (≠ S559)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V411 (= V398), G412 (= G399), Q413 (= Q400), H414 (= H401), M439 (= M426), G463 (= G450), D464 (≠ E451), A465 (= A452), S466 (= S453), N491 (= N478), E493 (≠ R480), Q494 (≠ L481), G495 (= G482), M496 (= M483), V497 (= V484)
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
43% identity, 97% coverage: 5:574/585 of query aligns to 10:578/593 of 6deoA
- active site: Y31 (= Y26), G33 (= G28), G34 (= G29), A35 (= A30), I36 (≠ V31), E57 (= E52), T80 (= T75), F119 (= F114), Q120 (= Q115), E121 (= E116), K169 (= K164), K224 (≠ Q225), M260 (= M261), V287 (≠ I288), V403 (= V398), L428 (= L423), G429 (= G424), M431 (= M426), D456 (≠ E451), N483 (= N478), E485 (≠ R480), Q486 (≠ L481), M488 (= M483), V489 (= V484), W492 (= W487), L514 (= L510), N519 (≠ G515), V520 (≠ A516)
- binding flavin-adenine dinucleotide: R159 (= R154), G213 (= G213), A214 (≠ G214), G215 (= G215), N218 (= N218), T240 (= T241), L241 (= L242), Q242 (≠ M243), L258 (= L259), G280 (= G281), A281 (= A282), R282 (= R283), D284 (= D285), R286 (= R287), V287 (≠ I288), E313 (≠ D305), I314 (= I306), N318 (≠ S310), D332 (= D324), V333 (≠ I325), M408 (= M403), G426 (= G421)
- binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (= M261), D285 (= D286), R286 (= R287), M488 (= M483), W492 (= W487)
- binding magnesium ion: D456 (≠ E451), N483 (= N478), E485 (≠ R480)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (= V398), G404 (= G399), Q405 (= Q400), H406 (= H401), G429 (= G424), M431 (= M426), G455 (= G450), D456 (≠ E451), A457 (= A452), S458 (= S453), M461 (= M456), N483 (= N478), E485 (≠ R480), Q486 (≠ L481), G487 (= G482), M488 (= M483), V489 (= V484)
7egvA Acetolactate synthase from trichoderma harzianum with inhibitor harzianic acid (see paper)
45% identity, 96% coverage: 6:568/585 of query aligns to 8:569/590 of 7egvA
- active site: Y28 (= Y26), G30 (= G28), G31 (= G29), A32 (= A30), I33 (≠ V31), E54 (= E52), T77 (= T75), F116 (= F114), Q117 (= Q115), K166 (= K164), E220 (≠ Q225), M256 (= M261), V283 (≠ I288), V400 (= V398), L425 (= L423), G426 (= G424), M428 (= M426), Q483 (≠ L481), M485 (= M483), V486 (= V484), W489 (= W487), L511 (= L510), G516 (= G515), I517 (≠ A516)
- binding flavin-adenine dinucleotide: R156 (= R154), G209 (= G213), Q210 (≠ G214), G211 (= G215), T236 (= T241), L237 (= L242), H238 (≠ M243), G276 (= G281), S277 (≠ A282), R278 (= R283), D280 (= D285), R282 (= R287), V283 (≠ I288), E309 (≠ D305), I310 (= I306), D328 (= D324), V329 (≠ I325), M405 (= M403), G423 (= G421), G424 (= G422)
- binding (2S)-3-methyl-2-[[(2S,4R)-1-methyl-4-[(2E,4E)-octa-2,4-dienoyl]-3,5-bis(oxidanylidene)pyrrolidin-2-yl]methyl]-2-oxidanyl-butanoic acid: F493 (≠ L491), Y494 (≠ H492)
- binding magnesium ion: D453 (≠ E451), N480 (= N478), E482 (≠ R480)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: P29 (= P27), E54 (= E52), Q117 (= Q115), V400 (= V398), G401 (= G399), Q402 (= Q400), H403 (= H401), G426 (= G424), M428 (= M426), D453 (≠ E451), A454 (= A452), S455 (= S453), E482 (≠ R480), Q483 (≠ L481), G484 (= G482), M485 (= M483), V486 (= V484)
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
42% identity, 96% coverage: 7:567/585 of query aligns to 99:661/670 of P17597
- A122 (= A30) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (≠ L32) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E52) binding
- S186 (= S94) binding
- P197 (= P105) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ F107) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q115) binding
- K220 (= K128) binding
- R246 (= R154) binding ; binding
- K256 (= K164) binding
- G308 (= G214) binding
- TL 331:332 (= TL 241:242) binding
- C340 (≠ A250) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (= LGMH 259:262) binding
- GVRFD 371:375 (≠ GARFD 281:285) binding
- DR 376:377 (= DR 286:287) binding
- DI 395:396 (= DI 305:306) binding
- DV 414:415 (≠ DI 324:325) binding
- QH 487:488 (= QH 400:401) binding
- GG 508:509 (= GG 421:422) binding
- GAM 511:513 (≠ GTM 424:426) binding
- D538 (≠ E451) binding
- DGS 538:540 (≠ EAS 451:453) binding
- N565 (= N478) binding
- NQHLGM 565:570 (≠ NERLGM 478:483) binding
- H567 (≠ R480) binding
- W574 (= W487) binding ; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
- S653 (= S559) binding ; mutation to A: No effect on catalytic activity or sensitivity to herbicides.; mutation to F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; mutation to N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; mutation to T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
Query Sequence
>3608378 FitnessBrowser__Dino:3608378
MSTQMTGAQMVVQALKDQGVDTVFGYPGGAVLPIYDEIFQQNEIKHILVRHEQAATHAAE
GYARSTGKPGVVLVTSGPGATNAVTGITDALMDSIPMVVLSGQVPTFMIGNDAFQEADTV
GITRPCTKHNWLVKETDLLADTIHQAFHVATSGRPGPVLVDIPKDVQFASGTYVPPAKAD
TRHYQPRVKGDVAAITAMVELMETAERPIFYTGGGVINSGPAASQLLREFVAETGFPITS
TLMGLGAYPASGENWIGMLGMHGLYEANLAMHGCDVMINIGARFDDRITGRVADFSPESK
KIHIDIDPSSINKVIRTDVPIIGDIAHVLEDALRIWKARGRKTNKAAVKAWWTQIEEWRT
VRCLDFKNSETTIKPQYAMQRLEALTKDHPKRFIATEVGQHQMWAAQYLGFDEPNRWMTS
GGLGTMGYGFPASIGVQVAHPDALVINVAGEASWLMNMQEMGTAIQYMLPVKQFILNNER
LGMVRQWQELLHGERYSHSWSDALPDFVKLAEAFGAKGILCKDPKDLDDAIMEMLEYDGP
VIFDCLVEKHENCFPMIPSGAPHNEMLLGEADTQGAIGAKGAVLV
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory