SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing 3608627 Dshi_2020 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I (RefSeq) to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

6snoA Crystal structures of human pgm1 isoform 2 (see paper)
52% identity, 100% coverage: 1:543/543 of query aligns to 15:573/573 of 6snoA

query
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active site: R36 (= R22), S130 (= S113), H131 (= H114), K143 (= K126), D301 (= D277), D303 (= D279), D305 (= D281), R306 (= R282), G393 (= G367)
binding 1-O-phosphono-alpha-D-glucopyranose: S33 (= S19), S130 (= S113), R306 (= R282), T370 (= T344), E389 (= E363), S391 (= S365), R514 (= R484), S516 (= S486), G517 (= G487), T518 (= T488), R526 (= R496)
binding zinc ion: S130 (= S113), D301 (= D277), D303 (= D279), D305 (= D281)

P00949 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Oryctolagus cuniculus (Rabbit) (see 2 papers)
51% identity, 99% coverage: 6:543/543 of query aligns to 7:562/562 of P00949

query
sites
P00949

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R23 (= R22) binding
S117 (= S113) active site, Phosphoserine intermediate; binding ; binding via phosphate group; modified: Phosphoserine
D288 (= D277) binding
D290 (= D279) binding
D292 (= D281) binding ; binding
R293 (= R282) binding
T357 (= T344) binding
E376 (= E363) binding
S378 (= S365) binding
K389 (= K376) binding

3pmgA Structure of rabbit muscle phosphoglucomutase at 2.4 angstroms resolution. Use of freezing point depressant and reduced temperature to enhance diffractivity (see paper)
51% identity, 99% coverage: 6:543/543 of query aligns to 6:561/561 of 3pmgA

query
sites
3pmgA

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L

C

D

P

A

D

Q

L

D

K

V

V

D

D

L

L

S

G

T

V

L

L

G

G

-

K

-

Q

-

F

-

D

-

L

E

E

T

N

R

K

L

F

G

K

Q

P

M

F

V

T

V

V

E

E

V

I

V

V

D

D

P

S

V

V

A

E

D

A

Y

Y

A

A

A

T

L

M

M

L

A

R

E

N

I

I

F

F

D

D

F

F

E

N

A

A

I

L

R

K

A

E

L

L

A

S

-

G

-

P

R

N

G

R

F

L

R

K

L

I

H

R

F

I

D

D

A

A

M

M

H

H

A

G

I

V

T

V

G

G

P

P

Y

Y

A

V

K

K

A

K

I

I

L

L

E

C

D

E

T

E

L

L

G

G

A

A

A

P

P

A

G

N

S

S

V

A

V

V

N

N

G

C

T

V

P

P

S

L

P

E

D

D

F

F

G

G

G

H

H

H

P

P

D

D

P

P

N

N

P

L

I

T

W

Y

A

A

K

A

E

D

L

L

V

V

D

E

R

T

M

M

M

K

G

S

P

G

D

E

A

H

P

-

D

D

F

F

G

G

A

A

S

F

D
|
D

G

G

D
|
D

G

G

D
|
D

R
|
R

N

N

M

M

I

I

M

L

G

G

R

K

-

H

G

G

I

F

Y

F

V

V

T

N

P

P

S

S

D

D

S

S

L

V

A

A

V

V

L

I

A

A

N

N

A

I

T

F

R

S

V

I

P

P

A

Y

Y

F

A

Q

D

Q

-

T

G

G

L

V

A

R

G

G

V

F

A

A

R

R

S

S

M

M

P

P

T

T

S

S

R

G

A

A

L

L

D

D

R

R

V

V

A

A

E

N

A

A

L

T

S

K

I

I

D

A

C

L

Y

Y

E

E

T

T

P

P

T

T

G

G

W

W

K

K

F

F

G

G

N

N

L

L

L

M

D

D

A

A

G

S

R

K

A

L

T

S

L

L

C

C

G

G

E

E

S

S

A

F

G
|
G

T

T

G

G

S

S

D

D

H

H

V

I

R

R

E

E

K
|
K

D

D

G

G

L

L

W

W

A

A

V

V

L

L

F

A

W

W

L

L

N

S

I

I

L

L

A

A

D

T

S

R

R

K

A

Q

S

S

V

V

A

E

D

D

L

I

M

L

A

K

D

D

H

H

W

W

A

H

R

K

F

F

G

G

R

R

H

N

Y

F

S

T

R

R

H

Y

D

D

Y

Y

E

E

A

E

V

V

D

E

T

A

A

E

A

G

A

A

K

T

G

K

V

M

M

M

D

K

A

D

L

L

R

E

A

A

R

L

L

M

A

F

D

D

L

-

P

-

G

-

T

R

T

S

A

F

A

V

G

G

R

K

Q

Q

-

F

-

S

-

A

-

N

-

D

-

K

-

V

-

Y

-

T

I

V

A

E

F

K

A

A

D

D

E

N

F

F

S

E

Y

Y

D

H

D

D

P

P

V

V

D

D

G

G

S

S

H

V

S

S

A

K

G

N

Q

Q

G

G

L

L

R

R

V

L

G

I

F

F

T

A

D

D

G

G

A

S

R

R

L

I

V

I

I

F

R

R

L

L

S

S

G

G

T

T

G

G

T

S

V

A

G

G

A

A

T

T

L

I

R

R

V

L

Y

Y

L

I

E

D

A

S

F

Y

V

E

P

K

G

D

P

N

E

A

G

K

L

I

D

N

R

Q

D

D

P

P

Q

Q

E

V

A

M

L

L

A

A

P

P

M

L

I

I

A

S

A

I

A

A

E

L

A

K

L

V

A

S

E

Q

I

L

A

Q

T

E

R

R

T

T

G

G

R

R

T

T

A

A

P

P

D

T

V

V

I

I

T

T

active site: R22 (= R22), S116 (= S113), H117 (= H114), K129 (= K126), D287 (= D277), D289 (= D279), D291 (= D281), R292 (= R282), G379 (= G367), K388 (= K376)
binding magnesium ion: S116 (= S113), D287 (= D277), D289 (= D279), D291 (= D281)

1c4gA Phosphoglucomutase vanadate based transition state analog complex
51% identity, 99% coverage: 6:543/543 of query aligns to 6:561/561 of 1c4gA

query
sites
1c4gA

V

V

Q

K

T

T

A

K

P

A

I

Y

P

P

G

D

Q

Q

K

K

P

P

G

G

T
|
T

S
|
S

G

G

L

L

R
|
R

K

K

T

R

T

V

R

K

E

V

F

F

Q

Q

A

S

P

S

-

T

H

N

F

Y

L

A

E

E

N

N

Y

F

V

I

Q

Q

A

S

I

I

W

I

N

S

G

T

I

V

G

E

G

P

V

A

A

Q

G

R

K

Q

-

E

-

A

T

T

L

L

V

V

L

V

G

G

D

D

G

G

R

R

Y

F

F

Y

N

M

A

K

E

E

A

A

A

I

Q

Q

V

L

V

I

L

V

R

R

M

I

A

A

S

N

G

G

A

I

A

G

R

R

V

L

I

V

V

I

G

G

Q

Q

G

N

A

G

L

I

L

L

S

S

T

T

P

P

A

A

A

V

S

S

H

C

L

I

I

I

R

R

K

K

R

I

G

K

T

A

D

I

G

G

I

I

L

L

S

T

A

A

S
|
S

H
|
H

N

N

P

P

G

G

P

P

E

N

G

G

D

D

F

F

G

G

V

I

K
|
K

Y

F

N

N

G

I

P

S

N

N

G

G

P

P

A

A

T

P

E

E

E

A

V

I

T

T

D

D

R

K

I

I

F

F

A

Q

A

I

T

S

Q

K

A

T

I

I

T

E

D

E

Y

Y

A

A

M

I

L

C

D

P

A

D

Q

L

D

K

V

V

D

D

L

L

S

G

T

V

L

L

G

G

-

K

-

Q

-

F

-

D

-

L

E

E

T

N

R

K

L

F

G

K

Q

P

M

F

V

T

V

V

E

E

V

I

V

V

D

D

P

S

V

V

A

E

D

A

Y

Y

A

A

A

T

L

M

M

L

A

R

E

N

I

I

F

F

D

D

F

F

E

N

A

A

I

L

R

K

A

E

L

L

A

S

-

G

-

P

R

N

G

R

F

L

R

K

L

I

H

R

F

I

D

D

A

A

M

M

H

H

A

G

I

V

T

V

G

G

P

P

Y

Y

A

V

K

K

A

K

I

I

L

L

E

C

D

E

T

E

L

L

G

G

A

A

A

P

P

A

G

N

S

S

V

A

V

V

N

N

G

C

T

V

P

P

S

L

P

E

D

D

F

F

G

G

G

H

H

H

P

P

D

D

P

P

N

N

P

L

I

T

W

Y

A

A

K

A

E

D

L

L

V

V

D

E

R

T

M

M

M

K

G

S

P

G

D

E

A

H

P

-

D

D

F

F

G

G

A

A

S

F

D
|
D

G

G

D
|
D

G

G

D
|
D

R
|
R

N

N

M

M

I

I

M

L

G

G

R

K

-

H

G

G

I

F

Y

F

V

V

T

N

P

P

S

S

D

D

S

S

L

V

A

A

V

V

L

I

A

A

N

N

A

I

T

F

R

S

V

I

P

P

A

Y

Y

F

A

Q

D

Q

-

T

G

G

L

V

A

R

G

G

V

F

A

A

R

R

S

S

M

M

P

P

T

T

S

S

R

G

A

A

L

L

D

D

R

R

V

V

A

A

E

N

A

A

L

T

S

K

I

I

D

A

C

L

Y

Y

E

E

T

T

P

P

T
|
T

G

G

W

W

K

K

F

F

G

G

N

N

L

L

L

M

D

D

A

A

G

S

R

K

A

L

T

S

L

L

C

C

G

G

E
|
E

E

E

S
|
S

A

F

G
|
G

T

T

G

G

S

S

D

D

H

H

V

I

R

R

E

E

K
|
K

D

D

G

G

L

L

W

W

A

A

V

V

L

L

F

A

W

W

L

L

N

S

I

I

L

L

A

A

D

T

S

R

R

K

A

Q

S

S

V

V

A

E

D

D

L

I

M

L

A

K

D

D

H

H

W

W

A

H

R

K

F

F

G

G

R

R

H

N

Y

F

S

T

R

R

H

Y

D

D

Y

Y

E

E

A

E

V

V

D

E

T

A

A

E

A

G

A

A

K

T

G

K

V

M

M

M

D

K

A

D

L

L

R

E

A

A

R

L

L

M

A

F

D

D

L

-

P

-

G

-

T

R

T

S

A

F

A

V

G

G

R

K

Q

Q

-

F

-

S

-

A

-

N

-

D

-

K

-

V

-

Y

-

T

I

V

A

E

F

K

A

A

D

D

E

N

F

F

S

E

Y

Y

D

H

D

D

P

P

V

V

D

D

G

G

S

S

H

V

S

S

A

K

G

N

Q

Q

G

G

L

L

R

R

V

L

G

I

F

F

T

A

D

D

G

G

A

S

R

R

L

I

V

I

I

F

R

R

L

L

S

S

G

G

T

T

G

G

T

S

V

A

G

G

A

A

T

T

L

I

R
|
R

V

L

Y

Y

L

I

E

D

A

S

F

Y

V

E

P

K

G

D

P

N

E

A

G

K

L

I

D

N

R

Q

D

D

P

P

Q

Q

E

V

A

M

L

L

A

A

P

P

M

L

I

I

A

S

A

I

A

A

E

L

A

K

L

V

A

S

E

Q

I

L

A

Q

T

E

R

R

T

T

G

G

R

R

T

T

A

A

P

P

D

T

V

V

I

I

T

T

active site: R22 (= R22), S116 (= S113), H117 (= H114), K129 (= K126), D287 (= D277), D289 (= D279), D291 (= D281), R292 (= R282), G379 (= G367), K388 (= K376)
binding cobalt (ii) ion: S116 (= S113), D287 (= D277), D289 (= D279), D291 (= D281)
binding alpha-d-glucose-1-phosphate-6-vanadate: T18 (= T18), S19 (= S19), R22 (= R22), S116 (= S113), H117 (= H114), K129 (= K126), D287 (= D277), D291 (= D281), R292 (= R282), T356 (= T344), E375 (= E363), S377 (= S365), K388 (= K376), R514 (= R496)

1c47A Binding driven structural changes in crystaline phosphoglucomutase associated with chemical reaction
51% identity, 99% coverage: 6:543/543 of query aligns to 6:561/561 of 1c47A

query
sites
1c47A

V

V

Q

K

T

T

A

K

P

A

I

Y

P

P

G

D

Q

Q

K

K

P

P

G

G

T

T

S
|
S

G

G

L

L

R
|
R

K

K

T

R

T

V

R

K

E

V

F

F

Q

Q

A

S

P

S

-

T

H

N

F

Y

L

A

E

E

N

N

Y

F

V

I

Q

Q

A

S

I

I

W

I

N

S

G

T

I

V

G

E

G

P

V

A

A

Q

G

R

K

Q

-

E

-

A

T

T

L

L

V

V

L

V

G

G

D

D

G

G

R

R

Y

F

F

Y

N

M

A

K

E

E

A

A

A

I

Q

Q

V

L

V

I

L

V

R

R

M

I

A

A

S

N

G

G

A

I

A

G

R

R

V

L

I

V

V

I

G

G

Q

Q

G

N

A

G

L

I

L

L

S

S

T

T

P

P

A

A

A

V

S

S

H

C

L

I

I

I

R

R

K

K

R

I

G

K

T

A

D

I

G

G

I

I

L

L

S

T

A

A

S
|
S

H
|
H

N

N

P

P

G

G

P

P

E

N

G

G

D

D

F

F

G

G

V

I

K
|
K

Y

F

N

N

G

I

P

S

N

N

G

G

P

P

A

A

T

P

E

E

E

A

V

I

T

T

D

D

R

K

I

I

F

F

A

Q

A

I

T

S

Q

K

A

T

I

I

T

E

D

E

Y

Y

A

A

M

I

L

C

D

P

A

D

Q

L

D

K

V

V

D

D

L

L

S

G

T

V

L

L

G

G

-

K

-

Q

-

F

-

D

-

L

E

E

T

N

R

K

L

F

G

K

Q

P

M

F

V

T

V

V

E

E

V

I

V

V

D

D

P

S

V

V

A

E

D

A

Y

Y

A

A

A

T

L

M

M

L

A

R

E

N

I

I

F

F

D

D

F

F

E

N

A

A

I

L

R

K

A

E

L

L

A

S

-

G

-

P

R

N

G

R

F

L

R

K

L

I

H

R

F

I

D

D

A

A

M

M

H

H

A

G

I

V

T

V

G

G

P

P

Y

Y

A

V

K

K

A

K

I

I

L

L

E

C

D

E

T

E

L

L

G

G

A

A

A

P

P

A

G

N

S

S

V

A

V

V

N

N

G

C

T

V

P

P

S

L

P

E

D

D

F

F

G

G

G

H

H

H

P

P

D

D

P

P

N

N

P

L

I

T

W

Y

A

A

K

A

E

D

L

L

V

V

D

E

R

T

M

M

M

K

G

S

P

G

D

E

A

H

P

-

D

D

F

F

G

G

A

A

S

F

D
|
D

G

G

D
|
D

G

G

D
|
D

R
|
R

N

N

M

M

I

I

M

L

G

G

R

K

-

H

G

G

I

F

Y

F

V

V

T

N

P

P

S

S

D

D

S

S

L

V

A

A

V

V

L

I

A

A

N

N

A

I

T

F

R

S

V

I

P

P

A

Y

Y

F

A

Q

D

Q

-

T

G

G

L

V

A

R

G

G

V

F

A

A

R

R

S

S

M

M

P

P

T

T

S

S

R

G

A

A

L

L

D

D

R

R

V

V

A

A

E

N

A

A

L

T

S

K

I

I

D

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active site: R22 (= R22), S116 (= S113), H117 (= H114), K129 (= K126), D287 (= D277), D289 (= D279), D291 (= D281), R292 (= R282), G379 (= G367), K388 (= K376)
binding 1,6-di-O-phosphono-alpha-D-glucopyranose: S19 (= S19), R22 (= R22), S116 (= S113), D291 (= D281), R292 (= R282), T356 (= T344), G357 (= G345), E375 (= E363), S377 (= S365), K388 (= K376)

P36871 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Homo sapiens (Human) (see 11 papers)
51% identity, 99% coverage: 6:543/543 of query aligns to 7:562/562 of P36871

query
sites
P36871

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T19 (= T18) to A: in CDG1T; reduces strongly phosphoglucomutase activity; dbSNP:rs1320810473
N38 (= N36) to Y: in CDG1T; reduces strongly solubility; increases aggregation; dbSNP:rs587777402
Q41 (= Q39) to R: in CDG1T; reduces solubility; increases aggregation; dbSNP:rs1300651770
D62 (= D58) to H: in CDG1T; reduces solubility; reduces strongly phosphoglucomutase activity; dbSNP:rs587777403
K68 (≠ A64) to M: in allele PGM1*7+, allele PGM1*7-, allele PGM1*3+ and allele PGM1*3-; phosphoglucomutase activity is similar to wild-type; dbSNP:rs200390982
T115 (≠ S111) to A: in CDG1T; reduces mildly phosphoglucomutase activity; dbSNP:rs121918371
S117 (= S113) active site, Phosphoserine intermediate; binding via phosphate groupe; modified: Phosphoserine
G121 (= G117) to R: in CDG1T; there is 7% enzyme residual phosphoglucomutase activity; dbSNP:rs398122912
R221 (≠ H209) to C: in allele PGM1*2+, allele PGM1*2-, allele PGM1*3+ and allele PGM1*3-; phosphoglucomutase activity is similar to wild-type; dbSNP:rs1126728
D263 (= D251) to G: in CDG1T; reduces strongly phosphoglucomutase activity; dbSNP:rs1465877146; to Y: in CDG1T; reduces strongly phosphoglucomutase activity; dbSNP:rs587777404
D288 (= D277) binding
D290 (= D279) binding
G291 (= G280) to R: in CDG1T; reduces strongly phosphoglucomutase activity; dbSNP:rs772768778
D292 (= D281) binding
G330 (= G317) to R: in CDG1T; decreases mildly solubility; dbSNP:rs777164338
E377 (= E364) to K: in CDG1T; decreases strongly solubility
E388 (= E375) to K: in CDG1T; decreases strongly solubility; dbSNP:rs1301021797
Y420 (≠ F407) to H: in allele PGM1*1-, allele PGM1*2-, allele PGM1*3- and allele PGM1*7-; phosphoglucomutase activity is similar to wild-type; dbSNP:rs11208257
T467 (vs. gap) modified: Phosphothreonine; by PAK1
L516 (≠ V497) to P: in CDG1T; decreases strongly solubility; dbSNP:rs587777401

6snqA Crystal structures of human pgm1 isoform 2 (see paper)
51% identity, 100% coverage: 1:543/543 of query aligns to 15:566/566 of 6snqA

query
sites
6snqA

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A

A

E

A

G

A

A

K

N

G

K

V

M

M

M

D

K

A

D

L

L

R

E

A

A

R

L

L

M

A

F

D

D

-

R

-

S

L

F

P

V

G

G

T

K

T

Q

A

F

A

S

G

V

R

Y

Q

T

I

V

A

E

F

K

A

A

D

D

E

N

F

F

S

E

Y

Y

D

S

D

D

P

P

V

V

D

D

G

G

S

S

H

I

S

S

A

R

G

N

Q

Q

G

G

L

L

R

R

V

L

G

I

F

F

T

T

D

D

G

G

A

S

R

R

L

I

V

V

I

F

R
|
R

L

L

S
|
S

G

-

T

-

G

-

T

-

V

-

G

G

A

A

T

T

L

I

R
|
R

V

L

Y

Y

L

I

E

D

A

S

F

Y

V

E

P

K

G

D

P

V

E

A

G

K

L

I

D

N

R

Q

D

D

P

P

Q

Q

E

V

A

M

L

L

A

A

P

P

M

L

I

I

A

S

A

I

A

A

E

L

A

K

L

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A

S

E

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I

L

A

Q

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E

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R

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T

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G

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I

T

T

active site: R36 (= R22), S130 (= S113), H131 (= H114), K143 (= K126), D301 (= D277), D303 (= D279), D305 (= D281), R306 (= R282), G393 (= G367)
binding 6-O-phosphono-alpha-D-glucopyranose: S130 (= S113), R306 (= R282), T370 (= T344), G371 (= G345), E389 (= E363), S391 (= S365), R512 (= R484), S514 (= S486), R519 (= R496)
binding zinc ion: S130 (= S113), D301 (= D277), D303 (= D279), D305 (= D281)

5jn5A Crystal structure of the d263y missense variant of human pgm1 (see paper)
50% identity, 99% coverage: 6:543/543 of query aligns to 8:559/559 of 5jn5A

query
sites
5jn5A

V

V

Q

K

T

T

A

Q

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A

I

Y

P

Q

G

D

Q

Q

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K

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P

G

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T

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S

G

G

L

L

R
|
R

K

K

T

R

T

V

R

K

E

V

F

F

Q

Q

A

S

P

S

-

A

H

N

F

Y

L

A

E

E

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N

Y

F

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I

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Q

A

S

I

I

W

I

N

S

G

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I

V

G

E

G

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V

A

A

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Q

-

E

-

A

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T

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L

V

V

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V

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G

D

D

G

G

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R

Y

F

F

Y

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M

A

K

E

E

A

A

A

I

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Q

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V

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L

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M

I

A

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N

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G

A

I

A

G

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R

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L

I

V

V

I

G

G

Q

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G

N

A

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P

A

A

A

V

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S

H

C

L

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I

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K

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K

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A

D

I

G

G

I

I

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A

A

S
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S

H
|
H

N

N

P

P

G

G

P

P

E

N

G

G

D

D

F

F

G

G

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K
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K

Y

F

N

N

G

I

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S

N

N

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E

E

E

A

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A

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C

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I

D

D

A

A

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M

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Y

A

V

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K

A

K

I

I

L

L

E

C

D

E

T

E

L

L

G

G

A

A

A

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P

A

G

N

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A

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N

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C

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L

P

E

D

D

F

F

G

G

G

H

H

H

P

P

D

Y

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P

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P

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Y

A

A

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A

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D

L

L

V

V

D

E

R

T

M

M

M

K

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G

D

E

A

H

P

-

D

D

F

F

G

G

A

A

S

F

D
|
D

G

G

D
|
D

G

G

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D

R
|
R

N

N

M

M

I

I

M

L

G

G

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K

-

H

G

G

I

F

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F

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N

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D

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L

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A

A

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L

I

A

A

N

N

A

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P

A

Y

Y

F

A

Q

D

Q

-

T

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G

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A

A

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D

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Y

E

E

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F

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G

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L

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A

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C

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G

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K

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D

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G

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A

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A

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A

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E

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D

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L

A

K

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D

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H

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W

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R

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Y

D

D

Y

Y

E

E

A

E

V

V

D

E

T

A

A

E

A

G

A

A

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G

K

V

M

M

M

D

K

A

D

L

L

R

E

A

A

R

L

L

M

A

F

D

D

L

-

P

-

G

-

T

R

T

S

A

F

A

V

G

G

R

K

Q

Q

-

F

-

S

-

A

-

N

-

D

-

K

-

V

-

Y

-

T

I

V

A

E

F

K

A

A

D

D

E

N

F

F

S

E

Y

Y

D

S

D

D

P

P

V

V

D

D

G

G

S

S

H

I

S

S

A

R

G

N

Q

Q

G

G

L

L

R

R

V

L

G

I

F

F

T

T

D

D

G

G

A

S

R

R

L

I

V

V

I

F

R

R

L

L

S

S

G

G

T

-

G

-

T

-

V

-

G

G

A

A

T

T

L

I

R

R

V

L

Y

Y

L

I

E

D

A

S

F

Y

V

E

P

K

G

D

P

V

E

A

G

K

L

I

D

N

R

Q

D

D

P

P

Q

Q

E

V

A

M

L

L

A

A

P

P

M

L

I

I

A

S

A

I

A

A

E

L

A

K

L

V

A

S

E

Q

I

L

A

Q

T

E

R

R

T

T

G

G

R

R

T

T

A

A

P

P

D

T

V

V

I

I

T

T

active site: R24 (= R22), S118 (= S113), H119 (= H114), K131 (= K126), D289 (= D277), D291 (= D279), D293 (= D281), R294 (= R282), G381 (= G367), K390 (= K376)
binding calcium ion: S118 (= S113), D289 (= D277), D291 (= D279), D293 (= D281)

O74374 Phosphoglucomutase; PGM; Glucose phosphomutase; EC 5.4.2.2 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
51% identity, 99% coverage: 6:543/543 of query aligns to 5:554/554 of O74374

query
sites
O74374

V

I

Q

P

T

T

A

K

P

P

I

Y

P

E

G

G

Q

Q

K

R

P

P

G

G

T

T

S

S

G

G

L

L

R

R

K

K

T

K

T

V

R

T

E

V

F

F

Q

E

A

Q

P

P

H

N

F

Y

L

V

E

E

N

N

Y

F

V

V

Q

Q

A

A

I

T

W

M

N

D

G

V

I

V

G

E

G

P

V

S