SitesBLAST
Comparing 3609047 FitnessBrowser__Dino:3609047 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5itvA Crystal structure of bacillus subtilis bacc dihydroanticapsin 7- dehydrogenase in complex with nadh (see paper)
36% identity, 37% coverage: 435:693/700 of query aligns to 4:251/255 of 5itvA
- active site: G18 (= G449), S141 (= S577), Y154 (= Y590), K158 (= K594)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G445), S17 (≠ G448), G18 (= G449), I19 (= I450), D38 (= D469), I39 (= I470), T61 (≠ M496), I63 (≠ V498), N89 (= N524), G91 (= G526), T139 (≠ V575), S141 (= S577), Y154 (= Y590), K158 (= K594), P184 (= P620), G185 (≠ D621), I186 (≠ A622), I187 (≠ V623)
3rwbA Crystal structure of complex of 4pal (4-pyridoxolactone) and pldh (tetrameric pyridoxal 4-dehydrogenase) from mesorhizobium loti
35% identity, 37% coverage: 436:696/700 of query aligns to 4:246/247 of 3rwbA
- active site: G17 (= G449), S140 (= S577), Y153 (= Y590), K157 (= K594)
- binding 7-hydroxy-6-methylfuro[3,4-c]pyridin-1(3H)-one: S140 (= S577), N141 (≠ K578), T142 (≠ N579), M150 (≠ A587), Y153 (= Y590), L185 (≠ A622), H196 (≠ G643)
- binding nicotinamide-adenine-dinucleotide: G13 (= G445), Q16 (≠ G448), G17 (= G449), I18 (= I450), D37 (= D469), I38 (= I470), D60 (≠ N497), I61 (≠ V498), N87 (= N524), A88 (= A525), S89 (≠ G526), I138 (≠ V575), S140 (= S577), Y153 (= Y590), K157 (= K594), P183 (= P620), L185 (≠ A622), I186 (≠ V623), S188 (≠ G632), G190 (≠ W634), V191 (≠ L635)
3ndrA Crystal structure of tetrameric pyridoxal 4-dehydrogenase from mesorhizobium loti
35% identity, 37% coverage: 436:696/700 of query aligns to 4:246/247 of 3ndrA
- active site: G17 (= G449), S140 (= S577), Y153 (= Y590), K157 (= K594)
- binding nicotinamide-adenine-dinucleotide: G13 (= G445), Q16 (≠ G448), G17 (= G449), I18 (= I450), D37 (= D469), I38 (= I470), D60 (≠ N497), I61 (≠ V498), N87 (= N524), A88 (= A525), S89 (≠ G526), V110 (≠ I547), I138 (≠ V575), S140 (= S577), Y153 (= Y590), K157 (= K594), P183 (= P620), L185 (≠ A622), I186 (≠ V623), S188 (≠ G632), G190 (≠ W634), V191 (≠ L635)
8dt1C Crystal structure of a putative d-beta-hydroxybutyrate dehydrogenase from burkholderia cenocepacia j2315 in complex with NAD
37% identity, 37% coverage: 435:693/700 of query aligns to 1:255/259 of 8dt1C
- binding nicotinamide-adenine-dinucleotide: G11 (= G445), S14 (≠ G448), G15 (= G449), I16 (= I450), D35 (= D469), L36 (≠ I470), M60 (= M496), V62 (= V498), N88 (= N524), A89 (= A525), M139 (≠ V575), Y154 (= Y590), K158 (= K594), P184 (= P620), G185 (≠ D621), F186 (≠ A622), V187 (= V623), T189 (vs. gap)
3m4rA Structure of the n-terminal class ii aldolase domain of a conserved protein from thermoplasma acidophilum
35% identity, 31% coverage: 10:229/700 of query aligns to 2:212/213 of 3m4rA
6zzpA Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from psychrobacter arcticus complexed with NAD+ and 3-oxovalerate (see paper)
35% identity, 36% coverage: 434:688/700 of query aligns to 6:256/265 of 6zzpA
- binding nicotinamide-adenine-dinucleotide: G17 (= G445), S20 (≠ G448), G21 (= G449), I22 (= I450), D41 (= D469), I42 (= I470), M66 (= M496), D67 (≠ N497), V68 (= V498), N94 (= N524), A95 (= A525), G96 (= G526), M145 (≠ V575), S147 (= S577), Y160 (= Y590), K164 (= K594), P190 (= P620), F192 (≠ A622), V193 (= V623), T195 (≠ S627), L197 (≠ I629), V198 (≠ W630)
- binding 3-oxidanylidenepentanoic acid: Q98 (≠ A528), S147 (= S577), H149 (≠ N579), K157 (≠ A587), Y160 (= Y590), F192 (≠ A622), Q201 (≠ D633)
6zzoC Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from psychrobacter arcticus complexed with NAD+ and acetoacetate (see paper)
35% identity, 36% coverage: 434:688/700 of query aligns to 6:256/265 of 6zzoC
- binding acetoacetic acid: Q98 (≠ A528), H149 (≠ N579), K157 (≠ A587), F192 (≠ A622), Q201 (≠ D633)
- binding nicotinamide-adenine-dinucleotide: G17 (= G445), S20 (≠ G448), G21 (= G449), I22 (= I450), D41 (= D469), I42 (= I470), M66 (= M496), D67 (≠ N497), V68 (= V498), N94 (= N524), A95 (= A525), G96 (= G526), M145 (≠ V575), Y160 (= Y590), K164 (= K594), P190 (= P620), F192 (≠ A622), V193 (= V623), T195 (≠ S627), L197 (≠ I629), V198 (≠ W630)
5itvD Crystal structure of bacillus subtilis bacc dihydroanticapsin 7- dehydrogenase in complex with nadh (see paper)
33% identity, 37% coverage: 435:693/700 of query aligns to 4:223/227 of 5itvD
- active site: G18 (= G449), S141 (= S577), Y154 (= Y590), K158 (= K594)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G445), S17 (≠ G448), G18 (= G449), I19 (= I450), D38 (= D469), I39 (= I470), T61 (≠ M496), D62 (≠ N497), I63 (≠ V498), N89 (= N524), T139 (≠ V575), S141 (= S577), Y154 (= Y590), K158 (= K594), P184 (= P620), G185 (≠ D621), I187 (≠ V623)
6zzsD Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and 3-oxovalerate (see paper)
35% identity, 37% coverage: 434:693/700 of query aligns to 3:257/261 of 6zzsD
- active site: G18 (= G449), S143 (= S577), Y156 (= Y590)
- binding nicotinamide-adenine-dinucleotide: G14 (= G445), S17 (≠ G448), I19 (= I450), D38 (= D469), M39 (≠ I470), D64 (≠ N497), V65 (= V498), N91 (= N524), A92 (= A525), G93 (= G526), M141 (≠ V575), A142 (= A576), S143 (= S577), Y156 (= Y590), K160 (= K594), P186 (= P620), G187 (≠ D621), V189 (= V623), T191 (vs. gap), L193 (vs. gap)
- binding 3-oxidanylidenepentanoic acid: Q95 (≠ A528), S143 (= S577), N145 (= N579), K153 (≠ A587), Y156 (= Y590), Q197 (≠ W634)
6zzqA Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and acetoacetate (see paper)
35% identity, 37% coverage: 434:693/700 of query aligns to 2:256/260 of 6zzqA
- active site: G17 (= G449), S142 (= S577), Y155 (= Y590)
- binding acetoacetic acid: Q94 (≠ A528), S142 (= S577), K152 (≠ A587), Y155 (= Y590), Q196 (≠ W634)
- binding nicotinamide-adenine-dinucleotide: G13 (= G445), S16 (≠ G448), G17 (= G449), I18 (= I450), D37 (= D469), M38 (≠ I470), D63 (≠ N497), V64 (= V498), N90 (= N524), A91 (= A525), G92 (= G526), M140 (≠ V575), A141 (= A576), S142 (= S577), Y155 (= Y590), K159 (= K594), Y187 (≠ A622), V188 (= V623), T190 (vs. gap)
7ejiB Crystal structure of kred f147l/l153q/y190p/l199a/m205f/m206f variant and methyl methacrylate complex
31% identity, 37% coverage: 436:693/700 of query aligns to 4:247/251 of 7ejiB
- binding methyl 2-methylprop-2-enoate: S142 (= S577), I143 (≠ K578), Y155 (= Y590), F205 (≠ Y653)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G445), T15 (≠ A447), L16 (≠ G448), G17 (= G449), I18 (= I450), R38 (vs. gap), H39 (vs. gap), D62 (≠ N497), A63 (≠ V498), N89 (= N524), A90 (= A525), V112 (≠ I547), M140 (≠ V575), S142 (= S577), Y155 (= Y590), K159 (= K594), P187 (= P620), P189 (≠ A622), I190 (≠ V623), T192 (≠ R625), P193 (≠ T641), L194 (≠ Y642)
7ejhA Crystal structure of kred mutant-f147l/l153q/y190p/l199a/m205f/m206f and 2-hydroxyisoindoline-1,3-dione complex
31% identity, 37% coverage: 436:693/700 of query aligns to 6:249/253 of 7ejhA
- binding 2-oxidanylisoindole-1,3-dione: S144 (= S577), I145 (≠ K578), E146 (≠ N579), Y157 (= Y590), V197 (≠ G643), F207 (≠ Y653)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G15 (= G445), T17 (≠ A447), I20 (= I450), R40 (vs. gap), H41 (vs. gap), D64 (≠ N497), A65 (≠ V498), N91 (= N524), A92 (= A525), V114 (≠ I547), M142 (≠ V575), S144 (= S577), Y157 (= Y590), K161 (= K594), P189 (= P620), G190 (≠ D621), P191 (≠ A622), I192 (≠ V623), T194 (≠ R625), P195 (≠ T641), L196 (≠ Y642)
1nfqA Rv2002 gene product from mycobacterium tuberculosis (see paper)
33% identity, 38% coverage: 436:698/700 of query aligns to 4:241/244 of 1nfqA
- active site: G17 (= G449), S139 (= S577), Y152 (= Y590), K156 (= K594)
- binding Androsterone: L91 (≠ A528), E141 (≠ N579), C149 (≠ A587), Y152 (= Y590), V193 (≠ L635), I197 (≠ M652), F198 (≠ Y653)
- binding 1,4-dihydronicotinamide adenine dinucleotide: R16 (≠ G448), G17 (= G449), M18 (≠ I450), D37 (= D469), L39 (≠ N471), L59 (≠ M496), D60 (≠ N497), V61 (= V498), N87 (= N524), A88 (= A525), I137 (≠ V575), S139 (= S577), Y152 (= Y590), K156 (= K594), P182 (= P620), V185 (= V623), T187 (≠ I629), P188 (≠ W630), M189 (≠ E631), T190 (≠ G632)
1nffA Crystal structure of rv2002 gene product from mycobacterium tuberculosis (see paper)
33% identity, 38% coverage: 436:698/700 of query aligns to 4:241/244 of 1nffA
- active site: G17 (= G449), S139 (= S577), Y152 (= Y590), K156 (= K594)
- binding nicotinamide-adenine-dinucleotide: G13 (= G445), R16 (≠ G448), G17 (= G449), M18 (≠ I450), D37 (= D469), I38 (= I470), L39 (≠ N471), L59 (≠ M496), D60 (≠ N497), V61 (= V498), N87 (= N524), A88 (= A525), G89 (= G526), I90 (= I527), I137 (≠ V575), S139 (= S577), Y152 (= Y590), K156 (= K594), P182 (= P620), V185 (= V623), T187 (≠ I629), P188 (≠ W630), M189 (≠ E631), T190 (≠ G632)
P9WGT1 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase; NADH-dependent 3alpha, 20beta-hydroxysteroid dehydrogenase; EC 1.1.1.53 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
33% identity, 38% coverage: 436:698/700 of query aligns to 5:242/260 of P9WGT1
- I6 (≠ A437) mutation to T: Maximal improvement in solubility; when associated with M-47 and K-69.
- RGM 17:19 (≠ GGI 448:450) binding
- D38 (= D469) binding
- V47 (≠ S483) mutation to M: Maximal improvement in solubility; when associated with T-6 and K-69.
- DV 61:62 (≠ NV 497:498) binding
- T69 (≠ A505) mutation to K: Maximal improvement in solubility; when associated with T-6 and M-47.
- N88 (= N524) binding
- S140 (= S577) mutation to A: Complete loss of both oxidation of androsterone and reduction of progesterone; when associated with T6; M-47 and K-69.
- Y153 (= Y590) binding ; mutation to F: Complete loss of both oxidation of androsterone and reduction of progesterone; when associated with T6; M-47 and K-69.
- K157 (= K594) binding
- 183:191 (vs. 620:632, 23% identical) binding
Q6WVP7 NADP-dependent (R)-specific alcohol dehydrogenase; (R)-specific ADH; Ketoreductase; KRED; EC 1.1.1.- from Lentilactobacillus kefiri (Lactobacillus kefiri) (see paper)
32% identity, 37% coverage: 436:693/700 of query aligns to 5:248/252 of Q6WVP7
Sites not aligning to the query:
3ai3C The crystal structure of l-sorbose reductase from gluconobacter frateurii complexed with NADPH and l-sorbose (see paper)
31% identity, 38% coverage: 436:698/700 of query aligns to 5:263/263 of 3ai3C
- active site: G18 (= G449), S144 (= S577), Y157 (= Y590), K161 (= K594)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G14 (= G445), S16 (≠ A447), S17 (≠ G448), G18 (= G449), I19 (= I450), A38 (≠ D469), R39 (≠ I470), Q40 (≠ N471), R43 (≠ S474), D65 (≠ N497), V66 (= V498), N92 (= N524), G94 (= G526), N142 (≠ V575), Y157 (= Y590), K161 (= K594), P187 (= P620), G188 (≠ D621), I190 (≠ V623), T192 (≠ R625), W195 (≠ K628)
- binding alpha-L-sorbopyranose: A252 (≠ I687), F254 (≠ N689), L263 (≠ F698)
- binding L-sorbose: G96 (≠ A528), E154 (≠ A587), Y157 (= Y590), W195 (≠ K628)
3ai3A The crystal structure of l-sorbose reductase from gluconobacter frateurii complexed with NADPH and l-sorbose (see paper)
31% identity, 38% coverage: 436:698/700 of query aligns to 5:263/263 of 3ai3A
- active site: G18 (= G449), S144 (= S577), Y157 (= Y590), K161 (= K594)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G14 (= G445), S16 (≠ A447), S17 (≠ G448), G18 (= G449), I19 (= I450), A38 (≠ D469), R39 (≠ I470), Q40 (≠ N471), R43 (≠ S474), V64 (≠ M496), D65 (≠ N497), V66 (= V498), N92 (= N524), G94 (= G526), N142 (≠ V575), S144 (= S577), Y157 (= Y590), K161 (= K594), P187 (= P620), G188 (≠ D621), I190 (≠ V623), T192 (≠ R625), W195 (≠ K628)
- binding L-sorbose: G96 (≠ A528), S144 (= S577), L151 (≠ S584), E154 (≠ A587), Y157 (= Y590), G188 (≠ D621)
8cxaA Crystal structure of 3-oxoacyl-[acyl-carrier-protein] reductase from mycobacterium smegmatis with bound NAD
34% identity, 37% coverage: 436:693/700 of query aligns to 3:247/251 of 8cxaA
- binding nicotinamide-adenine-dinucleotide: G12 (= G445), Q15 (≠ G448), G16 (= G449), I17 (= I450), D36 (= D469), V63 (= V498), N89 (= N524), A91 (≠ G526), S94 (= S529), I142 (≠ V575), S143 (≠ A576), S144 (= S577), Y157 (= Y590), K161 (= K594), P187 (= P620), H188 (≠ D621), I190 (≠ V623), I194 (vs. gap)
2q2qD Structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas putida (see paper)
31% identity, 37% coverage: 435:693/700 of query aligns to 1:251/255 of 2q2qD
- active site: G15 (= G449), S138 (= S577), Y151 (= Y590), K155 (= K594), R196 (= R638)
- binding nicotinamide-adenine-dinucleotide: G11 (= G445), T13 (≠ A447), S14 (≠ G448), G15 (= G449), I16 (= I450), F36 (≠ I470), D59 (≠ N497), L60 (≠ V498), N86 (= N524), G88 (= G526), L109 (≠ I547), I136 (≠ V575), S138 (= S577), Y151 (= Y590), K155 (= K594), P181 (= P620), G182 (≠ D621), W183 (≠ A622), V184 (= V623), T186 (≠ S627), L188 (≠ I629), V189 (≠ W630)
Query Sequence
>3609047 FitnessBrowser__Dino:3609047
MLKSLETQLLESRWDDEVAKGMSESELLLYRSNILGADKRVTNYGGGNTSAKVMEADPLT
GAQVEVLWVKGSGGDIGSIKMDGFATLYMDKLRALKGLYRGVAFEDEMVSYLPHCTFRLN
PRAASIDTPLHAYVPRKHVDHVHADAIIAIAASDNSKELTQEIFGNRIGWLPWKRPGFEL
GLWLEKFCRENPEADGVVLESHGLFTWADTAKECYDQTIDVINVATRWLAERSAGVPAFG
GAIHESLPAAARREVAARLMPAIRGFVSDNQHMVGHFNDSDAVLEFVNARDMEALAALGT
SCPDHFLRTKIRPLVVPFDPAQNNILAVLSELPDQVAAYREAYAAYYARCKHDDSPALRD
PNAVVYLVPGVGMITFAKDKATARISGEFYVNAINVMRGASAVSTYQGLPEQEAFDIEYW
LLEEAKLQRMPKPKSLAGRVALVTGGAGGIGAATAERFLAEGACVVLADINEDSLASTQE
RLSERFGADVVRSVVMNVTREEAVAAAFAEASVEFGGVDILVSNAGIASSAPIEETSLAL
WNKNMDILSTGYFLVSRAAFKLMRVQDMGGAVVFVASKNGLAASPNAAAYCTAKASEIHL
ARCLALEGAEAGIRVNVVNPDAVLRGSKIWEGDWLEQRAGTYGTDKDGLEEMYRQRSLLK
RSVLPEDIAEACYFFAADASSKSTGNIINVDAGNVQAFTR
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory