Comparing 3609178 FitnessBrowser__Dino:3609178 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3dv0D Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
30% identity, 42% coverage: 428:740/743 of query aligns to 23:324/324 of 3dv0D
3dv0B Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
30% identity, 42% coverage: 428:740/743 of query aligns to 23:324/324 of 3dv0B
3dufD Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
30% identity, 42% coverage: 428:740/743 of query aligns to 23:324/324 of 3dufD
1w85B The crystal structure of pyruvate dehydrogenase e1 bound to the peripheral subunit binding domain of e2 (see paper)
30% identity, 42% coverage: 428:740/743 of query aligns to 23:324/324 of 1w85B
1umdD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methyl-2-oxopentanoate as an intermediate (see paper)
31% identity, 44% coverage: 410:736/743 of query aligns to 5:318/323 of 1umdD
1umcD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methylpentanoate (see paper)
31% identity, 44% coverage: 410:736/743 of query aligns to 5:318/323 of 1umcD
1umbD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 in holo-form (see paper)
31% identity, 44% coverage: 410:736/743 of query aligns to 5:318/323 of 1umbD
Q5SLR3 2-oxoisovalerate dehydrogenase subunit beta; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta; EC 1.2.4.4 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
31% identity, 44% coverage: 410:736/743 of query aligns to 6:319/324 of Q5SLR3
1qs0B Crystal structure of pseudomonas putida 2-oxoisovalerate dehydrogenase (branched-chain alpha-keto acid dehydrogenase, e1b) (see paper)
30% identity, 40% coverage: 420:713/743 of query aligns to 16:311/338 of 1qs0B
1umdA Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methyl-2-oxopentanoate as an intermediate (see paper)
28% identity, 39% coverage: 44:336/743 of query aligns to 28:305/362 of 1umdA
1umcA Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methylpentanoate (see paper)
28% identity, 39% coverage: 44:336/743 of query aligns to 28:305/362 of 1umcA
1umbA Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 in holo-form (see paper)
28% identity, 39% coverage: 44:336/743 of query aligns to 28:305/362 of 1umbA
Q5SLR4 2-oxoisovalerate dehydrogenase subunit alpha; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDH E1-alpha; EC 1.2.4.4 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
28% identity, 39% coverage: 44:336/743 of query aligns to 33:310/367 of Q5SLR4
P21953 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDE1B; BCKDH E1-beta; EC 1.2.4.4 from Homo sapiens (Human) (see 2 papers)
29% identity, 37% coverage: 429:705/743 of query aligns to 92:353/392 of P21953
1dtwB Human branched-chain alpha-keto acid dehydrogenase (see paper)
29% identity, 37% coverage: 429:705/743 of query aligns to 26:287/326 of 1dtwB
2j9fD Human branched-chain alpha-ketoacid dehydrogenase-decarboxylase e1b (see paper)
29% identity, 37% coverage: 429:705/743 of query aligns to 29:290/329 of 2j9fD
P11960 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDE1A; BCKDH E1-alpha; EC 1.2.4.4 from Rattus norvegicus (Rat) (see paper)
25% identity, 38% coverage: 39:321/743 of query aligns to 88:354/441 of P11960
P11177 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; PDHE1-B; EC 1.2.4.1 from Homo sapiens (Human) (see 6 papers)
25% identity, 38% coverage: 420:699/743 of query aligns to 44:311/359 of P11177
Sites not aligning to the query:
6cfoB Human pyruvate dehydrogenase e1 component complex with covalent tdp adduct acetyl phosphinate (see paper)
25% identity, 38% coverage: 420:699/743 of query aligns to 15:282/330 of 6cfoB
6cerD Human pyruvate dehydrogenase complex e1 component v138m mutation (see paper)
24% identity, 38% coverage: 420:699/743 of query aligns to 16:283/331 of 6cerD
>3609178 FitnessBrowser__Dino:3609178
MGKPAATTGDRARAMDRADIVHQNFLRRVAARDLPPGAAPDGPLSADEARSIYRAACLTR
VLDLQSRKMQKAGQGFYTIGSSGHEAMAAVATALRPTDMAFLHYRDAAFQVARAAQVPGQ
TPARDLLLSFACSAEDPISGGRHKVLGSRALNIPPQTSTIASHLPKAVGAAYSIAPAARH
KPEHRVLDPDGIVCCSFGDASVNHSTAQGAFNTASCTAYRNIPLPLLFVCEDNGIGISTK
TPPGWISASLGARPGITYFHADGRDIYETFRVAREAAHHVRNKRRPAILHLETIRLYGHA
GADVPTSYLPRAEVEAAEADDPLLHMVRMLDAAGVLPSADALTLYTDCHGEVADLARDVV
KRPRLRTAAEVMHSLIPPKRPCRTGNGPAPDARAAAFGADFDSLDAPQPLSKILNFTLTD
LMLEHGEIVLMGEDIGRKGGVYGVTQKLAQRFGRDRVIDTLLDEQSILGLAIGMAQNGFV
PMPEIQFLAYLHNAEDQLRGEAATLPFFSNGQYTNPMVLRIAGLGYQKGFGGHFHNDNAL
AVLRDIPGVILACPSTGADAARMLRECVRLAREEQRVVVFLEPIALYPMRDLQGDKDGGW
MTRYPPPGERIDLGQVGQHGTGTDLALVSFGNGHYLCHKALPQLRAAGIDPRIIDLRWLS
PLPERSLLEAIDGIPNILIVDETRHSGGVAEGLMALLSERTNARLARDTAADSFIATGPA
YAATLPSVDSITTAARTLVFPPV
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory