SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing 3609569 FitnessBrowser__Dino:3609569 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 16 hits to proteins with known functional sites (download)

6czmE Crystal structure of medicago truncatula atp-phosphoribosyltransferase in tense form (see paper)
29% identity, 87% coverage: 3:209/239 of query aligns to 10:214/342 of 6czmE

query
sites
6czmE

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binding adenosine monophosphate: C104 (≠ A98), D182 (= D177), L183 (≠ I178), S185 (= S180), S186 (≠ T181), G187 (= G182), T189 (= T184)

Sites not aligning to the query:

binding histidine: 247, 249, 271, 273, 275, 295, 296, 317, 319

2vd3A The structure of histidine inhibited hisg from methanobacterium thermoautotrophicum
29% identity, 87% coverage: 3:209/239 of query aligns to 5:190/289 of 2vd3A

query
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2vd3A

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binding magnesium ion: E24 (≠ G22), Q43 (≠ V41), D160 (= D177), L161 (≠ I178)

Sites not aligning to the query:

binding histidine: 237, 238, 240, 242, 258

5u99A Transition state analysis of adenosine triphosphate phosphoribosyltransferase (see paper)
30% identity, 85% coverage: 3:206/239 of query aligns to 4:184/278 of 5u99A

query
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binding adenosine-5'-triphosphate: D72 (= D74), S92 (≠ A98), V157 (≠ I178)

5lhtA Atp phosphoribosyltransferase from mycobacterium tuberculosis in complex with the allosteric activator 3-(2-thienyl)-l-alanine (see paper)
30% identity, 85% coverage: 3:206/239 of query aligns to 2:182/284 of 5lhtA

query
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5lhtA

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Sites not aligning to the query:

binding beta(2-thienyl)alanine: 216, 217, 218

1nh8A Atp phosphoribosyltransferase (atp-prtase) from mycobacterium tuberculosis in complex with amp and histidine (see paper)
30% identity, 85% coverage: 3:206/239 of query aligns to 2:182/276 of 1nh8A

query
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1nh8A

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binding adenosine monophosphate: V155 (≠ I178), G157 (≠ S180), S158 (≠ T181), G159 (= G182), R160 (≠ E183), T161 (= T184)

Sites not aligning to the query:

binding histidine: 208, 209, 210, 265, 267

7dahC Adenosine triphosphate phosphoribosyltransferase from vibrio cholerae in complex with atp and prpp
27% identity, 85% coverage: 3:206/239 of query aligns to 4:193/288 of 7dahC

query
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7dahC

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I
x
L

T

V

S
|
S

T
|
T

G
|
G

E
x
A

T
|
T

L

L

R

E

A

A

N

N

H

G

L

L

K

K

I

-

L

-

K

E

G

V

E

E

P

V

V

I

L

F

K

E

S

S

Q

K

A

A

T

T

L

L

F

I

binding adenosine-5'-triphosphate: Q9 (≠ P8), R13 (= R12), R51 (≠ S53), D52 (≠ A54), D53 (≠ G55), N72 (≠ D74), G100 (≠ H97), C101 (≠ A98), L167 (≠ I178)
binding magnesium ion: D52 (≠ A54), D53 (≠ G55)
binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G150 (= G161), S151 (≠ A162), E153 (= E164), L167 (≠ I178), S169 (= S180), T170 (= T181), G171 (= G182), A172 (≠ E183), T173 (= T184)

6czmF Crystal structure of medicago truncatula atp-phosphoribosyltransferase in tense form (see paper)
28% identity, 87% coverage: 3:209/239 of query aligns to 3:187/315 of 6czmF

query
sites
6czmF

L

I

K

R

L

L

G

G

V

L

P

P

S

S

K

K

G

G

R

R

L

M

M

S

D

S

K

D

T

T

F

L

D

D

W

L

F

L

G

K

R

D

H

C

G

Q

I

L

T

S

L

V

Q

K

R

Q

T

V

G

-

S

N

E

P

R

R

E

Q

Y

Y

A

V

G

A

S

Q

V

I

D

P

G

Q

V

I

D

S

G

N

V

L

A

E

L

V

V

W

L

F

L

Q

S

R

A

P

G

K

E

D

I

I

P

V

R

R

E

K

L

L

A

L

A

S

G

-

R

-

I

L

H

D

L

L

G

G

V

I

T

V

G

G

T

L

D

D

L

V

V

L

Q

T

E

E

K

F

L

G

P

Q

D

G

W

N

M

E

R

D

Q

L

V

I

R

V

S

V

I

H

A

E

P

A

L

L

G

E

F

Y

G

G

H

D

A

C

D

R

L

L

I

S

L

I

A

A

V

I

P

P

K

-

C

-

W

F

I

E

D

N

V

V

E

N

T

S

L

L

D

E

D

E

L

L

D

-

A

-

V

-

A

-

A

-

Q

Q

F

W

R

T

A

E

N

D

H

K

G

P

F

-

R

-

L

L

R

R

I

V

A

A

T

T

K

G

Y

F

H

T

R

Y

L

L

V

G

H

P

S

K

H

F

L

M

S

K

A

D

H

N

G

G

V

I

A

K

D

H

Y

-

Q

-

L

-

V

V

D

A

S

F

Q

S

G

G

A

A

T

L

E

E

G

A

T

A

V

P

A

A

N

-

L

-

T

-

A

M

E

G

A

A

I

I

A

L

D

D

I

L

T

V

S
|
S

T
x
S

G
|
G

E

T

T
|
T

L

L

R

K

A

E

N

N

H

-

L

-

K

-

I

-

L

I

K

E

G

G

E

G

P

T

V

V

L

L

K

E

S

S

Q

Q

A

A

T

A

L

L

F

V

A

A

S

S

R

R

binding adenosine monophosphate: S162 (= S180), S163 (≠ T181), G164 (= G182), T166 (= T184)

Sites not aligning to the query:

binding histidine: 220, 222, 243, 244, 245, 246, 268, 290, 292

5ubgA Catalytic core domain of adenosine triphosphate phosphoribosyltransferase from campylobacter jejuni with bound phosphoribosyl-atp (see paper)
33% identity, 51% coverage: 90:211/239 of query aligns to 93:198/222 of 5ubgA

query
sites
5ubgA

I

L

A

K

P

K

L

L

G

D

F

F

G

G

H

Y

A
x
C

D

R

L

L

I

S

L

L

A

A

V

L

P

P

K

Q

C

-

W

E

I

N

D

K

V

F

E

Q

T

N

L

L

D

K

D

D

L

F

D

E

A

G

V

-

A

-

A

-

Q

-

F

-

R

-

A

-

N

-

H

-

G

-

F

-

R

-

L

L

R

R

I

I

A

A

T

T

K

S

Y

Y

H

P

R

Q

L

L

V

L

H

K

S

R

H

F

L

M

S

K

A

E

H

N

G

G

V

I

A

-

D

N

Y

Y

Q

K

L

N

V

C

D

T

S

L

Q

T

G

G

A

S

T

V

E

E

-

V

G

A

T

P

V

R

A

A

N

N

L

L

T

-

A

A

E

D

A

A

I

I

A

C

D

D

I
x
L

T

V

S
|
S

T
x
S

G
|
G

E
x
A

T
|
T

L

L

R

Q

A

A

N

N

H

N

L

L

K

K

I

E

L

V

K

K

G

-

E

-

P

V

V

I

L

Y

K

E

S

S

Q

R

A

A

T

C

L

L

F

I

A

Q

S

K

R

E

M

N

A

A

binding phosphoribosyl atp : C101 (≠ A98), L167 (≠ I178), S169 (= S180), S170 (≠ T181), G171 (= G182), A172 (≠ E183), T173 (= T184)

Sites not aligning to the query:

binding phosphoribosyl atp : 9, 12, 13, 51, 52, 72
binding zinc ion: 30, 32, 52, 53

5ubiA Catalytic core domain of adenosine triphosphate phosphoribosyltransferase from campylobacter jejuni with bound prpp (see paper)
33% identity, 51% coverage: 90:211/239 of query aligns to 93:198/218 of 5ubiA

query
sites
5ubiA

I

L

A

K

P

K

L

L

G

D

F

F

G

G

H

Y

A

C

D

R

L

L

I

S

L

L

A

A

V

L

P

P

K

Q

C

-

W

E

I

N

D

K

V

F

E

Q

T

N

L

L

D

K

D

D

L

F

D

E

A

G

V

-

A

-

A

-

Q

-

F

-

R

-

A

-

N

-

H

-

G

-

F

-

R

-

L

L

R

R

I

I

A

A

T

T

K

S

Y

Y

H

P

R

Q

L

L

V

L

H

K

S

R

H

F

L

M

S

K

A

E

H

N

G

G

V

I

A

-

D

N

Y

Y

Q

K

L

N

V

C

D

T

S

L

Q

T

G

G

A

S

T

V

E

E

-

V

G

A

T

P

V

R

A

A

N

N

L

L

T

-

A

A

E

D

A

A

I

I

A

C

D

D

I
x
L

T
x
V

S
|
S

T
x
S

G
|
G

E

A

T
|
T

L

L

R

Q

A

A

N

N

H

N

L

L

K

K

I

E

L

V

K

K

G

-

E

-

P

V

V

I

L

Y

K

E

S

S

Q

R

A

A

T

C

L

L

F

I

A

Q

S

K

R

E

M

N

A

A

binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: L167 (≠ I178), V168 (≠ T179), S169 (= S180), S170 (≠ T181), G171 (= G182), T173 (= T184)

Sites not aligning to the query:

binding zinc ion: 30, 30, 32, 32, 52, 53

1q1kA Structure of atp-phosphoribosyltransferase from e. Coli complexed with pr-atp (see paper)
26% identity, 85% coverage: 3:206/239 of query aligns to 3:192/288 of 1q1kA

query
sites
1q1kA

L

L

K

R

L

I

G

A

V

M

P

Q

S

K

K

S

G

G

R
|
R

L

L

M

S

D

D

K

D

T

S

F

R

D

E

W

L

F

L

G

A

R

R

H

C

G

G

I

I

T

K

L

I

Q

N

R

-

T

L

G

H

S

T

E

Q

R

R

E

L

Y

I

A

A

G

M

S

A

V

E

D

N

G

M

V

-

D

-

G

P

V

I

A

D

L

I

V

L

L

R

L

V

S

R

A
x
D

G
x
D

E

D

I

I

P

P

R

G

E

L

L

V

A

M

A

D

G

G

R

V

I

V

H

D

L

L

G

G

V

I

T

I

G

G

T

E

D
x
N

L
x
V

V

L

Q

E

E

E

K

E

L

L

P

L

D

N

W

R

M

R

R

A

Q

Q

-

G

-

E

-

D

-

P

-

R

V

Y

R

F

S

T

I

L

A

R

P

R

L

L

G

D

F

F

G

G

H

G

A
x
C

D

R

L

L

I

S

L

L

A

A

V

T

P

P

-

V

-

D

K

E

C

A

W

W

I

D

D

G

V

P

E

L

T

S

L

L

D

N

D

G

L

-

D

-

A

-

V

-

A

-

A

-

Q

-

F

-

R

-

A

-

N

-

H

-

G

-

F

-

R

-

L

K

R

R

I

I

A

A

T

T

K

S

Y
|
Y

H

P

R

H

L

L

V

L

H

K

S

R

H

Y

L

L

S

D

A

Q

H

K

G

G

V

I

A

S

D

-

Y

F

Q

K

L

S

V

C

D

L

S

L

Q

N

G

G

A

S

T

V

E
|
E

G

V

T

A

V

P

A

R

N

A

L

G

T

L

A

A

E

D

A

A

I

I

A

C

D

D

I
x
L

T

V

S
|
S

T
|
T

G
|
G

E
x
A

T
|
T

L

L

R

E

A

A

N

N

H

G

L

L

K

R

I

-

L

-

K

E

G

V

E

E

P

V

V

I

L

Y

K

R

S

S

Q

K

A

A

T

C

L

L

F

I

binding phosphoribosyl atp : R12 (= R12), D51 (≠ A54), D52 (≠ G55), N71 (≠ D74), V72 (≠ L75), C100 (≠ A98), Y127 (= Y138), E152 (= E164), L166 (≠ I178), S168 (= S180), T169 (= T181), G170 (= G182), A171 (≠ E183), T172 (= T184)

1h3dA Structure of the e.Coli atp-phosphoribosyltransferase (see paper)
26% identity, 85% coverage: 3:206/239 of query aligns to 3:192/288 of 1h3dA

query
sites
1h3dA

L

L

K

R

L

I

G

A

V

M

P

Q

S

K

K

S

G

G

R
|
R

L

L

M

S

D

D

K

D

T

S

F

R

D

E

W

L

F

L

G

A

R

R

H

C

G

G

I

I

T

K

L

I

Q

N

R

-

T

L

G

H

S

T

E

Q

R

R

E

L

Y

I

A

A

G

M

S

A

V

E

D

N

G

M

V

-

D

-

G

P

V

I

A

D

L

I

V

L

L

R

L

V

S

R

A

D

G

D

E

D

I

I

P

P

R

G

E

L

L

V

A

M

A

D

G

G

R

V

I

V

H

D

L

L

G

G

V

I

T

I

G

G

T

E

D

N

L

V

V

L

Q

E

E

E

K

E

L

L

P

L

D

N

W

R

M

R

R

A

Q

Q

-

G

-

E

-

D

-

P

-

R

V

Y

R

F

S

T

I

L

A

R

P

R

L

L

G

D

F

F

G

G

H

G

A

C

D

R

L

L

I

S

L

L

A

A

V

T

P

P

-

V

-

D

K

E

C

A

W

W

I

D

D

G

V

P

E

L

T

S

L

L

D

N

D

G

L

-

D

-

A

-

V

-

A

-

A

-

Q

-

F

-

R

-

A

-

N

-

H

-

G

-

F

-

R

-

L

K

R

R

I

I

A

A

T

T

K

S

Y

Y

H

P

R

H

L

L

V

L

H

K

S

R

H

Y

L

L

S

D

A

Q

H

K

G

G

V

I

A

S

D

-

Y

F

Q

K

L

S

V

C

D

L

S

L

Q

N

G

G

A

S

T

V

E
|
E

G

V

T

A

V

P

A

R

N

A

L

G

T

L

A

A

E

D

A

A

I

I

A

C

D
|
D

I
x
L

T

V

S
|
S

T
|
T

G
|
G

E
x
A

T
|
T

L

L

R

E

A

A

N

N

H

G

L

L

K

R

I

-

L

-

K

E

G

V

E

E

P

V

V

I

L

Y

K

R

S

S

Q

K

A

A

T

C

L

L

F

I

binding adenosine monophosphate: R12 (= R12), E152 (= E164), D165 (= D177), L166 (≠ I178), S168 (= S180), T169 (= T181), G170 (= G182), A171 (≠ E183), T172 (= T184)

4yb6E Adenosine triphosphate phosphoribosyltransferase from campylobacter jejuni in complex with the inhibitors amp and histidine (see paper)
33% identity, 50% coverage: 93:211/239 of query aligns to 93:195/293 of 4yb6E

query
sites
4yb6E

L

L

G

D

F

F

G

G

H

Y

A

C

D

R

L

L

I

S

L

L

A

A

V

L

P

P

K

Q

C

-

W

E

I

N

D

K

V

F

E

Q

T

N

L

L

D

K

D

D

L

F

D

E

A

G

V

-

A

-

A

-

Q

-

F

-

R

-

A

-

N

-

H

-

G

-

F

-

R

-

L

L

R

R

I

I

A

A

T

T

K

S

Y

Y

H

P

R

Q

L

L

V

L

H

K

S

R

H

F

L

M

S

K

A

E

H

N

G

G

V

I

A

-

D

N

Y

Y

Q

K

L

N

V

C

D

T

S

L

Q

T

G

G

A

S

T

V

E

E

-

V

G

A

T

P

V

R

A

A

N

N

L

L

T

-

A

A

E

D

A

A

I

I

A

C

D

D

I
x
L

T

V

S
|
S

T
x
S

G
|
G

E

A

T
|
T

L

L

R

Q

A

A

N

N

H

N

L

L

K

K

I

E

L

V

K

K

G

V

E

-

P

-

V

I

L

Y

K

E

S

S

Q

R

A

A

T

C

L

L

F

I

A

Q

S

K

R

E

M

N

A

A

binding adenosine monophosphate: L164 (≠ I178), S166 (= S180), S167 (≠ T181), G168 (= G182), T170 (= T184)

Sites not aligning to the query:

binding histidine: 226, 241, 242, 243, 244, 246, 262, 282, 284
binding magnesium ion: 220, 221

4yb7C Adenosine triphosphate phosphoribosyltransferase from campylobacter jejuni in complex with atp (see paper)
33% identity, 50% coverage: 93:211/239 of query aligns to 96:198/294 of 4yb7C

query
sites
4yb7C

L

L

G

D

F

F

G

G

H

Y

A
x
C

D

R

L

L

I

S

L

L

A

A

V

L

P

P

K

Q

C

-

W

E

I

N

D

K

V

F

E

Q

T

N

L

L

D

K

D

D

L

F

D

E

A

G

V

-

A

-

A

-

Q

-

F

-

R

-

A

-

N

-

H

-

G

-

F

-

R

-

L

L

R

R

I

I

A

A

T

T

K

S

Y

Y

H

P

R

Q

L

L

V

L

H

K

S

R

H

F

L

M

S

K

A

E

H

N

G

G

V

I

A

-

D

N

Y

Y

Q

K

L

N

V

C

D

T

S

L

Q

T

G

G

A

S

T

V

E

E

-

V

G

A

T

P

V

R

A

A

N

N

L

L

T

-

A

A

E

D

A

A

I

I

A

C

D

D

I
x
L

T
x
V

S
|
S

T
x
S

G
|
G

E

A

T
|
T

L

L

R

Q

A

A

N

N

H

N

L

L

K

K

I

E

L

V

K

K

G

V

E

-

P

-

V

I

L

Y

K

E

S

S

Q

R

A

A

T

C

L

L

F

I

A

Q

S

K

R

E

M

N

A

A

binding adenosine-5'-triphosphate: C101 (≠ A98), L167 (≠ I178), S169 (= S180)
binding phosphate ion: V168 (≠ T179), S169 (= S180), S170 (≠ T181), G171 (= G182), T173 (= T184)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 9, 12, 13, 51, 52, 72
binding magnesium ion: 52, 53

4yb7A Adenosine triphosphate phosphoribosyltransferase from campylobacter jejuni in complex with atp (see paper)
33% identity, 50% coverage: 93:211/239 of query aligns to 96:198/296 of 4yb7A

query
sites
4yb7A

L

L

G

D

F

F

G
|
G

H

Y

A
x
C

D

R

L

L

I

S

L

L

A

A

V

L

P

P

K

Q

C

-

W

E

I

N

D

K

V

F

E

Q

T

N

L

L

D

K

D

D

L

F

D

E

A

G

V

-

A

-

A

-

Q

-

F

-

R

-

A

-

N

-

H

-

G

-

F

-

R

-

L

L

R

R

I

I

A

A

T

T

K

S

Y

Y

H

P

R

Q

L

L

V

L

H

K

S

R

H

F

L

M

S

K

A

E

H

N

G

G

V

I

A

-

D

N

Y

Y

Q

K

L

N

V

C

D

T

S

L

Q

T

G

G

A

S

T

V

E

E

-

V

G

A

T

P

V

R

A

A

N

N

L

L

T

-

A

A

E

D

A

A

I

I

A

C

D

D

I
x
L

T

V

S
|
S

T

S

G

G

E

A

T

T

L

L

R

Q

A

A

N

N

H

N

L

L

K

K

I

E

L

V

K

K

G

V

E

-

P

-

V

I

L

Y

K

E

S

S

Q

R

A

A

T

C

L

L

F

I

A

Q

S

K

R

E

M

N

A

A

binding adenosine-5'-triphosphate: G99 (= G96), C101 (≠ A98), L167 (≠ I178), S169 (= S180)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 9, 12, 13, 14, 51, 52, 72
binding magnesium ion: 52, 53

4yb6A Adenosine triphosphate phosphoribosyltransferase from campylobacter jejuni in complex with the inhibitors amp and histidine (see paper)
33% identity, 50% coverage: 93:211/239 of query aligns to 96:198/296 of 4yb6A

query
sites
4yb6A

L

L

G

D

F

F

G

G

H

Y

A

C

D

R

L

L

I

S

L

L

A

A

V

L

P

P

K

Q

C

-

W

E

I

N

D

K

V

F

E

Q

T

N

L

L

D

K

D

D

L

F

D

E

A

G

V

-

A

-

A

-

Q

-

F

-

R

-

A

-

N

-

H

-

G

-

F

-

R

-

L

L

R

R

I

I

A

A

T

T

K

S

Y

Y

H

P

R

Q

L

L

V

L

H

K

S

R

H

F

L

M

S

K

A

E

H

N

G

G

V

I

A

-

D

N

Y

Y

Q

K

L

N

V

C

D

T

S

L

Q

T

G

G

A

S

T

V

E

E

-

V

G

A

T

P

V

R

A

A

N

N

L

L

T

-

A

A

E

D

A

A

I

I

A

C

D

D

I
x
L

T

V

S
|
S

T
x
S

G
|
G

E

A

T
|
T

L

L

R

Q

A

A

N

N

H

N

L

L

K

K

I

E

L

V

K

K

G

V

E

-

P

-

V

I

L

Y

K

E

S

S

Q

R

A

A

T

C

L

L

F

I

A

Q

S

K

R

E

M

N

A

A

binding adenosine monophosphate: L167 (≠ I178), S169 (= S180), S170 (≠ T181), G171 (= G182), T173 (= T184)

Sites not aligning to the query:

binding histidine: 229, 244, 245, 247, 249, 265, 287

5ub9A Catalytic core domain of adenosine triphosphate phosphoribosyltransferase from campylobacter jejuni (see paper)
32% identity, 51% coverage: 90:211/239 of query aligns to 92:196/220 of 5ub9A

query
sites
5ub9A

I

L

A

K

P

K

L

L

G

D

F

F

G

G

H

Y

A

C

D

R

L

L

I

S

L

L

A

A

V

L

P

P

K

Q

C

-

W

-

I

-

D

-

V

-

E

-

T

-

L

-

D

-

D

-

L

-

D

-

A

-

V

-

A

E

A

N

Q

K

F

F

R

N

A

L

N

K

H

D

G

F

F

E

R

G

L

L

R

R

I

I

A

A

T

T

K

S

Y

Y

H

P

R

Q

L

L

V

L

H

K

S

R

H

F

L

M

S

K

A

E

H

N

G

G

V

I

A

-

D

N

Y

Y

Q

K

L

N

V

C

D

T

S

L

Q

T

G

G

A

S

T

V

E

E

-

V

G

A

T

P

V

R

A

A

N

N

L

L

T

-

A

A

E

D

A

A

I

I

A

C

D

D

I

L

T

V

S

S

T

S

G

G

E

A

T

T

L

L

R

Q

A

A

N

N

H

N

L

L

K

K

I

E

L

V

K

K

G

-

E

-

P

V

V

I

L

Y

K

E

S

S

Q

R

A

A

T

C

L

L

F

I

A

Q

S

K

R

E

M

N

A

A

Sites not aligning to the query:

binding zinc ion: 29, 31

Query Sequence

>3609569 FitnessBrowser__Dino:3609569
MTLKLGVPSKGRLMDKTFDWFGRHGITLQRTGSEREYAGSVDGVDGVALVLLSAGEIPRE
LAAGRIHLGVTGTDLVQEKLPDWMRQVRSIAPLGFGHADLILAVPKCWIDVETLDDLDAV
AAQFRANHGFRLRIATKYHRLVHSHLSAHGVADYQLVDSQGATEGTVANLTAEAIADITS
TGETLRANHLKILKGEPVLKSQATLFASRMADWDPTARAAMRALGAAMGRDDATDGVFQ

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory