SitesBLAST
Comparing 3610446 FitnessBrowser__Dino:3610446 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
P77455 Bifunctional protein PaaZ; EC 3.3.2.12; EC 1.2.1.91 from Escherichia coli (strain K12) (see paper)
51% identity, 99% coverage: 8:675/678 of query aligns to 6:673/681 of P77455
- E256 (= E258) mutation to Q: Catalyzes the formation of 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde instead of 3-oxo-5,6-dehydrosuberyl-CoA.
6jqoA Structure of paaz, a bifunctional enzyme in complex with NADP+ and ccoa (see paper)
51% identity, 99% coverage: 8:675/678 of query aligns to 5:672/678 of 6jqoA
- active site: N157 (= N160), E255 (= E258), C294 (= C297), L483 (= L491)
- binding crotonyl coenzyme a: V97 (≠ I100), F107 (= F110), S111 (= S114), F158 (= F161), W161 (= W164), R638 (≠ A647)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: N154 (= N157), F156 (= F159), N157 (= N160), T183 (= T186), T230 (= T233), G231 (= G234), S232 (= S235), T235 (= T238), A256 (≠ Q259), D257 (= D260), C294 (= C297)
6jqnA Structure of paaz, a bifunctional enzyme in complex with NADP+ and ocoa (see paper)
51% identity, 99% coverage: 8:675/678 of query aligns to 5:672/678 of 6jqnA
- active site: N157 (= N160), E255 (= E258), C294 (= C297), L483 (= L491)
- binding octanoyl-coenzyme a: F562 (= F570), H565 (= H573), F576 (= F585), G583 (= G592), V595 (= V604), A604 (= A613), N605 (= N614), Y606 (≠ T615), F613 (= F622), I614 (≠ L623)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: R19 (= R22), I153 (= I156), N154 (= N157), A155 (= A158), F156 (= F159), K180 (= K183), A182 (= A185), T183 (= T186), T230 (= T233), G231 (= G234), S232 (= S235), T235 (= T238), L239 (= L242), E255 (= E258), A256 (≠ Q259), D257 (= D260), C294 (= C297), F396 (= F404), H471 (= H479)
6jqmA Structure of paaz with NADPH (see paper)
51% identity, 99% coverage: 8:675/678 of query aligns to 5:672/678 of 6jqmA
- active site: N157 (= N160), E255 (= E258), C294 (= C297), L483 (= L491)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: R19 (= R22), I153 (= I156), N154 (= N157), A155 (= A158), F156 (= F159), N157 (= N160), K180 (= K183), A182 (= A185), T183 (= T186), G231 (= G234), S232 (= S235), T235 (= T238), A256 (≠ Q259), D257 (= D260), C294 (= C297), E394 (= E402), F396 (= F404)
2vroA Crystal structure of aldehyde dehydrogenase from burkholderia xenovorans lb400 (see paper)
44% identity, 70% coverage: 6:479/678 of query aligns to 6:484/521 of 2vroA
- active site: N160 (= N160), K183 (= K183), E258 (= E258), C297 (= C297), E401 (= E402)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I156 (= I156), K183 (= K183), S217 (≠ L217), S235 (= S235), T238 (= T238), L242 (= L242), F403 (= F404)
Sites not aligning to the query:
2y53A Crystal structure of e257q mutant of the box pathway encoded aldh from burkholderia xenovorans lb400 (see paper)
45% identity, 70% coverage: 6:479/678 of query aligns to 6:483/529 of 2y53A
- active site: N160 (= N160), K183 (= K183), Q258 (≠ E258), C297 (= C297), E401 (= E402)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: I156 (= I156), N157 (= N157), F159 (= F159), N160 (= N160), K183 (= K183), A185 (= A185), T186 (= T186), S217 (≠ L217), F232 (= F232), G234 (= G234), S235 (= S235), A236 (= A236), T238 (= T238), A259 (≠ Q259), D260 (= D260), C297 (= C297), F403 (= F404)
Sites not aligning to the query:
4neaA 1.90 angstrom resolution crystal structure of betaine aldehyde dehydrogenase (betb) from staphylococcus aureus in complex with NAD+ and bme-free cys289 (see paper)
27% identity, 65% coverage: 62:501/678 of query aligns to 77:486/505 of 4neaA
- active site: N166 (= N160), K189 (= K183), E264 (≠ N263), C298 (= C297), E399 (= E402), E476 (= E490)
- binding nicotinamide-adenine-dinucleotide: P164 (≠ A158), K189 (= K183), E192 (≠ T186), G222 (vs. gap), G226 (= G218), G242 (= G234), G243 (≠ S235), T246 (= T238), H249 (= H247), I250 (≠ L248), C298 (= C297), E399 (= E402), F401 (= F404)
3b4wA Crystal structure of mycobacterium tuberculosis aldehyde dehydrogenase complexed with NAD+
27% identity, 65% coverage: 64:506/678 of query aligns to 67:475/483 of 3b4wA
- active site: N154 (= N160), K177 (= K183), E251 (= E258), C285 (= C297), E384 (= E402), E460 (≠ A485)
- binding nicotinamide-adenine-dinucleotide: I150 (= I156), V151 (≠ N157), W153 (≠ F159), N154 (= N160), K177 (= K183), I210 (≠ L217), G213 (= G218), T228 (= T233), G229 (= G234), S230 (= S235), V233 (≠ T238), E236 (≠ R241), E251 (= E258), L252 (≠ Q259), C285 (= C297), E384 (= E402), F386 (= F404)
6mvtA Structure of a bacterial aldh16 complexed with nadh (see paper)
28% identity, 72% coverage: 5:493/678 of query aligns to 17:458/751 of 6mvtA
- active site: N151 (= N160), E247 (≠ N263), C281 (= C297), E450 (≠ A485)
- binding 1,4-dihydronicotinamide adenine dinucleotide: V147 (≠ I156), I148 (≠ N157), K174 (= K183), E177 (≠ T186), G207 (vs. gap), G210 (= G218), E211 (≠ D219), F223 (= F232), S226 (= S235), V229 (≠ T238), D327 (≠ G343), R331 (= R353)
6mvsA Structure of a bacterial aldh16 complexed with NAD (see paper)
28% identity, 72% coverage: 5:493/678 of query aligns to 17:458/751 of 6mvsA
- active site: N151 (= N160), E247 (≠ N263), C281 (= C297), E450 (≠ A485)
- binding nicotinamide-adenine-dinucleotide: V147 (≠ I156), I148 (≠ N157), W150 (≠ F159), K174 (= K183), E177 (≠ T186), G207 (vs. gap), G210 (= G218), E211 (≠ D219), F223 (= F232), S226 (= S235), V229 (≠ T238)
7uyyA The crystal structure of the pseudomonas aeruginosa aldehyde dehydrogenase encoded by the pa4189 gene in complex with nadh (see paper)
30% identity, 44% coverage: 151:448/678 of query aligns to 160:448/496 of 7uyyA
- binding 1,4-dihydronicotinamide adenine dinucleotide: V165 (≠ I156), L166 (≠ N157), P167 (≠ A158), W168 (≠ F159), K192 (= K183), G225 (vs. gap), G229 (= G218), F243 (= F232), G245 (= G234), S246 (= S235), T249 (= T238), L252 (= L240), F253 (≠ R241), Y256 (≠ A244), C269 (≠ Q259), G270 (≠ D260), C303 (= C297), H350 (≠ Q344), K353 (≠ D347), F400 (= F404)
1ky8A Crystal structure of the non-phosphorylating glyceraldehyde-3- phosphate dehydrogenase (see paper)
27% identity, 46% coverage: 151:460/678 of query aligns to 157:449/499 of 1ky8A
- active site: N166 (= N160), K189 (= K183), E261 (= E258), C295 (= C297), E393 (= E402)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: I162 (= I156), T163 (≠ N157), F165 (= F159), N166 (= N160), K189 (= K183), S191 (≠ A185), I192 (≠ T186), P221 (≠ G216), G222 (= G218), A225 (≠ L221), E226 (≠ D222), F239 (= F232), T240 (= T233), G241 (= G234), S242 (= S235), V245 (≠ T238), E261 (= E258), L262 (≠ Q259), G263 (≠ D260), C295 (= C297), E393 (= E402), F395 (= F404)
Sites not aligning to the query:
O57693 NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase; Glyceraldehyde phosphate dehydrogenase (NAD(P)); GAPN; EC 1.2.1.90 from Thermoproteus tenax (see 2 papers)
27% identity, 46% coverage: 151:460/678 of query aligns to 159:451/501 of O57693
- T165 (≠ N157) binding ; binding
- N168 (= N160) binding
- Y184 (≠ A176) binding
- K191 (= K183) binding
- KPSI 191:194 (≠ KPAT 183:186) binding
- G224 (= G218) binding
- E228 (≠ D222) binding ; binding
- S244 (= S235) binding ; binding
- G265 (≠ D260) binding ; binding
- RCD 296:298 (≠ KCT 296:298) binding
- E395 (= E402) binding ; binding
Sites not aligning to the query:
- 72 binding ; binding ; binding
- 79 binding ; binding ; binding
- 134 binding
- 154:155 binding ; binding
- 455:456 binding
6mvuA Structure of a bacterial aldh16 active site mutant c295a complexed with p-nitrophenylacetate (see paper)
28% identity, 72% coverage: 5:493/678 of query aligns to 17:458/752 of 6mvuA
- active site: N151 (= N160), E247 (≠ N263), A281 (≠ C297), E450 (≠ A485)
- binding 4-nitrophenyl acetate: G207 (vs. gap), G210 (= G218), E211 (≠ D219), V214 (≠ L224), V229 (≠ T238), R232 (= R241), I233 (≠ L242), A236 (= A245)
3hazA Crystal structure of bifunctional proline utilization a (puta) protein (see paper)
29% identity, 54% coverage: 150:518/678 of query aligns to 642:983/983 of 3hazA
- active site: N652 (= N160), K675 (= K183), E752 (= E258), C786 (= C297), E878 (= E402), A960 (≠ L491)
- binding nicotinamide-adenine-dinucleotide: I648 (= I156), S649 (≠ N157), P650 (≠ A158), W651 (≠ F159), N652 (= N160), I657 (≠ G165), K675 (= K183), P676 (= P184), A677 (= A185), G708 (= G218), G711 (≠ L221), A712 (≠ D222), T726 (= T233), G727 (= G234), S728 (= S235), V731 (≠ T238), I735 (≠ L242), E752 (= E258), T753 (≠ Q259), C786 (= C297), E878 (= E402), F880 (= F404), F948 (≠ H479)
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 272, 273, 306, 333, 335, 336, 337, 338, 339, 340, 358, 359, 360, 361, 364, 387, 388, 389, 390, 435, 460, 461
4yweA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
29% identity, 51% coverage: 150:493/678 of query aligns to 137:464/476 of 4yweA
Sites not aligning to the query:
3jz4A Crystal structure of e. Coli NADP dependent enzyme (see paper)
25% identity, 72% coverage: 2:486/678 of query aligns to 6:463/481 of 3jz4A
- active site: N156 (= N160), K179 (= K183), E254 (≠ N263), C288 (= C297), E385 (= E402), E462 (≠ A485)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: P154 (≠ A158), W155 (≠ F159), K179 (= K183), A181 (= A185), S182 (≠ T186), A212 (≠ L217), G216 (≠ L221), G232 (= G234), S233 (= S235), I236 (≠ T238), C288 (= C297), K338 (≠ R353), E385 (= E402), F387 (= F404)
6dbbA Crystal structure of a putative aldehyde dehydrogenase family protein burkholderia cenocepacia j2315 in complex with partially reduced nadh
28% identity, 52% coverage: 151:503/678 of query aligns to 143:483/504 of 6dbbA
- active site: N152 (= N160), E259 (= E258), C293 (= C297), E471 (= E490)
- binding nicotinamide-adenine-dinucleotide: I148 (= I156), S149 (≠ N157), A150 (= A158), F151 (= F159), N152 (= N160), K175 (= K183), S177 (≠ A185), R218 (vs. gap), T236 (= T233), G237 (= G234), S238 (= S235), M241 (≠ T238), E259 (= E258), L260 (≠ Q259), G261 (≠ D260), C293 (= C297), E391 (= E402), F393 (= F404)
- binding beta-6-hydroxy-1,4,5,6-tetrhydronicotinamide adenine dinucleotide: I148 (= I156), S149 (≠ N157), A150 (= A158), F151 (= F159), N152 (= N160), K175 (= K183), S177 (≠ A185), R218 (vs. gap), T236 (= T233), G237 (= G234), S238 (= S235), M241 (≠ T238), E259 (= E258), L260 (≠ Q259), G261 (≠ D260), C293 (= C297), E391 (= E402), F393 (= F404)
4nmfB Crystal structure of proline utilization a (puta) from geobacter sulfurreducens pca inactivated by n-propargylglycine and complexed with menadione bisulfite (see paper)
26% identity, 53% coverage: 141:501/678 of query aligns to 613:955/979 of 4nmfB
Sites not aligning to the query:
- binding (2R)-2-methyl-1,4-dioxo-1,2,3,4-tetrahydronaphthalene-2-sulfonic acid: 184, 290, 387, 399, 402, 403
- binding (2S)-2-methyl-1,4-dioxo-1,2,3,4-tetrahydronaphthalene-2-sulfonic acid: 184, 366, 399, 402
- binding N-propargylglycine-modified flavin adenine dinucleotide: 184, 225, 226, 255, 257, 284, 286, 287, 288, 289, 291, 308, 309, 310, 311, 314, 337, 338, 339, 340, 364, 366, 387, 406, 411, 412, 413
6x9lA Crystal structure of aldehyde dehydrogenasE C (aldc) mutant (c291a) from pseudomonas syringae in complexed with NAD+ and octanal (see paper)
28% identity, 53% coverage: 151:508/678 of query aligns to 145:479/485 of 6x9lA
- active site: N154 (= N160), E252 (= E258), A286 (≠ C297), E462 (= E490)
- binding nicotinamide-adenine-dinucleotide: I150 (= I156), T151 (≠ N157), W153 (≠ F159), N154 (= N160), Q159 (≠ G165), K177 (= K183), E180 (≠ T186), G210 (vs. gap), P211 (vs. gap), G214 (= G218), T229 (= T233), G230 (= G234), S231 (= S235), E252 (= E258), L253 (≠ Q259), A286 (≠ C297), E386 (= E402), F388 (= F404), F451 (≠ H479)
- binding octanal: W155 (≠ F161), S285 (≠ K296)
Query Sequence
>3610446 FitnessBrowser__Dino:3610446
MSLLDVQSFAAGHWIAPDADARMIAHAVTGAPLARAGNGALDVQAMLDYARDTGGPALRA
LTFHDRARMLKALALHLGAHKQALYDLSFATGATQADHLIDIDGGIGTVFVFASKGRREM
PDAHVYLDGEVEQLSRTGTFLGQHIATPLQGVAVHINAFNFPVWGMLEKLAPTLLAGMPA
IVKPATASCYVTEKAVRIILDSGILPAGALQLVTGGLGDMLDRLTCQDVVSFTGSADTAL
RLRAAPHLLRNAVRFVAEQDSLNASILGPDAVPGTPEFDLFIREVAREMTAKAGQKCTAI
RRILAPQAQVDGVIAALGARLAKTVIGDPRDTATTMGALVSNGQKRDVLAKARVIATEAE
RVFGDPEAFTVHGADARTGAFLPPMLLHCADPDAAQRLHDTEAFGPVSTVMGYRDLDHAV
ALVNRGAGSLVASLITHDPEVARQVALGAGAFHGRLYINDRDSMGEATGHGAPLPHMIHG
GPGRAGGGEELGGVRGVMHYMQRTAIQGSPDMLTAIGGKWVPGATETPAPAHPFTRGFDA
LRIGETLHTPARQVTLADIEHFAAFTGDTFYAHMDDAAAARNPFFPGRVAHGYLLLSFAA
GLFVDPDEGPVLANTGLDSLRFLKPVAPGDSLKARLTVKHKTPRNDAYGEVRWHVSLTNQ
EDDLVAEYELLTMIAYAA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory